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Aliases for L3MBTL3 Gene

Aliases for L3MBTL3 Gene

  • L(3)Mbt-Like 3 (Drosophila) 2 3 5
  • H-L(3)Mbt-Like Protein 3 3 4
  • L(3)Mbt-Like Protein 3 3 4
  • MBT-1 3 4
  • MBT1 3 4
  • KIAA1798 4

External Ids for L3MBTL3 Gene

Previous GeneCards Identifiers for L3MBTL3 Gene

  • GC06P130320
  • GC06P130381
  • GC06P127920

Summaries for L3MBTL3 Gene

GeneCards Summary for L3MBTL3 Gene

L3MBTL3 (L(3)Mbt-Like 3 (Drosophila)) is a Protein Coding gene. An important paralog of this gene is L3MBTL1.

UniProtKB/Swiss-Prot for L3MBTL3 Gene

  • Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for L3MBTL3 Gene

Genomics for L3MBTL3 Gene

Regulatory Elements for L3MBTL3 Gene

Enhancers for L3MBTL3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around L3MBTL3 on UCSC Golden Path with GeneCards custom track

Genomic Location for L3MBTL3 Gene

Chromosome:
6
Start:
129,978,804 bp from pter
End:
130,141,451 bp from pter
Size:
162,648 bases
Orientation:
Plus strand

Genomic View for L3MBTL3 Gene

Genes around L3MBTL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
L3MBTL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for L3MBTL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for L3MBTL3 Gene

Proteins for L3MBTL3 Gene

  • Protein details for L3MBTL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96JM7-LMBL3_HUMAN
    Recommended name:
    Lethal(3)malignant brain tumor-like protein 3
    Protein Accession:
    Q96JM7
    Secondary Accessions:
    • Q4VXE1
    • Q5VUM9
    • Q6P9B5

    Protein attributes for L3MBTL3 Gene

    Size:
    780 amino acids
    Molecular mass:
    88337 Da
    Quaternary structure:
    • Interacts with RNF2.
    SequenceCaution:
    • Sequence=BAB47427.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for L3MBTL3 Gene

    Alternative splice isoforms for L3MBTL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for L3MBTL3 Gene

Proteomics data for L3MBTL3 Gene at MOPED

Post-translational modifications for L3MBTL3 Gene

  • Ubiquitination at Lys 692
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for L3MBTL3

No data available for DME Specific Peptides for L3MBTL3 Gene

Domains & Families for L3MBTL3 Gene

Protein Domains for L3MBTL3 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for L3MBTL3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96JM7

UniProtKB/Swiss-Prot:

LMBL3_HUMAN :
  • Contains 1 SAM (sterile alpha motif) domain.
  • Contains 3 MBT repeats.
Domain:
  • Contains 1 SAM (sterile alpha motif) domain.
Similarity:
  • Contains 3 MBT repeats.
genes like me logo Genes that share domains with L3MBTL3: view

Function for L3MBTL3 Gene

Molecular function for L3MBTL3 Gene

UniProtKB/Swiss-Prot Function:
Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Required for normal maturation of myeloid progenitor cells (By similarity).
genes like me logo Genes that share phenotypes with L3MBTL3: view

Animal Models for L3MBTL3 Gene

MGI Knock Outs for L3MBTL3:

Animal Model Products

CRISPR Products

miRNA for L3MBTL3 Gene

miRTarBase miRNAs that target L3MBTL3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for L3MBTL3 Gene

Localization for L3MBTL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for L3MBTL3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for L3MBTL3 Gene COMPARTMENTS Subcellular localization image for L3MBTL3 gene
Compartment Confidence
nucleus 4
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for L3MBTL3 Gene

Pathways & Interactions for L3MBTL3 Gene

SuperPathways for L3MBTL3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for L3MBTL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016568 chromatin modification IEA --
GO:0030099 myeloid cell differentiation IEA --
GO:0030851 granulocyte differentiation IEA --
genes like me logo Genes that share ontologies with L3MBTL3: view

No data available for Pathways by source and SIGNOR curated interactions for L3MBTL3 Gene

