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LAIR1 Gene

protein-coding   GIFtS: 57

GC19M059557
leukocyte-associated immunoglobulin-like receptor 1
(Previous name: leukocyte-associated Ig-like receptor 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for LAIR1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
CD305 1, 2, 3
LAIR-1 2, 3
hLAIR1 3
Descriptions
CD305 antigen 3
leukocyte-associated Ig-like receptor 1 1, 2
leukocyte-associated immunoglobulin-like receptor 1 2
External Ids
HGNC: 64771
Entrez Gene: 39032
UniProtKB: Q6GTX83
Ensembl: ENSG000001676137
Search outside databases for aliases for LAIR1 gene

Previous GC identifers: GC19M055728 GC19M055289 GC19M059541

Summaries
for LAIR1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for LAIR1:
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells,
including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to
prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin
superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of
19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding
leukocyte-expressed receptors of the immunoglobulin superfamily. [provided by RefSeq]

UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8
Function: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on
cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr
phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It
also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also
play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine
production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of
transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as
IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell
lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation
of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood
precursors towards dendritic cells

Gene Wiki entry for LAIR1

Genomic Location
for LAIR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LAIR1 gene  

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LAIR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M059557:     (about GC identifiers)

Start:
 59,557,047 bp from pter
End:
 59,573,977 bp from pter
Size:
 16,931 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  

Proteins
for LAIR1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8 (See protein sequence)
Recommended Name: Leukocyte-associated immunoglobulin-like receptor 1 precursor  
Size: 287 amino acids; 31412 Da
Subunit: Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The
interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK
Subcellular location: Cell membrane; Single-pass type I membrane protein
Developmental stage: Complete loss of expression when naive B-cells proliferates and differentiates
into Ig-producing plasma cells under in vitro stimulation
Alternative splicing: 4 isoforms:  Q6GTX8-1   Q6GTX8-2   Q6GTX8-3   Q6GTX8-4   

Post-translational modifications:

  • Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK1
  • N-glycosylated1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (2 alternative transcripts): 
    NP_002278.1  NP_068352.1  


    ENSEMBL proteins: 
    ENSP00000375623 ENSP00000375622 ENSP00000301193 ENSP00000319204 ENSP00000375621 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LAIR1)
    Human Recombinant Proteins from Abnova (LAIR1)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    2 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane IEA--
    GO:0016021 integral to membrane IEA--
    About this table

    Antibodies for LAIR1: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for LAIR1
    R&D Systems Antibodies for LAIR1
    Antibodies from Abcam (LAIR1), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (LAIR1)
    Novus Biologicals Antibodies for LAIR1

    Assays for LAIR1: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for LAIR1

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro domains/families:
     IPR013783 Ig-like_fold
     IPR003599 Ig_sub


       GeneDecks  LAIR1 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q6GTX8

    ProtoNet protein and cluster: Q6GTX8

    UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8
    Domain: ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present
    in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2
    domain of several SH2-containing phosphatases, leading to down-regulation of cell activation
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

    Gene Function
    for LAIR1

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (LAIR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (LAIR1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002287

                  Applied Biosystems Silencer® siRNAs for LAIR1

                  Sigma-Aldrich siRNA and siRNA Panels for LAIR1  
                         Sigma-Aldrich shRNA for LAIR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for LAIR1
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002287
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002287
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002287 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_002287

    UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8
    Function: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on
    cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr
    phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It
    also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also
    play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine
    production in CD4+ T-cells, downregulating IL2 and IFNG production while inducing secretion of
    transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as
    IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell
    lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation
    of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood
    precursors towards dendritic cells
    Induction: By T-cell receptor stimulation in a process that requires p38 MAP kinase and ERK
    signaling

    Genatlas biochemistry entry for LAIR1:
    leukocyte-associated immunoglobulin-like receptor 1,32kDa,expressed in monocytes

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872 receptor activity IEA--
    GO:0005515 protein binding IPI16754721
    About this table

    Pathways & Interactions
    for LAIR1

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  LAIR1  (Your Favorite Gene powered by Ingenuity) 
     Natural Killer Cell Signaling

