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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LAIR1 Gene

protein-coding   GIFtS: 59
GCID: GC19M054865

Leukocyte-Associated Immunoglobulin-Like Receptor 1

(Previous name: leukocyte-associated Ig-like receptor 1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Leukocyte-Associated Immunoglobulin-Like Receptor 11 2
Leukocyte-Associated Ig-Like Receptor 11 2
CD3052 3
LAIR-12 3
hLAIR12 3
CD305 Antigen3

External Ids:    HGNC: 64771   Entrez Gene: 39032   Ensembl: ENSG000001676137   OMIM: 6029925   UniProtKB: Q6GTX83   

Export aliases for LAIR1 gene to outside databases

Previous GC identifers: GC19M055728 GC19M055289 GC19M059541 GC19M059557 GC19M051187


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LAIR1 Gene:
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK
cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells
recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated
inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which
contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. (provided by
RefSeq, Jul 2008)

GeneCards Summary for LAIR1 Gene: 
LAIR1 (leukocyte-associated immunoglobulin-like receptor 1) is a protein-coding gene. Diseases associated with LAIR1 include chronic active epstein-barr virus infection, and cytomegalovirus infection. GO annotations related to this gene include protein binding. An important paralog of this gene is LAIR2.

UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8
Function: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic
function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in
recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular
calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing
phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while
inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as
well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines
as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B
alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells

Gene Wiki entry for LAIR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LAIR1 gene promoter:
         Bach1   ATF-2   SREBP-1c   LCR-F1   SREBP-1b   CRE-BP1   SREBP-1a   Pax-4a   ATF   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLAIR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for LAIR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAIR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.4   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.4

LAIR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAIR1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M054865:  view genomic region     (about GC identifiers)

Start:
54,865,235 bp from pter      End:
54,882,165 bp from pter
Size:
16,931 bases      Orientation:
minus strand

3 alternative locations:
Chr19-,NW_003571055 335,031-346,517      Chr19-,NW_003571061 335,587-347,074      Chr19-,NW_003571060 258,363-269,763     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8 (See protein sequence)
Recommended Name: Leukocyte-associated immunoglobulin-like receptor 1 precursor  
Size: 287 amino acids; 31412 Da
Subunit: Interacts with SH2 domains of tyrosine-protein phosphatases PTPN6 and PTPN11. The interaction with PTPN6
is constitutive. Interacts with the SH2 domain of CSK. Binds with high affinity to extracellular matrix
collagens, the interaction is functionally important
Subcellular location: Cell membrane; Single-pass type I membrane protein
Developmental stage: Complete loss of expression when naive B-cells proliferates and differentiates into
Ig-producing plasma cells under in vitro stimulation
2 PDB 3D structures from and Proteopedia for LAIR1:
3KGR (3D)        3RP1 (3D)    
Alternative splicing: 4 isoforms:  Q6GTX8-1   Q6GTX8-2   Q6GTX8-3   Q6GTX8-4   (Functions as an inhibitory receptor in NK cells and T-cells)

Explore the universe of human proteins at neXtProt for LAIR1: NX_Q6GTX8

Explore proteomics data for LAIR1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylation at Tyr-251 and Tyr-281 activates it. May be phosphorylated by LCK
  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6GTX8

  • LAIR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LAIR1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_002278.1  NP_068352.1  

    ENSEMBL proteins: 
     ENSP00000375623   ENSP00000301193   ENSP00000375622   ENSP00000391003   ENSP00000375621  
     ENSP00000418998   ENSP00000402727   ENSP00000412796   ENSP00000411632   ENSP00000399710  
     ENSP00000392722   ENSP00000397226   ENSP00000404124   ENSP00000392058   ENSP00000319204  

    Human Recombinant Protein Products for LAIR1: 
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    R&D Systems Recombinant & Natural Proteins for LAIR1
    Enzo Life Sciences proteins for LAIR1
    OriGene Purified Protein for LAIR1
    OriGene Protein Over-expression Lysate for LAIR1
    OriGene MassSpec for LAIR1 
    OriGene Custom Protein Services for LAIR1
    GenScript Custom Purified and Recombinant Proteins Services for LAIR1
    Novus Biologicals LAIR1 Proteins
    Novus Biologicals LAIR1 Lysates
    Sino Biological Recombinant Protein for LAIR1
    Sino Biological Cell Lysate for LAIR1 
    ProSpec Recombinant Protein for LAIR1
    Cloud-Clone Corp. Proteins for LAIR1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0016021integral to membrane IEA--

