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Aliases for LACTB Gene

Aliases for LACTB Gene

  • Lactamase Beta 2 3 5
  • MRPL56 3 4
  • Mitochondrial 39S Ribosomal Protein L56 3
  • Mitochondrial Ribosomal Protein L56 2
  • Lactamase, Beta 3
  • EC 3.4.-.- 4
  • G24 3

External Ids for LACTB Gene

Previous HGNC Symbols for LACTB Gene

  • MRPL56

Previous GeneCards Identifiers for LACTB Gene

  • GC15P059200
  • GC15P056461
  • GC15P060992
  • GC15P061129
  • GC15P061201
  • GC15P063413
  • GC15P040237
  • GC15P063465
  • GC15P063776

Summaries for LACTB Gene

Entrez Gene Summary for LACTB Gene

  • This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]

GeneCards Summary for LACTB Gene

LACTB (Lactamase Beta) is a Protein Coding gene. Diseases associated with LACTB include lung abscess and otitis media. GO annotations related to this gene include hydrolase activity.

Gene Wiki entry for LACTB Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LACTB Gene

Genomics for LACTB Gene

Regulatory Elements for LACTB Gene

Promoters for LACTB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around LACTB on UCSC Golden Path with GeneCards custom track

Genomic Location for LACTB Gene

Chromosome:
15
Start:
63,121,800 bp from pter
End:
63,142,065 bp from pter
Size:
20,266 bases
Orientation:
Plus strand

Genomic View for LACTB Gene

Genes around LACTB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
LACTB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for LACTB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LACTB Gene

Proteins for LACTB Gene

  • Protein details for LACTB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P83111-LACTB_HUMAN
    Recommended name:
    Serine beta-lactamase-like protein LACTB, mitochondrial
    Protein Accession:
    P83111
    Secondary Accessions:
    • P83096

    Protein attributes for LACTB Gene

    Size:
    547 amino acids
    Molecular mass:
    60694 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for LACTB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LACTB Gene

Proteomics data for LACTB Gene at MOPED

Post-translational modifications for LACTB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for LACTB Gene

Antibody Products

No data available for DME Specific Peptides for LACTB Gene

Domains & Families for LACTB Gene

Gene Families for LACTB Gene

Protein Domains for LACTB Gene

Suggested Antigen Peptide Sequences for LACTB Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P83111

UniProtKB/Swiss-Prot:

LACTB_HUMAN :
  • Belongs to the peptidase S12 family.
Family:
  • Belongs to the peptidase S12 family.
genes like me logo Genes that share domains with LACTB: view

Function for LACTB Gene

Enzyme Numbers (IUBMB) for LACTB Gene

Phenotypes for LACTB Gene

genes like me logo Genes that share phenotypes with LACTB: view

Animal Model Products

No data available for Molecular function , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for LACTB Gene

Localization for LACTB Gene

Subcellular locations from UniProtKB/Swiss-Prot for LACTB Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for LACTB Gene COMPARTMENTS Subcellular localization image for LACTB gene
Compartment Confidence
mitochondrion 5
cytosol 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for LACTB Gene

Pathways & Interactions for LACTB Gene

SuperPathways for LACTB Gene

No Data Available

Interacting Proteins for LACTB Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000261893%0d%0a9606.ENSP00000295050%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: P83111-LACTB_HUMAN ENSP00000261893 for LACTB Gene via I2D STRING

Gene Ontology (GO) - Biological Process for LACTB Gene

None

No data available for Pathways by source and SIGNOR curated interactions for LACTB Gene

Drugs & Compounds for LACTB Gene

(88) Drugs for LACTB Gene - From: Novoseek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tigecycline Approved Pharma Glycylcycline antibiotic 53
Sulbactam Pharma 31
Sulbactam sodium Pharma 0
Nafcillin Sodium Pharma 0

(29) Additional Compounds for LACTB Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) ApexBio Compounds for LACTB Gene

Compound Action Cas Number
Nafcillin Sodium 7177-50-6
Sulbactam 68373-14-8
Sulbactam sodium 69388-84-7
Tigecycline Glycylcycline antibiotic 220620-09-7
genes like me logo Genes that share compounds with LACTB: view

Transcripts for LACTB Gene

Unigene Clusters for LACTB Gene

Lactamase, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LACTB Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: - -
SP2: -
SP3: -
SP4:

