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Aliases for LALBA Gene

Aliases for LALBA Gene

  • Lactalbumin Alpha 2 3
  • Lactalbumin, Alpha- 2 3 5
  • Lactose Synthase B Protein 3 4
  • Lysozyme-Like Protein 7 3 4
  • Lysozyme G 3
  • LYZL7 4
  • LYZG 3

External Ids for LALBA Gene

Previous GeneCards Identifiers for LALBA Gene

  • GC12M048927
  • GC12M048678
  • GC12M047247
  • GC12M045995

Summaries for LALBA Gene

Entrez Gene Summary for LALBA Gene

  • This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for LALBA Gene

LALBA (Lactalbumin Alpha) is a Protein Coding gene. Diseases associated with LALBA include Mastitis and Allergic Hypersensitivity Disease. Among its related pathways are Lactose synthesis and Glycosaminoglycan metabolism. GO annotations related to this gene include calcium ion binding and lactose synthase activity. An important paralog of this gene is SPACA5B.

UniProtKB/Swiss-Prot for LALBA Gene

  • Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Gene Wiki entry for LALBA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LALBA Gene

Genomics for LALBA Gene

Regulatory Elements for LALBA Gene

Enhancers for LALBA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LALBA on UCSC Golden Path with GeneCards custom track

Genomic Location for LALBA Gene

48,567,684 bp from pter
48,600,111 bp from pter
32,428 bases
Minus strand

Genomic View for LALBA Gene

Genes around LALBA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LALBA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LALBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LALBA Gene

Proteins for LALBA Gene

  • Protein details for LALBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein Accession:
    Secondary Accessions:
    • Q6FGX0
    • Q9UDK4

    Protein attributes for LALBA Gene

    142 amino acids
    Molecular mass:
    16225 Da
    Quaternary structure:
    • Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).

    Three dimensional structures from OCA and Proteopedia for LALBA Gene

neXtProt entry for LALBA Gene

Proteomics data for LALBA Gene at MOPED

Post-translational modifications for LALBA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LALBA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LALBA Gene

Domains & Families for LALBA Gene

Gene Families for LALBA Gene

Protein Domains for LALBA Gene

Suggested Antigen Peptide Sequences for LALBA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the glycosyl hydrolase 22 family.
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LALBA: view

Function for LALBA Gene

Molecular function for LALBA Gene

GENATLAS Biochemistry:
lactalbumin,alpha,expressed in mammary gland,homolog to lypozyne,non catalytic regulatory protein,B chain of lactose synthase
UniProtKB/Swiss-Prot Function:
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.
genes like me logo Genes that share phenotypes with LALBA: view

Animal Models for LALBA Gene

MGI Knock Outs for LALBA:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LALBA Gene

Localization for LALBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for LALBA Gene


Subcellular locations from

Jensen Localization Image for LALBA Gene COMPARTMENTS Subcellular localization image for LALBA gene
Compartment Confidence
extracellular 5
golgi apparatus 5
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for LALBA Gene

Pathways & Interactions for LALBA Gene

genes like me logo Genes that share pathways with LALBA: view

Pathways by source for LALBA Gene

3 Reactome pathways for LALBA Gene
2 KEGG pathways for LALBA Gene
1 GeneGo (Thomson Reuters) pathway for LALBA Gene

Gene Ontology (GO) - Biological Process for LALBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005989 lactose biosynthetic process IEA,TAS --
GO:0007165 signal transduction TAS 7644538
GO:0044281 small molecule metabolic process TAS --
genes like me logo Genes that share ontologies with LALBA: view

No data available for SIGNOR curated interactions for LALBA Gene

Drugs & Compounds for LALBA Gene

(37) Drugs for LALBA Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lactose Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist, Target 22
Uridine diphosphategalactose Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0

(50) Additional Compounds for LALBA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • beta-D-Galactopyranosyl-(1->4)-beta-D-glucopyranose
  • beta-D-Galactopyranosyl-(1->4)-beta-D-glucose
  • beta-Lactose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
genes like me logo Genes that share compounds with LALBA: view

Transcripts for LALBA Gene

mRNA/cDNA for LALBA Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LALBA Gene

Lactalbumin, alpha-:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LALBA Gene

No ASD Table

Relevant External Links for LALBA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LALBA Gene

mRNA expression in normal human tissues for LALBA Gene

mRNA differential expression in normal tissues according to GTEx for LALBA Gene

This gene is overexpressed in Breast - Mammary Tissue (x51.8).

