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Aliases & Descriptions for LALBA
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| LYZL7 1, 3 | | MGC138521 2 | | MGC138523 2 |
| | | Descriptions |
|---|
| Lactose synthase B protein 2, 3 | | Lysozyme-like protein 7 3 | | lactalbumin, alpha- 2 |
|
| | Search outside databases for aliases for LALBA genePrevious GC identifers: GC12M048927 GC12M048678 |
Summaries for LALBA(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for LALBA: This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq] UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709Function: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteinsGene Wiki entry for LALBA (Alpha-lactalbumin) |
Genomic Location for LALBA
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LALBA gene 
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.11 HGNC cytogenetic band: 12q13LALBA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M047247:
(about GC identifiers)
Start:
|
47,247,734 bp from pter |
End:
|
47,250,096 bp from pter |
Size:
|
2,363 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000012.10 NT_029419.11
| Proteins for LALBA
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709 (See
protein sequence)Recommended Name: Alpha-lactalbumin precursor Size: 142 amino acids; 16225 Da
Subunit: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA)
Subcellular location: Secreted
PDB structures from and Proteopedia :1A4V (3D)
 1B9O (3D)
 1CB3 (3D)
 1HML (3D)
 
Secondary accessions: Q6FGX0REFSEQ proteins: NP_002280.1
ENSEMBL proteins: ENSP00000301046
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for LALBA: Assays for LALBA: | Protein
Domains/ Families for LALBA(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P00709
ProtoNet protein and cluster: P00709 1 Blocks protein family: IPB000545 Lactalbumin signature
UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709Similarity: Belongs to the glycosyl hydrolase 22 family | Gene Function for LALBA
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002289
Applied Biosystems Silencer® siRNAs for LALBA
Sigma-Aldrich siRNA for LALBA  Sigma-Aldrich shRNA Panels and shRNA for LALBA  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002289                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002289                                  untagged cDNA clone in CMV expression vector: NM_002289 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002289
UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709Function: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteinsGenatlas biochemistry entry for LALBA:lactalbumin,alpha,expressed in mammary gland,homolog to lypozyne,non catalytic regulatory protein,B chain of lactose synthase3 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Lalba):
2 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004461 | lactose synthase activity |
IEA | -- | | GO:0005509 | calcium ion binding |
IEA | -- | About this table | Pathways & Interactions for LALBA
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
1 Sigma-Aldrich "Your Favorite Gene" Pathway for LALBA (Your Favorite Gene powered by Ingenuity) 
5/23 Interacting proteins for LALBA (ENSP000003010463) via UniProtKB, MINT, and/or STRING (see all 23
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for LALBA(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LALBA 10/59 Novoseek chemical compound relationships for LALBA gene (see all 59
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| whey |
88.79 |
86 |
15930449 (5), 19185957 (4), 1452835 (3), 10376243 (2) (see all 52) |
| 3-hydroxyphthalic anhydride |
75.57 |
5 |
9282815 (2), 12834857 (1) |
| gamma-linolenate |
62.86 |
1 |
15323501 (1) |
| udpglucose |
56.41 |
4 |
2157218 (1), 8142006 (1), 10619705 (1), 11485999 (1) |
| oleic acid |
51.77 |
25 |
16678133 (4), 15659367 (1), 15867328 (1), 12888554 (1) (see all 16) |
| cmpa |
50.67 |
1 |
10202365 (1) |
| n-acetylglucosamine |
42.65 |
3 |
8444150 (1), 9792633 (1), 11485999 (1) |
| allergens |
40.40 |
5 |
8219782 (1), 2396443 (1), 7885948 (1), 11729348 (1) (see all 5) |
| 1-anilino-8-naphthalenesulfonate |
38.57 |
5 |
16741984 (2), 8679928 (1) |
| polyacrylamide |
35.94 |
4 |
9079390 (1), 15829652 (1), 10720481 (1), 15826076 (1) |
About this table
|
Transcripts for LALBA(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002289
Sigma-Aldrich siRNA for LALBA  Sigma-Aldrich shRNA Panels and shRNA for LALBA  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002289 REFSEQ mRNAs for LALBA gene: NM_002289.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002289               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002289                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002289                                  untagged cDNA clone in CMV expression vector: NM_002289  Additional cDNA sequence: BC069103.1 BC112316.1 BC112318.1 CR541987.1 CR542017.1 J00270.1 1 DOTS entry: DT.106363 5 AceView cDNA sequences:CR541987 NM_002289 CR542017 J00270 BC069103
highest scoring ESTs for LALBA:BC069103 J00270 CR541987 CR542017 NM_002289 AA864938 BC112316 BC112318 BX281629 CR746754 Unigene Cluster for LALBA: Lactalbumin, alpha- Hs.72938 [show with all ESTs]Unigene Representative Sequence: NM_002289
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000301046
|
Expression for LALBA
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LALBA expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LALBA
1 / 2 / 3 3 probe-sets matching LALBA gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TTTCACACCA
SOURCE GeneReport for Unigene cluster: Hs.72938
Expression variation in blood from EXPOLDB for LALBA UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709Tissue specificity: Mammary gland specific. Secreted in milk |
Orthologs for LALBA
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LALBA gene from 5 species
About this table Species with no ortholog for LALBA
ENSEMBL Gene Tree for LALBA | Paralogs for LALBA(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for LALBA gene
- LYZ2
|
SNPs/Variants for LALBA(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LALBA (up to first 250kb)
|
Disorders & Mutations for LALBA
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 149750
10/23 Novoseek disease relationships for LALBA gene (see all 23
)
About this table
|
Medical News for LALBA(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LALBA (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/438 PubMed articles for LALBA gene (see all 438
):- Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin. (PubMed id 9537992)1, 3, 4 Chandra N.... Acharya K.R. (1998)
- Crystallographic evaluation of internal motion of human alpha- lactalbumin refined by full-matrix least-squares method. (PubMed id 10080897)3, 4 Harata K.... Muraki M. (1999)
- Organization and sequence of the human alpha-lactalbumin gene. (PubMed id 2954544)3, 4 Hall L.... Craig R.K. (1987)
- Comparison of the nucleotide sequence of cloned human and guinea-pig pre-alpha-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene. (PubMed id 6285305)3, 4 Hall L.... Campbell P.N. (1982)
- The complete amino-acid sequence of human alpha-lactalbumin. (PubMed id 5049057)3, 4 Findlay J.B.C. and Brew K. (1972)
- Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells). (PubMed id 14627739)1, 3 Svensson M....Svanborg C. (2003)
- Effects of the stabilization of the molten globule state on the folding mechanism of alpha-lactalbumin: a study of a chimera of bovine and human alpha-lactalbumin. (PubMed id 16121399)1, 3 Mizuguchi M....Kawano K. (2005)
- The importance of alpha-lactalbumin in infant nutrition. (PubMed id 2002399)1, 3 Heine W.E....Reeds P.J. (1991)
- Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells. (PubMed id 10037730)1, 3 Svensson M....Linse S. (1999)
- The unusual amino acid triplet Asn-Ile-Cys is a glycosylation consensus site in human alpha-lactalbumin. (PubMed id 9365923)1, 3 Giuffrida M.G....Conti A. (1997)
|
Search for LALBA
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LALBA
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LALBA
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LALBA(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LALBA(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LALBA:

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Incremental update: 13 Oct 2009
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