Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LAMA1 Gene

protein-coding GIFtS: 63
GCID: GC18M006941

laminin, alpha 1

(Previous symbol: LAMA)

Explore 34 diseases affiliated with
LAMA1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Laminin, Alpha 1¹ ²		S-Laminin Subunit Alpha² ³
LAMA¹ ² ³		S-LAM-Alpha¹
Laminin A Chain² ³		Laminin Subunit Alpha-1²
Laminin-3 Subunit Alpha² ³		Laminin-1 Subunit Alpha³
S-LAM Alpha² ³

External Ids:	HGNC: 6481¹	Entrez Gene: 284217²	Ensembl: ENSG00000101680⁷	OMIM: 150320⁵	UniProtKB: P25391³

ORGUL members:
	NONCODE:n339785

Export aliases for LAMA1 gene to outside databases

Previous GC identifers: GC18M006877 GC18M007006 GC18M006931 GC18M006905

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and

organization of cells into tissues during embryonic development by interacting with other extracellular matrix

components

Gene Wiki entry for LAMA1 (Laminin, alpha 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000018.9 NC_018929.1 NT_010859.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LAMA1 gene promoter:
Max1 AML1a Sp1 E47 YY1 AREB6 MEF-2A aMEF-2 c-Myc
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LAMA1 promoter sequence

Search SABiosciences Chromatin IP Primers for LAMA1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMA1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.3 Ensembl cytogenetic band: 18p11.23 HGNC cytogenetic band: 18p11.3

LAMA1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAMA1 gene location

GeneLoc information about chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M006941: view genomic region (about GC identifiers)

Start:	6,941,743 bp from pter	End:	7,117,813 bp from pter
Size:	176,071 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391 (See protein sequence)

Recommended Name: Laminin subunit alpha-1 precursor

Size: 3075 amino acids; 337084 Da

Subunit: Laminin is a complex glycoprotein, consisting of three different polypeptide chains (alpha, beta, gamma),

which are bound to each other by disulfide bonds into a cross-shaped molecule comprising one long and three short arms

with globules at each end. Alpha-1 is a subunit of laminin-1 (laminin-111 or EHS laminin) and laminin-3 (laminin-121

or S-laminin)

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane. Note=Major component

Explore the universe of human proteins at neXtProt for LAMA1: NX_P25391

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P25391

LAMA1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005550.2

ENSEMBL proteins:

ENSP00000374309

Reactome Protein details: P25391
Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for LAMA1
	GenScript Custom Purified and Recombinant Proteins Services for LAMA1
	Novus Biologicals LAMA1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005578	proteinaceous extracellular matrix	ISS	--
GO:0005604	basement membrane	IDA	2099832
GO:0005606	laminin-1 complex	IPI	10964500
GO:0005608	laminin-3 complex	IPI	10964500

LAMA1 for ontologies About GeneDecksing

LAMA1 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMA1
	R&D Systems Antibodies for LAMA1 (Laminin alpha 1)
	OriGene Antibodies: LAMA1 OriGene Custom Antibody Services for LAMA1
	GenScript Custom Superior Antibodies Services for LAMA1
	Novus Biologicals LAMA1 Antibodies
	Search for Antibodies for LAMA1 at Abcam
	Browse Antibodies at Uscn
	ThermoFisher Antibody for LAMA1

Assay Products for LAMA1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LAMA1
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LAMA1 for domains About GeneDecksing

5/9 InterPro domains/families (see all 9):

IPR000034 Laminin_B_type_IV

IPR008211 Laminin_N

IPR013320 ConA-like_subgrp

IPR001791 Laminin_G

IPR009254 Laminin_I

Graphical View of Domain Structure for InterPro Entry P25391

ProtoNet protein and cluster: P25391

5 Blocks protein families:

IPB000034 Laminin B

IPB001791 Laminin G

IPB002049 Laminin-type EGF-like domain

IPB009254 Laminin I

IPB012679 Laminin G

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391

Domain: The alpha-helical domains I and II are thought to interact with other laminin chains to form a coiled coil

structure

Domain: Domains VI, IV and G are globular

Similarity: Contains 17 laminin EGF-like domains

Similarity: Contains 5 laminin G-like domains

Similarity: Contains 2 laminin IV type A domains

Similarity: Contains 1 laminin N-terminal domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: LAMA1_HUMAN, P25391