    LAIR1 for ontologies           About GeneDecksing



    LAIR1 Antibody Products: 
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    Abcam antibodies for LAIR1
    Cloud-Clone Corp. Antibodies for LAIR1 
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    LSBio Antibodies in human, mouse, rat for LAIR1 

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    Cloud-Clone Corp. ELISAs for LAIR1 
    Cloud-Clone Corp. CLIAs for LAIR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    LAIR: Leukocyte-associated Ig like receptors
    CD: CD molecules
    IGD: Immunoglobulin superfamily / Immunoglobulin-like domain containing

    2 InterPro protein domains:
     IPR003599 Ig_sub
     IPR013783 Ig-like_fold

    Graphical View of Domain Structure for InterPro Entry Q6GTX8

    ProtoNet protein and cluster: Q6GTX8

    UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8
    Domain: ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in
    the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several
    SH2-containing phosphatases, leading to down-regulation of cell activation
    Similarity: Contains 1 Ig-like C2-type (immunoglobulin-like) domain


    LAIR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LAIR1_HUMAN, Q6GTX8
    Function: Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic
    function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in
    recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular
    calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing
    phosphatases. Modulates cytokine production in CD4+ T-cells, down-regulating IL2 and IFNG production while
    inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as
    well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines
    as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B
    alpha/CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells
    Induction: By T-cell receptor stimulation in a process that requires p38 MAP kinase and ERK signaling

         Genatlas biochemistry entry for LAIR1:
    leukocyte-associated immunoglobulin-like receptor 1,32kDa,expressed in monocytes

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI10660620
         
    LAIR1 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Lair1):
     hematopoietic system  immune system  normal 

    LAIR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Lair1tm1.1Jco for LAIR1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for LAIR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for LAIR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for LAIR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for LAIR1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAIR1
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LAIR1:
    hsa-miR-875-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidLAIR1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LAIR1 (NM_021706)
    Sino Biological Human cDNA Clone for LAIR1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAIR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAIR1
    Sirion Biotech Customized lentivirus for stable overexpression of LAIR1 
                         Customized lentivirus expression plasmids for stable overexpression of LAIR1 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAIR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LAIR1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for LAIR1 (Q6GTX82, 3 ENSP000003756224) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSKP412402, 3, ENSP000002200034MINT-8033837 I2D: score=3 STRING: ENSP00000220003
    PTPN6P293502, 3, ENSP000003915924MINT-8033852 MINT-8038190 MINT-8033867 MINT-8038175 I2D: score=6 STRING: ENSP00000391592
    PTPN11Q061243, ENSP000003409444I2D: score=3 STRING: ENSP00000340944
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LAIR1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LAIR1

    1 HMDB Compound for LAIR1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--

    1 Novoseek inferred chemical compound relationship for LAIR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 34.4 15 10764762 (4), 15100296 (3), 15703304 (1), 14559247 (1) (see all 6)

    Search CenterWatch for drugs/clinical trials and news about LAIR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LAIR1 gene (3 alternative transcripts): 
    NM_002287.3  NM_021706.2  NM_021708.1  

    Unigene Cluster for LAIR1:

    Leukocyte-associated immunoglobulin-like receptor 1
    Hs.572535  [show with all ESTs]
    Unigene Representative Sequence: NM_002287
    18/24 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 24):
    ENST00000391743(uc002qfk.1 uc002qfl.1 uc002qfm.1 uc002qfn.1 uc010yex.2 uc002qfo.3)
    ENST00000475389 ENST00000348231 ENST00000391742 ENST00000434277 ENST00000498511
    ENST00000391741 ENST00000474878 ENST00000467269 ENST00000440716 ENST00000463489
    ENST00000418556 ENST00000460312 ENST00000468656 ENST00000436513 ENST00000420483
    ENST00000444687 ENST00000423853
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate LAIR1:
    hsa-miR-875-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidLAIR1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): LAIR1 (NM_021706)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAIR1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAIR1
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAIR1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAIR1

