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L3MBTL2 Gene

protein-coding   GIFtS: 52
GCID: GC22P041601

L(3)Mbt-Like 2 (Drosophila)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
L(3)Mbt-Like 2 (Drosophila)1 2
H-L(3)Mbt-Like Protein 22 3
L(3)Mbt-Like Protein 22 3
L3MBT2 5
H-l(3)mbt-l2
Lethal(3)Malignant Brain Tumor-Like Protein 22

External Ids:    HGNC: 185941   Entrez Gene: 837462   Ensembl: ENSG000001003957   OMIM: 6118655   UniProtKB: Q969R53   

Export aliases for L3MBTL2 gene to outside databases

Previous GC identifers: GC22P038215 GC22P039844 GC22P039925 GC22P024565


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for L3MBTL2 Gene:
L3MBTL2 (l(3)mbt-like 2 (Drosophila)) is a protein-coding gene. GO annotations related to this gene include methylated histone residue binding and transcription corepressor activity. An important paralog of this gene is L3MBTL1.

UniProtKB/Swiss-Prot: LMBL2_HUMAN, Q969R5
Function: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of
genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its
association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes
that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds
histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'

Gene Wiki entry for L3MBTL2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the L3MBTL2 gene promoter:
         Max1   SRF   AML1a   Pax-6   SRF (504 AA)   HTF   c-Ets-1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidL3MBTL2 promoter sequence
   Search Chromatin IP Primers for L3MBTL2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat L3MBTL2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.31-q13.33   Ensembl cytogenetic band:  22q13.2   HGNC cytogenetic band: 22q13.31-q13.33

L3MBTL2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
L3MBTL2 gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P041601:  view genomic region     (about GC identifiers)

Start:
41,601,209 bp from pter      End:
41,627,275 bp from pter
Size:
26,067 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LMBL2_HUMAN, Q969R5 (See protein sequence)
Recommended Name: Lethal(3)malignant brain tumor-like protein 2  
Size: 705 amino acids; 79110 Da
Subunit: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1,
RING1, RNF2, MBLR, BAT8 and YAF2
Sequence caution: Sequence=BAB84917.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAC04936.1;
Type=Miscellaneous discrepancy; Note=Intron retention;
3 PDB 3D structures from and Proteopedia for L3MBTL2:
2W0T (3D)        3CEY (3D)        3F70 (3D)    
Secondary accessions: Q8TEN1 Q96SC4 Q9BQI2 Q9UGS4
Alternative splicing: 3 isoforms:  Q969R5-1   Q969R5-2   Q969R5-3   

Explore the universe of human proteins at neXtProt for L3MBTL2: NX_Q969R5

Explore proteomics data for L3MBTL2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See L3MBTL2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_113676.2  
    ENSEMBL proteins: 
     ENSP00000216237   ENSP00000405849   ENSP00000414423   ENSP00000399405   ENSP00000403767  

    L3MBTL2 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for L3MBTL2

     
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    antibodies-online proteins for L3MBTL2 (5 products) 

     
    antibodies-online peptides for L3MBTL2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR004092 Mbt
     IPR012313 Znf_FCS

    Graphical View of Domain Structure for InterPro Entry Q969R5

    ProtoNet protein and cluster: Q969R5

    UniProtKB/Swiss-Prot: LMBL2_HUMAN, Q969R5
    Similarity: Contains 1 FCS-type zinc finger
    Similarity: Contains 4 MBT repeats


    Find genes that share domains with L3MBTL2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LMBL2_HUMAN, Q969R5
    Function: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of
    genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its
    association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes
    that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds
    histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003714transcription corepressor activity ----
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0035064methylated histone residue binding IDA19233876
    GO:0042393histone binding IPI17540172
         
    Find genes that share ontologies with L3MBTL2           About GenesLikeMe


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for L3mbtl2):
     mortality/aging 