Function: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and

organization of cells into tissues during embryonic development by interacting with other extracellular matrix

components

Genatlas biochemistry entry for LAMA1:

laminin,alpha 1 polypeptide,component of cutaneous basement membrane zone

miRNA Products:		OriGene 3'-UTR Clone: LAMA1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMA1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMA1:
		hsa-miR-219-1-3p hsa-miR-571 hsa-miR-202
		SwitchGear 3'UTR luciferase reporter plasmid: LAMA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAMA1 (see all 7) OriGene shRNA RFP: LAMA1 OriGene siRNA: LAMA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMA1

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for LAMA1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAMA1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAMA1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LAMA1 (NM_005559)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMA1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LAMA1
		Search LifeMap BioReagents cell lines for LAMA1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	IEA	--
GO:0005201	extracellular matrix structural constituent	ISS	--
GO:0005515	protein binding	--	--
GO:0043208	glycosphingolipid binding	IEA	--

LAMA1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-outs for LAMA1: Lama1^tm1.1Olf Lama1^tm1Ekb Lama1^tm1.2Arhi Lama1^tm1.1Ekb
     10 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Lama1):

behavior/neurological	cardiovascular system	cellular	embryogenesis	growth/size
mortality/aging	nervous system	normal	reproductive system	vision/eye

LAMA1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/20 super-pathways (see all 20) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

Cell adhesion_Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling Integrin outside-in signaling	0.37
Cell adhesion Integrin-mediated cell adhesion and migration	1.00	Cell adhesion_Endothelial cell contacts by non-junctional mechanisms	0.21
Cytoskeleton remodeling_Integrin outside-in signaling	0.37	Cell adhesion Endothelial cell contacts by non-junctional mechanisms	0.21

Integrin Pathway

Integrin Pathway	1.00	UPA-UPAR Pathway	0.51
FAK1 Signaling	0.67	Transendothelial Migration of Leukocytes	0.38
GnRH Signaling	0.56	Inhibition of Angiogenesis by TSP1	0.37

Rho Family GTPases

Rho Family GTPases	1.00	MAPK Signaling	0.51
ERK Signaling	0.61	ILK Signaling	0.45
Molecular Mechanisms of Cancer	0.51

Axon guidance

	Axon guidance	1.00			L1CAM interactions	0.39
	Developmental Biology	0.69

Cell adhesion_ECM remodeling

	Cell adhesion ECM remodeling	1.00			Metalloproteases in connective tissue degradation	0.31
	Cell adhesion_ECM remodeling	1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/7 EMD Millipore Pathways for LAMA1 (see all 7)

	Cell adhesion Integrin-mediated cell adhesion and migration
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion ECM remodeling
	Metalloproteases in connective tissue degradation

5/14 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for LAMA1 (see all 14)

	MAPK Signaling
	Molecular Mechanisms of Cancer
	PTEN Pathway
	CDK5 Pathway
	Transendothelial Migration of Leukocytes

5/6 GeneGo (Thomson Reuters) Pathways for LAMA1 (see all 6)

	Cell adhesion Endothelial cell contacts by non-junctional mechanisms
	Cytoskeleton remodeling Integrin outside-in signaling
	Cell adhesion Cell-matrix glycoconjugates
	Cell adhesion Integrin-mediated cell adhesion and migration
	Cell adhesion ECM remodeling

5 BioSystems Pathways for LAMA1

	Focal Adhesion
	Alpha6-Beta4 Integrin Signaling Pathway
	Glypican 1 network
	Syndecan-4-mediated signaling events
	Syndecan-2-mediated signaling events

