Aliases for LALBA Gene
External Ids for LALBA Gene
Previous GeneCards Identifiers for LALBA Gene
This gene encodes alpha-lactalbumin, a principal protein of milk. Alpha-lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and beta 1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transfering galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. A folding variant of alpha-lactalbumin, called HAMLET, likely induces apoptosis in tumor and immature cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for LALBA Gene
LALBA (Lactalbumin Alpha) is a Protein Coding gene. Diseases associated with LALBA include mastitis and allergic hypersensitivity disease. Among its related pathways are Metabolism and Glycosaminoglycan metabolism. GO annotations related to this gene include calcium ion binding and lactose synthase activity. An important paralog of this gene is SPACA5B.
UniProtKB/Swiss-Prot for LALBA Gene
Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins.