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Aliases for LAIR1 Gene

Aliases for LAIR1 Gene

  • Leukocyte-Associated Immunoglobulin-Like Receptor 1 2 3
  • Leukocyte-Associated Ig-Like Receptor 1 2 3
  • LAIR-1 3 4
  • CD305 3 4
  • CD305 Antigen 4
  • HLAIR1 4

External Ids for LAIR1 Gene

Previous GeneCards Identifiers for LAIR1 Gene

  • GC19M055728
  • GC19M055289
  • GC19M059541
  • GC19M059557
  • GC19M054865
  • GC19M051187

Summaries for LAIR1 Gene

Entrez Gene Summary for LAIR1 Gene

  • The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

GeneCards Summary for LAIR1 Gene

LAIR1 (Leukocyte-Associated Immunoglobulin-Like Receptor 1) is a Protein Coding gene. Diseases associated with LAIR1 include chronic active epstein-barr virus infection and cytomegalovirus infection. An important paralog of this gene is LAIR2.

UniProtKB/Swiss-Prot for LAIR1 Gene

  • Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.

Gene Wiki entry for LAIR1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAIR1 Gene

Genomics for LAIR1 Gene

Regulatory Elements for LAIR1 Gene

Genomic Location for LAIR1 Gene

Start:
54,351,384 bp from pter
End:
54,370,558 bp from pter
Size:
19,175 bases
Orientation:
Minus strand

Genomic View for LAIR1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LAIR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAIR1 Gene

Proteins for LAIR1 Gene

  • Protein details for LAIR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6GTX8-LAIR1_HUMAN
    Recommended name:
    Leukocyte-associated immunoglobulin-like receptor 1
    Protein Accession:
    Q6GTX8
    Secondary Accessions:

    Protein attributes for LAIR1 Gene

    Size:
    287 amino acids
    Molecular mass:
    31412 Da
    Quaternary structure:
    • Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6 is constitutive. Interacts with the SH2 domain of CSK. Binds with high affinity to extracellular matrix collagens, the interaction is functionally important.

    Three dimensional structures from OCA and Proteopedia for LAIR1 Gene

    Alternative splice isoforms for LAIR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LAIR1 Gene

Proteomics data for LAIR1 Gene at MOPED

Post-translational modifications for LAIR1 Gene

Antibody Products

Protein Products

No data available for DME Specific Peptides for LAIR1 Gene

Domains for LAIR1 Gene

Gene Families for LAIR1 Gene

HGNC:
  • CD :CD molecules
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing
  • LAIR :Leukocyte-associated Ig like receptors

Protein Domains for LAIR1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LAIR1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6GTX8

UniProtKB/Swiss-Prot:

LAIR1_HUMAN :
  • Q6GTX8
Domain:
  • ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down-regulation of cell activation.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
genes like me logo Genes that share domains with LAIR1: view

Function for LAIR1 Gene

Molecular function for LAIR1 Gene

GENATLAS Biochemistry: leukocyte-associated immunoglobulin-like receptor 1,32kDa,expressed in monocytes
UniProtKB/Swiss-Prot Function: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells.
UniProtKB/Swiss-Prot Induction: By T-cell receptor stimulation in a process that requires p38 MAP kinase and ERK signaling.

Gene Ontology (GO) - Molecular Function for LAIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10660620
genes like me logo Genes that share ontologies with LAIR1: view

Phenotypes for LAIR1 Gene

genes like me logo Genes that share phenotypes with LAIR1: view

Animal Models for LAIR1 Gene

MGI Knock Outs for LAIR1:

Animal Model Products

CRISPR Products

miRNA for LAIR1 Gene

miRTarBase miRNAs that target LAIR1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for LAIR1 Gene

Localization for LAIR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAIR1 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAIR1 Gene COMPARTMENTS Subcellular localization image for LAIR1 gene
Compartment Confidence
plasma membrane 5
extracellular 3
lysosome 1

Gene Ontology (GO) - Cellular Components for LAIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with LAIR1: view

Pathways for LAIR1 Gene

SuperPathways for LAIR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for LAIR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
genes like me logo Genes that share ontologies with LAIR1: view

No data available for Pathways by source for LAIR1 Gene

Compounds for LAIR1 Gene

(1) HMDB Compounds for LAIR1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2

(1) Novoseek inferred chemical compound relationships for LAIR1 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 34.4 11
genes like me logo Genes that share compounds with LAIR1: view