5 Reactome Pathways for LAMA1

	L1CAM interactions
	Developmental Biology
	Integrin cell surface interactions
	Signal Transduction
	Axon guidance

5/6 Kegg Pathways (Kegg details for LAMA1) (see all 6):

	Focal adhesion
	ECM-receptor interaction
	Toxoplasmosis
	Amoebiasis
	Pathways in cancer

LAMA1 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LAMA1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/56 Interacting proteins for LAMA1 (P25391^{2, 3} ENSP00000374309⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 56)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ITGA1	P56199³, ENSP00000282588⁴	I2D: score=2 STRING: ENSP00000282588
ITGA2	P17301³, ENSP00000296585⁴	I2D: score=2 STRING: ENSP00000296585
NID1	P14543³, ENSP00000264187⁴	I2D: score=2 STRING: ENSP00000264187
PLAT	P00750³, ENSP00000220809⁴	I2D: score=2 STRING: ENSP00000220809
APP	P05067³, ENSP00000284981⁴	I2D: score=1 STRING: ENSP00000284981

About this table

Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002011	morphogenesis of an epithelial sheet	IEA	--
GO:0007155	cell adhesion	IEA	--
GO:0007166	cell surface receptor signaling pathway	ISS	--
GO:0007411	axon guidance	TAS	--
GO:0009888	tissue development	--	--

LAMA1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LAMA1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LAMA1

1 HMDB Compound for LAMA1 About this table

Compound	Synonyms	CAS #	PubMed Ids
3-O-Sulfogalactosylceramide (d18:1/24:0)	Sulfatide (d18:1/24:0) (see all 16)	151122-71-3	--

4 Novoseek chemical compound relationships for LAMA1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
heparin	6.63	2	8068026 (1), 1532944 (1)
lysine	0	2	8360181 (1)
retinoic acid	0	2	9486851 (1)
cysteine	0	2	2071595 (1), 2049067 (1)

Search CenterWatch for drugs/clinical trials and news about LAMA1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LAMA1 gene:

NM_005559.3

Unigene Cluster for LAMA1:

Laminin, alpha 1

Hs.270364 [show with all ESTs]

Unigene Representative Sequence: NM_005559

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000389658(uc002knm.3) ENST00000492048(uc002knk.3) ENST00000488064(uc002knl.3)

ENST00000579014(uc010wzj.2) ENST00000488089 ENST00000490190 ENST00000484335

ENST00000585178

miRNA Products:		OriGene 3'-UTR Clone: LAMA1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAMA1
		3 QIAGEN miScript miRNA Assays for microRNAs that regulate LAMA1:
		hsa-miR-219-1-3p hsa-miR-571 hsa-miR-202
		SwitchGear 3'UTR luciferase reporter plasmid: LAMA1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAMA1 (see all 7) OriGene shRNA RFP: LAMA1 OriGene siRNA: LAMA1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMA1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAMA1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAMA1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LAMA1 (NM_005559)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAMA1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMA1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAMA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LAMA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAMA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMA1

Additional cDNA sequence:

AK091949.1 AK093376.1 BC016997.1 BC032758.1 BC039051.1 BC062318.1 BC107693.1 X58531.1

9 DOTS entries:

DT.101982347 DT.99962344 DT.209867 DT.99994509 DT.40295787 DT.101972320 DT.121103469 DT.91929959

DT.97785718

2 AceView cDNA sequences:

BC041471 BI837819

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for LAMA1 (see all 12) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^	22a	·	22b	^	23	^	24	^
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	25a	·	25b	^	26	^	27	^	28a	·	28b	^	29a	·	29b	·	29c	^	30	^	31	^	32a	·	32b	^	33	^	34	^	35	^	36a	·	36b	^	37	^	38	^	39	^	40	^	41	^	42
SP1:													-																				-
SP2:																							-										-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for LAMA1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LAMA1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAACAAAT

About this image

LAMA1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Epicardium

Mural Trophectoderm Cells

Extraembryonic Tissues

Hypoblast

Hypoblast Cells

Extraembryonic Tissues

Inner Cell Mass

Inner Cell Mass Cells

Early Embryo

Placenta

Chorionic Villus

Villous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Trophoblast

Trophoblast Cells

Extraembryonic Tissues

Kidney

Kidney

Ovary

Ovary

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Blimp1- mVenus and stella-ECFP genetically modified stem cells (Embryonic Stem Cell)

Early Embryo, Inner Cell Mass

Extraembryonic endoderm-like cells (Generation of extrae...)

