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Aliases for LAGE3 Gene

Aliases for LAGE3 Gene

  • L Antigen Family Member 3 2 3 4 5
  • L Antigen Family, Member 3 2 3
  • Protein ESO-3 3 4
  • DXS9879E 3 4
  • ITBA2 3 4
  • ESO3 3 4
  • DNA Segment On Chromosome X (Unique) 9879 Expressed Sequence 2
  • Protein ITBA2 4
  • DXS9951E 3
  • CVG5 3

External Ids for LAGE3 Gene

Previous GeneCards Identifiers for LAGE3 Gene

  • GC0XM153359
  • GC0XM153707
  • GC0XM142282

Summaries for LAGE3 Gene

Entrez Gene Summary for LAGE3 Gene

  • This gene belongs to the ESO/LAGE gene family, members of which are clustered together on chromosome Xq28, and have similar exon-intron structures. Unlike the other family members which are normally expressed only in testis and activated in a wide range of human tumors, this gene is ubiquitously expressed in somatic tissues. The latter, combined with the finding that it is highly conserved in mouse and rat, suggests that the encoded protein is functionally important. An intronless pseudogene with high sequence similarity to this gene is located on chromosome 9. [provided by RefSeq, Jul 2008]

GeneCards Summary for LAGE3 Gene

LAGE3 (L Antigen Family Member 3) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. An important paralog of this gene is CTAG1A.

UniProtKB/Swiss-Prot for LAGE3 Gene

  • Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LAGE3 Gene

Genomics for LAGE3 Gene

Regulatory Elements for LAGE3 Gene

Promoters for LAGE3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LAGE3 on UCSC Golden Path with GeneCards custom track

Genomic Location for LAGE3 Gene

Chromosome:
X
Start:
154,477,769 bp from pter
End:
154,479,257 bp from pter
Size:
1,489 bases
Orientation:
Minus strand

Genomic View for LAGE3 Gene

Genes around LAGE3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LAGE3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LAGE3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LAGE3 Gene

Proteins for LAGE3 Gene

  • Protein details for LAGE3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14657-LAGE3_HUMAN
    Recommended name:
    EKC/KEOPS complex subunit LAGE3
    Protein Accession:
    Q14657
    Secondary Accessions:
    • Q5HY39
    • Q8IZ78

    Protein attributes for LAGE3 Gene

    Size:
    143 amino acids
    Molecular mass:
    14804 Da
    Quaternary structure:
    • Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.
    SequenceCaution:
    • Sequence=CAA63489.1; Type=Frameshift; Positions=54; Evidence={ECO:0000305};

neXtProt entry for LAGE3 Gene

Proteomics data for LAGE3 Gene at MOPED

Post-translational modifications for LAGE3 Gene

  • Ubiquitination at Lys 95
  • Modification sites at PhosphoSitePlus

Other Protein References for LAGE3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for LAGE3 Gene

Domains & Families for LAGE3 Gene

Protein Domains for LAGE3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LAGE3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14657

UniProtKB/Swiss-Prot:

LAGE3_HUMAN :
  • Belongs to the CTAG/PCC1 family.
Family:
  • Belongs to the CTAG/PCC1 family.
genes like me logo Genes that share domains with LAGE3: view

No data available for Gene Families for LAGE3 Gene

Function for LAGE3 Gene

Molecular function for LAGE3 Gene

UniProtKB/Swiss-Prot Function:
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex (By similarity).

Phenotypes for LAGE3 Gene

GenomeRNAi human phenotypes for LAGE3:
genes like me logo Genes that share phenotypes with LAGE3: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for LAGE3 Gene

Localization for LAGE3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LAGE3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LAGE3 Gene COMPARTMENTS Subcellular localization image for LAGE3 gene
Compartment Confidence
nucleus 5
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for LAGE3 Gene

Pathways & Interactions for LAGE3 Gene

genes like me logo Genes that share pathways with LAGE3: view

Pathways by source for LAGE3 Gene

Gene Ontology (GO) - Biological Process for LAGE3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with LAGE3: view

No data available for SIGNOR curated interactions for LAGE3 Gene

Drugs & Compounds for LAGE3 Gene

No Compound Related Data Available

Transcripts for LAGE3 Gene

mRNA/cDNA for LAGE3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(135) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for LAGE3 Gene

L antigen family, member 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LAGE3 Gene

No ASD Table

Relevant External Links for LAGE3 Gene

GeneLoc Exon Structure for
LAGE3
ECgene alternative splicing isoforms for
LAGE3

Expression for LAGE3 Gene

mRNA expression in normal human tissues for LAGE3 Gene

Protein differential expression in normal tissues from HIPED for LAGE3 Gene

This gene is overexpressed in Lavage (33.8) and Peripheral blood mononuclear cells (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LAGE3 Gene



SOURCE GeneReport for Unigene cluster for LAGE3 Gene Hs.444619

mRNA Expression by UniProt/SwissProt for LAGE3 Gene

Q14657-LAGE3_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with LAGE3: view

Protein tissue co-expression partners for LAGE3 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LAGE3 Gene

Orthologs for LAGE3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LAGE3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LAGE3 35
  • 99.31 (n)
  • 97.94 (a)
LAGE3 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LOC782436 35
  • 77.98 (n)
  • 68.81 (a)
dog
(Canis familiaris)
Mammalia LOC100856548 35
  • 73.65 (n)
  • 63.81 (a)
-- 36
  • 58 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lage3 36
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lage3 35
  • 60.08 (n)
  • 58.02 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536597 35
  • 58.02 (n)
  • 56.79 (a)
CABZ01063556.1 36
  • 50 (a)
OneToMany
Species with no ortholog for LAGE3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LAGE3 Gene

ENSEMBL:
Gene Tree for LAGE3 (if available)
TreeFam:
Gene Tree for LAGE3 (if available)

Paralogs for LAGE3 Gene

Paralogs for LAGE3 Gene

(2) SIMAP similar genes for LAGE3 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for LAGE3 Gene

genes like me logo Genes that share paralogs with LAGE3: view

Variants for LAGE3 Gene

Sequence variations from dbSNP and Humsavar for LAGE3 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs10011 -- 154,477,866(-) GGCAG(G/T)AATTC utr-variant-3-prime
rs2276463 -- 154,478,825(+) AGCTG(C/T)GGCTG reference, missense
rs11538408 -- 154,478,846(-) GCTGC(A/C)GCGGG reference, missense
rs11538409 -- 154,478,737(-) GCGGC(C/T)GCACA reference, missense
rs11538410 -- 154,478,340(-) TGCCG(A/G)GCCCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for LAGE3 Gene

Variant ID Type Subtype PubMed ID
esv33199 CNV Gain+Loss 17666407
esv33784 CNV Gain+Loss 17666407
nsv519042 CNV Gain 19592680

Variation tolerance for LAGE3 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.62; 31.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LAGE3 Gene

HapMap Linkage Disequilibrium report
LAGE3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LAGE3 Gene

Disorders for LAGE3 Gene

Relevant External Links for LAGE3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LAGE3

No disorders were found for LAGE3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for LAGE3 Gene

Publications for LAGE3 Gene

  1. Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach. (PMID: 8786131) Faranda S. … Vezzoni P. (Genomics 1996) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. A newly uncovered group of distantly related lysine methyltransferases preferentially interact with molecular chaperones to regulate their activity. (PMID: 23349634) Cloutier P. … Coulombe B. (PLoS Genet. 2013) 3

Products for LAGE3 Gene

Sources for LAGE3 Gene

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