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Aliases for LALBA Gene

Aliases for LALBA Gene

  • Lactalbumin Alpha 2 3 5
  • Lactose Synthase B Protein 3 4
  • Lysozyme-Like Protein 7 3 4
  • Lactalbumin, Alpha- 2
  • Alpha-Lactalbumin 3
  • Lysozyme G 3
  • LYZL7 4
  • LYZG 3

External Ids for LALBA Gene

Previous GeneCards Identifiers for LALBA Gene

  • GC12M048927
  • GC12M048678
  • GC12M047247
  • GC12M045995

Summaries for LALBA Gene

Entrez Gene Summary for LALBA Gene

  • This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for LALBA Gene

LALBA (Lactalbumin Alpha) is a Protein Coding gene. Diseases associated with LALBA include Milk Allergy and Goat Milk Allergy. Among its related pathways are Metabolism and Galactose metabolism. GO annotations related to this gene include calcium ion binding and lactose synthase activity. An important paralog of this gene is LYZ.

UniProtKB/Swiss-Prot for LALBA Gene

  • Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Gene Wiki entry for LALBA Gene

Additional gene information for LALBA Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LALBA Gene

Genomics for LALBA Gene

Regulatory Elements for LALBA Gene

Enhancers for LALBA Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H049055 1.7 FANTOM5 ENCODE dbSUPER 14.6 -458.4 -458392 6 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF548 SP3 NFYC ZFP41 MEF2D DDX23 LOC390314 LMBR1L CCNT1 KANSL2 KMT2D SENP1 LOC100422296 PRPF40B OR5BK1P
GH12H049344 1.7 FANTOM5 Ensembl ENCODE 14.6 -746.7 -746714 4 HDGF FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF143 CCNT1 KANSL2 DDX23 LOC390314 KMT2D LIMA1 RPL35AP28 OR11M1P OR5BS1P LALBA
GH12H048714 1.4 ENCODE dbSUPER 14.7 -116.3 -116346 3 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 KANSL2 DDX23 LMBR1L SENP1 KMT2D CCNT1 LOC390314 CCDC184 OR11M1P LALBA
GH12H049296 1.3 Ensembl ENCODE 14.6 -697.0 -697028 2 PKNOX1 ATF1 GLI4 ZNF2 ZNF121 GLIS2 ZNF302 ZNF143 KLF7 ZNF548 LIMA1 LOC100422296 BCDIN3D ENSG00000257298 OR5BK1P CCNT1 DDX23 KANSL2 RPL35AP28 OR11M1P
GH12H048956 1.1 ENCODE 14.6 -356.7 -356708 2 HDGF PKNOX1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 ZNF207 ZNF548 CCNT1 KANSL2 LMBR1L LOC390314 DDX23 KMT2D SENP1 PRPF40B LOC101927267 CCDC65
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around LALBA on UCSC Golden Path with GeneCards custom track

Genomic Location for LALBA Gene

Chromosome:
12
Start:
48,567,684 bp from pter
End:
48,600,111 bp from pter
Size:
32,428 bases
Orientation:
Minus strand

Genomic View for LALBA Gene

Genes around LALBA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LALBA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LALBA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LALBA Gene

Proteins for LALBA Gene

  • Protein details for LALBA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P00709-LALBA_HUMAN
    Recommended name:
    Alpha-lactalbumin
    Protein Accession:
    P00709
    Secondary Accessions:
    • Q6FGX0
    • Q9UDK4

    Protein attributes for LALBA Gene

    Size:
    142 amino acids
    Molecular mass:
    16225 Da
    Quaternary structure:
    • Lactose synthase (LS) is a heterodimer of a catalytic component, beta1,4-galactosyltransferase (beta4Gal-T1) and a regulatory component, alpha-lactalbumin (LA).

