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Aliases & Descriptions for LAD1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| LAD 3 | | LADA 3 | | Lad-1 3 | | LadA 2 | | MGC10355 2 | | OTTHUMP00000033878 2 |
| | | Descriptions |
|---|
| Linear IgA disease antigen 3 | | ladinin 1 2 | | linear IgA bullous dermatosis antigen 2 | | linear IgA disease antigen homolog 2 |
|
| | Search outside databases for aliases for LAD1 genePrevious GC identifers: GC01P199048 GC01P196782 GC01M197816 GC01M198638 GC01M198081 |
Summaries for LAD1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for LAD1: The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. [provided by RefSeq] UniProtKB/Swiss-Prot: LAD1_HUMAN, O00515Function: Anchoring filament protein which is a component of the basement membrane zone (By similarity)Gene Wiki entry for LAD1 |
Genomic Location for LAD1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the LAD1 gene 
Entrez Gene cytogenetic band: 1q25.1-q32.3 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q25.1-q32.3LAD1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01M199617:
(about GC identifiers)
Start:
|
199,616,589 bp from pter |
End:
|
199,635,353 bp from pter |
Size:
|
18,765 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000001.9 NT_004487.18
| Proteins for LAD1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LAD1_HUMAN, O00515 (See
protein sequence)Recommended Name: Ladinin-1 Size: 517 amino acids; 57131 Da
Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane (By similarity)
Sequence caution: Sequence=AAD10849.1; Type=Erroneous gene model prediction;
Secondary accessions: O95614 Q96GD8Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_005549.2
ENSEMBL proteins: ENSP00000356282 ENSP00000375829 ENSP00000356283
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- | | GO:0005604 | basement membrane |
IEA | -- | About this table
Antibodies for LAD1: Assays for LAD1: | Protein
Domains/ Families for LAD1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O00515
ProtoNet protein and cluster: O00515 | Gene Function for LAD1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005558
Applied Biosystems Silencer® siRNAs for LAD1
Sigma-Aldrich siRNA for LAD1  Sigma-Aldrich shRNA Panels and shRNA for LAD1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_005558                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005558                                  untagged cDNA clone in CMV expression vector: NM_005558 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_005558
UniProtKB/Swiss-Prot: LAD1_HUMAN, O00515Function: Anchoring filament protein which is a component of the basement membrane zone (By similarity)Genatlas biochemistry entry for LAD1:ladinin 1,59kDa,component of the basement membranes,expressed in keratinocytes1 Gene Ontology (GO) molecular function term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005198 | structural molecule activity |
TAS | 9119369 | About this table | Pathways & Interactions for LAD1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for LAD1 
5/12 Interacting proteins for LAD1 (O005152 ENSP000003562823) via UniProtKB, MINT, and/or STRING (see all 12
)About this table
|
Drugs & Compounds for LAD1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for LAD1
|
Transcripts for LAD1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_005558
Sigma-Aldrich siRNA for LAD1  Sigma-Aldrich shRNA Panels and shRNA for LAD1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_005558 REFSEQ mRNAs for LAD1 gene: NM_005558.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_005558               OriGene GFP tagged cDNA clone in CMV expression vector: NM_005558                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_005558                                  untagged cDNA clone in CMV expression vector: NM_005558  Additional cDNA sequence: AK310917.1 AK313388.1 BC009742.2 BC071890.1 BX647307.1 U42408.1 6 DOTS entries: DT.412588 DT.100732808 DT.100748997 DT.92430379 DT.95083505 DT.95244606 24/143 AceView cDNA sequences (see all 143
):BF914747 BM792782 BI092904 AW081928 AI625947 BM552193 BC009742 NM_005558 CD364532 AA552111 AW291547 BM549092 BG403036 BG696264 BM908787 BQ022579 AW079392 BM852860 BM794531 BM797503 AW572265 BM817783 AI888802 AA300230
highest scoring ESTs for LAD1:U42408 BC009742 BC071890 BG540063 BI759430 BM794531 BM854604 BX479962 BX647307 AA159477 Unigene Cluster for LAD1: Ladinin 1 Hs.519035 [show with all ESTs]Unigene Representative Sequence: NM_005558
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LAD1 (see all 7
)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ | 14 | |
| SP1: | |   | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | - |   | |   | |   | |   | - |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for LAD1
3 Ensembl transcripts including schematic representations: ENST00000367313
ENST00000391967
ENST00000367314
|
Expression for LAD1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| LAD1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for LAD1
1 / 2 / 3 5 probe-sets matching LAD1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GCCAGGAGCT
SOURCE GeneReport for Unigene cluster: Hs.519035
Expression variation in blood from EXPOLDB for LAD1 |
Orthologs for LAD1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for LAD1 gene from 5 species
About this table Species with no ortholog for LAD1
ENSEMBL Gene Tree for LAD1 | Paralogs for LAD1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for LAD1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for LAD1 (up to first 250kb)
|
Disorders & Mutations for LAD1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 602314
5 Novoseek disease relationships for LAD1 gene
About this table
|
Medical News for LAD1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for LAD1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/26 PubMed articles for LAD1 gene (see all 26
):- Global phosphoproteome of HT-29 human colon adenocarcinoma cells. (PubMed id 16083285)3, 4 Kim J.-E.... White F.M. (2005)
- Cloning and chromosomal mapping of mouse ladinin, a novel basement membrane zone component. (PubMed id 9119369)2, 3 Motoki K....Uitto J. (1997)
- LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120- kDa anchoring filament protein synthesized by epidermal cells. (PubMed id 8618013)2, 3 Marinkovich M.P.... Zone J.J. (1996)
- The 97 kDa linear IgA bullous dermatosis antigen is not expressed in a patient with generalized atrophic benign epidermolysis bullosa with a novel homozygous G258X mutation in COL17A1. (PubMed id 9804354)1, 3 Shimizu H....Nishikawa T. (1998)
- 97 kDa linear IgA bullous dermatosis antigen localizes in the lamina lucida between the NC16A and carboxyl terminal domains of the 180 kDa bullous pemphigoid antigen. (PubMed id 9665393)1, 3 Ishiko A....Nishikawa T. (1998)
- Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. (PubMed id 15778465)3 Benzinger A.... Hermeking H. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)4 Ota T....Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)3 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )4 Aoki H.... Hino O. (2000)
|
Search for LAD1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing LAD1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing LAD1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LAD1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for LAD1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for LAD1:

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Incremental update: 13 Oct 2009
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