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Aliases for LALBA Gene

Aliases for LALBA Gene

  • Lactalbumin, Alpha- 2 3
  • Lactose Synthase B Protein 4
  • Lysozyme-Like Protein 7 4
  • LYZL7 4

External Ids for LALBA Gene

Previous GeneCards Identifiers for LALBA Gene

  • GC12M048927
  • GC12M048678
  • GC12M047247
  • GC12M045995

Summaries for LALBA Gene

Entrez Gene Summary for LALBA Gene

  • This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for LALBA Gene

LALBA (Lactalbumin, Alpha-) is a Protein Coding gene. Diseases associated with LALBA include breast cystic hypersecretory carcinoma and cutaneous adenocystic carcinoma. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include calcium ion binding and lactose synthase activity. An important paralog of this gene is SPACA5B.

UniProtKB/Swiss-Prot for LALBA Gene

  • Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins

Gene Wiki entry for LALBA Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LALBA Gene

Genomics for LALBA Gene

Regulatory Elements for LALBA Gene

Genomic Location for LALBA Gene

Chromosome:
12
Start:
48,567,684 bp from pter
End:
48,600,111 bp from pter
Size:
32,428 bases
Orientation:
Minus strand

Genomic View for LALBA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LALBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LALBA Gene

Proteins for LALBA Gene

  • Protein details for LALBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00709-LALBA_HUMAN
    Recommended name:
    Alpha-lactalbumin
    Protein Accession:
    P00709
    Secondary Accessions:
    • Q6FGX0
    • Q9UDK4

    Protein attributes for LALBA Gene

    Size:
    142 amino acids
    Molecular mass:
    16225 Da
    Quaternary structure:
    • Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA)

    Three dimensional structures from OCA and Proteopedia for LALBA Gene

neXtProt entry for LALBA Gene

Proteomics data for LALBA Gene at MOPED

Post-translational modifications for LALBA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LALBA Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LALBA Gene

Domains & Families for LALBA Gene

Gene Families for LALBA Gene

Protein Domains for LALBA Gene

Suggested Antigen Peptide Sequences for LALBA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P00709

UniProtKB/Swiss-Prot:

LALBA_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LALBA: view

Function for LALBA Gene

Molecular function for LALBA Gene

GENATLAS Biochemistry:
lactalbumin,alpha,expressed in mammary gland,homolog to lypozyne,non catalytic regulatory protein,B chain of lactose synthase
UniProtKB/Swiss-Prot Function:
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins

Gene Ontology (GO) - Molecular Function for LALBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004461 lactose synthase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with LALBA: view
genes like me logo Genes that share phenotypes with LALBA: view

Animal Models for LALBA Gene

MGI Knock Outs for LALBA:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LALBA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for LALBA Gene

Localization for LALBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for LALBA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LALBA Gene COMPARTMENTS Subcellular localization image for LALBA gene
Compartment Confidence
extracellular 5
golgi apparatus 4
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for LALBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005615 extracellular space TAS 7644538
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with LALBA: view

Pathways & Interactions for LALBA Gene

genes like me logo Genes that share pathways with LALBA: view

Pathways by source for LALBA Gene

3 Reactome pathways for LALBA Gene
2 KEGG pathways for LALBA Gene
1 GeneGo (Thomson Reuters) pathway for LALBA Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for LALBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005989 lactose biosynthetic process TAS --
GO:0006915 apoptotic process TAS 7644538
GO:0007165 signal transduction TAS 7644538
GO:0007267 cell-cell signaling TAS 7644538
genes like me logo Genes that share ontologies with LALBA: view

No data available for SIGNOR curated interactions for LALBA Gene

Drugs & Compounds for LALBA Gene

(37) Drugs for LALBA Gene - From: NovoSeek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Aprotinin Approved, Withdrawn Pharma Inhibitor of bovine pancreatic trypsin 24
Ethanol Approved Pharma 1708
Fluorescein Approved Pharma 104
Heparin Approved, Investigational Pharma Antagonist 672,226
Iron Approved Pharma 957

(50) Additional Compounds for LALBA Gene - From: NovoSeek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-Lactose
  • beta-D-Galactopyranosyl-(1->4)-beta-D-glucopyranose
  • beta-D-Galactopyranosyl-(1->4)-beta-D-glucose
  • beta-Lactose
5965-66-2
D-Glucose
  • Roferose ST
  • (+)-Glucose
  • Anhydrous dextrose
  • Cerelose
  • Cerelose 2001
50-99-7
1-Propanol
2-MERCAPTOETHANOL
3-Hydroxyphthalic anhydride
genes like me logo Genes that share compounds with LALBA: view

Transcripts for LALBA Gene

mRNA/cDNA for LALBA Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LALBA Gene

Lactalbumin, alpha-:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LALBA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LALBA Gene

No ASD Table

Relevant External Links for LALBA Gene

GeneLoc Exon Structure for
LALBA
ECgene alternative splicing isoforms for
LALBA

Expression for LALBA Gene

mRNA expression in normal human tissues for LALBA Gene

mRNA differential expression in normal tissues according to GTEx for LALBA Gene

This gene is overexpressed in Breast - Mammary Tissue (x51.8).

