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LACTB Gene

protein-coding   GIFtS: 53

GC15P061201
lactamase, beta
(Previous name: mitochondrial ribosomal protein L56 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MRPL56)
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
EC 3.4.-.- 3
FLJ14902 1, 2
G24 2
MRPL56 2, 3
Descriptions
lactamase, beta 2
mitochondrial 39S ribosomal protein L56 2
mitochondrial ribosomal protein L56 1, 2
serine beta lactamase-like protein LACTB 2
External Ids
HGNC: 164681
Entrez Gene: 1142942
UniProtKB: P831113
Ensembl: ENSG000001036427
Search outside databases for aliases for LACTB gene

Previous GC identifers: GC15P059200 GC15P056461 GC15P060992 GC15P061129

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for LACTB:
This gene encodes a protein from the large 39S subunit of the mitochondrial ribosome
(mitoribosome). The encoded protein has some sequence similarity to prokaryotic beta-lactamases
but most of the residues that are responsible for the beta-lactamase activity are not conserved
between the two proteins. [provided by RefSeq]

Gene Wiki entry for LACTB
(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the LACTB gene  

Entrez Gene cytogenetic band: 15q22.1   Ensembl cytogenetic band:  15q22.2   HGNC cytogenetic band: 15q22.1

LACTB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P061201:     (about GC identifiers)

Start:
61,201,072 bp from pter
End:
61,221,313 bp from pter
Size:
20,242 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000015.8  NT_010194.16  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LACTB_HUMAN, P83111 (See protein sequence)
Recommended Name: Serine beta-lactamase-like protein LACTB, mitochondrial precursor  
Size: 547 amino acids; 60694 Da
Subcellular location: Mitochondrion
Caution: Was originally (PubMed:11551941) identified as 39S ribosomal protein L56 (MRP-L56)
Secondary accessions: P83096
Alternative splicing: 2 isoforms:  P83111-1   P83111-2   

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_116246.2  NP_741982.1  


    ENSEMBL proteins: 
    ENSP00000261893 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (LACTB)
    Browse Abnova for Human Recombinant Proteins
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    1 Gene Ontology (GO) cellular component term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739 mitochondrion IEA--
    About this table

    Antibodies for LACTB: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of LACTB
    Sigma-Aldrich Antibodies for LACTB
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (LACTB), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for LACTB

    Assays for LACTB: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR001466 Beta_lactamase-related


       GeneDecks  LACTB for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P83111

    ProtoNet protein and cluster: P83111

    UniProtKB/Swiss-Prot: LACTB_HUMAN, P83111
    Similarity: Belongs to the peptidase S12 family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LACTB)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_032857

                  Applied Biosystems Silencer® siRNAs for LACTB

                  Sigma-Aldrich siRNA and siRNA Panels for LACTB  
                         Sigma-Aldrich shRNA for LACTB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_032857
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_032857
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_032857 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_032857

    1 Gene Ontology (GO) molecular function term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787 hydrolase activity IEA--
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    2 Interacting proteins for LACTB (ENSP000002618933) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPM1LENSP000002958393STRING (score=.917)
    INTS9ENSP000002656143STRING (score=.792)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for LACTB
    10/18 Novoseek chemical compound relationships for LACTB gene (see all 18 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    beta-lactam 93.63 330 8893121 (5), 12834367 (4), 11921490 (3), 11697463 (3) (see all 99)
    nitrocefin 90.95 74 7962627 (3), 8647771 (3), 9266340 (2), 2073109 (2) (see all 57)
    penicillins 90.74 154 16735415 (4), 17663900 (4), 9360991 (2), 9060050 (2) (see all 99)
    cephalosporin 89.89 95 11034276 (2), 11376058 (2), 2121781 (1), 2013215 (1) (see all 85)
    aminoglycosides 82.21 46 17728961 (3), 15156478 (2), 7740421 (1), 10097683 (1) (see all 41)
    doripenem 72.26 3 15273134 (1), 18321228 (1), 18778123 (1)
    olivanic acids 70.73 1 2024221 (1)
    cefcapene 64.68 1 9557272 (1)
    panipenem 61.62 3 12678575 (1), 12378871 (1), 8452364 (1)
    penicillin a 59.54 2 1317051 (1), 7481050 (1)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (LACTB)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_032857

                  Sigma-Aldrich siRNA and siRNA Panels for LACTB  
                         Sigma-Aldrich shRNA for LACTB  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_032857  NM_171846  

    REFSEQ mRNAs for LACTB gene (2 alternative transcripts): 

    NM_032857.2   NM_171846.1   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_032857  NM_171846  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_032857
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_032857
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_032857 

    Additional cDNA sequence: 

    AY358709.1 BC037198.1 BC067288.1 CR591560.1 CR602675.1 CR617302.1 CR618824.1 

    4 DOTS entries:

    DT.100685277  DT.91751689  DT.421330  DT.99953733 

    24/97 AceView cDNA sequences (see all 97 ):

    BC067288 CA427499 CR591560 AL553134 NM_032857 BX282284 AW592112 CR617302 
    CA840952 BU624474 F12137 AI539756 BQ010627 Z43913 BC037198 AY358709 
    CR618824 CF529448 F12456 BF940663 CR602675 NM_171846 BM823687 BX424512 

    highest scoring ESTs for LACTB:

    AA194033 AA195632 AA658161 AA659552 AA708192 AA758992 AA938525 AA975054 AI147917 AI332348 

    Unigene Cluster for LACTB:

    Lactamase, beta
    Hs.410388  [show with all ESTs]
    Unigene Representative Sequence: BC067288