    Find genes that share phenotypes with L3MBTL2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for L3MBTL2

    miRNA
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    miRTarBase miRNAs that target L3MBTL2:
    hsa-mir-744-5p (MIRT037598), hsa-mir-484 (MIRT042333)

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    1 qRT-PCR Assays for microRNA that regulate L3MBTL2:
    hsa-miR-22
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    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LMBL2_HUMAN, Q969R5: Nucleus (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    extracellular1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--

    Find genes that share ontologies with L3MBTL2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including L3MBTL2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for L3MBTL2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for L3MBTL2 (Q969R51, 2, 3 ENSP000002162374) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST4H4P628053, ENSP000003507674I2D: score=1 STRING: ENSP00000350767
    HIST1H4AP628053, ENSP000003529804I2D: score=1 STRING: ENSP00000352980
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--
    GO:0016568chromatin modification IEA--

    Find genes that share ontologies with L3MBTL2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for L3MBTL2 (LMBL2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for L3MBTL2 gene (2 alternative transcripts): 
    NM_001003689.1  NM_031488.4  

    Unigene Cluster for L3MBTL2:

    L(3)mbt-like 2 (Drosophila)
    Hs.517641  [show with all ESTs]
    Unigene Representative Sequence: BC017191
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216237(uc003azo.3) ENST00000481902 ENST00000489136 ENST00000466589(uc010gyi.1)
    ENST00000453659 ENST00000479978(uc003azn.3) ENST00000452106 ENST00000449635
    ENST00000450939
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate L3MBTL2:
    hsa-miR-22
    SwitchGear 3'UTR luciferase reporter plasmidL3MBTL2 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat L3MBTL2
      QuantiFast Probe-based Assays in human, mouse, rat L3MBTL2

    Additional mRNA sequence: 

    AJ305226.1 AK056443.1 AK097052.1 AK307763.1 AL136564.1 BC017191.2 BC102006.1 BC103626.1 
    CR456482.1 

    12 DOTS entries:

    DT.92430829  DT.91888833  DT.100822812  DT.100028061  DT.100829578  DT.100028062  DT.95218869  DT.95218874 
    DT.100653666  DT.100822815  DT.100831188  DT.100652993 

    13 AceView cDNA sequences:

    AW410406 BQ437709 N63530 AK057177 AI351341 BU838420 BF307973 AW410405 
    N94850 BG002228 N95732 AA355743 BI038667 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for L3MBTL2 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^
    SP1:                                -     -           -     -                                                     -                                             
    SP2:                                -     -           -     -     -                                                                                             
    SP3:                                      -           -     -     -                                                                                             
    SP4:                                -     -           -     -     -                             -                                                               
    SP5:                                                  -     -     -     -                                                                                       

    ExUns: 17a · 17b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for L3MBTL2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    L3MBTL2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGGAGGGG
    L3MBTL2 Expression
    About this image

    L3MBTL2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    L3MBTL2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.517641
        Pathway & Disease-focused RT2 Profiler PCR Array including L3MBTL2: 
              Polycomb & Trithorax Complexes in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for L3MBTL2 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia L3mbtl21 , 5 l(3)mbt-like 2 (Drosophila)1, 5 87.39(n)1
    91.18(a)1
      15 (38.19 cM)5
    2146691  NM_145993.41  NP_666105.21 
     816638895 
    chicken
    (Gallus gallus)
    Aves L3MBTL21 l(3)mbt-like 2 (Drosophila) 78.02(n)
    81.48(a)
      417999  NM_001006238.1  NP_001006238.1 
    lizard
    (Anolis carolinensis)
    Reptilia L3MBTL26
    l(3)mbt-like 2 (Drosophila)
    68(a)
    1 ↔ 1
    5(26205572-26237680)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004908821 lethal(3)malignant brain tumor-like protein 2-like 67.07(n)
    67.12(a)
      100490882  XM_002934736.2  XP_002934782.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufb04e092 wufb04e09 74.69(n)   336769  BC057540.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG169753   -- 49(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea rls-13
    lin-611
    lin-611 28(a)3
    45.21(n)1
    35.64(a)1
      I(7257041-7259347)3
    1724671  NM_059649.41  NP_492050.31 


