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Aliases & Descriptions for LAMA1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Laminin A chain 3 | | laminin, alpha 1 2 |
|
| | Search outside databases for aliases for LAMA1 genePrevious GC identifers: GC18M006877 GC18M007006 |
Summaries for LAMA1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix componentsGene Wiki entry for LAMA1 (Laminin%2C_alpha_1) |
Genomic Location for LAMA1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LAMA1 gene 
Entrez Gene cytogenetic band: 18p11.31 Ensembl cytogenetic band: 18p11.31 HGNC cytogenetic band: 18p11.3LAMA1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18M006931:
(about GC identifiers)
Start:
|
6,931,885 bp from pter |
End:
|
7,107,813 bp from pter |
Size:
|
175,929 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000018.8 NT_010859.14
| Proteins for LAMA1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391 (See
protein sequence)Recommended Name: Laminin subunit alpha-1 precursor Size: 3075 amino acids; 337158 Da
Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma), which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms with globules at each end. Alpha-1 is a subunit of laminin-1 (EHS laminin) and laminin-3 (S-laminin)
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major componentPost-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005550.2
ENSEMBL proteins: ENSP00000341000 ENSP00000374309
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for LAMA1: Assays for LAMA1: | Protein
Domains/ Families for LAMA1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P25391
ProtoNet protein and cluster: P25391 5 Blocks protein families: IPB000034 Laminin B IPB001791 Laminin G IPB002049 Laminin-type EGF-like domain IPB009254 Laminin I IPB012679 Laminin G
UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil structureDomain: Domains VI, IV and G are globularSimilarity: Contains 17 laminin EGF-like domainsSimilarity: Contains 5 laminin G-like domainsSimilarity: Contains 2 laminin IV type A domainsSimilarity: Contains 1 laminin N-terminal domain | Gene Function for LAMA1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005559
Applied Biosystems Silencer® siRNAs for LAMA1
Sigma-Aldrich siRNA for LAMA1  Sigma-Aldrich shRNA Panels and shRNA for LAMA1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005559                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005559                                  untagged cDNA clones in CMV expression vector (see all 2): AK091949 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005559
UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix componentsGenatlas biochemistry entry for LAMA1:laminin,alpha 1 polypeptide,component of cutaneous basement membrane zone5 MGI mutant phenotypes (inferred from 5 alleles ) (MGI details for Lama1):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for LAMA1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Sigma-Aldrich "Your Favorite Gene" Pathways for LAMA1 (Your Favorite Gene powered by Ingenuity) 
1 Interacting protein for LAMA1 (P253912) via UniProtKB, MINT, and/or STRINGAbout this table
5/9 Gene Ontology (GO) biological process terms (links to tree view) (see all 9
): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002011 | morphogenesis of an epithelial sheet |
IEA | -- | | GO:0007166 | cell surface receptor linked signal transduction |
IEA | -- | | GO:0007275 | multicellular organismal development |
NAS | -- | | GO:0009888 | tissue development |
IEA | -- | | GO:0030155 | regulation of cell adhesion |
IEA | -- | About this table
|
Drugs & Compounds for LAMA1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LAMA1 1 Novoseek chemical compound relationship for LAMA1 gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| lysine |
0.00 |
2 |
8360181 (1) |
About this table
|
Transcripts for LAMA1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005559
Sigma-Aldrich siRNA for LAMA1  Sigma-Aldrich shRNA Panels and shRNA for LAMA1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005559 REFSEQ mRNAs for LAMA1 gene: NM_005559.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005559               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005559                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005559                                  untagged cDNA clones in CMV expression vector (see all 2): AK091949  Additional cDNA sequence: BC041471.1 10 DOTS entries: DT.101982347 DT.99962344 DT.209867 DT.99994509 DT.101972320 DT.95325256 DT.40295787 DT.121103469 DT.91929959 DT.97785718 2 AceView cDNA sequences:BC041471 BI837819
highest scoring ESTs for LAMA1:AI750156 AW003207 X58531 AA062659 AA226874 AA227077 AA305124 AA514648 AF351616 AI039096 Unigene Clusters for LAMA1: Laminin, alpha 1 Hs.270364 [show with all ESTs], Hs.680444 [show with all ESTs]Unigene Representative Sequences: BC144590, BC041471
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for LAMA1 (see all 12
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28a | · | 28b | ^ | 29a | · | 29b | · | 29c | ^ | 30 | ^ | 31 | ^ | 32a | · | 32b | ^ | 33 | ^ | 34 | ^ | 35 | ^ | 36a | · | 36b | ^ | 37 | ^ | 38 | ^ | 39 | ^ | 40 | ^ | 41 | ^ | 42 | |
| SP1: | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for LAMA1
2 Ensembl transcripts including schematic representations: ENST00000344342
ENST00000389658
|
Expression for LAMA1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LAMA1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LAMA1
1 / 2 / 3 6 probe-sets matching LAMA1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.270364 Hs.680444
|
Orthologs for LAMA1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LAMA1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for LAMA1
ENSEMBL Gene Tree for LAMA1 | Paralogs for LAMA1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LAMA1 gene
- LAMA22
|
SNPs/Variants for LAMA1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LAMA1 (up to first 250kb)
|
Disorders & Mutations for LAMA1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 150320
4 Novoseek disease relationships for LAMA1 gene
About this table
Human Genome Epidemiology Navigator: LAMA1 (1 document)
|
Medical News for LAMA1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LAMA1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/143 PubMed articles for LAMA1 gene (see all 143
):- Primary structure of the human laminin A chain. Limited expression in human tissues. (PubMed id 2049067)1, 3, 4 Nissinen M....Tryggvason K. (1991)
- Molecular cloning of the cDNA encoding human laminin A chain. (PubMed id 1714537)1, 3, 4 Haaparanta T.... Engvall E. (1991)
- Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. (PubMed id 2591971)2, 3 Nagayoshi T....Uitto J. (1989)
- Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. (PubMed id 2733383)3, 4 Olsen D.... Uitto J. (1989)
- The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. (PubMed id 8360181)1, 3 Moser T.L....Stack M.S. (1993)
- Sulfatide-binding domain of the laminin A chain. (PubMed id 2373692)1, 3 Taraboletti G....Roberts D.D. (1990)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)4 Chen R.... Zou H. (2009)
- Molecular genetics of successful smoking cessation: convergent genome-wide association study results. (PubMed id 18519826)3 Uhl G.R....Lerman C. (2008)
- Ethanol increases fetal human neurosphere size and alters adhesion molecule gene expression. (PubMed id 18162078)3 Vangipuram S.D....Lyman W.D. (2008)
- CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and alpha6 integrin expression. (PubMed id 18436868)3 Castaldo C....Montagnani S. (2008)
|
Search for LAMA1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LAMA1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LAMA1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LAMA1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LAMA1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LAMA1:

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GeneCards Homepage - Last full update: 2 Jul 2009
Incremental update: 13 Oct 2009
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