Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

LAD1 Gene

protein-coding GIFtS: 53
GCID: GC01M201349

ladinin 1

Explore 11 diseases affiliated with
LAD1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Ladinin 1¹ ²		Linear IgA Disease Antigen Homolog²
LadA²		LAD³
Lad-1³		LADA³
Ladinin-1¹		Lad-1³
Linear IgA Bullous Dermatosis Antigen²		Linear IgA Disease Antigen³

External Ids:	HGNC: 6472¹	Entrez Gene: 3898²	Ensembl: ENSG00000159166⁷	OMIM: 602314⁵	UniProtKB: O00515³

Export aliases for LAD1 gene to outside databases

Previous GC identifers: GC01P199048 GC01P196782 GC01M197816 GC01M198638 GC01M198081 GC01M199617 GC01M172516

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LAD1:

The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may

contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. (provided by

RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: LAD1_HUMAN, O00515

Function: Anchoring filament protein which is a component of the basement membrane zone (By similarity)

Gene Wiki entry for LAD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000001.10 NC_018912.1 NT_004487.19

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the LAD1 gene promoter:
HOXA9 AhR GCNF Olf-1 E47 MZF-1 AREB6 c-Rel GCNF-1 GCNF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: LAD1 promoter sequence

Search SABiosciences Chromatin IP Primers for LAD1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAD1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q25.1-q32.3 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q25.1-q32.3

LAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LAD1 gene location

GeneLoc information about chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M201349: view genomic region (about GC identifiers)

Start:	201,342,372 bp from pter	End:	201,368,736 bp from pter
Size:	26,365 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: LAD1_HUMAN, O00515 (See protein sequence)

Recommended Name: Ladinin-1

Size: 517 amino acids; 57131 Da

Subcellular location: Secreted, extracellular space, extracellular matrix, basement membrane (By similarity)

Sequence caution: Sequence=AAD10849.1; Type=Erroneous gene model prediction;

Secondary accessions: O95614 Q96GD8

Explore the universe of human proteins at neXtProt for LAD1: NX_O00515

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O00515

LAD1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005549.2

ENSEMBL proteins:

ENSP00000422687 ENSP00000375829 ENSP00000356282

Human Recombinant Protein Products for LAD1:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: LAD1 Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for LAD1
	GenScript Custom Purified and Recombinant Proteins Services for LAD1
	Novus Biologicals LAD1 Protein
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for LAD1

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005604	basement membrane	IEA	--
GO:0015629	actin cytoskeleton	IDA	--

LAD1 for ontologies About GeneDecksing

LAD1 Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: LAD1 OriGene Custom Antibody Services for LAD1
	GenScript Custom Superior Antibodies Services for LAD1
	Novus Biologicals LAD1 Antibodies
	Abcam antibodies for LAD1
	Uscn Antibodies for LAD1
	ThermoFisher Antibody for LAD1

Assay Products for LAD1:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for LAD1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for LAD1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

LAD1 for domains About GeneDecksing

1 InterPro domain/family:

IPR017404 Ladinin_1

Graphical View of Domain Structure for InterPro Entry O00515

ProtoNet protein and cluster: O00515

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: LAD1_HUMAN, O00515

Function: Anchoring filament protein which is a component of the basement membrane zone (By similarity)

Genatlas biochemistry entry for LAD1:

ladinin 1,59kDa,component of the basement membranes,expressed in keratinocytes

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005198	structural molecule activity	TAS	9119369

LAD1 for ontologies About GeneDecksing

Phenotypes:
4 GenomeRNAi human phenotypes for LAD1:

Cell division defect

Decreased viability of wild-ty

Decreased viability with pacli

Increased S DNA content

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LAD1

miRNA Products:		OriGene 3'-UTR Clone: LAD1 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAD1
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate LAD1 (see all 9):
		hsa-miR-4324 hsa-miR-361-5p hsa-miR-512-3p hsa-miR-1253 hsa-miR-3667-3p hsa-miR-374a* hsa-miR-544b hsa-miR-3622b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: LAD1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAD1 (see all 7) OriGene shRNA RFP: LAD1 OriGene siRNA: LAD1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAD1
		Sirion Biotech Custom design and validation of potent shRNA sequences against LAD1

