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L3MBTL4 Gene

protein-coding GIFtS: 46

GC18M005946

l(3)mbt-like 4 (Drosophila)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
FLJ35936 ^¹
HsT1031 ^¹, ²

Descriptions
H-l(3)mbt-like protein ^³
L(3)mbt-like 4 protein ^³
l(3)mbt-like 4 ^²
l(3)mbt-like 4 (Drosophila) ^²

External Ids
HGNC: 26677¹
Entrez Gene: 91133²
UniProtKB: Q8NA19³
Ensembl: ENSG00000154655⁷

Search outside databases for aliases for L3MBTL4 gene

Previous GC identifer: GC18M005945

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the L3MBTL4 gene

Entrez Gene cytogenetic band: 18p11.31 Ensembl cytogenetic band: 18p11.31 HGNC cytogenetic band: 18p11.31-p11.23

L3MBTL4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 18 GeneLoc Exon Structure

GeneLoc location for GC18M005946: (about GC identifiers)

Start:	5,944,705 bp from pter
End:	6,404,910 bp from pter
Size:	460,206 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000018.8 NT_010859.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LMBL4_HUMAN, Q8NA19 (See protein sequence)

Recommended Name: Lethal(3)malignant brain tumor-like 4 protein

Size: 623 amino acids; 71190 Da

Subcellular location: Nucleus (Potential)

Secondary accessions: Q8IXS3

Alternative splicing: 2 isoforms: Q8NA19-1 Q8NA19-2

REFSEQ proteins: NP_775735.2

ENSEMBL proteins:

ENSP00000382975 ENSP00000318543 ENSP00000382976 ENSP00000284898

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (L3MBTL4)
	Human Recombinant Proteins from Abnova (L3MBTL4)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for L3MBTL4:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for L3MBTL4
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (L3MBTL4), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (L3MBTL4)
	Novus Biologicals Antibodies for L3MBTL4

Assays for L3MBTL4:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q8NA19

ProtoNet protein and cluster: Q8NA19

1 Blocks protein family: IPB001660 Sterile alpha motif SAM

UniProtKB/Swiss-Prot: LMBL4_HUMAN, Q8NA19

Similarity: Contains 3 MBT repeats

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (L3MBTL4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (L3MBTL4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173464

Applied Biosystems Silencer® siRNAs for L3MBTL4

Sigma-Aldrich siRNA for L3MBTL4

Sigma-Aldrich shRNA for L3MBTL4

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for L3MBTL4
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_173464
Myc/DDK tagged cDNA clone in CMV expression vector: NM_173464
untagged cDNA clones in CMV expression vector (see all 2): NM_173464

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_173464

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0008270	zinc ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for L3MBTL4

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (L3MBTL4)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (L3MBTL4)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_173464

Sigma-Aldrich siRNA for L3MBTL4

Sigma-Aldrich shRNA for L3MBTL4

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_173464

REFSEQ mRNAs for L3MBTL4 gene:

NM_173464.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_173464

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_173464
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_173464
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_173464

Additional cDNA sequence:

AK026733.1 AK091075.1 AK093255.1 BC039316.1

6 DOTS entries:

DT.108495 DT.100019989 DT.100019986 DT.107179 DT.99991400 DT.97777837

24/49 AceView cDNA sequences (see all 49 ):

CB161744 BI549985 CA313345 AL042961 CB164235 CA394809 CA394818 AK093255

BF755043 BG771878 AA453980 AK026733 AA453472 AI655128 BC039316 BF726581

AA024569 NM_173464 AX748017 AK091075 BM554025 AX746767 Z42422 AA514595

highest scoring ESTs for L3MBTL4:

BC039316 AK093255 AI927902 BG771878 BI549985 BI562494 BM554025 CA394809 CA394818 NM_173464

Unigene Cluster for L3MBTL4:

L(3)mbt-like 4 (Drosophila)

Hs.128279 [show with all ESTs]

Unigene Representative Sequence: BC039316

GeneLoc Exon Structure

4 Ensembl transcripts including schematic representations:

ENST00000400104 ENST00000317931 ENST00000400105 ENST00000284898

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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L3MBTL4 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for L3MBTL4

¹ / ² / ³

5 probe-sets matching L3MBTL4 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
72305_at²^{, 3}	U95-E	1	1.00	1.00	-0.28	0.51	AL042961	0.60	0.75	0.68	1
47572_at²^{, 3}	U95-B	1	1.00	1.00	1.00	1.00	AI927902	0.60	1.00	0.82	1
228557_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AK026733	0.40	0.67	0.55	1
228557_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1554699_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks L3MBTL4 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
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About these images

CGAP SAGE TAG: TTAAAATTTT

SOURCE GeneReport for Unigene cluster: Hs.128279

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for L3MBTL4 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	L3MBTL4¹	--	l(3)mbt-like 4 (Drosophila)	89.78(n) 91.49(a)	490541 XM_547663.2 XP_547663.2
chimpanzee (Pan troglodytes)	L3MBTL4¹	--	l(3)mbt-like 4 (Drosophila)	99.4(n) 99.51(a)	455306 XM_001142186.1 XP_001142186.1
mouse (Mus musculus)	L3mbtl4⁵	17	l(3)mbt-like 4 (Drosophila)	--	BC147119