See LAMA1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LAMA1

SOURCE GeneReport for Unigene cluster: Hs.270364

SABiosciences Expression via Pathway-Focused PCR Arrays including LAMA1:

Extracellular Matrix & Adhesion Molecules in human mouse rat

Atherosclerosis in human mouse rat

Embryonic Stem Cells in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAMA1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LAMA1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAMA1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMA1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LAMA1 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	LAMA1¹	laminin, alpha 1	68.91(n) 65.92(a)		374016 NM_001199806.1 NP_001186735.1
lizard (Anolis carolinensis)	Reptilia	LAMA1⁶	--	64(a)	1 ↔ 1	GL343431.1(47465-151585)
tropical clawed frog (Xenopus tropicalis)	Amphibia	137711043²	--	78.98(n)		137711043
zebrafish (Danio rerio)	Actinopterygii	lama1¹	laminin, alpha 1	58.12(n) 53.1(a)		569971 NM_001034986.1 NP_001030158.1
fruit fly (Drosophila melanogaster)	Insecta	wb⁶	wing blister	20(a)	1 → many	2L(14263027-14328262)
worm (Caenorhabditis elegans)	Secernentea	lam-3⁶	LAMinin related. See also lmb- family member (lam-...	25(a)	1 → many	I(10608455-10621417)

ENSEMBL Gene Tree for LAMA1 (if available)
TreeFam Gene Tree for LAMA1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LAMA1 gene

NTN4² NTN5² LAMA3² LAMA2² LAMB2² LAMC1² LAMC2² LAMA5²

NTN3² LAMB3² LAMC3² LAMA4² NTN1² NTNG1² USH2A² LAMB4²

NTNG2² LAMB1²

7 SIMAP similar genes for LAMA1 using alignment to 5 protein entries: LAMA1_HUMAN (see all proteins):

LAMA2 LAMB4 LAMA3 LamA3 LAMC1 LAMC3

NTN1

LAMA1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 18 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs150815120^1,2	C,F	other	6950940(+)	`GAGGCG/AAACGT`	2	/F	syn¹		2		NA EU	5851
rs12454688^1,2	C,F,H	--	6941244(+)	`ACGGAT/CAGCGG`	1	--	ds500¹		5		NS EA NA	422
rs114423513^1,2		--	6941322(+)	`AATCTG/CGGTCT`	1	--	ds500¹		1		WA	118
rs146795470^1,2		--	6941389(+)	`TTTCAA/CATTAC`	1	--	ds500¹		0	--	--	--	--
rs117504875^1,2	F,	--	6941449(+)	`AGTGAT/CGAAAA`	1	--	ds500¹		1		EA	120
rs140609376^1,2		--	6941506(+)	`TTCTTC/TTTTTC`	1	--	ds500¹		0	--	--	--	--
rs114664132^1,2	C,F,	--	6941631(+)	`AAAGGT/GTATGT`	1	--	ds500¹		1		WA	118
rs3810046^1,2	C,F,H,	--	6941662(-)	`TAATTC/ACAGAT`	1	--	ds500¹		28		NS EA NA CSA WA	2780
rs185502679^1,2		--	6941836(+)	`TGTGTA/GTAAAG`	1	--	ut3¹		0	--	--	--	--
rs145733881^1,2		--	6941962(+)	`CTCCCC/TAGAAA`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for LAMA1 (6941743 - 7117813 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for LAMA1
     6 CNVs: 67297 88708 88707 77796 77798 4050
     2 Indels: 77797 26106
     1 Inversion: 37198
Human Gene Mutation Database (HGMD): LAMA1

