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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LALBA Gene

protein-coding   GIFtS: 60
GCID: GC12M048927

Lactalbumin, Alpha-

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Lactalbumin, Alpha-1 2
Lactose Synthase B Protein2 3
Lysozyme-Like Protein 72 3
alpha-lactalbumin2
LYZL73

External Ids:    HGNC: 64801   Entrez Gene: 39062   Ensembl: ENSG000001675317   OMIM: 1497505   UniProtKB: P007093   

Export aliases for LALBA gene to outside databases

Previous GC identifers: GC12M048678 GC12M047247 GC12M045995


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LALBA Gene:
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit
of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic
component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As
a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor
activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature
cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for LALBA Gene: 
LALBA (lactalbumin, alpha-) is a protein-coding gene. Diseases associated with LALBA include acute thyroiditis, and skin papilloma, and among its related super-pathways are Galactose metabolism and Metabolism. GO annotations related to this gene include lactose synthase activity and calcium ion binding. An important paralog of this gene is LYZL6.

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709
Function: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in
the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize
lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose
onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins

Gene Wiki entry for LALBA (Alpha-lactalbumin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LALBA gene promoter:
         AML1a   Tal-1beta   YY1   HNF-4alpha1   c-Ets-1   Meis-1b   Meis-1a   ITF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLALBA promoter sequence
   Search SABiosciences Chromatin IP Primers for LALBA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LALBA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13

LALBA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LALBA gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048927:  view genomic region     (about GC identifiers)

Start:
48,961,467 bp from pter      End:
48,963,849 bp from pter
Size:
2,383 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709 (See protein sequence)
Recommended Name: Alpha-lactalbumin precursor  
Size: 142 amino acids; 16225 Da
Subunit: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase
(beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA)
Subcellular location: Secreted
6 PDB 3D structures from and Proteopedia for LALBA:
1A4V (3D)        1B9O (3D)        1CB3 (3D)        1HML (3D)        3B0I (3D)        3B0O (3D)    
Secondary accessions: Q6FGX0 Q9UDK4

Explore the universe of human proteins at neXtProt for LALBA: NX_P00709

Explore proteomics data for LALBA at MOPED 

LALBA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

LALBA Protein Expression

REFSEQ proteins: NP_002280.1  
ENSEMBL proteins: 
 ENSP00000301046   ENSP00000449780  

Human Recombinant Protein Products for LALBA: 
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Novus Biologicals LALBA Protein
Novus Biologicals LALBA Lysate
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Browse Sino Biological Cell Lysates 
Browse ProSpec Recombinant Proteins
Browse Proteins at Cloud-Clone Corp. 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005615extracellular space TAS7644538

LALBA for ontologies           About GeneDecksing



LALBA Antibody Products: 
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Assay Products for LALBA: 
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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
4 InterPro protein domains:
 IPR023346 Lysozyme-like_dom
 IPR000545 Lactalbumin
 IPR001916 Glyco_hydro_22
 IPR019799 Glyco_hydro_22_CS

Graphical View of Domain Structure for InterPro Entry P00709

ProtoNet protein and cluster: P00709

1 Blocks protein domain: IPB000545 Lactalbumin signature

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709
Similarity: Belongs to the glycosyl hydrolase 22 family


LALBA for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: LALBA_HUMAN, P00709
Function: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in
the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize
lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose
onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins

     Genatlas biochemistry entry for LALBA:
lactalbumin,alpha,expressed in mammary gland,homolog to lypozyne,non catalytic regulatory protein,B chain of
lactose synthase

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0004461lactose synthase activity IEA--
GO:0005509calcium ion binding IEA--
GO:0005515protein binding ----
     
LALBA for ontologies           About GeneDecksing


Phenotypes:
     3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lalba):
 endocrine/exocrine gland  integument  normal 

LALBA for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-outs for LALBA: Lalbatm1Asty Lalbatm1Jvt

   inGenious Targeting Laboratory - Custom generated mouse model solutions for LALBA 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LALBA

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LALBA 
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LALBA 

miRNA
Products:
    