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for LAD1
			Sirion Biotech Customized adenovirus for overexpression of LAD1 Sirion Biotech Customized adenovirus for potent knockdown of LAD1

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAD1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LAD1 (NM_005558)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAD1

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for LAD1
		Search LifeMap BioReagents cell lines for LAD1
		Sirion Biotech Customized stable knockdown cell line services for LAD1 Sirion Biotech Customized inducible knockdown cell line services for LAD1 Sirion Biotech Customized stable overexpressing cell line services for LAD1 Sirion Biotech Customized inducible overexpressing cell line services for LAD1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAD1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for LAD1

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for LAD1 (O00515^{2, 3} ENSP00000375829⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SFN	P31947²^,³, ENSP00000340989⁴	MINT-3975007 I2D: score=2 STRING: ENSP00000340989
ESR2	Q92731³, ENSP00000343925⁴	I2D: score=1 STRING: ENSP00000343925
COL17A1	Q9UMD9³, ENSP00000340937⁴	I2D: score=1 STRING: ENSP00000340937

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for LAD1
Search CenterWatch for drugs/clinical trials and news about LAD1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for LAD1 gene:

NM_005558.3

Unigene Cluster for LAD1:

Ladinin 1

Hs.519035 [show with all ESTs]

Unigene Representative Sequence: NM_005558

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000503578 ENST00000391967(uc001gwm.3 uc009wzu.1) ENST00000367313

ENST00000475136 ENST00000488842

miRNA Products:		OriGene 3'-UTR Clone: LAD1 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat LAD1
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate LAD1 (see all 9):
		hsa-miR-4324 hsa-miR-361-5p hsa-miR-512-3p hsa-miR-1253 hsa-miR-3667-3p hsa-miR-374a* hsa-miR-544b hsa-miR-3622b-3p

		SwitchGear 3'UTR luciferase reporter plasmid: LAD1 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAD1 (see all 7) OriGene shRNA RFP: LAD1 OriGene siRNA: LAD1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAD1
		Sirion Biotech Custom design and validation of potent shRNA sequences against LAD1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAD1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAD1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: LAD1 (NM_005558)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for LAD1
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAD1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAD1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LAD1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAD1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAD1

Additional cDNA sequence:

AK310917.1 AK313388.1 BC009742.2 BC071890.1 BX647307.1 U42408.1

6 DOTS entries:

DT.412588 DT.100732808 DT.100748997 DT.92430379 DT.95083505 DT.95244606

24/143 AceView cDNA sequences (see all 143):

AW572265 AA588706 NM_005558 CD364532 BQ022579 BI092904 AW081928 BX107960

BG751236 BF914747 BM792782 AI625947 BG696264 BG403036 AA300230 AW291547

AA552111 AW079392 BM852860 BM549092 BC009742 AI888802 BM552193 BM817783

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for LAD1 (see all 7) About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7a	·	7b	·	7c	·	7d	·	7e	^	8	^	9	^	10a	·	10b	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14
SP1:							-		-																		-						-								-
SP2:																																	-
SP3:							-
SP4:
SP5:			-		-		-		-

ECgene alternative splicing isoforms for LAD1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

LAD1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCAGGAGCT

About this image

LAD1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Sertoli cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

See LAD1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LAD1

SOURCE GeneReport for Unigene cluster: Hs.519035

SABiosciences Custom PCR Arrays for LAD1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAD1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat LAD1
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAD1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAD1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for LAD1 gene from 3/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Lad1^{1 , 5}	ladinin^{1, 5}	75.55(n)¹ 69.18(a)¹		1 (59.30 cM)⁵ 16763¹ NM_133664.3¹ NP_598425.2¹ 135818598⁵
chicken (Gallus gallus)	Aves	LAD1⁶	Uncharacterized protein	45(a)	1 ↔ 1	26(776460-782960)
lizard (Anolis carolinensis)	Reptilia	LAD1⁶	--	46(a)	1 ↔ 1	4(131409069-131417051)

ENSEMBL Gene Tree for LAD1 (if available)
TreeFam Gene Tree for LAD1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for LAD1 gene