    Three dimensional structures from OCA and Proteopedia for LALBA Gene

neXtProt entry for LALBA Gene

Post-translational modifications for LALBA Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LALBA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for LALBA Gene

Domains & Families for LALBA Gene

Gene Families for LALBA Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted secreted proteins

Protein Domains for LALBA Gene

Suggested Antigen Peptide Sequences for LALBA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P00709

UniProtKB/Swiss-Prot:

LALBA_HUMAN :
  • Belongs to the glycosyl hydrolase 22 family.
Family:
  • Belongs to the glycosyl hydrolase 22 family.
genes like me logo Genes that share domains with LALBA: view

Function for LALBA Gene

Molecular function for LALBA Gene

GENATLAS Biochemistry:
lactalbumin,alpha,expressed in mammary gland,homolog to lypozyne,non catalytic regulatory protein,B chain of lactose synthase
UniProtKB/Swiss-Prot Function:
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.

Gene Ontology (GO) - Molecular Function for LALBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003796 lysozyme activity IBA --
GO:0004461 lactose synthase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with LALBA: view
genes like me logo Genes that share phenotypes with LALBA: view

Animal Models for LALBA Gene

MGI Knock Outs for LALBA:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LALBA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for LALBA Gene

Localization for LALBA Gene

Subcellular locations from UniProtKB/Swiss-Prot for LALBA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for LALBA gene
Compartment Confidence
extracellular 5
golgi apparatus 5
plasma membrane 2
nucleus 2
cytosol 2
cytoskeleton 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for LALBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space TAS 7644538
GO:0005796 Golgi lumen TAS --
genes like me logo Genes that share ontologies with LALBA: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for LALBA Gene

Pathways & Interactions for LALBA Gene

genes like me logo Genes that share pathways with LALBA: view

Pathways by source for LALBA Gene

3 Reactome pathways for LALBA Gene
2 KEGG pathways for LALBA Gene
1 GeneGo (Thomson Reuters) pathway for LALBA Gene

Gene Ontology (GO) - Biological Process for LALBA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005989 lactose biosynthetic process TAS,IEA --
GO:0006915 apoptotic process TAS 7644538
GO:0007165 signal transduction TAS 7644538
GO:0007267 cell-cell signaling TAS 7644538
GO:0016998 cell wall macromolecule catabolic process IBA --
genes like me logo Genes that share ontologies with LALBA: view

No data available for SIGNOR curated interactions for LALBA Gene

Drugs & Compounds for LALBA Gene

(43) Drugs for LALBA Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
lactose Approved Pharma 0
D-glucose Approved Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist, Target 22
Uridine diphosphategalactose Experimental Pharma 0
Uridine-5'-Diphosphate Experimental Pharma 0

(44) Additional Compounds for LALBA Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
beta-Lactose
  • beta-D-Galactopyranosyl-(1->4)-beta-D-glucopyranose
  • beta-D-Galactopyranosyl-(1->4)-beta-D-glucose
  • beta-Lactose
5965-66-2
genes like me logo Genes that share compounds with LALBA: view

Transcripts for LALBA Gene

mRNA/cDNA for LALBA Gene

(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LALBA Gene

Lactalbumin, alpha-:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for LALBA
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for LALBA Gene

No ASD Table

Relevant External Links for LALBA Gene

GeneLoc Exon Structure for
LALBA
ECgene alternative splicing isoforms for
LALBA

Expression for LALBA Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for LALBA Gene

mRNA differential expression in normal tissues according to GTEx for LALBA Gene

This gene is overexpressed in Breast - Mammary Tissue (x51.8).

Protein differential expression in normal tissues from HIPED for LALBA Gene

This gene is overexpressed in Milk (68.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for LALBA Gene



Protein tissue co-expression partners for LALBA Gene

NURSA nuclear receptor signaling pathways regulating expression of LALBA Gene:

LALBA

SOURCE GeneReport for Unigene cluster for LALBA Gene:

Hs.72938

mRNA Expression by UniProt/SwissProt for LALBA Gene:

P00709-LALBA_HUMAN
Tissue specificity: Mammary gland specific. Secreted in milk.

Evidence on tissue expression from TISSUES for LALBA Gene

  • Nervous system(4.2)
  • Blood(2)
genes like me logo Genes that share expression patterns with LALBA: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for LALBA Gene

Orthologs for LALBA Gene

This gene was present in the common ancestor of animals.