Relevant External Links for LACTB Gene

GeneLoc Exon Structure for
LACTB
ECgene alternative splicing isoforms for
LACTB

Expression for LACTB Gene

mRNA expression in normal human tissues for LACTB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for LACTB Gene

This gene is overexpressed in Peripheral blood mononuclear cells (10.1), Lymph node (7.0), and Liver (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for LACTB Gene



SOURCE GeneReport for Unigene cluster for LACTB Gene Hs.410388

mRNA Expression by UniProt/SwissProt for LACTB Gene

P83111-LACTB_HUMAN
Tissue specificity: Expressed predominantly in skeletal muscle.
genes like me logo Genes that share expression patterns with LACTB: view

Protein tissue co-expression partners for LACTB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for LACTB Gene

Orthologs for LACTB Gene

This gene was present in the common ancestor of animals.

Orthologs for LACTB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LACTB 35
  • 90.98 (n)
  • 91.59 (a)
LACTB 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LACTB 35
  • 90.77 (n)
  • 91.67 (a)
LACTB 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lactb 35
  • 85.26 (n)
  • 88.81 (a)
Lactb 16
Lactb 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LACTB 35
  • 99.76 (n)
  • 99.45 (a)
LACTB 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lactb 35
  • 84.46 (n)
  • 87.71 (a)
oppossum
(Monodelphis domestica)
Mammalia LACTB 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LACTB 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves LACTB 35
  • 72.42 (n)
  • 72.79 (a)
LACTB 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LACTB 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia lactb 35
  • 66.2 (n)
  • 65.73 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19482 35
zebrafish
(Danio rerio)
Actinopterygii lactb 35
  • 62.34 (n)
  • 63.21 (a)
wufj21e07 35
lactb 36
  • 51 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lact-9 35
  • 51.55 (n)
  • 41.41 (a)
lact-9 36
  • 36 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for LACTB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for LACTB Gene

ENSEMBL:
Gene Tree for LACTB (if available)
TreeFam:
Gene Tree for LACTB (if available)

Paralogs for LACTB Gene

No data available for Paralogs for LACTB Gene

Variants for LACTB Gene

Sequence variations from dbSNP and Humsavar for LACTB Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs2729835 - 63,141,567(-) GTTTC(C/T)TTTCC nc-transcript-variant, downstream-variant-500B, reference, missense
rs8468 -- 63,141,911(+) TATAA(C/T)TGAAT nc-transcript-variant, utr-variant-3-prime
rs1126307 -- 63,137,572(-) tacac(A/G)agtga intron-variant
rs1126308 -- 63,136,887(-) AACTC(G/T)AAAAA intron-variant
rs1126309 -- 63,136,863(-) TATTA(C/T)AAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for LACTB Gene

Variant ID Type Subtype PubMed ID
nsv428305 CNV Gain 18775914
nsv904304 CNV Gain 21882294
esv27033 CNV Gain+Loss 19812545

Variation tolerance for LACTB Gene

Residual Variation Intolerance Score: 32.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for LACTB Gene

HapMap Linkage Disequilibrium report
LACTB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for LACTB Gene

Disorders for LACTB Gene

MalaCards: The human disease database

(15) MalaCards diseases for LACTB Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lung abscess
otitis media
  • otitis media, susceptibility to
mycobacterium fortuitum
  • m. fortuitum
meningitis
pneumonia
  • acute pneumonia
- elite association - COSMIC cancer census association via MalaCards
Search LACTB in MalaCards View complete list of genes associated with diseases

Relevant External Links for LACTB

Genetic Association Database (GAD)
LACTB
Human Genome Epidemiology (HuGE) Navigator
LACTB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
LACTB
genes like me logo Genes that share disorders with LACTB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for LACTB Gene

Publications for LACTB Gene

  1. Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain. (PMID: 11707067) Smith T.S. … Debouck C. (Genomics 2001) 2 3 4 23 67
  2. Evolution of a family of metazoan active-site-serine enzymes from penicillin-binding proteins: a novel facet of the bacterial legacy. (PMID: 18226203) Peitsaro N. … Eriksson O. (BMC Evol. Biol. 2008) 3 23
  3. An atlas of genetic influences on human blood metabolites. (PMID: 24816252) Shin S.Y. … Soranzo N. (Nat. Genet. 2014) 3
  4. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3
  5. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PMID: 22990118) Woods N.T. … Monteiro A.N. (Sci Signal 2012) 3

Products for LACTB Gene

Sources for LACTB Gene

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