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LACTB2 Gene

protein-coding GIFtS: 44

GC08M071712

lactamase, beta 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
CGI-83 ^¹, ²
EC 3.-.-.- ^³

Descriptions
lactamase, beta 2 ^²

External Ids
HGNC: 18512¹
Entrez Gene: 51110²
UniProtKB: Q53H82³
Ensembl: ENSG00000147592⁷

Search outside databases for aliases for LACTB2 gene

Previous GC identifer: GC08M071599

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the LACTB2 gene

Entrez Gene cytogenetic band: 8p22-q22.3 Ensembl cytogenetic band: 8q13.3 HGNC cytogenetic band: 8q13.3

LACTB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08M071712: (about GC identifiers)

Start:	71,712,045 bp from pter
End:	71,743,946 bp from pter
Size:	31,902 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000008.9 NT_008183.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LACB2_HUMAN, Q53H82 (See protein sequence)

Recommended Name: Beta-lactamase-like protein 2

Size: 288 amino acids; 32806 Da

Secondary accessions: Q9Y392

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_057111.1

ENSEMBL proteins:

ENSP00000276590

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Human Recombinant Proteins from Abnova (LACTB2)

OriGene Purified Recombinant Human Protein: LACTB2

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--

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Antibodies for LACTB2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for LACTB2

Assays for LACTB2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q53H82

ProtoNet protein and cluster: Q53H82

UniProtKB/Swiss-Prot: LACB2_HUMAN, Q53H82

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LACTB2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC000878

Applied Biosystems Silencer® siRNAs for LACTB2

Sigma-Aldrich siRNA and siRNA Panels for LACTB2

Sigma-Aldrich shRNA for LACTB2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for LACTB2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_016027
Myc/DDK tagged cDNA clone in CMV expression vector: NM_016027
untagged cDNA clones in CMV expression vector (see all 2): BC000878

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_016027

3 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--
GO:0016787	hydrolase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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2 Interacting proteins for LACTB2 (ENSP00000276590³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
AARSD1	ENSP00000353355³	STRING (score=.706)
MRI1	ENSP00000040663³	STRING (score=.706)

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LACTB2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (LACTB2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC000878

Sigma-Aldrich siRNA and siRNA Panels for LACTB2

Sigma-Aldrich shRNA for LACTB2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_016027

REFSEQ mRNAs for LACTB2 gene:

NM_016027.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_016027

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_016027
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_016027
                                 untagged cDNA clones in CMV expression vector (see all 2): BC000878

Additional cDNA sequence:

AF151841.1 AK222699.1 AK290201.1 BC000878.1 BC008505.1 CR623519.1

4 DOTS entries:

DT.101981209 DT.444705 DT.444706 DT.95270977

24/126 AceView cDNA sequences (see all 126 ):

CA397876 BG493282 CR623519 BE866654 AA863239 AA568261 BC008505 AA830860

BC000878 BX099977 BP428679 AA682545 BM560709 AA436098 BI756569 AA295495

BF725748 BF001755 BI824044 BU569055 AI078271 BQ012045 BM560501 CB242100

highest scoring ESTs for LACTB2:

AA205935 AA299314 AA344078 AA367137 AI148069 AV683263 BE548555 BF086250 BP428679 BX480319

Unigene Cluster for LACTB2:

Lactamase, beta 2

Hs.118554 [show with all ESTs]

Unigene Representative Sequence: NM_016027

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation:

ENST00000276590

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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LACTB2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for LACTB2

¹ / ² / ³

8 probe-sets matching LACTB2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
78373_r_at²^{, 3}	U95-E	1	1.00	1.00	0.85	0.52	AI525903	0.60	1.00	0.82	1
78375_s_at²^{, 3}	U95-E	1	1.00	1.00	0.93	0.93	AA682545	0.80	0.80	0.80	1
62806_at²^{, 3}	U95-C	1	1.00	1.00	0.92	1.28	AA205935	0.80	1.00	0.91	1
78369_s_at²^{, 3}	U95-E	1	1.00	1.00	0.94	1.29	AI525903	0.60	1.00	0.82	1
222714_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BC000878	0.80	0.88	0.84	1
218701_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_016027	0.60	1.00	0.82	1
222714_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
218701_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks LACTB2 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: AAATGGCTAA

SOURCE GeneReport for Unigene cluster: Hs.118554

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for LACTB2 gene from 5/16 species (see all 16 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LACTB2¹	--	lactamase, beta 2	89.81(n) 88.19(a)	486990 XM_544119.2 XP_544119.2
chimpanzee (Pan troglodytes)	LACTB2¹	--	lactamase, beta 2	99.54(n) 99.65(a)	464505 XM_001164196.1 XP_001164196.1
cow (Bos taurus)	LACTB2¹	--	lactamase, beta 2	89.7(n) 89.93(a)	535021 NM_001076045.1 NP_001069513.1
rat (Rattus norvegicus)	Lactb2¹	--	lactamase, beta 2	84.37(n) 82.99(a)	297768 NM_001024247.1 NP_001019418.1
mouse (Mus musculus)	Lactb2^{1, 5}	1⁵	lactamase, beta 2^{1, 5}	84.26(n)¹ 84.03(a)¹	212442¹ NM_145381.2¹ NP_663356.1¹ AI841387⁵ AK088932⁵ (see all 10)