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAMA1

DNA2.0 Custom Variant and Variant Library Synthesis for LAMA1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LAMA1 for disorders           About GeneDecksing

OMIM gene information: 150320    OMIM disorders: --

20/34 diseases for LAMA1 (see all 34):    About MalaCards

duchenne muscular dystrophy muscular dystrophy bullous pemphigoid neuromuscular disease

congenital muscular dystrophy oral squamous cell carcinoma patau syndrome squamous cell carcinoma

alport syndrome hirschsprung's disease familial colorectal cancer fainting

choriocarcinoma embryonal carcinoma myopia teratocarcinoma

toxoplasmosis colorectal cancer nephritis fibrosarcoma

4 Novoseek disease relationships for LAMA1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
neuromuscular diseases	31.5	2	7543975 (2)
choriocarcinoma	25	1	2049067 (1)
metastasis	0	1	1847824 (1)
tumors	0	5	7875421 (1), 8780383 (1), 17695722 (1), 1544440 (1) (see all 5)

Human Genome Epidemiology (HuGE) Navigator: LAMA1 (8 documents)

Export disorders for LAMA1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LAMA1 gene, integrated from 9 sources (see all 162):
(articles sorted by number of sources associating them with LAMA1)

Utopia: connect your pdf to the dynamic
world of online information

Primary structure of the human laminin A chain. Limited expression in human tissues. (PubMed id 2049067)^{1, 2, 9} Nissinen M....Tryggvason K. (1991)
Molecular cloning of the cDNA encoding human laminin A chain. (PubMed id 1714537)^{1, 2, 9} Haaparanta T.... Engvall E. (1991)
Human laminin A chain (LAMA) gene: chromosomal mapping to locus 18p11.3. (PubMed id 2591971)^{1, 3} Nagayoshi T....Uitto J. (1989)
Human laminin: cloning and sequence analysis of cDNAs encoding A, B1 and B2 chains, and expression of the corresponding genes in human skin and cultured cells. (PubMed id 2733383)^{1, 2} Olsen D.... Uitto J. (1989)
The extracellular matrix proteins laminin and fibronectin contain binding domains for human plasminogen and tissue plasminogen activator. (PubMed id 8360181)^{1, 9} Moser T.L....Stack M.S. (1993)
Sulfatide-binding domain of the laminin A chain. (PubMed id 2373692)^{1, 9} Taraboletti G....Roberts D.D. (1990)
Distribution and isolation of four laminin variants; tissue restricted distribution of heterotrimers assembled from five different subunits. (PubMed id 2099832)^{1, 9} Engvall E....Sanes J.R. (1990)
Stratifying type 2 diabetes cases by BMI identifies ge netic risk variants in LAMA1 and enrichment for risk variants in lean compared t o obese cases. (PubMed id 22693455)¹ Perry J.R....Cauchi S. (2012)
Laminin-a1 LG4-5 domain binding to dystroglycan mediat es muscle cell survival, growth, and the AP-1 and NF-kB transcription factors bu t also has adverse effects. (PubMed id 22159078)¹ Zhou Y.W....Jarrett H.W. (2012)
Genome-wide pharmacogenomic study of citalopram-induce d side effects in STAR*D. (PubMed id 22760553)¹ Adkins D.E....van den Oord E.J. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 284217	HGNC: 6481	AceView: LAMA1.1	Ensembl:ENSG00000101680	euGenes: HUgn284217
ECgene: LAMA1	Kegg: 284217	H-InvDB: LAMA1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LAMA1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LAMA1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LAMA1 gene:
Search GeneIP for patents involving LAMA1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of LAMA1
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Small Molecules at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for LAMA1 (Laminin alpha 1)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for LAMA1		OriGene shRNA RFP for LAMA1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAMA1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAMA1
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for LAMA1		OriGene 3'-UTR Clone for LAMA1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAMA1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAMA1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for LAMA1		OriGene Custom Protein Services for LAMA1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LAMA1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAMA1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAMA1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAMA1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAMA1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAMA1

