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Aliases & Descriptions for LACTB
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases EC 3.4.-.- 3 FLJ14902 1 , 2 G24 2 MRPL56 2 , 3
Descriptions lactamase, beta 2 mitochondrial 39S ribosomal protein L56 2 mitochondrial ribosomal protein L56 1 , 2 serine beta lactamase-like protein LACTB 2
Search outside databases for aliases for LACTB genePrevious GC identifers: GC15P059200 GC15P056461 GC15P060992 GC15P061129
Summaries for LACTB (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for LACTB : This gene encodes a protein from the large 39S subunit of the mitochondrial ribosome(mitoribosome). The encoded protein has some sequence similarity to prokaryotic beta-lactamasesbut most of the residues that are responsible for the beta-lactamase activity are not conservedbetween the two proteins. [provided by RefSeq] Gene Wiki entry for LACTB
Genomic Location for LACTB
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the LACTB gene Entrez Gene cytogenetic band: 15q22.1 Ensembl cytogenetic band: 15q22.2 HGNC cytogenetic band: 15q22.1 LACTB Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15P061201:
(about GC identifiers )
Start:
61,201,072 bp from pter
End:
61,221,313 bp from pter
Size:
20,242 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000015.8 NT_010194.16 Proteins for LACTB
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: LACTB_HUMAN, P83111 (See
protein sequence )Recommended Name: Serine beta-lactamase-like protein LACTB, mitochondrial precursor Size : 547 amino acids; 60694 Da
Subcellular location : Mitochondrion
Caution : Was originally (PubMed:11551941) identified as 39S ribosomal protein L56 (MRP-L56)
Secondary accessions : P83096Alternative splicing : 2 isoforms : P83111-1 P83111-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_116246.2 NP_741982.1 ENSEMBL proteins: ENSP00000261893 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005739 mitochondrion
IEA --
About this table Antibodies for LACTB: Assays for LACTB:
Protein
Domains/ Families for LACTB(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry P83111 ProtoNet protein and cluster: P83111
UniProtKB/Swiss-Prot: LACTB_HUMAN, P83111 Similarity : Belongs to the peptidase S12 family
Gene Function for LACTB
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_032857 Applied Biosystems Silencer ® siRNAs for LACTB Sigma-Aldrich siRNA and siRNA Panels for LACTB Sigma-Aldrich shRNA for LACTB Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_032857                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_032857                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_032857  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_032857 1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0016787 hydrolase activity
IEA --
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Pathways & Interactions for LACTB
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Interacting proteins for LACTB (ENSP00000261893 3 ) via UniProtKB, MINT, and/or STRING About this table
Drugs & Compounds for LACTB (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for LACTB 10/18 Novoseek chemical compound relationships for LACTB gene (see all 18
)
Compound
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
beta-lactam
93.63
330
8893121 (5), 12834367 (4), 11921490 (3), 11697463 (3) (see all 99 )
nitrocefin
90.95
74
7962627 (3), 8647771 (3), 9266340 (2), 2073109 (2) (see all 57 )
penicillins
90.74
154
16735415 (4), 17663900 (4), 9360991 (2), 9060050 (2) (see all 99 )
cephalosporin
89.89
95
11034276 (2), 11376058 (2), 2121781 (1), 2013215 (1) (see all 85 )
aminoglycosides
82.21
46
17728961 (3), 15156478 (2), 7740421 (1), 10097683 (1) (see all 41 )
doripenem
72.26
3
15273134 (1), 18321228 (1), 18778123 (1)
olivanic acids
70.73
1
2024221 (1)
cefcapene
64.68
1
9557272 (1)
panipenem
61.62
3
12678575 (1), 12378871 (1), 8452364 (1)
penicillin a
59.54
2
1317051 (1), 7481050 (1)
About this table
Transcripts for LACTB(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_032857 Sigma-Aldrich siRNA and siRNA Panels for LACTB Sigma-Aldrich shRNA for LACTB Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_032857 NM_171846
REFSEQ mRNAs for LACTB gene (2 alternative transcripts): NM_032857.2 NM_171846.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_032857 NM_171846
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_032857                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_032857                                  untagged cDNA clones in CMV expression vector (see all 3 ): NM_032857  
