LAIR2 Gene
protein-coding GIFtS: 51
GCID: GC19P055009
|
|
leukocyte-associated immunoglobulin-like receptor 2(Previous name: leukocyte-associated Ig-like receptor 2 )
| |
Aliases
for LAIR2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Leukocyte-Associated Immunoglobulin-Like Receptor 21 2 | | CD3061 2 3 | | Leukocyte-Associated Ig-Like Receptor 21 2 | | LAIR-22 3 | | Leukocyte-Associated Ig-Like Receptor-22 | | CD306 Antigen3 |
Export aliases for LAIR2 gene to outside databasesPrevious GC identifers: GC19P055877 GC19P055438 GC19P059689 GC19P059705 GC19P051337 |
Summaries
for LAIR2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LAIR2:
The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity toLAIR1, an inhibitory receptor present on mononuclear leukocytes. This gene maps to a region of 19q13.4, termed theleukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily, including LAIR1. The functionof this protein is unknown, although it is thought to be secreted and may help modulate mucosal tolerance. Twotranscript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)
Gene Wiki entry for LAIR2
|
Genomic Views
for LAIR2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011109.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LAIR2 gene promoter:
Bach1 NRSF form 1 NRSF form 2
Other transcription factors
Search SABiosciences Chromatin IP Primers for LAIR2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAIR2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.4LAIR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P055009: view genomic region
(about GC identifiers)
Start:
|
55,009,100 bp from pter |
End:
|
55,021,897 bp from pter |
Size:
|
12,798 bases |
Orientation:
|
plus strand |
|
Proteins
for LAIR2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LAIR2_HUMAN, Q6ISS4 (See
protein sequence)Recommended Name: Leukocyte-associated immunoglobulin-like receptor 2 precursor Size: 152 amino acids; 16280 Da
Subcellular location: Secreted
Secondary accessions: Q6PEZ4Alternative splicing: 2 isoforms: Q6ISS4-1 Q6ISS4-2 Explore the universe of human proteins at neXtProt for LAIR2: NX_Q6ISS4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ISS4
LAIR2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_002279.2 NP_067154.1
ENSEMBL proteins: ENSP00000390729 ENSP00000402295 ENSP00000301202 ENSP00000301203
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
LAIR2 for ontologies About GeneDecksing
LAIR2 Antibody Products:
Assay Products for LAIR2: |
Protein
Domains /
Families
for LAIR2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
LAIR2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6ISS4ProtoNet protein and cluster: Q6ISS4 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: LAIR2_HUMAN, Q6ISS4Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain |
Function
for LAIR2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for LAIR2:leukocyte-associated immunoglobulin-like receptor,32kDa,expressed in monocytes
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAIR2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAIR2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): LAIR2 (NM_021270) | |  | Sino Biological Human cDNA Clone for LAIR2 | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LAIR2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAIR2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
-- | -- |
LAIR2 for ontologies About GeneDecksing
|
Pathways & Interactions
for LAIR2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LAIR2
|
Drugs & Compounds
for LAIR2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for LAIR2
Search CenterWatch for drugs/clinical trials and news about LAIR2
|
Transcripts
for LAIR2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LAIR2 gene (2 alternative transcripts): NM_002288.4 NM_021270.3 Unigene Cluster for LAIR2: Leukocyte-associated immunoglobulin-like receptor 2 Hs.43803 [show with all ESTs]Unigene Representative Sequence: BC0577904 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000412608(uc002qga.1) ENST00000452094(uc002qgb.1) ENST00000301202(uc002qgc.3 uc002qgd.3 uc010erl.3)
ENST00000351841
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAIR2 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAIR2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): LAIR2 (NM_021270) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LAIR2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAIR2 |
Additional cDNA sequence: AF013250.1 BC057790.1 BC069366.1 DQ656002.2 DQ656003.2 EF174570.1 5 DOTS entries: DT.306715 DT.87046706 DT.121487195 DT.100026356 DT.95125636 18 AceView cDNA sequences: NM_002288 NM_021270 AI262718 AI189606 BV167967 BC057790 AI189280 BX106365 AA133300 BV178815 AA133246 CF527743 BC069366 AI126085 N26404 AF013250 CB991201 BG198445
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for LAIR2 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b |
|---|
|
| SP1: | | | | | | | | | | | |
| SP2: | | | | | - | | | | | |
ECgene alternative splicing isoforms for LAIR2
|
Expression
for LAIR2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LAIR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGAGGAGA
About this image
See LAIR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LAIR2
SOURCE GeneReport for Unigene cluster: Hs.43803
SABiosciences Custom PCR Arrays for LAIR2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAIR2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat LAIR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAIR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAIR2 |
Orthologs
for LAIR2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for LAIR2 (if available)
TreeFam Gene Tree for LAIR2 (if available) |
Paralogs
for LAIR2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for LAIR2 gene
- LAIR12
18/21 SIMAP similar genes for LAIR2 using alignment to 3 protein entries: LAIR2_HUMAN (see all proteins)
(see all similar genes):LAIR1 GP6 LILRA6 LILRA1 LILRA5 LILRB5
LILRB3 FLJ00275 KIR2DL5B LILRB4 LILRA3 LILRA2
OSCAR LILRB2 LILRB1 MIR cl-10 TARM1 KIR3DL3
LAIR2 for paralogs About GeneDecksing
|
Genomic Variants
for LAIR2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LAIR2 (55009100 - 55021897 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for LAIR2
2 CNVs: 4088 5116 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAIR2 |
|
Disorders
/ Diseases
for LAIR2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LAIR2 for disorders About GeneDecksing
OMIM gene information: 602993
OMIM disorders: --
4  diseases for LAIR2: About MalaCardshypergammaglobulinemia myopathy hepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: LAIR2 (1 document)
Export disorders for LAIR2 gene to outside databases
|
Publications
for LAIR2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LAIR2 gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with LAIR2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. (PubMed id 9285412)1, 2, 3 Meyaard L.... Phillips J.H. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. (PubMed id 10229813)1, 2 Meyaard L.... Phillips J.H. (1999)
- The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction. (PubMed id 18209062)1, 9 Lebbink R.J....Meyaard L. (2008)
- Identification of multiple potent binding sites for h uman leukocyte associated Ig-like receptor LAIR on collagens II and III. (PubMed id 19345263)1, 9 Lebbink R.J....Meyaard L. (2009)
- A high density SNP genotyping approach within the 19q1 3 chromosome region identifies an association of a CNOT3 polymorphism with ankyl osing spondylitis. (PubMed id 22294640)1 Diaz-Pena R....Lopez-Larrea C. (2012)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Efficient inhibition of collagen-induced platelet act ivation and adhesion by LAIR-2, a soluble Ig-like receptor family member. (PubMed id 20730098)1 Lenting P.J....Meyaard L. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (2007)
|
External Searches for LAIR2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LAIR2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LAIR2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LAIR2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LAIR2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LAIR2 gene:
Search GeneIP for patents involving LAIR2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LAIR2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LAIR2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAIR2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAIR2 | | | OriGene Protein Over-expression Lysate for LAIR2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LAIR2 | | OriGene 3'-UTR Clone for LAIR2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAIR2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAIR2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LAIR2 | | OriGene Custom Protein Services for LAIR2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LAIR2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAIR2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAIR2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAIR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAIR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAIR2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for LAIR2 |
| |  |  |  |  | | | | | | Recombinant Protein for LAIR2 |
|
 |
 |
 |
 | | | LAIR2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for LAIR2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAIR2 |
|
|
|
|
