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LACRT Gene

protein-coding   GIFtS: 48
GCID: GC12M055024

Lacritin

  See LACRT-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
lacritin1 2
Extracellular Glycoprotein Lacritin2

External Ids:    HGNC: 164301   Entrez Gene: 900702   Ensembl: ENSG000001354137   OMIM: 6073605   UniProtKB: Q9GZZ83   
ORGUL members:         

Export aliases for LACRT gene to outside databases

Previous GC identifers: GC12P049944 GC12M055138 GC12M054741 GC12M053310 GC12M052063


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for LACRT Gene:
The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory
granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and
stimulates signaling through tyrosine phosphorylation and release of calcium. (provided by RefSeq, Jul 2008)

GeneCards Summary for LACRT Gene:
LACRT (lacritin) is a protein-coding gene. Diseases associated with LACRT include blepharitis. GO annotations related to this gene include growth factor activity and collagen binding.

UniProtKB/Swiss-Prot: LACRT_HUMAN, Q9GZZ8
Function: Modulates secretion by lacrimal acinar cells

Gene Wiki entry for LACRT (Lacritin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the LACRT gene promoter:
         HOXA9B   HFH-3   LCR-F1   HNF-3beta   Evi-1   FOXI1   POU2F1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLACRT promoter sequence
   Search Chromatin IP Primers for LACRT

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LACRT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13

LACRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LACRT gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M055024:  view genomic region     (about GC identifiers)

Start:
55,024,595 bp from pter      End:
55,028,679 bp from pter
Size:
4,085 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: LACRT_HUMAN, Q9GZZ8 (See protein sequence)
Recommended Name: Extracellular glycoprotein lacritin precursor  
Size: 138 amino acids; 14246 Da

Explore the universe of human proteins at neXtProt for LACRT: NX_Q9GZZ8

Explore proteomics data for LACRT at MOPED

Post-translational modifications: 

  • Glycosylation2 at Thr75, Ser76, Ser77, Asn119
  • Modification sites at PhosphoSitePlus

  • See LACRT Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_150593.1  
    ENSEMBL proteins: 
     ENSP00000448193   ENSP00000447536   ENSP00000257867  

    LACRT Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9GZZ8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LACRT_HUMAN, Q9GZZ8
    Function: Modulates secretion by lacrimal acinar cells

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IDA11419941
    GO:0001968fibronectin binding IDA11419941
    GO:0005518collagen binding IDA11419941
    GO:0008083growth factor activity IDA16982797
    GO:0043237laminin-1 binding IDA11419941
         
    Find genes that share ontologies with LACRT           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LACRT
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    hsa-mir-148b-3p (MIRT019336)

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    Sino Biological Human cDNA Clone for LACRT
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    Addgene plasmids for LACRT 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LACRT_HUMAN, Q9GZZ8: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA17850790
    GO:0005615extracellular space IDA--
    GO:0030141secretory granule IDA11419941

    Find genes that share ontologies with LACRT           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for LACRT
    Interactions:

        GeneGlobe Interaction Network for LACRT

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for LACRT (Q9GZZ83 ENSP000002578674) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    NID1P145433, ENSP000002641874I2D: score=2 STRING: ENSP00000264187
    VTNP040043, ENSP000002262184I2D: score=2 STRING: ENSP00000226218
    SDC1P188273, ENSP000002543514I2D: score=2 STRING: ENSP00000254351
    MAP1LC3CQ9BXW43I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IDA11419941
    GO:0019722calcium-mediated signaling IDA11419941
    GO:0033173calcineurin-NFAT signaling cascade IDA16923831
    GO:0034067protein localization to Golgi apparatus IDA16923831
    GO:0050679positive regulation of epithelial cell proliferation IDA16923831

    Find genes that share ontologies with LACRT           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for LACRT

    1 Novoseek inferred chemical compound relationship for LACRT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 6.03 2 11419941 (1), 16488965 (1)



    Find genes that share compounds with LACRT           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for LACRT gene: 
    NM_033277.1  

    Unigene Cluster for LACRT:

    Lacritin
    Hs.307096  [show with all ESTs]
    Unigene Representative Sequence: CK429396
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546721 ENST00000547511 ENST00000257867(uc001sgi.1) ENST00000549816

    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat LACRT

    Additional mRNA sequence: 

    AF238867.1 BC062217.1 BC069317.1 

    2 DOTS entries:

    DT.100020180  DT.121171957 

    Selected AceView cDNA sequences (see all 89):

    CK429605 CD724040 CD723944 CD723861 CD722504 CD721917 CD721903 BQ111233 
    CD722839 CD724199 CD723643 CK430529 CD723966 CK429796 CA946369 CD724191 
    CA946497 CD724203 CD723836 CK429364 CK430159 CD722771 CK429952 CD722550 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LACRT    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
    SP1:                                -                 -         
    SP2:                                -     -           -         
    SP3:                                                            
    SP4:                                -     -                     


    ECgene alternative splicing isoforms for LACRT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    LACRT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGCTGAA
    LACRT Expression
    About this image

    LACRT Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    LACRT Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.307096

    UniProtKB/Swiss-Prot: LACRT_HUMAN, Q9GZZ8
    Tissue specificity: Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar
    cells of salivary glands

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for LACRT

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and chimp.