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LALBA
2 QIAGEN miScript miRNA Assays for microRNAs that regulate LALBA:
hsa-miR-3919 hsa-miR-24
SwitchGear 3'UTR luciferase reporter plasmidLALBA 3' UTR sequence
Inhib. RNA
Products:
    
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Gene Editing
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Sirion Biotech Customized adenovirus for overexpression of LALBA

Clone
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OriGene ORF clones in mouse, rat for LALBA
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GenScript: all cDNA clones in your preferred vector: LALBA (NM_002289)
Sino Biological Human cDNA Clone for LALBA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LALBA
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Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LALBA


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

SuperPaths for LALBA About                                                                                                See pathways by source

SuperPathContained pathways About
1Galactose metabolism
Galactose metabolism0.46
Galactose metabolism0.46
2Metabolism
Metabolic pathways0.40

Pathways by source                                                                                                                                                                 See SuperPaths
Show all pathways

1 EMD Millipore Pathway for LALBA
    Galactose metabolism


1 GeneGo (Thomson Reuters) Pathway for LALBA
    Galactose metabolism



2         Kegg Pathways  (Kegg details for LALBA):
    Galactose metabolism
Metabolic pathways


LALBA for pathways           About GeneDecksing

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for LALBA

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/12 Interacting proteins for LALBA (P007093 ENSP000003010464) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
InteractantInteraction Details
GeneCardExternal ID(s)
HIST2H3AQ71DI33, ENSP000003854794I2D: score=1 STRING: ENSP00000385479
HIST2H3CQ71DI33I2D: score=1 
HIST2H3DQ71DI33I2D: score=1 
CRYAAP024893, ENSP000002915544I2D: score=1 STRING: ENSP00000291554
B4GALT1P152913, ENSP000003690554I2D: score=3 STRING: ENSP00000369055
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005989lactose biosynthetic process IEA--
GO:0006915apoptotic process TAS7644538
GO:0007165signal transduction TAS7644538
GO:0007267cell-cell signaling TAS7644538
GO:0042742defense response to bacterium TAS7644538

LALBA for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LALBA for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LALBA

4 HMDB Compounds for LALBA    About this table
CompoundSynonyms CAS #PubMed Ids
Alpha-Lactose(+)-lactose (see all 40)63-42-3--
D-Glucose(+)-Glucose (see all 23)50-99-7--
Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
Uridine diphosphategalactoseGDU (see all 39)2956-16-3--

1 DrugBank Compound for LALBA    About this table
CompoundSynonyms CAS #TypeActionsPubMed Ids
Palmitic Acid1-Hexyldecanoic Acid (see all 11)57-10-3target--18620538

10/82 Novoseek inferred chemical compound relationships for LALBA gene (see all 82)    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
whey 89.2 97 15930449 (5), 19185957 (4), 1452835 (3), 10376243 (2) (see all 61)
3-hydroxyphthalic anhydride 75 5 9282815 (2), 12834857 (1)
lactose 70.8 49 8142006 (5), 9249575 (4), 18694425 (3), 9535717 (2) (see all 32)
gamma-linolenate 62.1 1 15323501 (1)
oleic acid 59.3 46 16678133 (4), 20053771 (4), 19968717 (3), 19766653 (2) (see all 24)
udpglucose 54.8 4 2157218 (1), 8142006 (1), 10619705 (1), 11485999 (1)
guanidine hydrochloride 53.9 9 7986345 (2), 16438927 (1), 9684889 (1), 11112553 (1) (see all 7)
cmpa 48.9 1 10202365 (1)
8-anilino-1-naphthalenesulfonic acid 44.8 5 16741984 (2), 8679928 (1)
sodium dodecylsulfate 41.9 10 7986345 (2), 15545361 (1), 10867181 (1), 14613211 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about LALBA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LALBA gene: 
NM_002289.2  

Unigene Cluster for LALBA:

Lactalbumin, alpha-
Hs.72938  [show with all ESTs]
Unigene Representative Sequence: NM_002289
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000301046(uc001rrt.3) ENST00000549817
Congresses - knowledge worth sharing:  
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

miRNA
Products:
     
