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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LALBA Gene

protein-coding GIFtS: 57
GCID: GC12M048927

lactalbumin, alpha-

Explore 23 diseases affiliated with
LALBA via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Lactalbumin, Alpha-¹ ²
LYZL7¹ ³
Lactose Synthase B Protein² ³
Lysozyme-Like Protein 7² ³
Alpha-Lactalbumin¹

External Ids:	HGNC: 6480¹	Entrez Gene: 3906²	Ensembl: ENSG00000167531⁷	OMIM: 149750⁵	UniProtKB: P00709³

Export aliases for LALBA gene to outside databases

Previous GC identifers: GC12M048678 GC12M047247 GC12M045995

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LALBA:

This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the

lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component.

Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer,

alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding

variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709

Function: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the

mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the

major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the

N-acetylglucosamine of the oligosaccharide chains in glycoproteins

Gene Wiki entry for LALBA (Alpha-lactalbumin)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_029419.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LALBA gene promoter:
AML1a Tal-1beta YY1 HNF-4alpha1 c-Ets-1 Meis-1b Meis-1a ITF-2 Meis-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LALBA promoter sequence

Search SABiosciences Chromatin IP Primers for LALBA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LALBA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.11 HGNC cytogenetic band: 12q13

LALBA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LALBA gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12M048927: view genomic region (about GC identifiers)

Start:	48,961,467 bp from pter	End:	48,963,849 bp from pter
Size:	2,383 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709 (See protein sequence)

Recommended Name: Alpha-lactalbumin precursor

Size: 142 amino acids; 16225 Da

Subunit: Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1)

and a regulatory component, alpha-lactalbumin (LA)

Subcellular location: Secreted

6 PDB 3D structures from and Proteopedia for LALBA:

1A4V (3D)

1B9O (3D)

1CB3 (3D)

1HML (3D)

3B0I (3D)

3B0O (3D)

Secondary accessions: Q6FGX0 Q9UDK4

Explore the universe of human proteins at neXtProt for LALBA: NX_P00709

LALBA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_002280.1

ENSEMBL proteins:

ENSP00000301046 ENSP00000449780

Human Recombinant Protein Products for LALBA:

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	Browse Proteins at Uscn

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005615	extracellular space	TAS	7644538

LALBA for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LALBA for domains About GeneDecksing

4 InterPro domains/families:

IPR023346 Lysozyme-like_dom

IPR001916 Glyco_hydro_22

IPR000545 Lactalbumin

IPR019799 Glyco_hydro_22_CS

Graphical View of Domain Structure for InterPro Entry P00709

ProtoNet protein and cluster: P00709

1 Blocks protein family: IPB000545 Lactalbumin signature

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709

Similarity: Belongs to the glycosyl hydrolase 22 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LALBA_HUMAN, P00709

Function: Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the

mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the

major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the

N-acetylglucosamine of the oligosaccharide chains in glycoproteins

Genatlas biochemistry entry for LALBA:

lactalbumin,alpha,expressed in mammary gland,homolog to lypozyne,non catalytic regulatory protein,B chain of lactose

synthase

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004461	lactose synthase activity	IEA	--
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	--	--

LALBA for ontologies About GeneDecksing

Phenotypes:
3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Lalba):

endocrine/exocrine gland

integument

normal

LALBA for phenotypes About GeneDecksing

Animal Models:
Mouse knock-outs for LALBA: Lalba^tm1Asty Lalba^tm1Jvt

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LALBA

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LALBA
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		hsa-miR-3919 hsa-miR-24
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LALBA

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Galactose metabolism

	Galactose metabolism	1.00			Galactose metabolism	0.47
	Galactose metabolism	0.95

Metabolism

Metabolic pathways

0.38

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for LALBA

Galactose metabolism

1 GeneGo (Thomson Reuters) Pathway for LALBA

Galactose metabolism

2 Kegg Pathways (Kegg details for LALBA):

	Galactose metabolism
	Metabolic pathways

LALBA for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for LALBA

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/12 Interacting proteins for LALBA (P00709³ ENSP00000301046⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST2H3A	Q71DI3³, ENSP00000385479⁴	I2D: score=1 STRING: ENSP00000385479
HIST2H3C	Q71DI3³	I2D: score=1
HIST2H3D	Q71DI3³	I2D: score=1
CRYAA	P02489³, ENSP00000291554⁴	I2D: score=1 STRING: ENSP00000291554
B4GALT1	P15291³, ENSP00000369055⁴	I2D: score=3 STRING: ENSP00000369055

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005989	lactose biosynthetic process	IEA	--
GO:0006917	induction of apoptosis	TAS	7644538
GO:0007165	signal transduction	TAS	7644538
GO:0007267	cell-cell signaling	TAS	7644538
GO:0042742	defense response to bacterium	TAS	7644538