Drugs & Compounds for L3MBTL3 Gene

No Compound Related Data Available

Transcripts for L3MBTL3 Gene

Unigene Clusters for L3MBTL3 Gene

L(3)mbt-like 3 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for L3MBTL3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23
SP1: - -
SP2: -
SP3:

Relevant External Links for L3MBTL3 Gene

GeneLoc Exon Structure for
L3MBTL3
ECgene alternative splicing isoforms for
L3MBTL3

Expression for L3MBTL3 Gene

mRNA expression in normal human tissues for L3MBTL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for L3MBTL3 Gene

This gene is overexpressed in CD8 Tcells (27.8), Ovary (21.7), and CD4 Tcells (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for L3MBTL3 Gene



SOURCE GeneReport for Unigene cluster for L3MBTL3 Gene Hs.658051

genes like me logo Genes that share expression patterns with L3MBTL3: view

Protein tissue co-expression partners for L3MBTL3 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for L3MBTL3 Gene

Orthologs for L3MBTL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for L3MBTL3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia L3MBTL3 35
  • 91.56 (n)
  • 96.29 (a)
L3MBTL3 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia L3MBTL3 35
  • 84.54 (n)
  • 87.05 (a)
L3MBTL3 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia L3mbtl3 35
  • 86.09 (n)
  • 89.44 (a)
L3mbtl3 16
L3mbtl3 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia L3MBTL3 35
  • 99.7 (n)
  • 99.87 (a)
L3MBTL3 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia L3mbtl3 35
  • 84.19 (n)
  • 87.56 (a)
oppossum
(Monodelphis domestica)
Mammalia L3MBTL3 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 84 (a)
OneToMany
-- 36
  • 89 (a)
OneToMany
chicken
(Gallus gallus)
Aves L3MBTL3 35
  • 75.39 (n)
  • 76.89 (a)
L3MBTL3 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia L3MBTL3 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia l3mbtl3 35
  • 60.96 (n)
  • 56.67 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.5963 35
zebrafish
(Danio rerio)
Actinopterygii l3mbtl1b 35
  • 57.3 (n)
  • 50.47 (a)
l3mbtl3 36
  • 59 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta l(3)mbt 35
  • 47.03 (n)
  • 39.28 (a)
l(3)mbt 36
  • 16 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 45 (a)
OneToMany
Species with no ortholog for L3MBTL3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for L3MBTL3 Gene

ENSEMBL:
Gene Tree for L3MBTL3 (if available)
TreeFam:
Gene Tree for L3MBTL3 (if available)

Paralogs for L3MBTL3 Gene

Paralogs for L3MBTL3 Gene

(5) SIMAP similar genes for L3MBTL3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with L3MBTL3: view

Variants for L3MBTL3 Gene

Sequence variations from dbSNP and Humsavar for L3MBTL3 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs9388768 - 130,052,957(+) TGACA(A/C)CAAGG reference, missense
rs1112265 -- 129,985,060(+) taact(C/G)atttt intron-variant
rs1112847 -- 130,013,964(-) ACATC(A/G)TAAGG intron-variant
rs1114494 -- 129,985,053(+) aaatg(A/G)ataac intron-variant
rs5006716 -- 130,048,967(+) ACACA(C/T)ACATA intron-variant

Variation tolerance for L3MBTL3 Gene

Residual Variation Intolerance Score: 6.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.69; 32.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for L3MBTL3 Gene

Disorders for L3MBTL3 Gene

Relevant External Links for L3MBTL3

Genetic Association Database (GAD)
L3MBTL3
Human Genome Epidemiology (HuGE) Navigator
L3MBTL3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
L3MBTL3

No disorders were found for L3MBTL3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for L3MBTL3 Gene

Publications for L3MBTL3 Gene

  1. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PMID: 20881960) Lango Allen H. … Hirschhorn J.N. (Nature 2010) 3 48 67
  2. Screening of LRRK2 interactants by yeast 2-hybrid analysis. (PMID: 19001729) Zheng X.Y. … Zhang Z.H. (Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008) 3 23
  3. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  4. Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. (PMID: 25429064) He M. … Qi L. (Hum. Mol. Genet. 2015) 3
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for L3MBTL3 Gene

Sources for L3MBTL3 Gene

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