Additional cDNA sequence: AY358709.1 BC037198.1 BC067288.1 CR591560.1 CR602675.1 CR617302.1 CR618824.1
4 DOTS entries : DT.100685277 DT.91751689 DT.421330 DT.99953733
24/97 AceView cDNA sequences (see all 97
):BC067288 CA427499 CR591560 AL553134 NM_032857 BX282284 AW592112 CR617302 CA840952 BU624474 F12137 AI539756 BQ010627 Z43913 BC037198 AY358709 CR618824 CF529448 F12456 BF940663 CR602675 NM_171846 BM823687 BX424512
highest scoring ESTs for LACTB :AA194033 AA195632 AA658161 AA659552 AA708192 AA758992 AA938525 AA975054 AI147917 AI332348
Unigene Cluster for LACTB: Lactamase, beta Hs.410388 [show with all ESTs ] Unigene Representative Sequence: BC067288 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for LACTB ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 SP1 :   -             -     SP2 :   -                 SP3 :   -                 SP4 :                  
About this scheme ECgene alternative splicing isoforms for LACTB 1 Ensembl transcript including schematic representation : ENST00000261893
Expression for LACTB
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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LACTB expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for LACTB 1 / 2 / 3
6 probe-sets matching LACTB gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: ACATTTTTAASOURCE GeneReport for Unigene cluster: Hs.410388 UniProtKB/Swiss-Prot: LACTB_HUMAN, P83111 Tissue specificity : Expressed predominantly in skeletal muscle
Orthologs for LACTB
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for LACTB gene from 5/8 species (see all 8
)
About this table Species with no ortholog for LACTB ENSEMBL Gene Tree for LACTB Paralogs for LACTB (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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SNPs/Variants for LACTB (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for LACTB (up to first 250kb)
Disorders & Mutations for LACTB
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 608440 10/86 Novoseek disease relationships for LACTB gene (see all 86
)
Disease
Score
Articles
PubMed IDs for Articles with Shared Sentences (# sentences)
respiratory tract infections
77.87
41
11118860 (2), 9053534 (2), 18998749 (2), 15090319 (2) (see all 31 )
nosocomial infections
77.20
25
10705312 (1), 12108091 (1), 17701716 (1), 14508155 (1) (see all 25 )
acute otitis media
76.98
9
18998749 (2), 9041622 (1), 12534334 (1), 11997157 (1) (see all 8 )
community-acquired infections
69.06
8
14998075 (1), 10804787 (1), 1286574 (1), 8669389 (1) (see all 7 )
tonsillitis
67.67
4
9597292 (1), 9951080 (1), 7805681 (1), 9727652 (1)
pneumonia
66.48
19
9475836 (3), 11212394 (1), 15153355 (1), 18778123 (1) (see all 13 )
bacteremia
64.85
20
2203306 (2), 14699457 (2), 15711657 (2), 18173077 (1) (see all 17 )
soft tissue infections
62.63
2
7752213 (1), 15156358 (1)
otitis media
57.50
4
2060691 (1), 2375816 (1), 9727652 (1)
bacterial infections
56.15
13
9688450 (2), 1725151 (1), 11060675 (1), 7893090 (1) (see all 11 )
About this table Human Genome Epidemiology Navigator: LACTB (1 document)
Medical News for LACTB (Possibly Related Articles in
Doctor's Guide )
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Publications for LACTB (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/645 PubMed articles for LACTB gene (see all 645
): Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain. (PubMed id 11707067) 2, 3, 4 Smith T.S....Debouck C. (2001) Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309) 3, 4 Clark H.F....Gray A. (2003) The large subunit of the mammalian mitochondrial ribosome. Analysis of the complement of ribosomal proteins present. (PubMed id 11551941) 3, 4 Koc E.C....Spremulli L.L. (2001) An improved beta-lactamase reporter assay: multiplexing with a cytotoxicity readout for enhanced accuracy of hit identification. (PubMed id 17517902) 1, 3 Hallis T.M....Turek-Etienne T. (2007) Clinical and genetic risk factors of self-reported penicillin allergy. (PubMed id 18538381) 3 Apter A.J....Rebbeck T. (2008) Differential expression of a novel gene in response to hsp27 and cell differentiation in human keratinocytes. (PubMed id 12164938) 3 Hell-Pourmojib M....Trautinger F. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002)
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Genome Databases showing LACTB
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing LACTB
(According to HUGE )
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Specialized Databases showing LACTB (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for LACTB (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for LACTB:
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