    Additional mRNA sequence: 

    AF013249.1 AF109683.1 AF251509.2 AK097869.1 AK290415.1 AK303261.1 AK309895.1 AK315419.1 
    BC027899.1 BC118642.1 CR542051.1 DQ655942.2 

    24/25 DOTS entries (see all 25):

    DT.209648  DT.100026356  DT.95125636  DT.100784848  DT.101969436  DT.121487316  DT.91873796  DT.121487338 
    DT.86858159  DT.100026357  DT.121487396  DT.121487416  DT.75134247  DT.121487252  DT.99953756  DT.100730601 
    DT.100784850  DT.121487544  DT.91849101  DT.91918051  DT.95174123  DT.97767483  DT.100704380  DT.121487195 

    24/127 AceView cDNA sequences (see all 127):

    BC027899 BU730788 AI632166 BQ712304 BX380072 AW958328 NM_002287 AW468149 
    NM_021708 AF251509 AI075828 AF251510 CR542051 AK097869 BI518488 CA447356 
    AA311548 BI836604 AW013968 CR592817 BI756388 BM663029 AW104126 CR602665 

    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for LAIR1 (see all 16)    About this scheme

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c · 11d · 11e · 11f
    SP1:        -                 -                 -     -     -                             -                                             
    SP2:        -                                   -     -     -                             -                                             
    SP3:        -                       -           -     -     -                             -                                             
    SP4:        -                                   -     -     -                             -                                             
    SP5:        -                       -           -     -     -                             -                                             


    ECgene alternative splicing isoforms for LAIR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LAIR1 expression in normal human tissues (normalized intensities)      LAIR1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    LAIR1 Expression
    About this image


    LAIR1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/15 selected tissues (see all 15) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 10 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
             lung ; macrophages   
             c-kit+ gr1+ mac1- myeloblasts   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; macrophages   
             bronchoalveolar lavage cells   
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 3 entries
             Myoblasts Mandibular Arch Muscles
             skeletal muscle ; myocytes   
     
     Spleen (Hematopoietic System)    fully expand to see all 2 entries
             spleen ; cells in white pulp   
     
     Breast (Uncategorized)    fully expand to see all 2 entries
             breast ; myoepithelial cells   

    See LAIR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LAIR1

    SOURCE GeneReport for Unigene cluster: Hs.572535

    UniProtKB/Swiss-Prot: LAIR1_HUMAN, Q6GTX8
    Tissue specificity: Expressed on the majority of peripheral mononuclear cells, including natural killer (NK)
    cells, T-cells, B-cells, monocytes, and dendritic cells. Highly expressed in naive T-cells and B-cells but no
    expression on germinal center B-cells. Abnormally low expression in naive B-cells from HIV-1 infected patients.
    Very low expression in NK cells from a patient with chronic active Epstein-Barr virus infection

        SABiosciences Custom PCR Arrays for LAIR1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAIR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for LAIR1 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Lair11 , 5 leukocyte-associated Ig-like receptor 11, 5 61(n)1
    48.26(a)1
      7 (2.31 cM)5
    528551  NM_001113474.11  NP_001106945.11 
     40080595 


    ENSEMBL Gene Tree for LAIR1 (if available)
    TreeFam Gene Tree for LAIR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for LAIR1 gene
    LAIR22  
    9 SIMAP similar genes for LAIR1 using alignment to 8 protein entries:     LAIR1_HUMAN (see all proteins):
    LAIR2    GP6    LILRA6    LILRB3    LILRA3    LILRA2
    LILRB1    LILRB4    VSTM1

    LAIR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for LAIR1
    PGOHUM00000234785


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/442 SNPs in LAIR1 are shown (see all 442)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs104253601,2
    C,A,H--54864736(+) ATTGCC/ACTCCA 2 -- ds50013Minor allele frequency- A:0.17NA WA 6
    rs1487634001,2
    C--54864771(+) ATCTC-/A/AA  
            
    AAAGA
    2 -- ds50010--------
    rs585312721,2
    C--54864774(+) TCAAA-/A/AGAA
            