About this table Species with no ortholog for LACTB2

ENSEMBL Gene Tree for LACTB2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/186 NCBI SNPs in LACTB2 are shown (see all 186 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 68)

AB	SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1979452^1,2	A,C,F,H	71712168(-)	`ACTATC/GTATTG`	1	--	ut3¹ ese³		4		EU EA WA	418
--	rs9918763^1,2	A,C	71711561(+)	`aacatC/Tagcca`	1	--	ng5¹		0	--	--	--	--
--	rs268570^1,2	C	71711793(+)	`ATTCTG/TGGCTT`	1	--	ng5¹		0	--	--	--	--
--	rs268571^1,2	C	71712612(+)	`TCTCTC/GAAAGC`	1	--	ut3¹ ese³		0	--	--	--	--
	rs7830986^1,2	A,C,F,H	71713386(+)	`TTATGT/CTTAGC`	1	K/K	syn¹		12		EU EA WA NS NA	668
	rs49195^1,2	A,C,F,H,O	71713262(+)	`TTTTTC/TCTCAA`	1	--	int¹		16		NA EU EA WA	1416
	rs433017^1,2	A,C,F,H,O	71739130(-)	`TGTGAT/CGTGAT`	1	--	int¹		7		EU EA WA NA	560
	rs448036^1,2	A,C,F,H,O	71733109(+)	`GCTACG/AAGTAC`	1	--	int¹		16		MN NA EU EA WA	1522
	rs441890^1,2	A,C,F,H,O	71727221(-)	`TTCTCG/ATTAAG`	1	--	int¹		14		EA NA EU WA	1036
	rs406703^1,2	A,C,F,H,O	71727136(-)	`CCCAAT/CTGTTT`	1	--	int¹		11		EU EA WA NA	980

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HapMap Linkage Disequilibrium images for LACTB2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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4 PubMed articles for LACTB2 gene:

Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)^{3, 4} Lai C.H....Lin W. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Construction and characterization of a full length-enriched and a 5'- end-enriched cDNA library. (PubMed id 9373149)³ Suzuki Y.... Sugano S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 51110	HGNC: 18512	AceView: LACTB2	Ensembl:ENSG00000147592	euGenes: HUgn51110
ECgene: LACTB2	H-InvDB: LACTB2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for LACTB2
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for LACTB2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for LACTB2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for LACTB2		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for LACTB2		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (LACTB2)
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	Custom Service for Rabbit Pab from Full-length Protein

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	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for LACTB2

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for LACTB2

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LACTB2 Gene

protein-coding GIFtS: 44

Aliases &
Descriptions
for LACTB2

Summaries
for LACTB2

Genomic Location
for LACTB2

Proteins
for LACTB2

Protein Domains/
Families
for LACTB2

Gene Function
for LACTB2

Pathways & Interactions
for LACTB2

Drugs & Compounds
for LACTB2

Transcripts
for LACTB2

Expression
for LACTB2

Orthologs
for LACTB2

Paralogs
for LACTB2

SNPs/Variants
for LACTB2

Disorders & Mutations
for LACTB2

Medical News
for LACTB2

Publications
for LACTB2

Search for LACTB2

Genome Databases showing LACTB2

Other Databases showing LACTB2

Specialized Databases showing LACTB2

Licensable Technologies
for LACTB2

Services
for LACTB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

LACTB2 Gene

protein-coding GIFtS: 44

Aliases & Descriptionsfor LACTB2

Summariesfor LACTB2

Genomic Locationfor LACTB2

Proteinsfor LACTB2

Protein Domains/Familiesfor LACTB2

Gene Functionfor LACTB2

Pathways & Interactionsfor LACTB2

Drugs & Compoundsfor LACTB2

Transcriptsfor LACTB2

Expression for LACTB2

Orthologsfor LACTB2

Paralogsfor LACTB2

SNPs/Variantsfor LACTB2

Disorders & Mutationsfor LACTB2

Medical Newsfor LACTB2

Publicationsfor LACTB2

Search for LACTB2

Genome Databases showing LACTB2

Other Databases showing LACTB2

Specialized Databases showing LACTB2

Licensable Technologiesfor LACTB2

Servicesfor LACTB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for LACTB2

Summaries
for LACTB2

Genomic Location
for LACTB2

Proteins
for LACTB2

Protein Domains/
Families
for LACTB2

Gene Function
for LACTB2

Pathways & Interactions
for LACTB2

Drugs & Compounds
for LACTB2

Transcripts
for LACTB2

Expression
for LACTB2

Orthologs
for LACTB2

Paralogs
for LACTB2

SNPs/Variants
for LACTB2

Disorders & Mutations
for LACTB2

Medical News
for LACTB2

Publications
for LACTB2

Licensable Technologies
for LACTB2

Services
for LACTB2