Transcripts for LAIR1 Gene

Unigene Clusters for LAIR1 Gene

Leukocyte-associated immunoglobulin-like receptor 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for LAIR1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for LAIR1 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f
SP1: - - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - -
SP6: - - - -
SP7: - - - - -
SP8: -
SP9: -
SP10: - - -
SP11: -
SP12: - - - - - - -
SP13: - -
SP14: -
SP15: - -
SP16:

Relevant External Links for LAIR1 Gene

GeneLoc Exon Structure for
LAIR1
ECgene alternative splicing isoforms for
LAIR1

Expression for LAIR1 Gene

mRNA expression in normal human tissues for LAIR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for LAIR1 Gene

This gene is overexpressed in Whole Blood (13.8) and Spleen (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAIR1 Gene

SOURCE GeneReport for Unigene cluster for LAIR1 Gene Hs.572535

mRNA Expression by UniProt/SwissProt for LAIR1 Gene

Q6GTX8-LAIR1_HUMAN
Tissue specificity: Expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients. Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection.
genes like me logo Genes that share expressions with LAIR1: view

In Situ Assay Products

Orthologs for LAIR1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for LAIR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAIR1 35
  • 98.6 (n)
  • 97.55 (a)
LAIR1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 50 (a)
OneToMany
LAIR1 35
  • 69.48 (n)
  • 55.94 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 51 (a)
OneToMany
LAIR1 35
  • 70.53 (n)
  • 54.05 (a)
mouse
(Mus musculus)
Mammalia Lair1 35
  • 61.63 (n)
  • 47.67 (a)
Lair1 16
Lair1 36
  • 43 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Lair1 35
  • 60.62 (n)
  • 46.72 (a)
Species with no ortholog for LAIR1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for LAIR1 Gene

ENSEMBL:
Gene Tree for LAIR1 (if available)
TreeFam:
Gene Tree for LAIR1 (if available)

Paralogs for LAIR1 Gene

Paralogs for LAIR1 Gene

Pseudogenes.org Pseudogenes for LAIR1 Gene

genes like me logo Genes that share paralogs with LAIR1: view

Variants for LAIR1 Gene

Sequence variations from dbSNP and Humsavar for LAIR1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs918543 -- 54,365,171(+) CGGTC(A/G)CAGCT upstream-variant-2KB, intron-variant
rs1054033 -- 54,354,580(-) AGGAC(C/T)CTACG utr-variant-3-prime, nc-transcript-variant
rs1801988 -- 54,354,810(-) GCCCT(A/G)CTGAC utr-variant-3-prime, nc-transcript-variant
rs1985840 -- 54,368,469(-) TGAAA(A/G)GAGGC intron-variant
rs1985841 -- 54,368,368(-) GCCTC(A/G)TGTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LAIR1 Gene

Variant ID Type Subtype PubMed ID
nsv428371 CNV Gain+Loss 18775914
dgv1119e1 CNV Complex 17122850
nsv833878 CNV Loss 17160897
nsv527908 CNV Gain 19592680

Relevant External Links for LAIR1 Gene

HapMap Linkage Disequilibrium report
LAIR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAIR1 Gene

Disorders for LAIR1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for LAIR1 Gene including...

Search for LAIR1 Gene in MalaCards »

(5) Novoseek inferred disease relationships for LAIR1 Gene

Disease -log(P) Hits PubMed IDs
cmv infection 31.5 1
leukemia 0 2
virus infection 0 1
necrosis 0 1
tumors 0 4

Relevant External Links for LAIR1

Human Genome Epidemiology (HuGE) Navigator
LAIR1
genes like me logo Genes that share disorders with LAIR1: view

No data available for UniProtKB/Swiss-Prot for LAIR1 Gene

Publications for LAIR1 Gene

  1. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. (PMID: 9285412) Meyaard L. … Phillips J.H. (Immunity 1997) 2 3 4 23
  2. Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. (PMID: 10229813) Meyaard L. … Phillips J.H. (J. Immunol. 1999) 3 4 23
  3. Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling. (PMID: 10540327) van der Vuurst de Vries A.-R. … Meyaard L. (Eur. J. Immunol. 1999) 3 4 23
  4. Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. (PMID: 10764762) Xu M.-J. … Zhao Z.J. (J. Biol. Chem. 2000) 3 4 23
  5. Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias. (PMID: 11069054) Poggi A. … Zocchi M.R. (Eur. J. Immunol. 2000) 3 4 23

Products for LAIR1 Gene

Sources for LAIR1 Gene

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