	GenScript Custom Purified and Recombinant Proteins Services for LAMA1		GenScript cDNA clones with any tag delivered in your preferred vector for LAMA1
	GenScript Custom Assay Services for LAMA1		GenScript Custom Superior Antibodies Services for LAMA1
	GenScript Custom overexpressing Cell Line Services for LAMA1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in LAMA1 promoter
	Search Chromatin IP Primers for LAMA1
	RT² qPCR Primer Assay in human, mouse, rat LAMA1
	Search GNC Networks for LAMA1
	SABiosciences PCR Arrays including human, mouse, rat LAMA1

Search Tocris compounds for LAMA1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	LAMA1 antibodies
	LAMA1 proteins

	Search for Antibodies for LAMA1 at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for LAMA1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for LAMA1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAMA1

	SwitchGear 3'UTR luciferase reporter plasmids for LAMA1
	SwitchGear Promoter luciferase reporter plasmids for LAMA1

ThermoFisher Antibody for LAMA1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAMA1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes LAMA1 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

LAMA1 Gene

laminin, alpha 1

Aliases
for LAMA1 gene

Summaries
for LAMA1 gene

Genomic Views
for LAMA1 gene

Proteins
for LAMA1 gene

Protein Domains /
Families
for LAMA1 gene

Function
for LAMA1 gene

Pathways & Interactions
for LAMA1 gene

Drugs & Compounds
for LAMA1 gene

Transcripts
for LAMA1 gene

Expression
for LAMA1 gene

Orthologs
for LAMA1 gene

Paralogs
for LAMA1 gene

Genomic Variants
for LAMA1 gene

Disorders / Diseases
for LAMA1 gene

Publications
for LAMA1 gene

External Searches for LAMA1 gene

Genome Databases showing LAMA1 gene

Other Databases showing LAMA1 gene

Specialized Databases showing LAMA1 gene

Intellectual Property
for LAMA1 gene

Products
for LAMA1 gene

View Random Gene

Advanced Search

Export list of displayed genes

LAMA1 Gene

laminin, alpha 1

Aliasesfor LAMA1 gene

Summariesfor LAMA1 gene

Genomic Viewsfor LAMA1 gene

Proteinsfor LAMA1 gene

Protein Domains /Familiesfor LAMA1 gene

Functionfor LAMA1 gene

Pathways & Interactionsfor LAMA1 gene

Drugs & Compoundsfor LAMA1 gene

Transcriptsfor LAMA1 gene

Expression for LAMA1 gene

Orthologsfor LAMA1 gene

Paralogsfor LAMA1 gene

Genomic Variantsfor LAMA1 gene

Disorders / Diseasesfor LAMA1 gene

Publicationsfor LAMA1 gene

External Searches for LAMA1 gene

Genome Databases showing LAMA1 gene

Other Databases showing LAMA1 gene

Specialized Databases showing LAMA1 gene

Intellectual Propertyfor LAMA1 gene

Productsfor LAMA1 gene

View Random Gene

Aliases
for LAMA1 gene

Summaries
for LAMA1 gene

Genomic Views
for LAMA1 gene

Proteins
for LAMA1 gene

Protein Domains /
Families
for LAMA1 gene

Function
for LAMA1 gene

Pathways & Interactions
for LAMA1 gene

Drugs & Compounds
for LAMA1 gene

Transcripts
for LAMA1 gene

Expression
for LAMA1 gene

Orthologs
for LAMA1 gene

Paralogs
for LAMA1 gene

Genomic Variants
for LAMA1 gene

Disorders / Diseases
for LAMA1 gene

Publications
for LAMA1 gene

Intellectual Property
for LAMA1 gene

Products
for LAMA1 gene