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LACE1 Gene

protein-coding   GIFtS: 47

GC06P108722
lactation elevated 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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Aliases &
Descriptions
for LACE1

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
AFG1 1, 2, 3
OTTHUMP00000016943 2
Descriptions
ATPase family gene 1 homolog 2
CG8520 gene product 2
lactation elevated 1 2
External Ids
HGNC: 164111
Entrez Gene: 2462692
UniProtKB: Q8WV933
Ensembl: ENSG000001355377
Search outside databases for aliases for LACE1 gene

Previous GC identifers: GC06P108480 GC06P108638 GC06P108661

Summaries
for LACE1

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for LACE1:
This gene encodes a protein with possible ATPase function. The protein contains a P-loop motif and
a five-domain structure that is conserved in fly, yeast, and bacteria. Two conserved estrogen
receptor binding sites are located within 2.5 kb of this gene. [provided by RefSeq]

Genomic Location
for LACE1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q22.1   Ensembl cytogenetic band:  6q21   HGNC cytogenetic band: 6q22.1

LACE1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P108722:     (about GC identifiers)

Start:
 108,722,791 bp from pter
End:
 108,950,951 bp from pter
Size:
 228,161 bases
Orientation:
 plus strand
RefSeq DNA sequence:
NC_000006.10  NT_025741.14  

Proteins
for LACE1

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: LACE1_HUMAN, Q8WV93 (See protein sequence)
Recommended Name: Lactation elevated protein 1  
Size: 481 amino acids; 54845 Da
Secondary accessions: Q8N6A3

REFSEQ proteins: NP_660358.2  

ENSEMBL proteins: 
ENSP00000357973 


Human Recombinant Proteins 
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse Abcam for Recombinant Proteins
Human Recombinant Proteins from Abnova (LACE1)
                Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


Antibodies for LACE1: 
Browse Antibodies Central at Invitrogen
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
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Search Novus for antibodies for LACE1

Assays for LACE1: 
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Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for LACE1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro domain/family:
 IPR005654 ATPase_AFG1-like


   GeneDecks  LACE1 for the domains selected above  
About GeneDecksing

Graphical View of Domain Structure for InterPro Entry Q8WV93

ProtoNet protein and cluster: Q8WV93

1 Blocks protein family: IPB005654 AFG1-like ATPase

UniProtKB/Swiss-Prot: LACE1_HUMAN, Q8WV93
Similarity: Belongs to the AFG1 ATPase family

Gene Function
for LACE1

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (LACE1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145315

              Applied Biosystems Silencer® siRNAs for LACE1

              Sigma-Aldrich siRNA for LACE1  
                     Sigma-Aldrich shRNA for LACE1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Clones:Invitrogen Clones for LACE1
Browse Clones for the Expression of Recombinant Proteins Available from Millipore
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145315
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145315
                                 untagged cDNA clone in CMV expression vector: NM_145315 

Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
              OriGene genome-wide validated SYBR primer pairs: NM_145315

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0000166 nucleotide binding IEA--
GO:0005524 ATP binding IEA--
About this table

Pathways & Interactions
for LACE1

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section



3 Interacting proteins for LACE1 (ENSP000003579733) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
SDHBENSP000003646493STRING (score=.765)
SPATA5ENSP000002740083STRING (score=.75)
COX11ENSP000002993353STRING (score=.708)
About this table

Drugs & Compounds
for LACE1

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences
Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for LACE1

Transcripts
for LACE1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section
Inhib.
RNA:		Invitrogen RNAi Products for gene knock-down (LACE1)
Browse for Gene Knock-down Tools from Millipore
Browse Abnova for Chimera RNAi Products
              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145315

              Sigma-Aldrich siRNA for LACE1  
                     Sigma-Aldrich shRNA for LACE1  
                     Explore Sigma-Aldrich super-pooled esiRNAs  

Applied Biosystems Silencer® siRNAs: 

NM_145315  

REFSEQ mRNAs for LACE1 gene: 

NM_145315.3   

Applied Biosystems TaqMan ® Gene Expression Assays: 

NM_145315  

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_145315
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_145315
                                 untagged cDNA clone in CMV expression vector: NM_145315 

Additional cDNA sequence: 

AF520418.1 BC018445.1 

6 DOTS entries:

DT.75164445  DT.91650058  DT.100700497  DT.100774609  DT.121392749  DT.97813031 

24/30 AceView cDNA sequences (see all 30 ):

BC018445 AW087728 CD367398 CA314095 BG432009 BX329832 BX463684 AI825202 
BE258784 AL832793 BI754108 AW263495 BE780155 BE259250 NM_145315 AF520418 
BX374574 BX452738 AI434204 BI091257 BX333092 BX333091 BX395362 BM789838 

highest scoring ESTs for LACE1:

AI434204 AI825202 AW263495 BG206498 BX115687 CA314095 AF520418 BC018445 AL516176 AL516177 

Unigene Cluster for LACE1:

Lactation elevated 1
Hs.259666  [show with all ESTs]
Unigene Representative Sequence: AF520418


GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for LACE1

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13
SP1:                                                        -                       -         
SP2:                                                                    -                     

