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LALBA Gene

protein-coding   GIFtS: 57

GC12M047247
lactalbumin, alpha-
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
LYZL7 1, 3
MGC138521 2
MGC138523 2
Descriptions
Lactose synthase B protein 2, 3
Lysozyme-like protein 7 3
lactalbumin, alpha- 2
External Ids
HGNC: 64801
Entrez Gene: 39062
UniProtKB: P007093
Ensembl: ENSG000001675317
Search outside databases for aliases for LALBA gene

Previous GC identifers: GC12M048927 GC12M048678

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for LALBA:
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the
regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase
(beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose
by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds
calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of
alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided
by RefSeq]

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709
Function: Regulatory subunit of lactose synthase, changes the substrate specificity of
galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this
enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other
tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the
oligosaccharide chains in glycoproteins

Gene Wiki entry for LALBA (Alpha-lactalbumin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LALBA gene  

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13

LALBA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M047247:     (about GC identifiers)

Start:
47,247,734 bp from pter
End:
47,250,096 bp from pter
Size:
2,363 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000012.10  NT_029419.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709 (See protein sequence)
Recommended Name: Alpha-lactalbumin precursor  
Size: 142 amino acids; 16225 Da
Subunit: Lactose synthase (LS) is a heterodimer of a catalytic component,
beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA)
Subcellular location: Secreted
PDB structures from and Proteopedia :
1A4V (3D)    1B9O (3D)    1CB3 (3D)    1HML (3D)    
Secondary accessions: Q6FGX0

REFSEQ proteins: NP_002280.1  

ENSEMBL proteins: 
ENSP00000301046 


Human Recombinant Proteins 
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Sigma-Aldrich Proteins for LALBA  
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Recombinant Proteins from Abcam (alpha Lactalbumin)
Human Recombinant Proteins from Abnova (LALBA)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005576 extracellular region IEA--
GO:0005615 extracellular space TAS7644538
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Antibodies for LALBA: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Sigma-Aldrich Antibodies for LALBA
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Antibodies from Abcam (alpha Lactalbumin), each with their AbpromiseSM
Monoclonal and Polyclonal Antibodies from Abnova (LALBA)
Novus Biologicals Antibodies for LALBA

Assays for LALBA: 
Browse Invitrogen for biochemical assays
Browse Kits and Assays available from Millipore
Browse R&D Systems for biochemical assays
Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

3 InterPro domains/families:
 IPR000545 Lactalbumin
 IPR001916 Glyco_hydro_22
 IPR019799 Glyco_hydro_22_CS


   GeneDecks  LALBA for the domains selected above  
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Graphical View of Domain Structure for InterPro Entry P00709

ProtoNet protein and cluster: P00709

1 Blocks protein family: IPB000545 Lactalbumin signature

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709
Similarity: Belongs to the glycosyl hydrolase 22 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (LALBA)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (LALBA)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002289

              Applied Biosystems Silencer® siRNAs for LALBA

              Sigma-Aldrich siRNA for LALBA  
                     Sigma-Aldrich shRNA Panels and shRNA for LALBA  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Browse Clone Ranger at Invitrogen for clones
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002289
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002289
                                 untagged cDNA clone in CMV expression vector: NM_002289 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_002289

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709
Function: Regulatory subunit of lactose synthase, changes the substrate specificity of
galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this
enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other
tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the
oligosaccharide chains in glycoproteins

Genatlas biochemistry entry for LALBA:
lactalbumin,alpha,expressed in mammary gland,homolog to lypozyne,non catalytic regulatory protein,B
chain of lactose synthase

3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lalba):

endocrine/exocrine glandnormalreproductive system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004461 lactose synthase activity IEA--
GO:0005509 calcium ion binding IEA--
About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Invitrogen iPath™ Online BioAtlas - Pathway for LALBA (Maps provided by GeneGo):
 Galactose metabolism

   GeneDecks  LALBA for the pathways selected above  
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1 Millipore Pathway for LALBA
 Galactose metabolism

   GeneDecks  LALBA for the pathways selected above  
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for  LALBA  (Your Favorite Gene powered by Ingenuity) 
 Galactose Metabolism