1 SIMAP similar gene for LAD1 using alignment to 4 protein entries: LAD1_HUMAN (see all proteins):

DKFZp686M21196

LAD1 for paralogs About GeneDecksing

1 Pseudogenes.org Pseudogene for LAD1
PGOHUM00000234274

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 1 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs200375153^1,2	C	--	172532980(-)	`CTTATA/GTNNNN`	1	--	us2k¹		0	--	--	--	--
rs113832607^1,2	C	--	172533275(+)	`GCGATA/GAGCTG`	1	--	us2k¹		0	--	--	--	--
rs78799983^1,2	F	--	172533767(+)	`GATGTC/TCAGCA`	1	--	us2k¹		1		EA	120
rs55914949^1,2		--	172533918(+)	`GCGTCC/TTTAGT`	1	--	us2k¹		0	--	--	--	--
rs113515093^1,2		--	172534939(+)	`GTTAGA/C/GGCAGG`	2	--	nc-transcript-variant		1		CSA	1
rs6700332^1,2	C,F	--	172535555(+)	`CAGGAT/GGAGAA`	1	--	int¹		1		WA	118
rs77359316^1,2	F	--	172536013(+)	`CTCCAG/AGGAGT`	1	--	nc-transcript-variant		1		WA	118
rs74777109^1,2	F	--	172536200(+)	`ACACCT/CCAACA`	1	--	nc-transcript-variant		1		WA	118
rs201118736^1,2	C	--	172536306(-)	`GGCTGG/TTAGAT`	1	--	nc-transcript-variant		0	--	--	--	--
rs12072156^1,2	C,F	--	172536446(+)	`GGATAC/TTTTCT`	1	--	nc-transcript-variant		1		WA	118

HapMap Linkage Disequilibrium report for LAD1 (201342372 - 201368736 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LAD1: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAD1

DNA2.0 Custom Variant and Variant Library Synthesis for LAD1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

LAD1 for disorders           About GeneDecksing

OMIM gene information: 602314    OMIM disorders: --

11 diseases for LAD1:    About MalaCards

epidermolysis bullosa acquisita epidermolysis bullosa linear iga disease junctional epidermolysis bullosa

cicatricial pemphigoid bullous pemphigoid b-cell lymphomas basal cell carcinoma

skin disease ovarian cancer carcinoma

1 disease from the University of Copenhagen DISEASES database for LAD1:

Diabetes mellitus

5 Novoseek disease relationships for LAD1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
gabeb	88.8	2	9666845 (1), 9804354 (1)
pemphigoid bullous	80.2	2	9666845 (1), 9665393 (1)
pemphigoid cicatricial	73.7	1	9672190 (1)
epidermolysis bullosa acquisita	73.5	2	16088162 (1), 9672190 (1)
skin diseases	70.7	13	9804354 (2), 9886264 (1), 10397589 (1), 14870985 (1) (see all 9)

Export disorders for LAD1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for LAD1 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with LAD1)

Utopia: connect your pdf to the dynamic
world of online information

Cloning and chromosomal mapping of mouse ladinin, a n ovel basement membrane zone component. (PubMed id 9119369)^{1, 3} Motoki K....Uitto J. (1997)
LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120- kDa anchoring filament protein synthesized by epidermal cells. (PubMed id 8618013)^{1, 3} Marinkovich M.P.... Zone J.J. (1996)
The 97 kDa linear IgA bullous dermatosis antigen is not expressed in a patient with generalized atrophic benign epidermolysis bullosa with a novel homozygous G258X mutation in COL17A1. (PubMed id 9804354)^{1, 9} Shimizu H....Nishikawa T. (1998)
97 kDa linear IgA bullous dermatosis antigen localizes in the lamina lucida between the NC16A and carboxyl terminal domains of the 180 kDa bullous pemphigoid antigen. (PubMed id 9665393)^{1, 9} Ishiko A....Nishikawa T. (1998)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)¹ OlA!h J....OvA!di J. (2011)
Calcium regulation of EGF-induced ERK5 activation: ro le of Lad1-MEKK2 interaction. (PubMed id 20830310)¹ Yao Z....Seger R. (2010)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer. (PubMed id 15778465)¹ Benzinger A.... Hermeking H. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 3898	HGNC: 6472	AceView: LAD1	Ensembl:ENSG00000159166	euGenes: HUgn3898
ECgene: LAD1	H-InvDB: LAD1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for LAD1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for LAD1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for LAD1 gene:
Search GeneIP for patents involving LAD1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for LAD1		OriGene shRNA RFP for LAD1
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LAD1		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LAD1
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for LAD1		OriGene 3'-UTR Clone for LAD1
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LAD1		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LAD1
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for LAD1		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for LAD1		OriGene Custom Protein Services for LAD1
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LAD1
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LAD1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LAD1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LAD1
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LAD1
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LAD1