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LACTB

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
    SP1:        -                                   -         
    SP2:        -                                             
    SP3:        -                                             
    SP4:                                                      

    About this scheme

    ECgene alternative splicing isoforms for LACTB

    1 Ensembl transcript including schematic representation:
    ENST00000261893  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    LACTB expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for LACTB

    1 / 2 / 3

    6 probe-sets matching LACTB gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    63373_at2, 3 U95-C 1 1.00 1.00 0.94 1.01 AA194033 1.00 1.00 1.00 1
    83479_at2, 3 U95-E 1 0.88 1.00 0.95 0.99 AI273225 0.60 1.00 0.82 1

    226354_at2, 3 U133-B 1 1.00 1.00 -- -- BE892574 0.80 1.00 0.91 1

    1552486_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    226354_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    1552485_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    GeneDecks  LACTB for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACATTTTTAA

    SOURCE GeneReport for Unigene cluster: Hs.410388

    UniProtKB/Swiss-Prot: LACTB_HUMAN, P83111
    Tissue specificity: Expressed predominantly in skeletal muscle

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for LACTB gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LACTB1   -- lactamase, beta 92.52(n)
    93.69(a)
    487588  XM_544713.2  XP_544713.2 
    rat
    (Rattus norvegicus)
    Lactb1   -- lactamase, beta 84.46(n)
    87.89(a)
    300803  XM_217181.4  XP_217181.2 
    mouse
    (Mus musculus)
    Lactb1, 5 95
    lactamase, beta1, 5 85.26(n)1
    88.99(a)1
    809071  NM_030717.11  NP_109642.11 
     AF3179005  AF3179015  (see all 16)
    chicken
    (Gallus gallus)
    LACTB1   -- lactamase, beta 71.68(n)
    71.34(a)
    415373  NM_001030546.1  NP_001025717.1 
    zebrafish
    (Danio rerio)
    wufj21e072   -- Transcribed sequence with weak similarity to protein more 72.53(n)  57073261 
    About this table        Species with no ortholog for LACTB

    ENSEMBL Gene Tree for LACTB
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/161 NCBI SNPs in LACTB are shown (see all 161 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 74)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs27298351,2
    A,C,F,H,O61220819(-) GTTTCT/CTTTCC 1 K/R mis1 ese3 trp311Minor allele frequency- C:0.23NA EU EA WA 978
    rs84681,2
    A,C,F,H,O61221163(+) TATAAT/CTGAAT 1 -- ut3113Minor allele frequency- C:0.19MN EU EA WA NA 1259
    rs27298151,2
    A,C,F,H61199896(+) TAGGTG/ATGGAT 2 -- ng514Minor allele frequency- A:0.14EU EA WA 402
    rs10070761,2
    A,C,F,H61200424(-) AAGATG/AAAGTG 2 -- ng51 tfbs34Minor allele frequency- A:0.19EU EA WA 412
    rs27298161,2
    A,C,F,H61200137(+) AAGATC/TGTGTG 2 -- ng514Minor allele frequency- T:0.15EU EA WA 420
    rs10070751,2
    C,F,H,O61200554(-) ATGTCC/TCATTT 2 -- ng51 tfbs38Minor allele frequency- T:0.20MN EU EA WA NA 736
    rs27298131,2
    C,F,H61199207(+) aggtcG/Atgact 2 -- ng514Minor allele frequency- A:0.15EU EA WA 418
    rs27298141,2
    C,F,H61199527(+) tcattG/Atcttg 2 -- ng514Minor allele frequency- A:0.02EU EA WA 420
    rs26527911,2
    F,H61199955(-) CCTCAA/GAATAA 2 -- ng51 tfbs34Minor allele frequency- G:0.02EU EA WA 410
    --
    rs27298171,2
    A,C61200164(+) tgtgtA/Gtgtat 2 -- ng510--------
    About this table

    HapMap Linkage Disequilibrium images for LACTB (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 608440

    10/86 Novoseek disease relationships for LACTB gene (see all 86 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    respiratory tract infections 77.87 41 11118860 (2), 9053534 (2), 18998749 (2), 15090319 (2) (see all 31)
    nosocomial infections 77.20 25 10705312 (1), 12108091 (1), 17701716 (1), 14508155 (1) (see all 25)
    acute otitis media 76.98 9 18998749 (2), 9041622 (1), 12534334 (1), 11997157 (1) (see all 8)
    community-acquired infections 69.06 8 14998075 (1), 10804787 (1), 1286574 (1), 8669389 (1) (see all 7)
    tonsillitis 67.67 4 9597292 (1), 9951080 (1), 7805681 (1), 9727652 (1)
    pneumonia 66.48 19 9475836 (3), 11212394 (1), 15153355 (1), 18778123 (1) (see all 13)
    bacteremia 64.85 20 2203306 (2), 14699457 (2), 15711657 (2), 18173077 (1) (see all 17)
    soft tissue infections 62.63 2 7752213 (1), 15156358 (1)
    otitis media 57.50 4 2060691 (1), 2375816 (1), 9727652 (1)
    bacterial infections 56.15 13 9688450 (2), 1725151 (1), 11060675 (1), 7893090 (1) (see all 11)
    About this table

    Human Genome Epidemiology Navigator: LACTB (1 document)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/645 PubMed articles for LACTB gene (see all 645 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 114294 HGNC: 16468 AceView: LACTB Ensembl:ENSG00000103642 euGenes: HUgn114294
    ECgene: LACTB H-InvDB: LACTB
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

      --
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for LACTB:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
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      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LACTB-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for LACTB Antibodies for LACTB
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for LACTB Browse small molecules at Sigma-Aldrich
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