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LALBA Gene

protein-coding   GIFtS: 60
GCID: GC12M048927

Lactalbumin, Alpha-

  See LALBA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Lactalbumin, Alpha-1 2
Lactose Synthase B Protein2 3
Lysozyme-Like Protein 72 3
alpha-lactalbumin2
LYZL73

External Ids:    HGNC: 64801   Entrez Gene: 39062   Ensembl: ENSG000001675317   OMIM: 1497505   UniProtKB: P007093   

Export aliases for LALBA gene to outside databases

Previous GC identifers: GC12M048678 GC12M047247 GC12M045995


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LALBA Gene:
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit
of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic
component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As
a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor
activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature
cells. (provided by RefSeq, Jul 2008)

GeneCards Summary for LALBA Gene:
LALBA (lactalbumin, alpha-) is a protein-coding gene. Diseases associated with LALBA include skin papilloma, and mammary paget's disease. GO annotations related to this gene include lactose synthase activity and calcium ion binding. An important paralog of this gene is LYZL6.

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709
Function: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in
the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize
lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose
onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins

Gene Wiki entry for LALBA (Alpha-lactalbumin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the LALBA gene promoter:
         AML1a   Tal-1beta   YY1   HNF-4alpha1   c-Ets-1   Meis-1b   Meis-1a   ITF-2   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLALBA promoter sequence
   Search Chromatin IP Primers for LALBA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LALBA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.11   HGNC cytogenetic band: 12q13

LALBA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LALBA gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M048927:  view genomic region     (about GC identifiers)

Start:
48,961,467 bp from pter      End:
48,963,849 bp from pter
Size:
2,383 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709 (See protein sequence)
Recommended Name: Alpha-lactalbumin precursor  
Size: 142 amino acids; 16225 Da
Subunit: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase
(beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA)
Selected PDB 3D structures from and Proteopedia for LALBA (see all 7):
1A4V (3D)        1B9O (3D)        1CB3 (3D)        1HML (3D)        3B0I (3D)        3B0O (3D)    
Secondary accessions: Q6FGX0 Q9UDK4

Explore the universe of human proteins at neXtProt for LALBA: NX_P00709

Post-translational modifications: 

  • Glycosylation2 at Asn64, Asn90
  • REFSEQ proteins: NP_002280.1  
    ENSEMBL proteins: 
     ENSP00000301046   ENSP00000449780  

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    antibodies-online proteins for LALBA (23 products) 

     
    antibodies-online peptides for LALBA

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR023346 Lysozyme-like_dom
     IPR000545 Lactalbumin
     IPR001916 Glyco_hydro_22
     IPR019799 Glyco_hydro_22_CS

    Graphical View of Domain Structure for InterPro Entry P00709

    ProtoNet protein and cluster: P00709

    1 Blocks protein domain: IPB000545 Lactalbumin signature

    UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709
    Similarity: Belongs to the glycosyl hydrolase 22 family


    Find genes that share domains with LALBA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LALBA_HUMAN, P00709
    Function: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in
    the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize
    lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose
    onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins

         Genatlas biochemistry entry for LALBA:
    lactalbumin,alpha,expressed in mammary gland,homolog to lypozyne,non catalytic regulatory protein,B chain of
    lactose synthase

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004461lactose synthase activity IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding ----
         
    Find genes that share ontologies with LALBA           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Lalba):
     endocrine/exocrine gland  integument  normal 

    Find genes that share phenotypes with LALBA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for LALBA: Lalbatm1Asty Lalbatm1Jvt

       genOway: Develop your customized and physiologically relevant rodent model for LALBA

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LALBA_HUMAN, P00709: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    golgi apparatus2
    nucleus2
    plasma membrane2
    cytoskeleton1
    cytosol1
    endoplasmic reticulum1
    lysosome1
    vacuole1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS7644538

    Find genes that share ontologies with LALBA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for LALBA About    
    See pathways by source

    SuperPathContained pathways About
    1Galactose metabolism
    Galactose metabolism0.44
    Galactose metabolism0.44
    2Metabolism
    Metabolic pathways0.38


    Find genes that share SuperPaths with LALBA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for LALBA
        Galactose metabolism