Protein differential expression in normal tissues from HIPED for LALBA Gene

This gene is overexpressed in Milk (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LALBA Gene



SOURCE GeneReport for Unigene cluster for LALBA Gene Hs.72938

mRNA Expression by UniProt/SwissProt for LALBA Gene

P00709-LALBA_HUMAN
Tissue specificity: Mammary gland specific. Secreted in milk
genes like me logo Genes that share expression patterns with LALBA: view

Protein tissue co-expression partners for LALBA Gene

Primer Products

In Situ Assay Products

Orthologs for LALBA Gene

This gene was present in the common ancestor of animals.

Orthologs for LALBA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LALBA 35
  • 84.51 (n)
  • 73.94 (a)
LALBA 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LALBA 35
  • 87.79 (n)
  • 78.87 (a)
LALBA 36
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lalba 35
  • 75.89 (n)
  • 68.09 (a)
Lalba 16
Lalba 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LALBA 35
  • 99.46 (n)
  • 99.19 (a)
LALBA 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lalba 35
  • 78.01 (n)
  • 69.5 (a)
oppossum
(Monodelphis domestica)
Mammalia LALBA 36
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 34 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG11159 36
  • 27 (a)
ManyToMany
CG16756 36
  • 28 (a)
ManyToMany
CG16799 36
  • 22 (a)
ManyToMany
CG30062 36
  • 23 (a)
ManyToMany
CG7798 36
  • 26 (a)
ManyToMany
CG8492 36
  • 3 (a)
ManyToMany
LysB 36
  • 26 (a)
ManyToMany
LysC 36
  • 26 (a)
ManyToMany
LysD 36
  • 26 (a)
ManyToMany
LysE 36
  • 27 (a)
ManyToMany
LysP 36
  • 28 (a)
ManyToMany
LysS 36
  • 27 (a)
ManyToMany
LysX 36
  • 27 (a)
ManyToMany
Species with no ortholog for LALBA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LALBA Gene

ENSEMBL:
Gene Tree for LALBA (if available)
TreeFam:
Gene Tree for LALBA (if available)

Paralogs for LALBA Gene

Paralogs for LALBA Gene

(7) SIMAP similar genes for LALBA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LALBA: view

Variants for LALBA Gene

Sequence variations from dbSNP and Humsavar for LALBA Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs2071380 -- 48,568,348(-) GCTCC(A/G)CTCCT intron-variant
rs2232565 - 48,569,238(-) CAGTG(A/G)TCTGT reference, missense
rs2232566 -- 48,569,086(-) TCCTG(C/T)GACAG synonymous-codon, reference
rs2232567 -- 48,569,027(-) TGGGA(C/T)AATCT intron-variant
rs2232568 -- 48,568,698(-) CACAA(A/G)CCTTG intron-variant

Variation tolerance for LALBA Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LALBA Gene

HapMap Linkage Disequilibrium report
LALBA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LALBA Gene

Disorders for LALBA Gene

MalaCards: The human disease database

(8) MalaCards diseases for LALBA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
breast cystic hypersecretory carcinoma
  • cystic hypersecretory duct carcinoma of the breast
cutaneous adenocystic carcinoma
  • adenoid cystic carcinoma of the skin
adenoid basal cell carcinoma
  • skin adenoid basal cell carcinoma
acute thyroiditis
  • acute thyroiditis nos
melkersson-rosenthal syndrome
  • melkersson's syndrome
- elite association
Search LALBA in MalaCards View complete list of genes associated with diseases

Relevant External Links for LALBA

Genetic Association Database (GAD)
LALBA
Human Genome Epidemiology (HuGE) Navigator
LALBA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LALBA
genes like me logo Genes that share disorders with LALBA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LALBA Gene

Publications for LALBA Gene

  1. Interaction of human alpha-lactalbumin with fatty acids: determination of binding parameters. (PMID: 18620538) Barbana C. … Wehbi Z. (Biochemistry Mosc. 2008) 23 25 67
  2. BAMLET activates a lysosomal cell death program in cancer cells. (PMID: 20053771) Rammer P. … JAoAottelAo M. (Mol. Cancer Ther. 2010) 23 67
  3. Short communication: effect of kefir grains on proteolysis of major milk proteins. (PMID: 20059900) Ferreira I.M. … Tavares P. (J. Dairy Sci. 2010) 23 67
  4. Surface adsorption alters the susceptibility of whey proteins to pepsin-digestion. (PMID: 20116801) Nik A.M. … Corredig M. (J Colloid Interface Sci 2010) 23 67
  5. Correlation between lactosylation and denaturation of major whey proteins: an investigation by liquid chromatography-electrospray ionization mass spectrometry. (PMID: 20151114) Losito I. … Palmisano F. (Anal Bioanal Chem 2010) 23 67

Products for LALBA Gene

Sources for LALBA Gene

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