       GeneDecks  LAIR1 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  LAIR1 


    5 Interacting proteins for LAIR1 (ENSP000003192043) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PTPN6ENSP000003260103STRING (score=.999)
    PTPN11ENSP000003409443STRING (score=.978)
    CSKENSP000002200033STRING (score=.951)
    PILRAENSP000001985363STRING (score=.854)
    KLRG1ENSP000002665513STRING (score=.807)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006955 immune response IEA--
    About this table

    Drugs & Compounds
    for LAIR1

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for LAIR1
    1 Novoseek chemical compound relationship for LAIR1 gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 35.67 15 10764762 (4), 15100296 (3), 15703304 (1), 14559247 (1) (see all 6)
    About this table


    Transcripts
    for LAIR1

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (LAIR1)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (LAIR1)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_002287

                  Sigma-Aldrich siRNA and siRNA Panels for LAIR1  
                         Sigma-Aldrich shRNA for LAIR1  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_002287  NM_021706  

    REFSEQ mRNAs for LAIR1 gene (2 alternative transcripts): 

    NM_002287.3   NM_021706.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_002287  NM_021706  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_002287
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_002287
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_002287 

    Additional cDNA sequence: 

    AF013249.1 AF109683.1 AF251509.2 AK097869.1 AK290415.1 AK303261.1 AK309895.1 AK315419.1 
    BC027899.1 BC118642.1 CR542051.1 CR592817.1 CR602665.1 CR610686.1 DQ655942.2 

    24/26 DOTS entries (see all 26 ):

    DT.209648  DT.95125636  DT.100026356  DT.101969436  DT.100784848  DT.91873796  DT.121487316  DT.121487338 
    DT.86858159  DT.100026357  DT.121487396  DT.121487416  DT.75134247  DT.121487252  DT.99953756  DT.100730601 
    DT.100784850  DT.121487544  DT.75135538  DT.91737059  DT.91849101  DT.91918051  DT.95174123  DT.97767483 

    24/127 AceView cDNA sequences (see all 127 ):

    CD369975 BQ712304 NM_021708 CR592817 AU076738 BC027899 CR602665 AI075828 
    BI906511 CR542051 BQ709450 AW468149 CD365990 BQ574472 CD367788 BG619812 
    CR610686 AW104126 BI756388 AI632166 NM_002287 NM_021706 AK097869 CA431460 

    highest scoring ESTs for LAIR1:

    AF013249 AF109683 AF251509 AK097869 AL552821 AU122160 BC027899 BI819960 BI836604 BI906511 

    Unigene Cluster for LAIR1:

    Leukocyte-associated immunoglobulin-like receptor 1
    Hs.572535  [show with all ESTs]
    Unigene Representative Sequence: NM_002287


    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for LAIR1 (see all 16 )

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f
    SP1:        -                 -                 -     -     -                             -                                             
    SP2:        -                                   -     -     -                             -                                             
    SP3:        -                       -           -     -     -                             -                                             
    SP4:        -                                   -     -     -                             -                                             
    SP5:        -                       -           -     -     -                             -                                             

    About this scheme

    ECgene alternative splicing isoforms for LAIR1

    5 Ensembl transcripts including schematic representations:
    ENST00000391743  ENST00000391742  ENST00000348231  ENST00000313038  ENST00000391741  

    Expression
    for LAIR1

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    LAIR1 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for LAIR1

    1 / 2 / 3

    5 probe-sets matching LAIR1 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37470_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 AF013249 1.00 1.00 1.00 1

    		210644_s_at2, 3 U133-A 1 1.00 1.00 -- -- AF109683 0.80 1.00 0.91 1

    		208071_s_at2, 3 U133-A 2 1.00 0.95 -- -- NM_021708 0.40 1.00 0.76 1

    		210644_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		208071_s_at2 U133Plus2 2 1.00 0.95 -- -- -- -- -- -- --
    GeneDecks  LAIR1 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.572535

    Expression variation in blood from EXPOLDB for LAIR1

    UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8
    Tissue specificity: Expressed on the majority of peripheral mononuclear cells, including natural
    killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive
    T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in
    naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with
    chronic active Epstein-Barr virus infection