About this table Species with no ortholog for L3MBTL4

ENSEMBL Gene Tree for L3MBTL4

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for L3MBTL4 gene

L3MBTL² L3MBTL3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/3032 NCBI SNPs in L3MBTL4 are shown (see all 3032 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 856)

AB	SNP ID	Valid	Chr 18 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
--	rs1940622^1,2	A,C,F,H,O	5945181(+)	`CCTCCG/AATACA`	1	--	ut3¹ ese³		15	NS EU EA WA NA	2326
--	rs719153^1,2	A,C,F,H,O	5945554(-)	`AGTAAC/TGAGAG`	1	--	ut3¹ ese³		17	NA EA NS MN EU WA	2698
--	rs1940621^1,2	A,C,F,O	5944987(+)	`CTTTCT/CTAAAC`	1	--	ut3¹ ese³		6	NA EA	412
--	rs7228756^1,2	A,C,F,H	5944396(+)	`TGTTCA/GAGGCC`	1	--	ng5¹		11	EU EA WA NA	976
--	rs3737353^1,2	A,C,F,H	5946238(+)	`CTTGGC/TCTGAG`	1	G/D	mis¹ ese³		9	EA EU WA	2330
--	rs3811^1,2	A,C,F,H	5944871(+)	`ATTCCA/TTTTAG`	1	--	ut3¹ ese³		4	EU EA WA	412
--	rs2298535^1,2	A,C,F,H	5945911(-)	`TCTCCG/ATCACC`	1	--	ut3¹ ese³		12	EA NA EU WA	2458
--	rs3737352^1,2	A,C,F,H	5946145(+)	`TCACAT/CCAAAT`	1	--	ut3¹		8	EA EU WA NA	2162
--	rs3737351^1,2	C,F,H	5946116(+)	`ATTCAG/ATGTGG`	1	--	ut3¹ ese³		16	EA NA EU WA	2072
--	rs3745091^1,2	C,F,H	5945083(-)	`CTACAA/GATACT`	1	--	ut3¹ ese³		18	EA NS NA EU WA	2628

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HapMap Linkage Disequilibrium images for L3MBTL4 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for L3MBTL4 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{2, 3, 4} Ota T....Sugano S. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)³ Bonaldo M.F....Soares M.B. (1996)
Molecular cloning and chemical synthesis of a region of platelet glycoprotein IIb involved in adhesive function. (PubMed id 2444974)³ Loftus J.C.... Ginsberg M.H. (1987)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 91133	HGNC: 26677	AceView: L3MBTL4	Ensembl:ENSG00000154655	euGenes: HUgn91133
ECgene: L3MBTL4	H-InvDB: L3MBTL4

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for L3MBTL4
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for L3MBTL4:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for L3MBTL4-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for L3MBTL4		Antibodies for L3MBTL4
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for L3MBTL4		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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L3MBTL4 Gene

protein-coding GIFtS: 46

Aliases &
Descriptions
for L3MBTL4

Summaries
for L3MBTL4

Genomic Location
for L3MBTL4

Proteins
for L3MBTL4

Protein Domains/
Families
for L3MBTL4

Gene Function
for L3MBTL4

Pathways & Interactions
for L3MBTL4

Drugs & Compounds
for L3MBTL4

Transcripts
for L3MBTL4

Expression
for L3MBTL4

Orthologs
for L3MBTL4

Paralogs
for L3MBTL4

SNPs/Variants
for L3MBTL4

Disorders & Mutations
for L3MBTL4

Medical News
for L3MBTL4

Publications
for L3MBTL4

Search for L3MBTL4

Genome Databases showing L3MBTL4

Other Databases showing L3MBTL4

Specialized Databases showing L3MBTL4

Licensable Technologies
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Services
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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

L3MBTL4 Gene

protein-coding GIFtS: 46

Aliases & Descriptionsfor L3MBTL4

Summariesfor L3MBTL4

Genomic Locationfor L3MBTL4

Proteinsfor L3MBTL4

Protein Domains/Familiesfor L3MBTL4

Gene Functionfor L3MBTL4

Pathways & Interactionsfor L3MBTL4

Drugs & Compoundsfor L3MBTL4

Transcriptsfor L3MBTL4

Expression for L3MBTL4

Orthologsfor L3MBTL4

Paralogsfor L3MBTL4

SNPs/Variantsfor L3MBTL4

Disorders & Mutationsfor L3MBTL4

Medical Newsfor L3MBTL4

Publicationsfor L3MBTL4

Search for L3MBTL4

Genome Databases showing L3MBTL4

Other Databases showing L3MBTL4

Specialized Databases showing L3MBTL4

Licensable Technologiesfor L3MBTL4

Servicesfor L3MBTL4

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for L3MBTL4

Summaries
for L3MBTL4

Genomic Location
for L3MBTL4

Proteins
for L3MBTL4

Protein Domains/
Families
for L3MBTL4

Gene Function
for L3MBTL4

Pathways & Interactions
for L3MBTL4

Drugs & Compounds
for L3MBTL4

Transcripts
for L3MBTL4

Expression
for L3MBTL4

Orthologs
for L3MBTL4

Paralogs
for L3MBTL4

SNPs/Variants
for L3MBTL4

Disorders & Mutations
for L3MBTL4

Medical News
for L3MBTL4

Publications
for L3MBTL4

Licensable Technologies
for L3MBTL4

Services
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