    GAAAA
    2 -- ds50010--------
    rs750858351,2
    C,F--54865181(+) TGTCTC/TGGTCC 2 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1929077671,2
    --54865316(+) GAGTTG/TTTGCT 2 -- ut310--------
    rs126102731,2
    C,F,H--54865355(+) CTTTTC/TTTTTT 2 -- ut3111Minor allele frequency- T:0.37NA WA CSA EA 259
    rs126087311,2
    C,F,A,H--54865423(+) TGCAAA/GCTCCG 2 -- ut317Minor allele frequency- G:0.27NA WA CSA 15
    rs1848045601,2
    --54865428(+) GCTCCA/GCCTCC 2 -- ut310--------
    rs72485621,2
    C,H--54865454(+) CTCCTC/GCCTCA 2 -- ut314Minor allele frequency- G:0.10NA WA 10
    rs1900556941,2
    C--54865486(+) ACAGGC/TGCCCG 2 -- ut310--------

    HapMap Linkage Disequilibrium report for LAIR1 (54865235 - 54882165 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for LAIR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833878CNV Loss17160897
    nsv527908CNV Gain19592680
    nsv428371CNV Gain+Loss18775914
    dgv1119e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602992    OMIM disorders: --

    13 diseases for LAIR1:    About MalaCards
    chronic active epstein-barr virus infection    cytomegalovirus infection    tonsillitis    acute myeloid leukemia
    myopathy    influenza    myeloid leukemia    hepatitis b
    systemic lupus erythematosus    lupus erythematosus    leukemia    hepatitis
    endotheliitis


    LAIR1 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for LAIR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cmv infection 31.5 1 17339449 (1)
    leukemia 0 2 15151743 (1), 11745387 (1)
    virus infection 0 1 15350516 (1)
    necrosis 0 2 16461736 (1)
    tumors 0 7 18394348 (3), 16461736 (1)

    Human Genome Epidemiology (HuGE) Navigator: LAIR1 (1 document)

    Export disorders for LAIR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LAIR1 gene, integrated from 9 sources (see all 82):
    (articles sorted by number of sources associating them with LAIR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. (PubMed id 9285412)1, 2, 3, 9 Meyaard L.... Phillips J.H. (1997)
    2. The inhibitory leukocyte-associated Ig-like receptor-1 (LAIR-1) is expressed at high levels by human naive T cells and inhibits TCR mediated activation. (PubMed id 15950745)1, 2, 9 Maasho K.... Borrego F. (2005)
    3. Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents NF-kappaB nuclear translocation in human myeloid leukemias. (PubMed id 11069054)1, 2, 9 Poggi A.... Zocchi M.R. (2000)
    4. Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is differentially expressed during human B cell differentiation and inhibits B cell receptor-mediated signaling. (PubMed id 10540327)1, 2, 9 van der Vuurst de Vries A.-R.... Meyaard L. (1999)
    5. Identification and characterization of leukocyte-associated Ig-like receptor-1 as a major anchor protein of tyrosine phosphatase SHP-1 in hematopoietic cells. (PubMed id 10764762)1, 2, 9 Xu M.-J.... Zhao Z.J. (2000)
    6. Leukocyte-associated Ig-like receptor-1 functions as an inhibitory receptor on cytotoxic T cells. (PubMed id 10229813)1, 2, 9 Meyaard L.... Phillips J.H. (1999)
    7. Differential contribution of the immunoreceptor tyrosine-based inhibitory motifs of human leukocyte-associated Ig-like receptor-1 to inhibitory function and phosphatase recruitment. (PubMed id 14565933)1, 2, 9 Verbrugge A.... Meyaard L. (2003)
    8. Constitutive association of SHP-1 with leukocyte-associated Ig-like receptor-1 in human T cells. (PubMed id 11160222)1, 2, 9 Sathish J.G.... Matthews R.J. (2001)
    9. Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by pl atelet receptor GPVI. (PubMed id 20007810)1, 2, 9 Brondijk T.H....Huizinga E.G. (2010)
    10. Inhibitory receptors CD85j, LAIR-1, and CD152 down-regulate immunoglobulin and cytokine production by human B lymphocytes. (PubMed id 15939744)1, 2, 9 Merlo A....Saverino D. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3903 HGNC: 6477 AceView: LAIR1 Ensembl:ENSG00000167613 euGenes: HUgn3903
    ECgene: LAIR1 H-InvDB: LAIR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LAIR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LAIR1 gene:
    Search GeneIP for patents involving LAIR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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