LALBA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

LALBA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LALBA

4 HMDB Compounds for LALBA About this table

Compound	Synonyms	CAS #	PubMed Ids
Alpha-Lactose	(+)-lactose (see all 40)	63-42-3	--
D-Glucose	(+)-Glucose (see all 23)	50-99-7	--
Uridine 5'-diphosphate	5'-UDP (see all 9)	58-98-0	--
Uridine diphosphategalactose	GDU (see all 39)	2956-16-3	--

1 DrugBank Compound for LALBA About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Palmitic Acid	1-Hexyldecanoic Acid (see all 11)	57-10-3	target	--	18620538

10/82 Novoseek chemical compound relationships for LALBA gene (see all 82) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
whey	89.2	97	15930449 (5), 19185957 (4), 1452835 (3), 10376243 (2) (see all 61)
3-hydroxyphthalic anhydride	75	5	9282815 (2), 12834857 (1)
lactose	70.8	49	8142006 (5), 9249575 (4), 18694425 (3), 9535717 (2) (see all 32)
gamma-linolenate	62.1	1	15323501 (1)
oleic acid	59.3	46	16678133 (4), 20053771 (4), 19968717 (3), 19766653 (2) (see all 24)
udpglucose	54.8	4	2157218 (1), 8142006 (1), 10619705 (1), 11485999 (1)
guanidine hydrochloride	53.9	9	7986345 (2), 16438927 (1), 9684889 (1), 11112553 (1) (see all 7)
cmpa	48.9	1	10202365 (1)
8-anilino-1-naphthalenesulfonic acid	44.8	5	16741984 (2), 8679928 (1)
sodium dodecylsulfate	41.9	10	7986345 (2), 15545361 (1), 10867181 (1), 14613211 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about LALBA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LALBA gene:

NM_002289.2

Unigene Cluster for LALBA:

Lactalbumin, alpha-

Hs.72938 [show with all ESTs]

Unigene Representative Sequence: NM_002289

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000301046(uc001rrt.3) ENST00000549817

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LALBA
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate LALBA:
		hsa-miR-3919 hsa-miR-24
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Additional cDNA sequence:

BC069103.1 BC112316.1 BC112318.1 CR541987.1 CR542017.1 J00270.1

1 DOTS entry:

DT.106363

5 AceView cDNA sequences:

NM_002289 CR542017 CR541987 J00270 BC069103

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LALBA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCACACCA

About this image

LALBA expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Spinal Cord

Spinal Ventral Columns

Spinal Cord

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See LALBA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LALBA

SOURCE GeneReport for Unigene cluster: Hs.72938

UniProtKB/Swiss-Prot: LALBA_HUMAN, P00709

Tissue specificity: Mammary gland specific. Secreted in milk

SABiosciences Expression via Pathway-Focused PCR Array including LALBA:

Apoptosis 384HT in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LALBA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for LALBA gene from 2/11 species (see all 11) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	-- -- (see all 3)	--	33(a) 33(a) (see all 3)	1 ↔ many 1 ↔ many (see all 3)	2(69290713-69293930) 2(69277911-69286685)
fruit fly (Drosophila melanogaster)	Insecta	LysS⁶ CG8492⁶ (see all 13)	--	30(a) 3(a) (see all 13)	many ↔ many many ↔ many (see all 13)	3L(1227747-1228238) 3L(7720904-7725087)

ENSEMBL Gene Tree for LALBA (if available)
TreeFam Gene Tree for LALBA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LALBA gene

LYZL4² SPACA5B² SPACA5² LYZL6² LYZ² SPACA3² LYZL2² LYZL1²

7 SIMAP similar genes for LALBA using alignment to 2 protein entries: LALBA_HUMAN (see all proteins):

LYZL1 LYZL2 LYZ SPACA5 SPACA5B SPACA3

LYZL6

LALBA for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147486140^1,2		--	48961105(+)	`CCAGAC/TAATTT`	1	--	ds500¹		0	--	--	--	--
rs139941537^1,2		--	48961232(+)	`TGCACC/GCGGCC`	1	--	ds500¹		0	--	--	--	--
rs114271883^1,2		--	48961234(+)	`CACCCG/AGCCAG`	1	--	ds500¹		1		WA	118
rs12582811^1,2	C,F,H	--	48961244(+)	`GTGTTT/GAGCCA`	1	--	ds500¹		27		NS EA NA CSA WA	2803
rs2409044^1,2	C,F,A,H	--	48961390(+)	`TGGCTA/CTGACC`	1	--	ds500¹		18		NS EA NA CSA WA	1974
rs139291677^1,2		--	48961459(+)	`AATTA-/CCAGCC`	1	--	ds500¹		0	--	--	--	--
rs114584089^1,2	C,F	--	48961533(+)	`CATCGA/GAGGCA`	1	--	ut3¹		1		WA	118
rs113682506^1,2	C	--	48961544(+)	`CTGAGT/CAAGGG`	1	--	ut3¹		2		CSA WA	120
rs151045624^1,2		--	48961550(+)	`AAGGGA/TCTAGA`	1	--	ut3¹		0	--	--	--	--
rs112447012^1,2	C	--	48961600(+)	`CAAGAG/ATTCGG`	1	--	ut3¹		1		CSA	2