    Orthologs
    for LAIR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for LAIR1 gene from 5 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 LAIR11   -- leukocyte-associated immunoglobulin-like receptor 1 71.77(n)
    54.47(a)    		 484308  XM_541424.2  XP_541424.2 
    chimpanzee
    (Pan troglodytes)    		 LAIR11   -- leukocyte-associated immunoglobulin-like receptor 1 98.4(n)
    97.04(a)    		 456283  XM_512892.2  XP_512892.1 
    cow
    (Bos taurus)    		 LAIR11   -- leukocyte-associated immunoglobulin-like receptor 1 68.45(n)
    54.02(a)    		 615295  XM_867060.2  XP_872153.2 
    rat
    (Rattus norvegicus)    		 Lair11   -- leukocyte-associated immunoglobulin-like receptor 1 61.07(n)
    46.48(a)    		 574531  XM_001078788.1  XP_001078788.1 
    mouse
    (Mus musculus)    		 Lair11, 5 7 (4.50 cM)5
    		 leukocyte-associated Ig-like receptor 11, 5 67.72(n)1
    53.97(a)1    		 528551  NM_178611.31  NP_848726.11 
     AF4796855  AF4918295  (see all 27)
    About this table        Species with no ortholog for LAIR1

    ENSEMBL Gene Tree for LAIR1

    Paralogs
    for LAIR1

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for LAIR1 gene
    LAIR22  

    SNPs/Variants
    for LAIR1

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/107 NCBI SNPs in LAIR1 are shown (see all 107 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 33)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs37866401,2
    		A,C,F,H59558001(-) AGGACC/TTACGA 2 -- ut31 ese37Minor allele frequency- T:0.17MN EU EA NA 600
    rs72502691,2
    		A,C,F,H59569794(+) GAAATA/GAGGAT 2 -- ng313Minor allele frequency- G:0.07EU EA 292
    rs38267531,2
    		A,C,F,H59557863(-) CCATCG/ACCACG 2 -- ut313Minor allele frequency- A:0.28EA WA 270
    rs65098671,2
    		A,C,F,H59557747(+) CTTCAC/ACCAGC 2 -- ut317Minor allele frequency- A:0.26EU EA WA NA 520
    --
    rs72505481,2
    		A,C,F,H59570003(+) cccagA/Gttcaa 2 -- ng314Minor allele frequency- G:0.18EU EA WA 416
    rs37454421,2
    		C,F,H59564510(-) AGGGAG/CAGTAG 2 D/E mis1 trp312Minor allele frequency- C:0.04EA NA EU WA 2474
    rs133468571,2
    		F,H59568464(+) GCTTAG/CAGGCA 2 -- ut514Minor allele frequency- C:0.02EU EA WA 420
    --
    rs116702961,2
    		A,C59569313(+) tagaaG/Taattg 2 -- ng310--------
    rs38267541,2
    		A,C59557857(-) CCACGA/GATACG 2 -- ut310--------
    --
    rs72503731,2
    		A,C59569786(+) CTCAGC/TTGGAA 2 -- ng310--------
    About this table

    HapMap Linkage Disequilibrium images for LAIR1 (up to first 250kb)

    Disorders & Mutations
    for LAIR1

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 602992

    5 Novoseek disease relationships for LAIR1 gene

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    cmv infection 32.82 1 17339449 (1)
    necrosis 0.00 2 16461736 (1)
    tumors 0.00 6 18394348 (3), 16461736 (1)
    leukemia 0.00 2 15151743 (1), 11745387 (1)
    virus infection 0.00 1 15350516 (1)
    About this table

    1 PharmGKB disease relationship for LAIR1 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872 12730115
    About this table

    Medical News
    for LAIR1

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for LAIR1

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/70 PubMed articles for LAIR1 gene (see all 70 ):

    Search for LAIR1

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing LAIR1

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 3903 HGNC: 6477 AceView: LAIR1 Ensembl:ENSG00000167613 euGenes: HUgn3903
    ECgene: LAIR1 H-InvDB: LAIR1

    Other Databases showing LAIR1

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing LAIR1

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for LAIR1

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for LAIR1

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LAIR1:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LAIR1-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for LAIR1 Antibodies for LAIR1
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for LAIR1 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (LAIR1)
     Antibodies (LAIR1)
     Chimera RNAi (LAIR1)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Search for Antibodies & Assays

     Recombinant Proteins
    (LAIR1)
     Antibodies (LAIR1)
     Search OriGene for LAIR1
     Search Tocris compounds for LAIR1




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for LAIR1

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

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