    2 Kegg Pathways  (Kegg details for LALBA):
        Galactose metabolism
    Metabolic pathways

        Pathway & Disease-focused RT2 Profiler PCR Array including LALBA: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for LALBA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for LALBA (P007093 ENSP000003010464) via UniProtKB, MINT, STRING, and/or I2D (see all 12)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST2H3AQ71DI33, ENSP000003854794I2D: score=1 STRING: ENSP00000385479
    HIST2H3CQ71DI33I2D: score=1 
    HIST2H3DQ71DI33I2D: score=1 
    CRYAAP024893, ENSP000002915544I2D: score=1 STRING: ENSP00000291554
    B4GALT1P152913, ENSP000003690554I2D: score=3 STRING: ENSP00000369055
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005989lactose biosynthetic process IEA--
    GO:0006915apoptotic process TAS7644538
    GO:0007165signal transduction TAS7644538
    GO:0007267cell-cell signaling TAS7644538
    GO:0042742defense response to bacterium TAS7644538

    Find genes that share ontologies with LALBA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LALBA

    4 HMDB Compounds for LALBA    About this table
    CompoundSynonyms CAS #PubMed Ids
    Alpha-Lactose(+)-lactose (see all 40)63-42-3--
    D-Glucose(+)-Glucose (see all 23)50-99-7--
    Uridine 5'-diphosphate5'-UDP (see all 9)58-98-0--
    Uridine diphosphategalactoseGDU (see all 39)2956-16-3--

    1 DrugBank Compound for LALBA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Palmitic Acid1-Hexyldecanoic Acid (see all 11)57-10-3target--18620538

    Selected Novoseek inferred chemical compound relationships for LALBA gene (see all 82)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    whey 89.2 97 15930449 (5), 19185957 (4), 1452835 (3), 10376243 (2) (see all 61)
    3-hydroxyphthalic anhydride 75 5 9282815 (2), 12834857 (1)
    lactose 70.8 49 8142006 (5), 9249575 (4), 18694425 (3), 9535717 (2) (see all 32)
    gamma-linolenate 62.1 1 15323501 (1)
    oleic acid 59.3 46 16678133 (4), 20053771 (4), 19968717 (3), 19766653 (2) (see all 24)
    udpglucose 54.8 4 2157218 (1), 8142006 (1), 10619705 (1), 11485999 (1)
    guanidine hydrochloride 53.9 9 7986345 (2), 16438927 (1), 9684889 (1), 11112553 (1) (see all 7)
    cmpa 48.9 1 10202365 (1)
    8-anilino-1-naphthalenesulfonic acid 44.8 5 16741984 (2), 8679928 (1)
    sodium dodecylsulfate 41.9 10 7986345 (2), 15545361 (1), 10867181 (1), 14613211 (1) (see all 5)



    Find genes that share compounds with LALBA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LALBA gene: 
    NM_002289.2  

    Unigene Cluster for LALBA:

    Lactalbumin, alpha-
    Hs.72938  [show with all ESTs]
    Unigene Representative Sequence: NM_002289
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301046(uc001rrt.3) ENST00000549817
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    BC069103.1 BC112316.1 BC112318.1 CR541987.1 CR542017.1 J00270.1 

    1 DOTS entry:

    DT.106363 

    5 AceView cDNA sequences:

    NM_002289 CR541987 J00270 CR542017 BC069103 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LALBA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCACACCA
    LALBA Expression
    About this image


    LALBA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
    LALBA Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.72938

    UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709
    Tissue specificity: Mammary gland specific. Secreted in milk

        Pathway & Disease-focused RT2 Profiler PCR Array including LALBA: 
              Apoptosis 384HT in human mouse rat

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for LALBA gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lalba1 , 5 lactalbumin, alpha1, 5 75.89(n)1
    68.09(a)1
      15 (54.48 cM)5
    167701  NM_010679.11  NP_034809.11 
     984804005 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    34(a)
    31(a)
    (see all 5)
    1 ↔ many
    1 ↔ many
    (see all 5)
    2(69277910-69287353)
    2(69290713-69293930)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84926
    CG167566
    (see all 13)
    --
    3(a)
    28(a)
    (see all 13)
    many ↔ many
    many ↔ many
    (see all 13)
    3L(7720904-7725087)
    X(5321550-5322248)


    ENSEMBL Gene Tree for LALBA (if available)
    TreeFam Gene Tree for LALBA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LALBA gene
    LYZL62  LYZL42  LYZ2  SPACA32  SPACA5B2  LYZL22  SPACA52  LYZL12  
    7 SIMAP similar genes for LALBA using alignment to 2 protein entries:     LALBA_HUMAN (see all proteins):
    LYZL1    LYZL2    LYZ    LYZL6    SPACA5    SPACA5B
    SPACA3

