LACRT Gene
protein-coding GIFtS: 44
GCID: GC12M055024
|
|
lacritin
| |
Aliases
for LACRT gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Lacritin1 | | LACRITIN1 | | Extracellular Glycoprotein Lacritin2 |
Export aliases for LACRT gene to outside databasesPrevious GC identifers: GC12P049944 GC12M055138 GC12M054741 GC12M053310 GC12M052063 |
Summaries
for LACRT gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for LACRT:
The protein encoded by this gene is highly expressed in the lacrimal glands and localized primarily to secretorygranules and secretory fluid. It augments lacrimal acinar cell secretion, promotes ductal cell proliferation, andstimulates signaling through tyrosine phosphorylation and release of calcium. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: LACRT_HUMAN, Q9GZZ8Function: Modulates secretion by lacrimal acinar cells
Gene Wiki entry for LACRT (Lacritin)
|
Genomic Views
for LACRT gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the LACRT gene promoter:
HOXA9B HFH-3 LCR-F1 HNF-3beta Evi-1 FOXI1 POU2F1 POU2F1a Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for LACRT
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LACRT |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13LACRT Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M055024: view genomic region
(about GC identifiers)
Start:
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55,024,595 bp from pter |
End:
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55,028,679 bp from pter |
Size:
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4,085 bases |
Orientation:
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minus strand |
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Proteins
for LACRT gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: LACRT_HUMAN, Q9GZZ8 (See
protein sequence)Recommended Name: Extracellular glycoprotein lacritin precursor Size: 138 amino acids; 14246 Da
Subcellular location: SecretedExplore the universe of human proteins at neXtProt for LACRT: NX_Q9GZZ8
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9GZZ8
LACRT Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_150593.1
ENSEMBL proteins: ENSP00000448193 ENSP00000447536 ENSP00000257867
Human Recombinant Protein Products for LACRT:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
LACRT for ontologies About GeneDecksing
LACRT Antibody Products:
Assay Products for LACRT: |
Protein
Domains /
Families
for LACRT gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9GZZ8 |
Function
for LACRT gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: LACRT_HUMAN, Q9GZZ8Function: Modulates secretion by lacrimal acinar cells Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
LACRT for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LACRT
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LACRT
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: LACRT (NM_033277) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LACRT | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LACRT |
|
Pathways & Interactions
for LACRT gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for LACRT
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/6 Interacting proteins for LACRT (Q9GZZ83 ENSP000002578674) via UniProtKB, MINT, STRING, and/or I2D (see all 6)About this table
Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10): About this table
LACRT for ontologies About GeneDecksing
|
Drugs & Compounds
for LACRT gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
LACRT for compounds About GeneDecksing
 Browse Tocris compounds for LACRT
1 Novoseek chemical compound relationship for LACRT gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tyrosine |
6.03 |
2 |
11419941 (1), 16488965 (1) |
Search CenterWatch for drugs/clinical trials and news about LACRT
|
Transcripts
for LACRT gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for LACRT gene: NM_033277.1 Unigene Cluster for LACRT: Lacritin Hs.307096 [show with all ESTs]Unigene Representative Sequence: CK4293964 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000546721 ENST00000547511 ENST00000257867(uc001sgi.1) ENST00000549816
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LACRT
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LACRT
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: LACRT (NM_033277) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for LACRT | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LACRT |
Additional cDNA sequence: AF238867.1 BC062217.1 BC069317.1 2 DOTS entries: DT.100020180 DT.121171957 24/89 AceView cDNA sequences (see all 89): CK430586 CK429527 CD723861 CK429721 CD723311 CD721903 CD723803 CD721852 CD723622 CK429406 CD724016 CD722974 CK429760 CD721917 CD723135 CD724258 CD722415 CK431089 CK430309 CA946497 CK429762 CK431018 BQ111233 CD721861
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for LACRT About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | · | 4c | ^ | 5 |
|---|
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| SP1: | | | | | | | | | | | - | | | | | | - | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | - | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | | | | | | |
ECgene alternative splicing isoforms for LACRT
|
Expression
for LACRT gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| LACRT expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAAGCTGAA
About this image
See LACRT Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for LACRT
SOURCE GeneReport for Unigene cluster: Hs.307096
UniProtKB/Swiss-Prot: LACRT_HUMAN, Q9GZZ8Tissue specificity: Expressed in secretory granules of many acinar cells in lacrimal gland and in scattered acinarcells of salivary glands
SABiosciences Custom PCR Arrays for LACRT
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LACRT
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat LACRT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LACRT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LACRT |
Orthologs
for LACRT gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for LACRT (if available)
TreeFam Gene Tree for LACRT (if available) |
Paralogs
for LACRT gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for LACRT gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for LACRT (55024595 - 55028679 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for LACRT: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LACRT |
|
Disorders
/ Diseases
for LACRT gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
LACRT for disorders About GeneDecksing
OMIM gene information: 607360
OMIM disorders: --
2  diseases for LACRT: About MalaCardsblepharitis keratopathy
2 diseases from the University of Copenhagen DISEASES database for LACRT:Blepharitis Dry eye syndrome Export disorders for LACRT gene to outside databases
|
Publications
for LACRT gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for LACRT gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with LACRT) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- cDNA and genomic cloning of lacritin, a novel secretion enhancing factor from the human lacrimal gland. (PubMed id 11419941)1, 2, 3, 9 Sanghi S.... Laurie G.W. (2001)
- Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry. (PubMed id 16740002)1, 2 Ramachandran P....Loo J.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Establishment of an appropriate animal model for lacritin studies: cloning and characterization of lacritin in monkey eyes. (PubMed id 17850790)1, 9 Nakajima T....Azuma M. (2007)
- Restricted epithelial proliferation by lacritin via PKCalpha-dependent NFAT and mTOR pathways. (PubMed id 16923831)1, 9 Wang J....Laurie G.W. (2006)
- Expression of a novel lacrimal gland gene lacritin in human breast tissues. (PubMed id 14574570)1, 9 Weigelt B....van 't Veer L.J. (2003)
- Lacritin and other new proteins of the lacrimal functional unit. (PubMed id 18840430)1, 9 McKown R.L....Laurie G.W. (2008)
- Heparanase deglycanation of syndecan-1 is required for binding of the epithelial-restricted prosecretory mitogen lacritin. (PubMed id 16982797)1, 9 Ma P....Laurie G.W. (2006)
- Quantitative analysis of N-linked glycoproteins in te ar fluid of climatic droplet keratopathy by glycopeptide capture and iTRAQ. (PubMed id 19714880)1, 9 Lei Z....Serra H.M. (2009)
- Mass spectrometry-based proteomic analyses in contact lens-related dry eye. (PubMed id 19770725)1, 9 Nichols J.J. and Green-Church K.B. (2009)
|
External Searches for LACRT gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing LACRT gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing LACRT gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing LACRT gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for LACRT | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for LACRT gene:
Search GeneIP for patents involving LACRT
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for LACRT gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for LACRT | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for LACRT | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for LACRT | | | OriGene Protein Over-expression Lysate for LACRT | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for LACRT | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for LACRT | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for LACRT | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for LACRT | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for LACRT | | OriGene Custom Protein Services for LACRT | | | OriGene Custom Immunoassay Development | | |
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 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat LACRT | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing LACRT | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat LACRT | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat LACRT | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat LACRT | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat LACRT |
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 |  |  |  | |
| | | | Search Tocris compounds for LACRT |
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 | | | LACRT Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for LACRT |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat LACRT |
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