Protein differential expression in normal tissues from HIPED for LALBA Gene

This gene is overexpressed in Milk (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LALBA Gene

SOURCE GeneReport for Unigene cluster for LALBA Gene Hs.72938

mRNA Expression by UniProt/SwissProt for LALBA Gene

Tissue specificity: Mammary gland specific. Secreted in milk.
genes like me logo Genes that share expression patterns with LALBA: view

Protein tissue co-expression partners for LALBA Gene

Primer Products

Orthologs for LALBA Gene

This gene was present in the common ancestor of animals.

Orthologs for LALBA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia LALBA 35
  • 84.51 (n)
  • 73.94 (a)
  • 74 (a)
(Canis familiaris)
Mammalia LALBA 35
  • 87.79 (n)
  • 78.87 (a)
  • 80 (a)
(Mus musculus)
Mammalia Lalba 35
  • 75.89 (n)
  • 68.09 (a)
Lalba 16
Lalba 36
  • 66 (a)
(Pan troglodytes)
Mammalia LALBA 35
  • 99.46 (n)
  • 99.19 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Lalba 35
  • 78.01 (n)
  • 69.5 (a)
(Monodelphis domestica)
Mammalia LALBA 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
-- 36
  • 31 (a)
-- 36
  • 29 (a)
-- 36
  • 24 (a)
-- 36
  • 27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11159 36
  • 27 (a)
CG16756 36
  • 28 (a)
CG16799 36
  • 22 (a)
CG30062 36
  • 23 (a)
CG7798 36
  • 26 (a)
CG8492 36
  • 3 (a)
LysB 36
  • 26 (a)
LysC 36
  • 26 (a)
LysD 36
  • 26 (a)
LysE 36
  • 27 (a)
LysP 36
  • 28 (a)
LysS 36
  • 27 (a)
LysX 36
  • 27 (a)
Species with no ortholog for LALBA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LALBA Gene

Gene Tree for LALBA (if available)
Gene Tree for LALBA (if available)

Paralogs for LALBA Gene

Paralogs for LALBA Gene

(7) SIMAP similar genes for LALBA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LALBA: view

Variants for LALBA Gene

Sequence variations from dbSNP and Humsavar for LALBA Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2232565 - 48,569,238(-) CAGTG(A/G)TCTGT reference, missense
rs2071380 -- 48,568,348(-) GCTCC(A/G)CTCCT intron-variant
rs12818124 -- 48,587,290(+) aaatc(A/C)aaaaa intron-variant
rs12818300 -- 48,587,289(+) aaaat(A/C)aaaaa intron-variant
rs7305017 -- 48,581,564(+) CTACA(A/G)GCACC intron-variant

Variation tolerance for LALBA Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for LALBA Gene

Disorders for LALBA Gene

MalaCards: The human disease database

(10) MalaCards diseases for LALBA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
  • breast inflammation
allergic hypersensitivity disease
  • allergic disease
cutaneous adenocystic carcinoma
  • adenoid cystic carcinoma of the skin
breast cystic hypersecretory carcinoma
  • cystic hypersecretory carcinoma of the breast
adenoid basal cell carcinoma
  • skin adenoid basal cell carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search LALBA in MalaCards View complete list of genes associated with diseases

Relevant External Links for LALBA

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with LALBA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LALBA Gene

Publications for LALBA Gene

  1. Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin. (PMID: 9537992) Chandra N. … Acharya K.R. (Biochemistry 1998) 3 4 23 67
  2. The oleic acid complexes of proteolytic fragments of alpha-lactalbumin display apoptotic activity. (PMID: 19968717) Tolin S. … Fontana A. (FEBS J. 2010) 3 23
  3. Interaction of human alpha-lactalbumin with fatty acids: determination of binding parameters. (PMID: 18620538) Barbana C. … Wehbi Z. (Biochemistry Mosc. 2008) 23 25
  4. Characterization of the denaturation of human alpha-lactalbumin in urea by molecular dynamics simulations. (PMID: 15558602) Smith L.J. … van Gunsteren W.F. (Proteins 2005) 3 23
  5. Effects of the stabilization of the molten globule state on the folding mechanism of alpha-lactalbumin: a study of a chimera of bovine and human alpha-lactalbumin. (PMID: 16121399) Mizuguchi M. … Kawano K. (Proteins 2005) 3 23

Products for LALBA Gene

Sources for LALBA Gene