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LAIR2 Gene

protein-coding   GIFtS: 54
GCID: GC19P055009

Leukocyte-Associated Immunoglobulin-Like Receptor 2

(Previous name: leukocyte-associated Ig-like receptor 2)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Leukocyte-Associated Immunoglobulin-Like Receptor 21 2
Leukocyte-Associated Ig-Like Receptor 21 2
CD3062 3
LAIR-22 3
Leukocyte-Associated Ig-Like Receptor-22
CD306 Antigen3

External Ids:    HGNC: 64781   Entrez Gene: 39042   Ensembl: ENSG000001676187   OMIM: 6029935   UniProtKB: Q6ISS43   

Export aliases for LAIR2 gene to outside databases

Previous GC identifers: GC19P055877 GC19P055438 GC19P059689 GC19P059705 GC19P051337


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LAIR2 Gene:
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its
similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates
innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both
inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene
maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin
superfamily. Alternatively spliced transcript variants have been described for this gene. (provided by RefSeq,
Sep 2013)

GeneCards Summary for LAIR2 Gene:
LAIR2 (leukocyte-associated immunoglobulin-like receptor 2) is a protein-coding gene. Diseases associated with LAIR2 include spondylitis, and ankylosing spondylitis. An important paralog of this gene is LAIR1.

Gene Wiki entry for LAIR2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  NT_187693.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the LAIR2 gene promoter:
         Bach1   NRSF form 1   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAIR2 promoter sequence
   Search Chromatin IP Primers for LAIR2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LAIR2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LAIR2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAIR2 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055009:  view genomic region     (about GC identifiers)

Start:
55,009,100 bp from pter      End:
55,021,900 bp from pter
Size:
12,801 bases      Orientation:
plus strand

2 alternative locations:
Chr19+,NW_003571054 409,002-416,891      Chr19+,NW_003571060 407,512-415,408     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: LAIR2_HUMAN, Q6ISS4 (See protein sequence)
Recommended Name: Leukocyte-associated immunoglobulin-like receptor 2 precursor  
Size: 152 amino acids; 16280 Da
Secondary accessions: Q6PEZ4
Alternative splicing: 2 isoforms:  Q6ISS4-1   Q6ISS4-2   

Explore the universe of human proteins at neXtProt for LAIR2: NX_Q6ISS4

Explore proteomics data for LAIR2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See LAIR2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_002279.2  NP_067154.1  

    ENSEMBL proteins: 
     ENSP00000390729   ENSP00000301202   ENSP00000301203  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    LAIR: Leukocyte-associated Ig like receptors
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6ISS4

    ProtoNet protein and cluster: Q6ISS4

    1 Blocks protein domain: IPB003599 Immunoglobulin subtype

    UniProtKB/Swiss-Prot: LAIR2_HUMAN, Q6ISS4
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    LAIR2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for LAIR2:
    leukocyte-associated immunoglobulin-like receptor,32kDa,expressed in monocytes

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LAIR2
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    hsa-mir-335-5p (MIRT017705)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LAIR2_HUMAN, Q6ISS4: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    LAIR2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LAIR2
    Interactions:

        GeneGlobe Interaction Network for LAIR2

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LAIR2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for LAIR2 gene (2 alternative transcripts): 
    NM_002288.5  NM_021270.4  

    Unigene Cluster for LAIR2:

    Leukocyte-associated immunoglobulin-like receptor 2
    Hs.43803  [show with all ESTs]
    Unigene Representative Sequence: BC057790
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412608(uc002qga.1) ENST00000301202(uc002qgc.3 uc002qgd.3 uc010erl.3)
    ENST00000351841
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    OriGene qPCR primer pairs and template standards for LAIR2
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      QuantiTect SYBR Green Assays in human, mouse, rat LAIR2
      QuantiFast Probe-based Assays in human, mouse, rat LAIR2

    Additional mRNA sequence: 

    AF013250.1 BC057790.1 BC069366.1 DQ656002.2 DQ656003.2 EF174570.1 

    5 DOTS entries:

    DT.306715  DT.87046706  DT.121487195  DT.100026356  DT.95125636 

    18 AceView cDNA sequences:

    AI262718 NM_002288 NM_021270 BC057790 AI189606 AI189280 AA133246 AA133300 
    BV178815 BV167967 BX106365 CF527743 N26404 AI126085 BC069366 AF013250 
    CB991201 BG198445 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for LAIR2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for LAIR2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LAIR2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATGAGGAGA
    LAIR2 Expression
    About this image