   GeneDecks  LALBA for the pathways selected above  
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1 Kegg Pathway  (Kegg details for LALBA):
 hsa00052 Galactose metabolism

   GeneDecks  LALBA for the pathways selected above  
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5/23 Interacting proteins for LALBA (ENSP000003010463) via UniProtKB, MINT, and/or STRING (see all 23 )
InteractantInteraction Details
GeneCardExternal ID(s)
B4GALT1ENSP000003690553STRING (score=.997)
PRLENSP000003021503STRING (score=.953)
HSPD1P4ENSP000003400193STRING (score=.942)
LCTENSP000002641623STRING (score=.922)
GLB1ENSP000003069203STRING (score=.913)
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5 Gene Ontology (GO) biological process terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005989 lactose biosynthetic process TAS7708733
GO:0006917 induction of apoptosis TAS7644538
GO:0007165 signal transduction TAS7644538
GO:0007267 cell-cell signaling TAS7644538
GO:0042742 defense response to bacterium TAS7644538
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LALBA
10/59 Novoseek chemical compound relationships for LALBA gene (see all 59 )
Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
whey 88.79 86 15930449 (5), 19185957 (4), 1452835 (3), 10376243 (2) (see all 52)
3-hydroxyphthalic anhydride 75.57 5 9282815 (2), 12834857 (1)
gamma-linolenate 62.86 1 15323501 (1)
udpglucose 56.41 4 2157218 (1), 8142006 (1), 10619705 (1), 11485999 (1)
oleic acid 51.77 25 16678133 (4), 15659367 (1), 15867328 (1), 12888554 (1) (see all 16)
cmpa 50.67 1 10202365 (1)
n-acetylglucosamine 42.65 3 8444150 (1), 9792633 (1), 11485999 (1)
allergens 40.40 5 8219782 (1), 2396443 (1), 7885948 (1), 11729348 (1) (see all 5)
1-anilino-8-naphthalenesulfonate 38.57 5 16741984 (2), 8679928 (1)
polyacrylamide 35.94 4 9079390 (1), 15829652 (1), 10720481 (1), 15826076 (1)
About this table


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib.
RNA:
Invitrogen RNAi Products for gene knock-down (LALBA)
Browse for Gene Knock-down Tools from Millipore
Abnova Chimera RNAi Products for Gene knock-down (LALBA)
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002289

              Sigma-Aldrich siRNA for LALBA  
                     Sigma-Aldrich shRNA Panels and shRNA for LALBA  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_002289  

REFSEQ mRNAs for LALBA gene: 

NM_002289.2   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_002289  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002289
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_002289
                                 untagged cDNA clone in CMV expression vector: NM_002289 

Additional cDNA sequence: 

BC069103.1 BC112316.1 BC112318.1 CR541987.1 CR542017.1 J00270.1 

1 DOTS entry:

DT.106363 

5 AceView cDNA sequences:

CR541987 NM_002289 CR542017 J00270 BC069103 

highest scoring ESTs for LALBA:

BC069103 J00270 CR541987 CR542017 NM_002289 AA864938 BC112316 BC112318 BX281629 CR746754 

Unigene Cluster for LALBA:

Lactalbumin, alpha-
Hs.72938  [show with all ESTs]
Unigene Representative Sequence: NM_002289


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:
ENST00000301046  
(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LALBA expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for LALBA

1 / 2 / 3

3 probe-sets matching LALBA gene


Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

34625_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 X05153 0.20 1.00 0.72 1

207816_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002289 0.60 1.00 0.82 1

207816_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
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Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TTTCACACCA

SOURCE GeneReport for Unigene cluster: Hs.72938

Expression variation in blood from EXPOLDB for LALBA

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709
Tissue specificity: Mammary gland specific. Secreted in milk