	GenScript Custom Purified and Recombinant Proteins Services for LAD1		GenScript cDNA clones with any tag delivered in your preferred vector for LAD1
	GenScript Custom Assay Services for LAD1		GenScript Custom Superior Antibodies Services for LAD1
	GenScript Custom overexpressing Cell Line Services for LAD1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in LAD1 promoter
	Search Chromatin IP Primers for LAD1
	RT² qPCR Primer Assay in human, mouse, rat LAD1
	GNC Network for LAD1
	SABiosciences Custom PCR Arrays for LAD1

Search Tocris compounds for LAD1

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	LAD1 antibodies
	LAD1 proteins

	Antibodies for LAD1
	See all of Abcam's Antibodies, Kits and Proteins for LAD1
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

LAD1 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for LAD1

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LAD1

	SwitchGear 3'UTR luciferase reporter plasmids for LAD1
	SwitchGear Promoter luciferase reporter plasmids for LAD1

ThermoFisher Antibody for LAD1

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LAD1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for LAD1

Sirion Biotech Customized:

	stable knockdown cell line services for LAD1
	inducible knockdown cell line services for LAD1
	design and validation of potent shRNA sequences against LAD1
	adenovirus for potent knockdown of LAD1
	adenovirus for overexpression of LAD1
	stable overexpressing cell line services for LAD1
	inducible overexpressing cell line services for LAD1

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes LAD1 gene at Home site.

hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

LAD1 Gene

ladinin 1

Aliases
for LAD1 gene

Summaries
for LAD1 gene

Genomic Views
for LAD1 gene

Proteins
for LAD1 gene

Protein Domains /
Families
for LAD1 gene

Function
for LAD1 gene

Pathways & Interactions
for LAD1 gene

Drugs & Compounds
for LAD1 gene

Transcripts
for LAD1 gene

Expression
for LAD1 gene

Orthologs
for LAD1 gene

Paralogs
for LAD1 gene

Genomic Variants
for LAD1 gene

Disorders / Diseases
for LAD1 gene

Publications
for LAD1 gene

External Searches for LAD1 gene

Genome Databases showing LAD1 gene

Other Databases showing LAD1 gene

Specialized Databases showing LAD1 gene

Intellectual Property
for LAD1 gene

Products
for LAD1 gene

View Random Gene

Advanced Search

Export list of displayed genes

LAD1 Gene

ladinin 1

Aliasesfor LAD1 gene

Summariesfor LAD1 gene

Genomic Viewsfor LAD1 gene

Proteinsfor LAD1 gene

Protein Domains /Familiesfor LAD1 gene

Functionfor LAD1 gene

Pathways & Interactionsfor LAD1 gene

Drugs & Compoundsfor LAD1 gene

Transcriptsfor LAD1 gene

Expression for LAD1 gene

Orthologsfor LAD1 gene

Paralogsfor LAD1 gene

Genomic Variantsfor LAD1 gene

Disorders / Diseasesfor LAD1 gene

Publicationsfor LAD1 gene

External Searches for LAD1 gene

Genome Databases showing LAD1 gene

Other Databases showing LAD1 gene

Specialized Databases showing LAD1 gene

Intellectual Propertyfor LAD1 gene

Productsfor LAD1 gene

View Random Gene

Aliases
for LAD1 gene

Summaries
for LAD1 gene

Genomic Views
for LAD1 gene

Proteins
for LAD1 gene

Protein Domains /
Families
for LAD1 gene

Function
for LAD1 gene

Pathways & Interactions
for LAD1 gene

Drugs & Compounds
for LAD1 gene

Transcripts
for LAD1 gene

Expression
for LAD1 gene

Orthologs
for LAD1 gene

Paralogs
for LAD1 gene

Genomic Variants
for LAD1 gene

Disorders / Diseases
for LAD1 gene

Publications
for LAD1 gene

Intellectual Property
for LAD1 gene

Products
for LAD1 gene