    LAIR2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Epithelial Cells
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Blood (Hematopoietic System)
             Natural Killer Cells Peripheral Blood
     
     Eye (Sensory Organs)
             Mature Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
     
     Placenta (Extraembryonic Tissues)
    LAIR2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LAIR2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.43803
        Custom PCR Arrays for LAIR2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAIR2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    ENSEMBL Gene Tree for LAIR2 (if available)
    TreeFam Gene Tree for LAIR2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for LAIR2 gene
    LAIR12  
    Selected SIMAP similar genes for LAIR2 using alignment to 2 protein entries:     LAIR2_HUMAN (see all proteins) (see all similar genes):
    LAIR1    LILRA6    LILRA1    LILRA5    GP6    LILRB3
    LILRB5    FLJ00275    LILRA2    LILRB4    LILRA3    LILRB1
    LILRB2    MIR cl-10    OSCAR    TARM1    KIR3DL3    LILRA4

    LAIR2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LAIR2 (see all 315)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1836628801,2
    --55012108(+) ACCCTA/CGTCAA 2 -- us2k10--------
    rs1873724311,2
    --55012241(+) TCCTGG/TTCCTG 2 -- us2k10--------
    rs592972111,2
    C--55012335(+) CCCTT-/ACGGGA 2 -- us2k10--------
    rs679465321,2
    C,F--55012392(+) GACACT/CGTAGG 2 -- us2k17Minor allele frequency- C:0.25NA WA EA 366
    rs611319771,2
    C,F--55012428(+) TAGAGT/AGTGTG 2 -- us2k12Minor allele frequency- A:0.50CSA 4
    rs581328841,2
    C--55012431(+) AGTGTG/ATGTGT 2 -- us2k14Minor allele frequency- A:0.29CSA WA NA EA 360
    rs757549871,2
    C--55012456(+) GTGTGA/TATGTG 2 -- us2k10--------
    rs780777371,2
    C--55012457(+) TGTGAA/GTGTGT 2 -- us2k10--------
    rs610733161,2
    C--55012516(+) GGGCGC/TGGTGG 2 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs621315641,2
    C--55012559(+) TGAGAC/TGGGCA 2 -- us2k13Minor allele frequency- T:0.00NA CSA 5

    HapMap Linkage Disequilibrium report for LAIR2 (55009100 - 55021900 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LAIR2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718872CNV Deletion23290073
    esv2667609CNV Deletion23128226
    nsv833878CNV Loss17160897
    dgv1119e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): LAIR2
    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for LAIR2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602993    OMIM disorders: --

    6 diseases for LAIR2:    
    About MalaCards
    spondylitis    ankylosing spondylitis    myopathy    hepatitis b
    hepatitis    retinitis


    LAIR2 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: LAIR2 (1 document)

    Export disorders for LAIR2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LAIR2 gene, integrated from 10 sources (see all 21):
    (articles sorted by number of sources associating them with LAIR2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. (PubMed id 9285412)1, 2, 3 Meyaard L.... Phillips J.H. (Immunity 1997)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. (PubMed id 10229813)1, 2 Meyaard L.... Phillips J.H. (J. Immunol. 1999)
    4. The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction. (PubMed id 18209062)1, 9 Lebbink R.J....Meyaard L. (J. Immunol. 2008)
    5. Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III. (PubMed id 19345263)1, 9 Lebbink R.J....Meyaard L. (Matrix Biol. 2009)
    6. LAIR2-expressing extravillous trophoblasts associate with maternal spiral arterioles undergoing physiologic conversion. (PubMed id 23332415)1 Founds S.A....Parks W.T. (Placenta 2013)
    7. Serum LAIR-2 is increased in autoimmune thyroid diseases. (PubMed id 23691008)1 Simone R....Saverino D. (PLoS ONE 2013)
    8. A high density SNP genotyping approach within the 19q13 chromosome region identifies an association of a CNOT3 polymorphism with ankylosing spondylitis. (PubMed id 22294640)1 DA-az-PeA+a R....LA^pez-Larrea C. (Ann. Rheum. Dis. 2012)
    9. New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (Genes Immun. 2010)
    10. Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member. (PubMed id 20730098)1 Lenting P.J....Meyaard L. (PLoS ONE 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3904 HGNC: 6478 AceView: LAIR2 Ensembl:ENSG00000167618 euGenes: HUgn3904
    ECgene: LAIR2 H-InvDB: LAIR2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LAIR2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LAIR2 gene:
    Search GeneIP for patents involving LAIR2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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