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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

LACRT Gene

protein-coding   GIFtS: 45
GCID: GC12M055024

Lacritin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
lacritin1 2
Extracellular Glycoprotein Lacritin2

External Ids:    HGNC: 164301   Entrez Gene: 900702   Ensembl: ENSG000001354137   OMIM: 6073605   UniProtKB: Q9GZZ83   

Export aliases for LACRT gene to outside databases

Previous GC identifers: GC12P049944 GC12M055138 GC12M054741 GC12M053310 GC12M052063


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for LACRT Gene:
The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretory
granules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, and
stimulates signaling through tyrosine phosphorylation and release of calcium. (provided by RefSeq, Jul 2008)

GeneCards Summary for LACRT Gene: 
LACRT (lacritin) is a protein-coding gene. Diseases associated with LACRT include blepharitis, and dry eye syndrome. GO annotations related to this gene include growth factor activity and collagen binding.

UniProtKB/Swiss-Prot: LACRT_HUMAN, Q9GZZ8
Function: Modulates secretion by lacrimal acinar cells

Gene Wiki entry for LACRT (Lacritin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the LACRT gene promoter:
         HOXA9B   HFH-3   LCR-F1   HNF-3beta   Evi-1   FOXI1   POU2F1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidLACRT promoter sequence
   Search SABiosciences Chromatin IP Primers for LACRT

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LACRT


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13

LACRT Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
LACRT gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M055024:  view genomic region     (about GC identifiers)

Start:
55,024,595 bp from pter      End:
55,028,679 bp from pter
Size:
4,085 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: LACRT_HUMAN, Q9GZZ8 (See protein sequence)
Recommended Name: Extracellular glycoprotein lacritin precursor  
Size: 138 amino acids; 14246 Da
Subcellular location: Secreted

Explore the universe of human proteins at neXtProt for LACRT: NX_Q9GZZ8

Explore proteomics data for LACRT at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9GZZ8

  • LACRT Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    LACRT Protein Expression
    REFSEQ proteins: NP_150593.1  
    ENSEMBL proteins: 
     ENSP00000448193   ENSP00000447536   ENSP00000257867  

    Human Recombinant Protein Products for LACRT: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IDA17850790
    GO:0030141secretory granule IDA11419941

    LACRT for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9GZZ8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LACRT_HUMAN, Q9GZZ8
    Function: Modulates secretion by lacrimal acinar cells

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001948glycoprotein binding IDA11419941
    GO:0001968fibronectin binding IDA11419941
    GO:0005518collagen binding IDA11419941
    GO:0008083growth factor activity IDA16982797
    GO:0043237laminin-1 binding IDA11419941
         
    LACRT for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LACRT

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for LACRT (Q9GZZ83 ENSP000002578674) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FN1P027513, ENSP000003468394I2D: score=2 STRING: ENSP00000346839
    NID1P145433, ENSP000002641874I2D: score=2 STRING: ENSP00000264187
    VTNP040043, ENSP000002262184I2D: score=2 STRING: ENSP00000226218
    SDC1P188273, ENSP000002543514I2D: score=2 STRING: ENSP00000254351
    MAP1LC3CQ9BXW43I2D: score=1 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008284positive regulation of cell proliferation IDA11419941
    GO:0019722calcium-mediated signaling IDA11419941
    GO:0033173calcineurin-NFAT signaling cascade IDA16923831
    GO:0034067protein localization to Golgi apparatus IDA16923831
    GO:0050679positive regulation of epithelial cell proliferation IDA16923831

    LACRT for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    LACRT for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for LACRT

    1 Novoseek inferred chemical compound relationship for LACRT gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 6.03 2 11419941 (1), 16488965 (1)

    Search CenterWatch for drugs/clinical trials and news about LACRT

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for LACRT gene: 
    NM_033277.1  

    Unigene Cluster for LACRT:

    Lacritin
    Hs.307096  [show with all ESTs]
    Unigene Representative Sequence: CK429396
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000546721 ENST00000547511 ENST00000257867(uc001sgi.1) ENST00000549816

    miRNA
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    Inhib. RNA
    Products:
         
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    Clone
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LACRT

    Additional mRNA sequence: 