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section


Orthologs for LALBA gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LALBA1   -- lactalbumin, alpha- 87.79(n)
78.87(a)
403730  NM_001003129.1  NP_001003129.1 
chimpanzee
(Pan troglodytes)
LALBA1   -- lactalbumin, alpha- 99.46(n)
99.19(a)
743291  XM_001160401.1  XP_001160401.1 
cow
(Bos taurus)
LALBA1   -- lactalbumin, alpha- 84.51(n)
73.94(a)
281894  NM_174378.2  NP_776803.1 
rat
(Rattus norvegicus)
Lalba1   -- lactalbumin, alpha 78.01(n)
69.5(a)
24528  NM_012594.1  NP_036726.1 
mouse
(Mus musculus)
Lalba1, 5 155
lactalbumin, alpha1, 5 75.89(n)1
68.09(a)1
167701  NM_010679.11  NP_034809.11 
 AW2088275  BC0069225  (see all 8)
About this table        Species with no ortholog for LALBA

ENSEMBL Gene Tree for LALBA
(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

Paralogs for LALBA gene
LYZ2  

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/30 NCBI SNPs in LALBA are shown (see all 30 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 48)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
------------
rs24090441,2
A,C,F,H47247657(+) TGGCTA/CTGACC 1 -- ng514Minor allele frequency- C:0.16EU EA WA 418
rs111686431,2
A,F,H47251728(+) gagccG/Actgcg 1 -- ng311Minor allele frequency- A:0.03EU 118
rs125828111,2
C,F,H47247511(+) GTGTTT/GAGCCA 1 -- ng5111Minor allele frequency- G:0.06EU EA WA NA 968
rs22325651,2
C,F,H47249288(-) CAGTGA/GTCTGT 1 I/V mis1 ese313Minor allele frequency- G:0.05EA NA EU WA 1132
rs37591491,2
F,H47251788(-) CAGTAT/CGTAAG 1 -- ng314Minor allele frequency- C:0.01EU EA WA 416
--
rs108758351,2
A,C47251693(+) gcctcA/Ggcctc 1 -- ng310--------
rs123721101,2
H47250107(+) CATCAC/ATCAGT 1 -- ng314Minor allele frequency- A:0.00EU EA WA 420
rs22325661,2
C,F,H,O47249136(-) TCCTGT/CGACAG 1 C/C syn117Minor allele frequency- C:0.09NS NA EU EA WA 1166
rs22325701,2
C,F,H47248248(-) TTAACC/GCTACA 1 -- int18Minor allele frequency- G:0.03EU EA WA 838
rs20713801,2
C,F,H47248398(-) GCTCCG/ACTCCT 1 -- int112Minor allele frequency- A:0.08NS EU EA WA NA 660
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HapMap Linkage Disequilibrium images for LALBA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 149750

10/23 Novoseek disease relationships for LALBA gene (see all 23 )

Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
allergy milk 77.82 5 11419710 (1), 8648027 (1), 12170271 (1), 16784012 (1) (see all 5)
papilloma skin 56.49 2 15215482 (1)
allergy 42.57 4 16499641 (1), 11420027 (1), 12170271 (1), 9250594 (1)
cytopathic effect viral 41.31 2 10363676 (1), 11750941 (1)
stasis 11.06 2 16160046 (2)
dermatitis atopic 8.99 2 8123876 (2)
chemically induced 5.81 2 16420472 (1), 16851644 (1)
atopy 4.80 1 17300640 (1)
immunodeficiency 4.62 1 11105990 (1)
inflammation 2.57 1 14596456 (1)
About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

  --

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

10/438 PubMed articles for LALBA gene (see all 438 ):
(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)
(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 3906 HGNC: 6480 AceView: LALBA Ensembl:ENSG00000167531 euGenes: HUgn3906
ECgene: LALBA H-InvDB: LALBA
(According to HUGE)
About This Section

  --
(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

  --
(Available from WIS Yeda, Salk, Tufts)
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  --
(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for LALBA:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
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 Predesigned and custom siRNAs for LALBA Antibodies for LALBA
 Explore super-pooled esiRNAs Proteins for LALBA
 Lentivirus-delivered shRNAs for LALBA Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Recombinant Proteins
(alpha Lactalbumin)
 Antibodies (alpha Lactalbumin)
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 Search Tocris compounds for LALBA




 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Antibodies for LALBA

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