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LALBA
2 QIAGEN miScript miRNA Assays for microRNAs that regulate LALBA:
hsa-miR-3919 hsa-miR-24
SwitchGear 3'UTR luciferase reporter plasmidLALBA 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
OriGene RNAi products in human, mouse, rat for LALBA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LALBA
Clone
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GenScript: all cDNA clones in your preferred vector: LALBA (NM_002289)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for LALBA
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LALBA
Sirion Biotech Customized lentivirus for stable overexpression of LALBA 
                     Customized lentivirus expression plasmids for stable overexpression of LALBA 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for LALBA
OriGene qSTAR qPCR primer pairs in human, mouse for LALBA
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LALBA
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LALBA

Additional mRNA sequence: 

BC069103.1 BC112316.1 BC112318.1 CR541987.1 CR542017.1 J00270.1 

1 DOTS entry:

DT.106363 

5 AceView cDNA sequences:

NM_002289 CR541987 CR542017 J00270 BC069103 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LALBA expression in normal human tissues (normalized intensities)      LALBA embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTCACACCA
LALBA Expression
About this image


LALBA expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/18 selected tissues (see all 18) fully expand
 
 Brain (Nervous System)    fully expand to see all 9 entries
         Cerebral Cortex
         ganglion/cranial/facial VII   
 
 Neural Tube (Nervous System)    fully expand to see all 3 entries
         Metencephalon
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         sensory organ/ear/inner ear   
 
 Limb (Muscoskeletal System)    fully expand to see all 2 entries
         limb/hindlimb   
 
 Eye (Sensory Organs)
         Retina

See LALBA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LALBA

SOURCE GeneReport for Unigene cluster: Hs.72938

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709
Tissue specificity: Mammary gland specific. Secreted in milk

    SABiosciences Expression via Pathway-Focused PCR Array including LALBA: 
          Apoptosis 384HT in human mouse rat

Primer
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QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LALBA
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LALBA
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LALBA

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LALBA gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Lalba1 , 5 lactalbumin, alpha1, 5 75.89(n)1
68.09(a)1
  15 (54.48 cM)5
167701  NM_010679.11  NP_034809.11 
 984804005 
lizard
(Anolis carolinensis)
Reptilia --
--
(see all 6)
--
37(a)
34(a)
(see all 6)
1 ↔ many
1 ↔ many
(see all 6)
2(69254027-69263483)
2(69277910-69287353)
fruit fly
(Drosophila melanogaster)
Insecta CG167566
CG84926
(see all 4)
--
30(a)
3(a)
(see all 4)
1 ↔ many
1 ↔ many
(see all 4)
X(5321550-5322248)
3L(7720904-7725087)


ENSEMBL Gene Tree for LALBA (if available)
TreeFam Gene Tree for LALBA (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for LALBA gene
LYZL62  LYZL42  LYZ2  SPACA32  SPACA5B2  LYZL22  SPACA52  LYZL12  
7 SIMAP similar genes for LALBA using alignment to 2 protein entries:     LALBA_HUMAN (see all proteins):
LYZL1    LYZL2    LYZ    SPACA5    SPACA5B    SPACA3
LYZL6

LALBA for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/113 SNPs in LALBA are shown (see all 113)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1874731731,2
--48798822(+) CTGAGA/GGTGAC 1 -- us2k10--------
rs1474861401,2
--48961105(+) CCAGAC/TAATTT 1 -- ds50010--------
rs1399415371,2
--48961232(+) TGCACC/GCGGCC 1 -- ds50010--------
rs1142718831,2
C,F--48961234(+) CACCCG/AGCCAG 1 -- ds50011Minor allele frequency- A:0.01WA 118
rs125828111,2
C,F,H--48961244(+) GTGTTT/GAGCCA 1 -- ds500127Minor allele frequency- G:0.06NS EA NA CSA WA 2803
rs24090441,2
C,F,A,H--48961390(+) TGGCTA/CTGACC 1 -- ds500118Minor allele frequency- C:0.23NS EA NA CSA WA 1974
rs1392916771,2
--48961459(+) AATTA-/CCAGCC 1 -- ds50010--------
rs1145840891,2
C,F--48961533(+) CATCGA/GAGGCA 1 -- ut311Minor allele frequency- G:0.02WA 118
rs1136825061,2
C--48961544(+) CTGAGT/CAAGGG 1 -- ut312Minor allele frequency- C:0.03CSA WA 120
rs1510456241,2
--48961550(+) AAGGGA/TCTAGA 1 -- ut310--------