    AF238867.1 BC062217.1 BC069317.1 

    2 DOTS entries:

    DT.100020180  DT.121171957 

    24/89 AceView cDNA sequences (see all 89):

    CK429762 CD721917 CK430309 CD723351 CD724040 CK429581 CK430809 CD723944 
    CD723966 CK431089 CD722974 CK429796 CD724287 CK429527 CD723803 CD723861 
    NM_033277 CD724199 CK430529 CD723836 CK430906 CK429364 CK429406 CD723135 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for LACRT    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c ^ 5
    SP1:                                -                 -         
    SP2:                                -     -           -         
    SP3:                                                            
    SP4:                                -     -                     


    ECgene alternative splicing isoforms for LACRT

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    LACRT expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGAAGCTGAA
    LACRT Expression
    About this image


    See LACRT Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for LACRT

    SOURCE GeneReport for Unigene cluster: Hs.307096

    UniProtKB/Swiss-Prot: LACRT_HUMAN, Q9GZZ8
    Tissue specificity: Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinar
    cells of salivary glands

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for LACRT gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia LACRT1 lacritin 99.27(n)
    99.27(a)
      748041  XM_001170736.2  XP_001170736.1 


    ENSEMBL Gene Tree for LACRT (if available)
    TreeFam Gene Tree for LACRT (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/150 SNPs in LACRT are shown (see all 150)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1450534851,2
    --55024210(+) AGAGGC/GCAGGA 1 -- ds50010--------
    rs1380559901,2
    --55024285(+) TTTTCA/GGGATG 1 -- ds50010--------
    rs1872171161,2
    --55024441(+) GTGAAA/TAAAAG 1 -- ds50010--------
    rs1166476041,2
    F--55024470(+) CCTTCC/TAGGCA 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1904575721,2
    C--55024537(+) GGAGGG/TCTTTT 1 -- ds50010--------
    rs1826957111,2
    C--55024538(+) GAGGGC/TTTTTC 1 -- ds50010--------
    rs1869242321,2
    C--55024606(+) GCTTTC/TGTTTT 1 -- ds50010--------
    rs1924534751,2
    --55024621(+) GCTCTG/TGGCTA 1 -- ds50010--------
    rs1842977821,2
    C--55024720(+) TTTTTA/GTGCAA 2 Q * stg10--------
    rs2015742881,2
    --55024759(+) GACAAA/GTGAGG 1 -- int10--------

    HapMap Linkage Disequilibrium report for LACRT (55024595 - 55028679 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for LACRT:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv832421CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for LACRT

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607360    OMIM disorders: --

    3 diseases for LACRT:    About MalaCards
    blepharitis    dry eye syndrome    keratopathy

    1 disease from the University of Copenhagen DISEASES database for LACRT:
    Blepharitis

    LACRT for disorders           About GeneDecksing


    Export disorders for LACRT gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for LACRT gene, integrated from 9 sources (see all 36):
    (articles sorted by number of sources associating them with LACRT)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. (PubMed id 11419941)1, 2, 3, 9 Sanghi S.... Laurie G.W. (2001)
    2. Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes. (PubMed id 17850790)1, 9 Nakajima T....Azuma M. (2007)
    5. Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways. (PubMed id 16923831)1, 9 Wang J....Laurie G.W. (2006)
    6. Expression of a novel lacrimal gland gene lacritin in human breast tissues. (PubMed id 14574570)1, 9 Weigelt B....van 't Veer L.J. (2003)
    7. Lacritin and other new proteins of the lacrimal functional unit. (PubMed id 18840430)1, 9 McKown R.L....Laurie G.W. (2008)
    8. Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. (PubMed id 16982797)1, 9 Ma P....Laurie G.W. (2006)
    9. Quantitative analysis of N-linked glycoproteins in te ar fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ. (PubMed id 19714880)1, 9 Lei Z....Serra H.M. (2009)
    10. Mass spectrometry-based proteomic analyses in contact lens-related dry eye. (PubMed id 19770725)1, 9 Nichols J.J. and Green-Church K.B. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 90070 HGNC: 16430 AceView: LACRT Ensembl:ENSG00000135413 euGenes: HUgn90070
    ECgene: LACRT H-InvDB: LACRT

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for LACRT Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for LACRT gene:
    Search GeneIP for patents involving LACRT

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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