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Aliases & Descriptions for LAG3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CD223 1, 2 | | FDC 3 | | LAG-3 3 |
| | | Descriptions |
|---|
| CD223 antigen 3 | | FDC protein 3 | | lymphocyte-activation gene 3 2 | | lymphocyte-activation protein 3 2 |
|
| | Search outside databases for aliases for LAG3 genePrevious GC identifers: GC12M006669 GC12M006794 GC12P006760 |
Summaries for LAG3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for LAG3: Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq] UniProtKB/Swiss-Prot: LAG3_HUMAN, P18627Function: Involved in lymphocyte activation. Binds to HLA class-II antigensGene Wiki entry for LAG3 |
Genomic Location for LAG3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LAG3 gene 
Entrez Gene cytogenetic band: 12p13.32 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.3LAG3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P006751:
(about GC identifiers)
Start:
|
6,751,931 bp from pter |
End:
|
6,757,880 bp from pter |
Size:
|
5,950 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000012.10 NT_009759.15
| Proteins for LAG3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LAG3_HUMAN, P18627 (See
protein sequence)Recommended Name: Lymphocyte activation gene 3 protein precursor Size: 525 amino acids; 57437 Da
Subcellular location: Membrane; Single-pass type I membrane proteinREFSEQ proteins: NP_002277.4
ENSEMBL proteins: ENSP00000203629
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0009897 | external side of plasma membrane |
IEA | -- | | GO:0016020 | membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- | About this table
Antibodies for LAG3: Assays for LAG3: | Protein
Domains/ Families for LAG3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P18627
ProtoNet protein and cluster: P18627 1 Blocks protein family: IPB003599 Immunoglobulin subtype
UniProtKB/Swiss-Prot: LAG3_HUMAN, P18627Similarity: Contains 3 Ig-like C2-type (immunoglobulin-like) domainsSimilarity: Contains 1 Ig-like V-type (immunoglobulin-like) domain | Gene Function for LAG3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002286
Applied Biosystems Silencer® siRNAs for LAG3
Sigma-Aldrich siRNA and siRNA Panels for LAG3  Sigma-Aldrich shRNA Panels and shRNA for LAG3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_002286                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002286                                  untagged cDNA clone in CMV expression vector: NM_002286 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_002286
UniProtKB/Swiss-Prot: LAG3_HUMAN, P18627Function: Involved in lymphocyte activation. Binds to HLA class-II antigensGenatlas biochemistry entry for LAG3:lymphocyte activation gene-3,with three transcriptional initiation sites,highly homolog to CD4,expressed exclusively in activated T and NK lymphocytes,major histocompatibility complex (MHC) class 2 ligand potentially involved in the regulation of immune response2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Lag3):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for LAG3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for LAG3 
5/8 Interacting proteins for LAG3 (ENSP000002036293) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
4 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007166 | cell surface receptor linked signal transduction |
IEA | -- | | GO:0045085 | negative regulation of interleukin-2 biosynthetic process |
IEA | -- | | GO:0045954 | positive regulation of natural killer cell mediated cytotoxicity |
IEA | -- | | GO:0050868 | negative regulation of T cell activation |
IEA | -- | About this table
|
Drugs & Compounds for LAG3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LAG3
|
Transcripts for LAG3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_002286
Sigma-Aldrich siRNA and siRNA Panels for LAG3  Sigma-Aldrich shRNA Panels and shRNA for LAG3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_002286 REFSEQ mRNAs for LAG3 gene: NM_002286.5
Applied Biosystems TaqMan ® Gene Expression Assays: NM_002286               OriGene GFP tagged cDNA clone in CMV expression vector: NM_002286                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_002286                                  untagged cDNA clone in CMV expression vector: NM_002286  Additional cDNA sequence: AK292104.1 BC037962.1 BC052589.1 X51985.3 5 DOTS entries: DT.405739 DT.99963620 DT.70100595 DT.95360560 DT.97791328 4 AceView cDNA sequences:BC037962 BC052589 NM_002286 X51985
highest scoring ESTs for LAG3:X51985 AW978655 BC037962 AA687676 AA991723 AI263860 AI264375 AI274900 AI949108 AW003135 Unigene Cluster for LAG3: Lymphocyte-activation gene 3 Hs.409523 [show with all ESTs]Unigene Representative Sequence: BC037962
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000203629
|
Expression for LAG3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LAG3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LAG3
1 / 2 / 3 4 probe-sets matching LAG3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TATAACCTCA
SOURCE GeneReport for Unigene cluster: Hs.409523
Expression variation in blood from EXPOLDB for LAG3 UniProtKB/Swiss-Prot: LAG3_HUMAN, P18627Tissue specificity: On cell surface of activated NK and T-lymphocytes |
Orthologs for LAG3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LAG3 gene from 5 species
About this table Species with no ortholog for LAG3
ENSEMBL Gene Tree for LAG3 | Paralogs for LAG3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for LAG3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LAG3 (up to first 250kb)
|
Disorders & Mutations for LAG3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 153337
4 Novoseek disease relationships for LAG3 gene
About this table
Genetic Association Database: LAG3 Human Genome Epidemiology Navigator: LAG3 (3 documents)
|
Medical News for LAG3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LAG3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/64 PubMed articles for LAG3 gene (see all 64
):- Characterization of the lymphocyte activation gene 3-encoded protein. A new ligand for human leukocyte antigen class II antigens. (PubMed id 1380059)1, 3, 4 Baixeras E.... Piatier-Tonneau D. (1992)
- LAG-3, a novel lymphocyte activation gene closely related to CD4. (PubMed id 1692078)1, 3, 4 Triebel F.... Hercend T. (1990)
- Two genes encoding immune-regulatory molecules (LAG3 and IL7R) confer susceptibility to multiple sclerosis. (PubMed id 15674389)3, 6 Zhang Z....Anvret M. (2005)
- Characterization of the major histocompatibility complex class II binding site on LAG-3 protein. (PubMed id 9159144)1, 3 Huard B....Triebel F. (1997)
- Regulation of expression of the human lymphocyte activation gene-3 (LAG-3) molecule, a ligand for MHC class II. (PubMed id 9634475)1, 3 Bruniquel D....Triebel F. (1998)
- MHC class II signal transduction in human dendritic cells induced by a natural ligand, the LAG-3 protein (CD223). (PubMed id 12775570)1, 3 Andreae S....Triebel F. (2003)
- Expression of LAG-3 by tumor-infiltrating lymphocytes is coincident with the suppression of latent membrane antigen-specific CD8+ T-cell function in Hodgkin lymphoma patients. (PubMed id 16757686)1, 3 Gandhi M.K....Khanna R. (2006)
- The MHC class II ligand lymphocyte activation gene-3 is co-distributed with CD8 and CD3-TCR molecules after their engagement by mAb or peptide-MHC class I complexes. (PubMed id 10545478)1, 3 Hannier S. and Triebel F. (1999)
- CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling. (PubMed id 9780176)1, 3 Hannier S....Triebel F. (1998)
- LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination. (PubMed id 14644131)1, 3 Triebel F. (2003)
|
Search for LAG3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LAG3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LAG3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LAG3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LAG3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LAG3:

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