    Find genes that share paralogs with LALBA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LALBA (see all 113)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1874731731,2
    --48798822(+) CTGAGA/GGTGAC 1 -- us2k10--------
    rs1474861401,2
    --48961105(+) CCAGAC/TAATTT 1 -- ds50010--------
    rs1399415371,2
    --48961232(+) TGCACC/GCGGCC 1 -- ds50010--------
    rs1142718831,2
    C,F--48961234(+) CACCCG/AGCCAG 1 -- ds50011Minor allele frequency- A:0.01WA 118
    rs125828111,2
    C,F,H--48961244(+) GTGTTT/GAGCCA 1 -- ds500127Minor allele frequency- G:0.06NS EA NA CSA WA 2803
    rs24090441,2
    C,F,A,H--48961390(+) TGGCTA/CTGACC 1 -- ds500118Minor allele frequency- C:0.23NS EA NA CSA WA 1974
    rs1392916771,2
    --48961459(+) AATTA-/CCAGCC 1 -- ds50010--------
    rs1145840891,2
    C,F--48961533(+) CATCGA/GAGGCA 1 -- ut311Minor allele frequency- G:0.02WA 118
    rs1136825061,2
    C--48961544(+) CTGAGT/CAAGGG 1 -- ut312Minor allele frequency- C:0.03CSA WA 120
    rs1510456241,2
    --48961550(+) AAGGGA/TCTAGA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for LALBA (48961467 - 48963849 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for LALBA: --
    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 149750    OMIM disorders: --

    4 diseases for LALBA:    
    About MalaCards
    skin papilloma    mammary paget's disease    atopy    celiac disease

    3 diseases from the University of Copenhagen DISEASES database for LALBA:
    Hypersensitivity reaction type I disease     Mastitis     Breast cancer

    Find genes that share disorders with LALBA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for LALBA gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    allergy milk 76.6 5 11419710 (1), 8648027 (1), 12170271 (1), 16784012 (1) (see all 5)
    papilloma skin 55.1 2 15215482 (1)
    allergy 41.5 4 16499641 (1), 11420027 (1), 12170271 (1), 9250594 (1)
    cytopathic effect viral 39.7 2 10363676 (1), 11750941 (1)
    stasis 8.87 2 16160046 (2)
    allergic reaction 7.58 1 20466413 (1)
    dermatitis atopic 6.47 2 8123876 (2)
    immunodeficiency 4.32 1 11105990 (1)
    chemically induced 3.73 2 16420472 (1), 16851644 (1)
    necrosis 3 4 19836376 (1), 14757184 (1), 9589588 (1)

    Genetic Association Database (GAD): LALBA
    Human Genome Epidemiology (HuGE) Navigator: LALBA (1 document)

    Export disorders for LALBA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LALBA gene, integrated from 10 sources (see all 491):
    (articles sorted by number of sources associating them with LALBA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin. (PubMed id 9537992)1, 2, 9 Chandra N.... Acharya K.R. (Biochemistry 1998)
    2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    3. Crystallographic evaluation of internal motion of human alpha- lactalbumin refined by full-matrix least-squares method. (PubMed id 10080897)1, 2 Harata K.... Muraki M. (J. Mol. Biol. 1999)
    4. Organization and sequence of the human alpha-lactalbumin gene. (PubMed id 2954544)1, 2 Hall L.... Craig R.K. (Biochem. J. 1987)
    5. Comparison of the nucleotide sequence of cloned human and guinea-pig pre-alpha-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene. (PubMed id 6285305)1, 2 Hall L.... Campbell P.N. (Nucleic Acids Res. 1982)
    6. The complete amino-acid sequence of human alpha-lactalbumin. (PubMed id 5049057)1, 2 Findlay J.B.C. and Brew K. (Eur. J. Biochem. 1972)
    7. Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells). (PubMed id 14627739)1, 9 Svensson M....Svanborg C. (Protein Sci. 2003)
    8. Effects of the stabilization of the molten globule state on the folding mechanism of alpha-lactalbumin: a study of a chimera of bovine and human alpha-lactalbumin. (PubMed id 16121399)1, 9 Mizuguchi M....Kawano K. (Proteins 2005)
    9. The importance of alpha-lactalbumin in infant nutrition. (PubMed id 2002399)1, 9 Heine W.E....Reeds P.J. (J. Nutr. 1991)
    10. Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells. (PubMed id 10037730)1, 9 Svensson M....Linse S. (J. Biol. Chem. 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3906 HGNC: 6480 AceView: LALBA Ensembl:ENSG00000167531 euGenes: HUgn3906
    ECgene: LALBA Kegg: 3906 H-InvDB: LALBA

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LALBA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for LALBA gene:
    Search GeneIP for patents involving LALBA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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