    Orthologs for LACRT gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia LACRT1 lacritin 99.27(n)
    99.27(a)
      748041  XM_001170736.2  XP_001170736.1 


    ENSEMBL Gene Tree for LACRT (if available)
    TreeFam Gene Tree for LACRT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for LACRT (see all 150)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1450534851,2
    --55024210(+) AGAGGC/GCAGGA 1 -- ds50010--------
    rs1380559901,2
    --55024285(+) TTTTCA/GGGATG 1 -- ds50010--------
    rs1872171161,2
    --55024441(+) GTGAAA/TAAAAG 1 -- ds50010--------
    rs1166476041,2
    F--55024470(+) CCTTCC/TAGGCA 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1904575721,2
    C--55024537(+) GGAGGG/TCTTTT 1 -- ds50010--------
    rs1826957111,2
    C--55024538(+) GAGGGC/TTTTTC 1 -- ds50010--------
    rs1869242321,2
    C--55024606(+) GCTTTC/TGTTTT 1 -- ds50010--------
    rs1924534751,2
    --55024621(+) GCTCTG/TGGCTA 1 -- ds50010--------
    rs1842977821,2
    C--55024720(+) TTTTTA/GTGCAA 2 Q * stg10--------
    rs2015742881,2
    --55024759(+) GACAAA/GTGAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for LACRT (55024595 - 55028679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LACRT:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832421CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing LACRT
    DNA2.0 Custom Variant and Variant Library Synthesis for LACRT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607360    OMIM disorders: --

    1 disease for LACRT:    
    About MalaCards
    blepharitis

    1 disease from the University of Copenhagen DISEASES database for LACRT:
    Blepharitis

    Find genes that share disorders with LACRT           About GenesLikeMe


    Export disorders for LACRT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for LACRT gene, integrated from 10 sources (see all 37):
    (articles sorted by number of sources associating them with LACRT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. (PubMed id 11419941)1, 2, 3, 9 Sanghi S.... Laurie G.W. (J. Mol. Biol. 2001)
    2. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (J. Proteome Res. 2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes. (PubMed id 17850790)1, 9 Nakajima T....Azuma M. (Exp. Eye Res. 2007)
    5. Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways. (PubMed id 16923831)1, 9 Wang J....Laurie G.W. (J. Cell Biol. 2006)
    6. Expression of a novel lacrimal gland gene lacritin in human breast tissues. (PubMed id 14574570)1, 9 Weigelt B....van 't Veer L.J. (J. Cancer Res. Clin. Oncol. 2003)
    7. Lacritin and other new proteins of the lacrimal functional unit. (PubMed id 18840430)1, 9 McKown R.L....Laurie G.W. (Exp. Eye Res. 2009)
    8. Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. (PubMed id 16982797)1, 9 Ma P....Laurie G.W. (J. Cell Biol. 2006)
    9. Quantitative analysis of N-linked glycoproteins in tear fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ. (PubMed id 19714880)1, 9 Lei Z....Serra H.M. (J. Proteome Res. 2009)
    10. Mass spectrometry-based proteomic analyses in contact lens-related dry eye. (PubMed id 19770725)1, 9 Nichols J.J. and Green-Church K.B. (Cornea 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 90070 HGNC: 16430 AceView: LACRT Ensembl:ENSG00000135413 euGenes: HUgn90070
    ECgene: LACRT H-InvDB: LACRT

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for LACRT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for LACRT gene:
    Search GeneIP for patents involving LACRT

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for LACRT  
     OriGene qPCR primer pairs and template standards for LACRT   OriGene Protein Over-expression Lysate for LACRT  
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     OriGene Custom Antibody Services for LACRT   OriGene Custom Protein Services for LACRT  

     
     
     Block miRNA regulation of human, mouse, rat LACRT using miScript Target Protectors SeqTarget long-range PCR primers for resequencing LACRT
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat LACRT Predesigned siRNA for gene silencing in human, mouse, rat LACRT
     QuantiFast Probe-based Assays in human, mouse, rat LACRT QuantiTect SYBR Green Assays in human, mouse, rat LACRT
     Custom PCR Arrays for LACRT Search Chromatin IP Primers for LACRT
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat LACRT  GeneGlobe Interaction Network for LACRT
     Regulatory tfbs in LACRT promoter
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     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
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     Search Tocris compounds for LACRT
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     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
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     Browse ESI BIO Cell Lines and PureStem Progenitors for LACRT
     Gene Synthesis
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for LACRT
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LACRT
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for LACRT
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     Addgene plasmids for LACRT
      Search eBioscience for proteins for LACRT
      Search eBioscience for elisas for LACRT
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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