HapMap Linkage Disequilibrium report for LALBA (48961467 - 48963849 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LALBA: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LALBA

DNA2.0 Custom Variant and Variant Library Synthesis for LALBA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LALBA for disorders           About GeneDecksing

OMIM gene information: 149750    OMIM disorders: --

20/23 diseases for LALBA (see all 23):    About MalaCards

mammary paget's disease papilloma skin papilloma celiac disease

atopic dermatitis atopy dermatitis mastitis

bronchitis breast cancer eczema ovarian cancer

acute thyroiditis colon adenocarcinoma duodenitis glioblastoma

glomerulonephritis carcinoma immunodeficiency breast carcinoma

3 diseases from the University of Copenhagen DISEASES database for LALBA:

Hypersensitivity reaction type I disease Mastitis Breast cancer

10/24 Novoseek disease relationships for LALBA gene (see all 24) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
allergy milk	76.6	5	11419710 (1), 8648027 (1), 12170271 (1), 16784012 (1) (see all 5)
papilloma skin	55.1	2	15215482 (1)
allergy	41.5	4	16499641 (1), 11420027 (1), 12170271 (1), 9250594 (1)
cytopathic effect viral	39.7	2	10363676 (1), 11750941 (1)
stasis	8.87	2	16160046 (2)
allergic reaction	7.58	1	20466413 (1)
dermatitis atopic	6.47	2	8123876 (2)
immunodeficiency	4.32	1	11105990 (1)
chemically induced	3.73	2	16420472 (1), 16851644 (1)
necrosis	3	4	19836376 (1), 14757184 (1), 9589588 (1)

Human Genome Epidemiology (HuGE) Navigator: LALBA (1 document)

Export disorders for LALBA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for LALBA gene, integrated from 9 sources (see all 491):
(articles sorted by number of sources associating them with LALBA)

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Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin. (PubMed id 9537992)^{1, 2, 9} Chandra N.... Acharya K.R. (1998)
Crystallographic evaluation of internal motion of human alpha- lactalbumin refined by full-matrix least-squares method. (PubMed id 10080897)^{1, 2} Harata K.... Muraki M. (1999)
Organization and sequence of the human alpha-lactalbumin gene. (PubMed id 2954544)^{1, 2} Hall L.... Craig R.K. (1987)
Comparison of the nucleotide sequence of cloned human and guinea-pig pre-alpha-lactalbumin cDNA with that of chick pre-lysozyme cDNA suggests evolution from a common ancestral gene. (PubMed id 6285305)^{1, 2} Hall L.... Campbell P.N. (1982)
The complete amino-acid sequence of human alpha-lactalbumin. (PubMed id 5049057)^{1, 2} Findlay J.B.C. and Brew K. (1972)
Alpha-lactalbumin unfolding is not sufficient to cause apoptosis, but is required for the conversion to HAMLET (human alpha-lactalbumin made lethal to tumor cells). (PubMed id 14627739)^{1, 9} Svensson M....Svanborg C. (2003)
Effects of the stabilization of the molten globule state on the folding mechanism of alpha-lactalbumin: a study of a chimera of bovine and human alpha-lactalbumin. (PubMed id 16121399)^{1, 9} Mizuguchi M....Kawano K. (2005)
The importance of alpha-lactalbumin in infant nutrition. (PubMed id 2002399)^{1, 9} Heine W.E....Reeds P.J. (1991)
Molecular characterization of alpha-lactalbumin folding variants that induce apoptosis in tumor cells. (PubMed id 10037730)^{1, 9} Svensson M....Linse S. (1999)
The unusual amino acid triplet Asn-Ile-Cys is a glycosylation consensus site in human alpha-lactalbumin. (PubMed id 9365923)^{1, 9} Giuffrida M.G....Conti A. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 3906	HGNC: 6480	AceView: LALBA	Ensembl:ENSG00000167531	euGenes: HUgn3906
ECgene: LALBA	Kegg: 3906	H-InvDB: LALBA

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for LALBA	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LALBA gene
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Patent Information for LALBA gene:
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