Orthologs for LALBA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LALBA 33 34
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia LALBA 33 34
  • 87.79 (n)
cow
(Bos Taurus)
Mammalia LALBA 33 34
  • 84.51 (n)
rat
(Rattus norvegicus)
Mammalia Lalba 33
  • 78.01 (n)
mouse
(Mus musculus)
Mammalia Lalba 33 16 34
  • 75.89 (n)
oppossum
(Monodelphis domestica)
Mammalia LALBA 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 35 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 34 (a)
OneToMany
-- 34
  • 31 (a)
OneToMany
-- 34
  • 29 (a)
OneToMany
-- 34
  • 27 (a)
OneToMany
-- 34
  • 24 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG16756 34
  • 28 (a)
ManyToMany
LysP 34
  • 28 (a)
ManyToMany
CG11159 34
  • 27 (a)
ManyToMany
LysE 34
  • 27 (a)
ManyToMany
LysS 34
  • 27 (a)
ManyToMany
LysX 34
  • 27 (a)
ManyToMany
CG7798 34
  • 26 (a)
ManyToMany
LysB 34
  • 26 (a)
ManyToMany
LysC 34
  • 26 (a)
ManyToMany
LysD 34
  • 26 (a)
ManyToMany
CG30062 34
  • 23 (a)
ManyToMany
CG16799 34
  • 22 (a)
ManyToMany
CG8492 34
  • 3 (a)
ManyToMany
Species where no ortholog for LALBA was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LALBA Gene

ENSEMBL:
Gene Tree for LALBA (if available)
TreeFam:
Gene Tree for LALBA (if available)

Paralogs for LALBA Gene

Paralogs for LALBA Gene

(7) SIMAP similar genes for LALBA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LALBA: view

Variants for LALBA Gene

Sequence variations from dbSNP and Humsavar for LALBA Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000205309 -- 48,571,621(+) CTCAG(A/G)CAATT intron-variant, upstream-variant-2KB
rs1000724046 -- 48,571,851(+) GGCAT(A/G)AGTGA upstream-variant-2KB
rs1001001577 -- 48,567,614(+) GACCT(A/T)TGGCT downstream-variant-500B
rs1001324354 -- 48,573,032(+) GGCAG(G/T)AGTCT upstream-variant-2KB
rs1001608635 -- 48,572,823(+) GAACA(A/G)AATAA upstream-variant-2KB

Variation tolerance for LALBA Gene

Residual Variation Intolerance Score: 63.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LALBA Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
LALBA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LALBA Gene

Disorders for LALBA Gene

MalaCards: The human disease database

(11) MalaCards diseases for LALBA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
milk allergy
  • milk allergic reaction
goat milk allergy
  • capra hircus milk allergy
mastitis
  • breast inflammation
allergic hypersensitivity disease
  • allergic disease
cutaneous adenocystic carcinoma
  • adenoid cystic carcinoma of the skin
- elite association - COSMIC cancer census association via MalaCards
Search LALBA in MalaCards View complete list of genes associated with diseases

Relevant External Links for LALBA

Genetic Association Database (GAD)
LALBA
Human Genome Epidemiology (HuGE) Navigator
LALBA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LALBA
genes like me logo Genes that share disorders with LALBA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LALBA Gene

Publications for LALBA Gene

  1. Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin. (PMID: 9537992) Chandra N … Acharya KR (Biochemistry 1998) 3 4 22 60
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 45 60
  3. The oleic acid complexes of proteolytic fragments of alpha-lactalbumin display apoptotic activity. (PMID: 19968717) Tolin S … Fontana A (The FEBS journal 2010) 3 22 60
  4. Characterization of the denaturation of human alpha-lactalbumin in urea by molecular dynamics simulations. (PMID: 15558602) Smith LJ … van Gunsteren WF (Proteins 2005) 3 22 60
  5. Effects of the stabilization of the molten globule state on the folding mechanism of alpha-lactalbumin: a study of a chimera of bovine and human alpha-lactalbumin. (PMID: 16121399) Mizuguchi M … Kawano K (Proteins 2005) 3 22 60

Products for LALBA Gene

Sources for LALBA Gene

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