HapMap Linkage Disequilibrium report for LALBA (48961467 - 48963849 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for LALBA: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing LALBA
DNA2.0 Custom Variant and Variant Library Synthesis for LALBA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
OMIM gene information: 149750    OMIM disorders: --

20 diseases for LALBA:    About MalaCards
acute thyroiditis    skin papilloma    mastitis    mammary paget's disease
papilloma    atopy    celiac disease    bronchitis
eczema    atopic dermatitis    dermatitis    colon adenocarcinoma
duodenitis    glioblastoma    glomerulonephritis    breast cancer
pneumonia    ovarian cancer    thyroiditis    adenocarcinoma

3 diseases from the University of Copenhagen DISEASES database for LALBA:
Hypersensitivity reaction type I disease     Mastitis     Breast cancer

LALBA for disorders           About GeneDecksing

10/24 Novoseek inferred disease relationships for LALBA gene (see all 24)    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
allergy milk 76.6 5 11419710 (1), 8648027 (1), 12170271 (1), 16784012 (1) (see all 5)
papilloma skin 55.1 2 15215482 (1)
allergy 41.5 4 16499641 (1), 11420027 (1), 12170271 (1), 9250594 (1)
cytopathic effect viral 39.7 2 10363676 (1), 11750941 (1)
stasis 8.87 2 16160046 (2)
allergic reaction 7.58 1 20466413 (1)
dermatitis atopic 6.47 2 8123876 (2)
immunodeficiency 4.32 1 11105990 (1)
chemically induced 3.73 2 16420472 (1), 16851644 (1)
necrosis 3 4 19836376 (1), 14757184 (1), 9589588 (1)

Genetic Association Database (GAD): LALBA
Human Genome Epidemiology (HuGE) Navigator: LALBA (1 document)

Export disorders for LALBA gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for LALBA gene, integrated from 9 sources (see all 491):
(articles sorted by number of sources associating them with LALBA)
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  1. Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin. (PubMed id 9537992)1, 2, 9 Chandra N.... Acharya K.R. (1998)
  2. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
  3. Crystallographic evaluation of internal motion of human alpha- lactalbumin refined by full-matrix least-squares method. (PubMed id 10080897)1, 2 Harata K.... Muraki M. (1999)
  4. Organization and sequence of the human alpha-lactalbumin gene. (PubMed id 2954544)1, 2 Hall L.... Craig R.K. (1987)
  5. Comparison of the nucleotide sequence of cloned human and guinea-pig pre-alpha-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene. (PubMed id 6285305)1, 2 Hall L.... Campbell P.N. (1982)
  6. The complete amino-acid sequence of human alpha-lactalbumin. (PubMed id 5049057)1, 2 Findlay J.B.C. and Brew K. (1972)
  7. Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells). (PubMed id 14627739)1, 9 Svensson M....Svanborg C. (2003)
  8. Effects of the stabilization of the molten globule state on the folding mechanism of alpha-lactalbumin: a study of a chimera of bovine and human alpha-lactalbumin. (PubMed id 16121399)1, 9 Mizuguchi M....Kawano K. (2005)
  9. The importance of alpha-lactalbumin in infant nutrition. (PubMed id 2002399)1, 9 Heine W.E....Reeds P.J. (1991)
  10. Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells. (PubMed id 10037730)1, 9 Svensson M....Linse S. (1999)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 3906 HGNC: 6480 AceView: LALBA Ensembl:ENSG00000167531 euGenes: HUgn3906
ECgene: LALBA Kegg: 3906 H-InvDB: LALBA

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for LALBA Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for LALBA gene:
Search GeneIP for patents involving LALBA

GeneCards and IP:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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