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LAGE3 Gene

protein-coding GIFtS: 41

GC0XM153359

L antigen family, member 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CVG5 ^¹, ²
DXS9879E ^¹, ², ³
DXS9951E ^¹, ²
ESO3 ^¹, ², ³
ITBA2 ^¹, ², ³
OTTHUMP00000032119 ^²
OTTHUMP00000061461 ^²

Descriptions
L antigen family, member 3 ^²
Protein ESO-3 ^³
Protein ITBA2 ^³

External Ids
HGNC: 26058¹
Entrez Gene: 8270²
UniProtKB: Q14657³
Ensembl: ENSG00000196976⁷

Search outside databases for aliases for LAGE3 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for LAGE3:

This gene belongs to the ESO/LAGE gene family, members of which are clustered together on

chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which

are normally expressed only in testis and activated in a wide range of human tumors, this gene is

ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly

conserved in mouse and rat, suggests that the encoded protein is functionally important. An

intronless pseudogene with high sequence similarity to this gene is located on chromosome 9.

[provided by RefSeq]

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LAGE3 gene

Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28

LAGE3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM153359: (about GC identifiers)

Start:	153,358,435 bp from pter
End:	153,360,790 bp from pter
Size:	2,356 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000023.9 NT_011726.13

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LAGE3_HUMAN, Q14657 (See protein sequence)

Recommended Name: L antigen family member 3

Size: 143 amino acids; 14804 Da

Sequence caution: Sequence=CAA63489.1; Type=Frameshift; Positions=54;

Secondary accessions: Q5HY39 Q8IZ78

REFSEQ proteins: NP_006005.2

ENSEMBL proteins:

ENSP00000349923 ENSP00000383988

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
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	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--

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Antibodies for LAGE3:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for LAGE3

Assays for LAGE3:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q14657

ProtoNet protein and cluster: Q14657

UniProtKB/Swiss-Prot: LAGE3_HUMAN, Q14657

Similarity: Belongs to the CTAG family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAGE3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006014

Applied Biosystems Silencer® siRNAs for LAGE3

Sigma-Aldrich siRNA for LAGE3

Sigma-Aldrich shRNA for LAGE3

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LAGE3
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_006014
Myc/DDK tagged cDNA clone in CMV expression vector: NM_006014
untagged cDNA clone in CMV expression vector: NM_006014

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_006014

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0005515	protein binding	IPI	17353931

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Interacting proteins for LAGE3 (Q14657¹ ENSP00000349923³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OSGEP	Q9NPF4¹	EBI-1052105, EBI-1056510
UBL4A	ENSP00000358667³	STRING (score=.752)

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008150	biological_process	ND	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LAGE3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LAGE3)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_006014

Sigma-Aldrich siRNA for LAGE3

Sigma-Aldrich shRNA for LAGE3

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_006014

REFSEQ mRNAs for LAGE3 gene:

NM_006014.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_006014

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_006014
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_006014
                                 untagged cDNA clone in CMV expression vector: NM_006014

Additional cDNA sequence:

BC015744.1 BC019012.2 BC062330.1 X92896.1

4 DOTS entries:

DT.121294196 DT.452789 DT.80100290 DT.95270046

24/135 AceView cDNA sequences (see all 135 ):

AA733101 AA479062 BI524388 AI369456 AI335887 BM055276 AI914194 AW161857

BQ687170 NM_006014 CA412926 AI459299 AI191741 AI970592 BQ649305 BF431412

BF222175 BM761910 BE327262 AI341996 BF437229 BE551626 AI817289 BM069626

highest scoring ESTs for LAGE3:

X92896 AA149580 AA151797 AA494384 AA515080 AA527315 AA564411 AA682581 AA688383 AA733101

Unigene Cluster for LAGE3:

L antigen family, member 3

Hs.444619 [show with all ESTs]

Unigene Representative Sequence: NM_006014

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000357360 ENST00000407062

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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LAGE3 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LAGE3

¹ / ² / ³

3 probe-sets matching LAGE3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40891_f_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X92896	1.00	1.00	1.00	1
219061_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006014	0.60	1.00	0.82	1
219061_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTTTATCTGG

SOURCE GeneReport for Unigene cluster: Hs.444619
UniProtKB/Swiss-Prot: LAGE3_HUMAN, Q14657
Tissue specificity: Ubiquitous

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for LAGE3 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LAGE3¹	--	L antigen family, member 3	100(n) 100(a)	465946 XM_521343.2 XP_521343.2
cow (Bos taurus)	LAGE3¹	--	L antigen family, member 3	71.74(n) 61.59(a)	782436 XM_001251062.1 XP_001251063.1
rat (Rattus norvegicus)	Lage3¹	--	L antigen family, member 3	64.79(n) 54.93(a)	293863 XM_215227.4 XP_215227.2
mouse (Mus musculus)	Lage3^{1, 5}	X⁵	L antigen family, member 3^{1, 5}	65.26(n)¹ 55.63(a)¹	66192¹ NM_025410.2¹ NP_079686.1¹ AK002539⁵ AK004210⁵ (see all 8)