    ENSEMBL Gene Tree for L3MBTL2 (if available)
    TreeFam Gene Tree for L3MBTL2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for L3MBTL2 gene
    L3MBTL12  SCML42  L3MBTL32  SFMBT12  SCML12  L3MBTL42  SCMH12  SCML22  
    SFMBT22  MBTD12  
    Selected SIMAP similar genes for L3MBTL2 using alignment to 4 protein entries:     LMBL2_HUMAN (see all proteins) (see all similar genes):
    NEU3    PCCB    RNF121    TTC7A    MDM2    PAM16
    FANCD2OS    KIAA0586    NCF1    SHC1    MRPS28    TXNRD1
    ABCG5    ADCY7    NAA15    DDX19A    ETFA    HK1

    Find genes that share paralogs with L3MBTL2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for L3MBTL2 (see all 340)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1866908171,2
    --41599334(+) CTTGAC/GTTGGC 1 -- us2k10--------
    rs734265671,2
    C,F--41599360(+) CTTGCT/CGTTCC 1 -- us2k12Minor allele frequency- C:0.07WA 120
    rs789473681,2
    C,F--41599420(+) TTTCAC/GCACTA 1 -- us2k11Minor allele frequency- G:0.11NA 120
    rs1408829741,2
    --41599509(+) GTGCAA/GTCTCG 1 -- us2k10--------
    rs1932077241,2
    --41599513(+) AATCTC/TGGCTC 1 -- us2k10--------
    rs1857411081,2
    C--41599612(+) GCTAAC/TAGTTG 1 -- us2k10--------
    rs1447109301,2
    --41599669(+) CGATCA/TCCTGA 1 -- us2k10--------
    rs1902144261,2
    --41599723(+) CAGGCA/GTGATC 1 -- us2k10--------
    rs2020910201,2
    C--41599875(+) CCATC-/TCAA  
            
    TCAAT
    1 -- us2k10--------
    rs1118154821,2
    C--41599897(+) TCAATC/AAAAGA 1 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for L3MBTL2 (41601209 - 41627275 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for L3MBTL2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv915117CNV Loss21882294
    nsv915116CNV Loss21882294
    nsv524585CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611865    OMIM disorders: --


    Find genes that share disorders with L3MBTL2           About GenesLikeMe

    Genetic Association Database (GAD): L3MBTL2

    Export disorders for L3MBTL2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for L3MBTL2 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with L3MBTL2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular characterization of h-l(3)mbt-like: a new member of the human mbt family. (PubMed id 11682070)1, 2, 3 Wismar J. (FEBS Lett. 2001)
    2. Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2. (PubMed id 19233876)1, 2 Guo Y.... Min J. (Nucleic Acids Res. 2009)
    3. Solution structure of the FCS zinc finger domain of the human polycomb group protein L(3)mbt-like 2. (PubMed id 19241375)1, 2 Lechtenberg B.C....Bycroft M. (Protein Sci. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (Genome Biol. 2004)
    7. A complex with chromatin modifiers that occupies E2F- and Myc- responsive genes in G0 cells. (PubMed id 12004135)1, 2 Ogawa H.... Nakatani Y. (Science 2002)
    8. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (Genome Res. 2001)
    9. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)
    10. Histone deacetylase 3 is selectively involved in L3MBTL2-mediated transcriptional repression. (PubMed id 20385135)1, 9 Yoo J.Y....Yoon H.G. (FEBS Lett. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 83746 HGNC: 18594 AceView: L3MBTL2.1 Ensembl:ENSG00000100395 euGenes: HUgn83746
    ECgene: L3MBTL2 H-InvDB: L3MBTL2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for L3MBTL2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for L3MBTL2 gene:
    Search GeneIP for patents involving L3MBTL2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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