About this scheme

ECgene alternative splicing isoforms for LACE1

1 Ensembl transcript including schematic representation:
ENST00000368977  

Expression
for LACE1

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

LACE1 expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for LACE1

1 / 2 / 3

3 probe-sets matching LACE1 gene


Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
84685_at2, 3 U95-D 1 1.00 1.00 1.00 1.00 AI434204 1.00 1.00 1.00 1

1552490_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

1563671_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
GeneDecks  LACE1 for binary patterns associated with the probe-sets selected above  
About GeneDecksing
About this table    
Data from (Publications) and GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: TTTACCGGAG

SOURCE GeneReport for Unigene cluster: Hs.259666

Orthologs
for LACE1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for LACE1 gene from 5/18 species (see all 18 )
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 LACE11   -- lactation elevated 1 92.18(n)
93.33(a)		 481952  XM_539073.2  XP_539073.2 
chimpanzee
(Pan troglodytes)		 LACE11   -- lactation elevated 1 99.93(n)
100(a)		 462920  XM_518672.2  XP_518672.2 
cow
(Bos taurus)		 LACE11   -- lactation elevated 1 93.12(n)
93.12(a)		 537689  XM_617866.3  XP_617866.3 
mouse
(Mus musculus)		 Lace11, 5 10 (25.50 cM)5
 lactation elevated 11, 5 87.99(n)1
87.08(a)1		 2159511  NM_145743.21  NP_665686.21 
 AF3979095  AF5204175  (see all 14)
chicken
(Gallus gallus)		 LACE11   -- lactation elevated 1 80.15(n)
80.46(a)		 421770  XM_419799.2  XP_419799.2 
About this table        Species with no ortholog for LACE1

ENSEMBL Gene Tree for LACE1

Paralogs
for LACE1

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section

  --

SNPs/Variants
for LACE1

(According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section


10/844 NCBI SNPs in LACE1 are shown (see all 844 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 192)
ABGenomic DataTranscription DataAllele Frequencies
SNP IDValidChr 6 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
------------
rs132187851,2
C,H108950497(+) TTAACA/GTTTTT 1 -- ut314Minor allele frequency- G:0.00EU EA WA 416
rs5494981,2
H108722839(-) GACCTC/TCAGTA 1 -- ut51 ese34Minor allele frequency- T:0.00EU EA WA 416
rs20325501,2
F108722807(-) CCCGTG/CCCCTC 1 -- ut51 ese31Minor allele frequency- C:0.42MN 184
--
rs8610331,2
A108720960(-) tttttG/Tttttt 1 -- ng51 trp30--------
rs123746161,2
H108784688(+) AAGAAG/ACATGT 1 T/A mis14Minor allele frequency- A:0.00EU EA WA 420
rs8475951,2
F,H108751792(+) TTGGCC/TGTTTG 1 A/A syn14Minor allele frequency- T:0.01EU EA WA 420
rs13362391,2
A,C,F,H,O108831900(-) TTAGAC/TATTTT 1 -- int111Minor allele frequency- T:0.42NA EU EA WA 922
rs19678821,2
A,C,F,H,O108845595(-) GGAGGG/CACAAT 1 -- int111Minor allele frequency- C:0.43EU EA WA NA 978
rs5926151,2
A,C,F,H,O108750901(+) ACTCCG/CTAAAG 1 -- int110Minor allele frequency- C:0.26EA NA EU WA 814
rs9145561,2
A,C,F,H,O108811458(+) CGGTCA/GTGTAG 1 -- int116Minor allele frequency- N:0.00EA NA EU WA 1412
About this table

HapMap Linkage Disequilibrium images for LACE1 (up to first 250kb)

Disorders & Mutations
for LACE1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

 Human Genome Epidemiology Navigator: LACE1 (1 document)

Medical News
for LACE1

(Possibly Related Articles in Doctor's Guide)
About This Section

   --

Publications
for LACE1

(in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
About This Section

5 PubMed articles for LACE1 gene:

Search for LACE1

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing LACE1

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section
Entrez Gene: 246269 HGNC: 16411 AceView: LACE1 Ensembl:ENSG00000135537 euGenes: HUgn246269
ECgene: LACE1 H-InvDB: LACE1

Other Databases showing LACE1

(According to HUGE)
About This Section

   --

Specialized Databases showing LACE1

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

   --

Licensable Technologies
for LACE1

(Available from WIS Yeda, Salk, Tufts)
About This Section

  --

Services
for LACE1

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section



Products for LACE1:
 TaqMan ® Gene Expression Assays
 TaqMan ® Genotyping Assays
  Free SNP selection tool



  Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
  Invitrogen Antibodies  Invitrogen Assays
  Invitrogen Clones  Invitrogen Q-PCR Products
  Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
  Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for LACE1-related products

 Millipore Custom Antibody & Bulk Services
 Millipore Preclinical / Clinical Development Services
 Millipore Immunoassay Services
 Millipore Target Screening & Profiling Services


 Predesigned and custom siRNAs for LACE1 Browse antibodies at Sigma-Aldrich
 Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
 Lentivirus-delivered shRNAs for LACE1 Browse small molecules at Sigma-Aldrich
 "Your Favorite Gene" Pathwaysfeedback


  
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 Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
 Search Novus for antibodies for LACE1

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