About this table Species with no ortholog for LAGE3

ENSEMBL Gene Tree for LAGE3

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for LAGE3 gene

CTAG2² CTAG1A² CTAG1B²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/26 NCBI SNPs in LAGE3 are shown (see all 26 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 29)

AB	SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4542114^1,2	A,C,F,H	153362383(+)	`ttctcA/Gctctc`	1	--	ng3¹		4		EU EA WA	418
	rs6567^1,2	C,F	153359458(+)	`TCGCTC/GCATTT`	1	--	ut3¹		1		MN	184
--	rs12006970^1,2	C	153361913(+)	`GACATC/TAGTcc`	1	--	ng3¹		0	--	--	--	--
	rs12850928^1,2	H	153358651(+)	`cagctG/Ctcccc`	1	--	ut3¹		4		EU EA WA	418
	rs12392443^1,2	F,H	153359978(+)	`TGATAC/GGATCT`	1	--	int¹		4		EU EA WA	418
--	rs11538408^1,2	--	153360379(-)	`GCTGCA/CGCGGG`	1	R/S	mis¹ ese³		0	--	--	--	--
--	rs10011^1,2	--	153359399(-)	`GGCAGG/TAATTC`	1	--	ut3¹ ese³		1		MN	184
--	rs12862868^1,2	--	153358707(+)	`cagggG/Tgccca`	1	--	ut3¹		0	--	--	--	--
	rs11538409^1,2	--	153360270(-)	`GCGGCC/TGCACA`	1	P/L	mis¹		0	--	--	--	--
--	rs73573421^1,2	--	153358762(+)	`AAGAGC/TTGCTC`	1	--	ut3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for LAGE3 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 300060

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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7 PubMed articles for LAGE3 gene:

Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach. (PubMed id 8786131)^{2, 3, 4} Faranda S.... Vezzoni P. (1996)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{3, 4} Ross M.T.... Bentley D.R. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
A new member of the NY-ESO-1 gene family is ubiquitously expressed in somatic tissues and evolutionarily conserved. (PubMed id 12384295)^{3, 4} Alpen B.... Chen Y.-T. (2002)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)³ Ewing R.M....Figeys D. (2007)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci. (PubMed id 8733135)³ Chen E.Y....D'Urso M. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 8270	HGNC: 26058	AceView: DXS9879E	Ensembl:ENSG00000196976	euGenes: HUgn8270
ECgene: LAGE3	H-InvDB: LAGE3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LAGE3
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for LAGE3:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LAGE3-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LAGE3		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LAGE3		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for LAGE3

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LAGE3 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for LAGE3

Summaries
for LAGE3

Genomic Location
for LAGE3

Proteins
for LAGE3

Protein Domains/
Families
for LAGE3

Gene Function
for LAGE3

Pathways & Interactions
for LAGE3

Drugs & Compounds
for LAGE3

Transcripts
for LAGE3

Expression
for LAGE3

Orthologs
for LAGE3

Paralogs
for LAGE3

SNPs/Variants
for LAGE3

Disorders & Mutations
for LAGE3

Medical News
for LAGE3

Publications
for LAGE3

Search for LAGE3

Genome Databases showing LAGE3

Other Databases showing LAGE3

Specialized Databases showing LAGE3

Licensable Technologies
for LAGE3

Services
for LAGE3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LAGE3 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor LAGE3

Summariesfor LAGE3

Genomic Locationfor LAGE3

Proteinsfor LAGE3

Protein Domains/Familiesfor LAGE3

Gene Functionfor LAGE3

Pathways & Interactionsfor LAGE3

Drugs & Compoundsfor LAGE3

Transcriptsfor LAGE3

Expression for LAGE3

Orthologsfor LAGE3

Paralogsfor LAGE3

SNPs/Variantsfor LAGE3

Disorders & Mutationsfor LAGE3

Medical Newsfor LAGE3

Publicationsfor LAGE3

Search for LAGE3

Genome Databases showing LAGE3

Other Databases showing LAGE3

Specialized Databases showing LAGE3

Licensable Technologiesfor LAGE3

Servicesfor LAGE3

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LAGE3

Summaries
for LAGE3

Genomic Location
for LAGE3

Proteins
for LAGE3

Protein Domains/
Families
for LAGE3

Gene Function
for LAGE3

Pathways & Interactions
for LAGE3

Drugs & Compounds
for LAGE3

Transcripts
for LAGE3

Expression
for LAGE3

Orthologs
for LAGE3

Paralogs
for LAGE3

SNPs/Variants
for LAGE3

Disorders & Mutations
for LAGE3

Medical News
for LAGE3

Publications
for LAGE3

Licensable Technologies
for LAGE3

Services
for LAGE3