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Aliases & Descriptions for L3MBTL3
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases KIAA1798 1 , 3 MBT-1 2 MBT1 2 OTTHUMP00000017192 2 RP11-73O6.1 2
Descriptions H-l(3)mbt-like protein 3 L(3)mbt-like 3 protein 3 l(3)mbt-like 3 2 l(3)mbt-like 3 (Drosophila) 2
Search outside databases for aliases for L3MBTL3 genePrevious GC identifer: GC06P130320
Summaries for L3MBTL3 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Location for L3MBTL3
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the L3MBTL3 gene Entrez Gene cytogenetic band: 6q23 Ensembl cytogenetic band: 6q22.33 HGNC cytogenetic band: 6q23 L3MBTL3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure
GeneLoc location for GC06P130381:
(about GC identifiers )
Start:
130,381,427 bp from pter
End:
130,504,278 bp from pter
Size:
122,852 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000006.10 NT_025741.14 Proteins for L3MBTL3
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: LMBL3_HUMAN, Q96JM7 (See
protein sequence )Recommended Name: Lethal(3)malignant brain tumor-like 3 protein Size : 780 amino acids; 88337 Da
Subcellular location : Nucleus (Potential)
PDB structure from and Proteopedia : 1WJQ (3D)
 1WJS (3D)
 
Secondary accessions : Q5VUM9 Q6P9B5Alternative splicing : 2 isoforms : Q96JM7-1 Q96JM7-2
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_001007103.1 NP_115814.1 ENSEMBL proteins: ENSP00000354526 ENSP00000357121 ENSP00000357118 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: L3MBTL3 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
NAS --
About this table Antibodies for L3MBTL3: Assays for L3MBTL3:
Protein
Domains/ Families for L3MBTL3(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q96JM7 ProtoNet protein and cluster: Q96JM7
1 Blocks protein family : IPB001660 Sterile alpha motif SAM UniProtKB/Swiss-Prot: LMBL3_HUMAN, Q96JM7 Similarity : Contains 3 MBT repeatsSimilarity : Contains 1 SAM (sterile alpha motif) domain
Gene Function for L3MBTL3
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): XM_027074 Applied Biosystems Silencer ® siRNAs for L3MBTL3 Sigma-Aldrich siRNA for L3MBTL3 Sigma-Aldrich shRNA for L3MBTL3 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001007102                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001007102                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001007102  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_032438
2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for L3mbtl3) :1 Gene Ontology (GO) molecular function term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
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Pathways & Interactions for L3MBTL3
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Interacting proteins for L3MBTL3 (Q96JM7 2 ENSP00000357118 3 ) via UniProtKB, MINT, and/or STRING About this table 1 Gene Ontology (GO) biological process term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0045449 regulation of transcription
IEA --
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Drugs & Compounds for L3MBTL3 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for L3MBTL3
Transcripts for L3MBTL3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): XM_027074 Sigma-Aldrich siRNA for L3MBTL3 Sigma-Aldrich shRNA for L3MBTL3 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001007102 NM_032438
REFSEQ mRNAs for L3MBTL3 gene (2 alternative transcripts): NM_001007102.1 NM_032438.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001007102 NM_032438
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001007102                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001007102                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001007102  
Additional cDNA sequence: AB058701.1 AK092756.1 AK094137.1 AK290219.1 BC060845.1
4 DOTS entries : DT.100689126 DT.443100 DT.99927658 DT.102824821
24/33 AceView cDNA sequences (see all 33
):BQ373135 AA903233 AA250725 CB999994 CK429855 BC060845 AA308446 AA121480 AB058701 CB989189 BF979664 AL710435 AA360824 AA419583 AA253428 AK094137 AW271825 AA148554 AA055472 BM724153 AX747709 AA055608 BG255574 N45057
highest scoring ESTs for L3MBTL3 :AA088346 AI074017 AA055472 AA055608 AA088345 AA121480 AA122367 AA148554 AA150178 AA250725
Unigene Cluster for L3MBTL3: L(3)mbt-like 3 (Drosophila) Hs.658051 [show with all ESTs ] Unigene Representative Sequence: NM_032438 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for L3MBTL3 ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 SP1 :         -                 -                         SP2 :                         -                         SP3 :                                                
About this scheme ECgene alternative splicing isoforms for L3MBTL3 3 Ensembl transcripts including schematic representations : ENST00000361794
ENST00000368139
ENST00000368136
Expression for L3MBTL3
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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L3MBTL3 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for L3MBTL3 1 / 2 / 3
4 probe-sets matching L3MBTL3 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.658051
Orthologs for L3MBTL3
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for L3MBTL3 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for L3MBTL3 ENSEMBL Gene Tree for L3MBTL3 Paralogs for L3MBTL3 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for L3MBTL3 gene L3MBTL4 2 L3MBTL 2
SNPs/Variants for L3MBTL3 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for L3MBTL3 (up to first 250kb)
Disorders & Mutations for L3MBTL3
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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Medical News for L3MBTL3 (Possibly Related Articles in
Doctor's Guide )
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Publications for L3MBTL3 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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9 PubMed articles for L3MBTL3 gene : Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983) 3, 4 Olsen J.V....Mann M. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404) 3, 4 Mungall A.J.... Beck S. (2003) Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906) 3, 4 Nagase T....Ohara O. (2001) Many sequence variants affecting diversity of adult human height. (PubMed id 18391951) 3 Gudbjartsson D.F....Stefansson K. (2008) Impaired maturation of myeloid progenitors in mice lacking novel Polycomb group protein MBT-1. (PubMed id 15889154) 3 Arai S. and Miyazaki T. (2005) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3 Ota T....Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 3 Strausberg R.L....Marra M.A. (2002) Screening of LRRK2 interactants by yeast 2-hybrid analysis. (PubMed id 19001729) 1 Zheng X.Y....Zhang Z.H. (2008)
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Genome Databases showing L3MBTL3
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing L3MBTL3
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Specialized Databases showing L3MBTL3 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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