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Aliases for LAIR2 Gene

Aliases for LAIR2 Gene

  • Leukocyte Associated Immunoglobulin Like Receptor 2 2 3
  • Leukocyte-Associated Immunoglobulin-Like Receptor 2 2 5
  • Leukocyte-Associated Ig-Like Receptor 2 2 3
  • LAIR-2 3 4
  • CD306 3 4
  • Leukocyte-Associated Ig-Like Receptor-2 3
  • CD306 Antigen 4

External Ids for LAIR2 Gene

Previous GeneCards Identifiers for LAIR2 Gene

  • GC19P055877
  • GC19P055438
  • GC19P059689
  • GC19P059705
  • GC19P055009
  • GC19P051337

Summaries for LAIR2 Gene

Entrez Gene Summary for LAIR2 Gene

  • The protein encoded by this gene is a member of the immunoglobulin superfamily. It was identified by its similarity to leukocyte-associated immunoglobulin-like receptor 1, a membrane-bound receptor that modulates innate immune response. The protein encoded by this locus is a soluble receptor that may play roles in both inhibition of collagen-induced platelet aggregation and vessel formation during placental implantation. This gene maps to a region of 19q13.4, termed the leukocyte receptor cluster, which contains 29 genes in the immunoglobulin superfamily. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]

GeneCards Summary for LAIR2 Gene

LAIR2 (Leukocyte Associated Immunoglobulin Like Receptor 2) is a Protein Coding gene. Among its related pathways are Immune System and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. An important paralog of this gene is LAIR1.

Gene Wiki entry for LAIR2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAIR2 Gene

Genomics for LAIR2 Gene

Regulatory Elements for LAIR2 Gene

Enhancers for LAIR2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around LAIR2 on UCSC Golden Path with GeneCards custom track

Promoters for LAIR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LAIR2 on UCSC Golden Path with GeneCards custom track

Genomic Location for LAIR2 Gene

54,497,879 bp from pter
54,510,690 bp from pter
12,812 bases
Plus strand

Genomic View for LAIR2 Gene

Genes around LAIR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAIR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAIR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAIR2 Gene

Proteins for LAIR2 Gene

  • Protein details for LAIR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Leukocyte-associated immunoglobulin-like receptor 2
    Protein Accession:
    Secondary Accessions:
    • Q6PEZ4

    Protein attributes for LAIR2 Gene

    152 amino acids
    Molecular mass:
    16280 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LAIR2 Gene


neXtProt entry for LAIR2 Gene

Proteomics data for LAIR2 Gene at MOPED

Post-translational modifications for LAIR2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LAIR2 Gene

Antibody Products

  • Abcam antibodies for LAIR2

No data available for DME Specific Peptides for LAIR2 Gene

Domains & Families for LAIR2 Gene

Protein Domains for LAIR2 Gene

Suggested Antigen Peptide Sequences for LAIR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with LAIR2: view

Function for LAIR2 Gene

Molecular function for LAIR2 Gene

GENATLAS Biochemistry:
leukocyte-associated immunoglobulin-like receptor,32kDa,expressed in monocytes

Phenotypes for LAIR2 Gene

genes like me logo Genes that share phenotypes with LAIR2: view

Animal Model Products

CRISPR Products

miRNA for LAIR2 Gene

miRTarBase miRNAs that target LAIR2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LAIR2 Gene

Localization for LAIR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAIR2 Gene


Subcellular locations from

Jensen Localization Image for LAIR2 Gene COMPARTMENTS Subcellular localization image for LAIR2 gene
Compartment Confidence
extracellular 4
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for LAIR2 Gene

Pathways & Interactions for LAIR2 Gene

genes like me logo Genes that share pathways with LAIR2: view

Pathways by source for LAIR2 Gene

Interacting Proteins for LAIR2 Gene

Selected Interacting proteins: Q6ISS4-LAIR2_HUMAN for LAIR2 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for LAIR2 Gene


No data available for SIGNOR curated interactions for LAIR2 Gene

Drugs & Compounds for LAIR2 Gene

No Compound Related Data Available

Transcripts for LAIR2 Gene

Unigene Clusters for LAIR2 Gene

Leukocyte-associated immunoglobulin-like receptor 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAIR2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b
SP2: -

Relevant External Links for LAIR2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for LAIR2 Gene

mRNA expression in normal human tissues for LAIR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LAIR2 Gene

This gene is overexpressed in Whole Blood (x22.7) and Pituitary (x6.1).

Protein differential expression in normal tissues from HIPED for LAIR2 Gene

This gene is overexpressed in Urine (61.2) and Placenta (7.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for LAIR2 Gene

SOURCE GeneReport for Unigene cluster for LAIR2 Gene Hs.43803

genes like me logo Genes that share expression patterns with LAIR2: view

Protein tissue co-expression partners for LAIR2 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for LAIR2 Gene

Orthologs for LAIR2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LAIR2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LAIR2 35
  • 98.9 (n)
  • 98.68 (a)
LAIR2 36
  • 99 (a)
(Bos Taurus)
Mammalia -- 36
  • 24 (a)
(Canis familiaris)
Mammalia -- 36
  • 23 (a)
(Mus musculus)
Mammalia Lair1 36
  • 18 (a)
Species with no ortholog for LAIR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LAIR2 Gene

Gene Tree for LAIR2 (if available)
Gene Tree for LAIR2 (if available)

Paralogs for LAIR2 Gene

Paralogs for LAIR2 Gene

(20) SIMAP similar genes for LAIR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with LAIR2: view

Variants for LAIR2 Gene

Sequence variations from dbSNP and Humsavar for LAIR2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
VAR_049882 -
VAR_049883 -
VAR_049884 -
rs111754128 -- 54,503,458(+) GTCTC(-/CAA)CCAAC intron-variant
rs61605037 -- 54,504,124(+) TTTTT(-/TT/TTT)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAIR2 Gene

Variant ID Type Subtype PubMed ID
dgv1119e1 CNV Complex 17122850
nsv833878 CNV Loss 17160897
esv2667609 CNV Deletion 23128226
esv2718872 CNV Deletion 23290073

Variation tolerance for LAIR2 Gene

Residual Variation Intolerance Score: 76.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.87; 58.97% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for LAIR2 Gene

Disorders for LAIR2 Gene

Relevant External Links for LAIR2

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for LAIR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LAIR2 Gene

Publications for LAIR2 Gene

  1. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. (PMID: 9285412) Meyaard L. … Phillips J.H. (Immunity 1997) 2 3 4 67
  2. Identification of multiple potent binding sites for human leukocyte associated Ig-like receptor LAIR on collagens II and III. (PMID: 19345263) Lebbink R.J. … Meyaard L. (Matrix Biol. 2009) 3 23
  3. The soluble leukocyte-associated Ig-like receptor (LAIR)-2 antagonizes the collagen/LAIR-1 inhibitory immune interaction. (PMID: 18209062) Lebbink R.J. … Meyaard L. (J. Immunol. 2008) 3 23
  4. Inhibition of the classical and lectin pathway of the complement system by recombinant LAIR-2. (PMID: 24192271) Olde Nordkamp M.J. … Meyaard L. (J Innate Immun 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for LAIR2 Gene

Sources for LAIR2 Gene