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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LAIR1 Gene

protein-coding GIFtS: 56
GCID: GC19M054865

leukocyte-associated immunoglobulin-like receptor 1

(Previous name: leukocyte-associated Ig-like receptor 1 )

Explore 11 diseases affiliated with
LAIR1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Leukocyte-Associated Immunoglobulin-Like Receptor 1¹ ²
CD305¹ ² ³
Leukocyte-Associated Ig-Like Receptor 1¹ ²
LAIR-1² ³
HLAIR1¹
CD305 Antigen³

External Ids:	HGNC: 6477¹	Entrez Gene: 3903²	Ensembl: ENSG00000167613⁷	OMIM: 602992⁵	UniProtKB: Q6GTX8³

Export aliases for LAIR1 gene to outside databases

Previous GC identifers: GC19M055728 GC19M055289 GC19M059541 GC19M059557 GC19M051187

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LAIR1:

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T

cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self.

The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family.

The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding

leukocyte-expressed receptors of the immunoglobulin superfamily. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8

Function: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function

of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and

activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by

B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates

cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming

growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion.

Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation

of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the

differentiation of peripheral blood precursors towards dendritic cells

Gene Wiki entry for LAIR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LAIR1 gene promoter:
Bach1 ATF-2 SREBP-1c LCR-F1 SREBP-1b CRE-BP1 SREBP-1a Pax-4a ATF
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LAIR1 promoter sequence

Search SABiosciences Chromatin IP Primers for LAIR1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAIR1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.4

LAIR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAIR1 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M054865: view genomic region (about GC identifiers)

Start:	54,865,235 bp from pter	End:	54,882,165 bp from pter
Size:	16,931 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8 (See protein sequence)

Recommended Name: Leukocyte-associated immunoglobulin-like receptor 1 precursor

Size: 287 amino acids; 31412 Da

Subunit: Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is

constitutive. Interacts with the SH2 domain of CSK. Binds with high affinity to extracellular matrix collagens, the

interaction is functionally important

Subcellular location: Cell membrane; Single-pass type I membrane protein

Developmental stage: Complete loss of expression when naive B-cells proliferates and differentiates into Ig-producing

plasma cells under in vitro stimulation

2 PDB 3D structures from and Proteopedia for LAIR1:

3KGR (3D)

3RP1 (3D)

Alternative splicing: 4 isoforms: Q6GTX8-1 Q6GTX8-2 Q6GTX8-3 Q6GTX8-4 (Functions as an inhibitory receptor in NK cells and T-cells)

Explore the universe of human proteins at neXtProt for LAIR1: NX_Q6GTX8

Post-translational modifications:

Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK¹

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6GTX8

LAIR1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_002278.1 NP_068352.1

ENSEMBL proteins:

ENSP00000375623 ENSP00000375622 ENSP00000391003 ENSP00000301193 ENSP00000375621

ENSP00000418998 ENSP00000402727 ENSP00000412796 ENSP00000411632 ENSP00000399710

ENSP00000392722 ENSP00000397226 ENSP00000404124 ENSP00000392058 ENSP00000319204

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for LAIR1
	Enzo Life Sciences proteins for LAIR1
	OriGene Purified Protein: LAIR1 OriGene Protein Over-expression Lysate (see all 3): LAIR1 OriGene Custom Protein Services for LAIR1
	GenScript Custom Purified and Recombinant Proteins Services for LAIR1
	Novus Biologicals LAIR1 Proteins Novus Biologicals LAIR1 Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for LAIR1
	Uscn Proteins for LAIR1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IDA	--
GO:0016021	integral to membrane	IEA	--

LAIR1 for ontologies About GeneDecksing

LAIR1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	R&D Systems Antibodies for LAIR1
	Browse OriGene Antibodies OriGene Custom Antibody Services for LAIR1
	GenScript Custom Superior Antibodies Services for LAIR1
	Novus Biologicals LAIR1 Antibodies
	Search for Antibodies for LAIR1 at Abcam
	Uscn Antibodies for LAIR1
	ThermoFisher Antibodies for LAIR1

Assay Products for LAIR1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems Multiplex/Array Assay Kits & Reagents for LAIR1
	GenScript Custom Assay Services for LAIR1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LAIR1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LAIR1 for domains About GeneDecksing

2 InterPro domains/families:

IPR013783 Ig-like_fold

IPR003599 Ig_sub

Graphical View of Domain Structure for InterPro Entry Q6GTX8

ProtoNet protein and cluster: Q6GTX8

UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8

Domain: ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the

intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing

phosphatases, leading to down-regulation of cell activation

Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary: