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Aliases & Descriptions for L3MBTL2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DKFZP761I141 1 | | H-l(3)mbt-l 1, 2 | | L3MBT 2, 5 | | OTTHUMP00000028919 2 | | dJ756G23.3 1 |
| | | Descriptions |
|---|
| H-l(3)mbt-like protein 2, 3 | | L(3)mbt-like 2 protein 3 | | l(3)mbt-like 2 2 | | l(3)mbt-like 2 (Drosophila) 2 |
|
| | Search outside databases for aliases for L3MBTL2 genePrevious GC identifers: GC22P038215 GC22P039844 |
Summaries for L3MBTL2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: LMBL2_HUMAN, Q969R5Function: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosisGene Wiki entry for L3MBTL2 |
Genomic Location for L3MBTL2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the L3MBTL2 gene 
Entrez Gene cytogenetic band: 22q13.31-q13.33 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.31-q13.33L3MBTL2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22P039925:
(about GC identifiers)
Start:
|
39,931,259 bp from pter |
End:
|
39,957,221 bp from pter |
Size:
|
25,963 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000022.9 NT_011520.11
| Proteins for L3MBTL2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: LMBL2_HUMAN, Q969R5 (See
protein sequence)Recommended Name: Lethal(3)malignant brain tumor-like 2 protein Size: 705 amino acids; 79110 Da
Subunit: Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2
Subcellular location: Nucleus (Probable)
Sequence caution: Sequence=BAB84917.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=BAC04936.1; Type=Miscellaneous discrepancy; Note=Intron retention;
PDB structures from and Proteopedia :2W0T (3D)
 3CEY (3D)
 3F70 (3D)
 
Secondary accessions: Q8TEN1 Q96SC4 Q9BQI2 Q9UGS4Alternative splicing: 3 isoforms: Q969R5-1 Q969R5-2 Q969R5-3 Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_113676.2
ENSEMBL proteins: ENSP00000216237
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for L3MBTL2: Assays for L3MBTL2: | Protein
Domains/ Families for L3MBTL2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q969R5
ProtoNet protein and cluster: Q969R5 UniProtKB/Swiss-Prot: LMBL2_HUMAN, Q969R5Similarity: Contains 1 FCS-type zinc fingerSimilarity: Contains 4 MBT repeats | Gene Function for L3MBTL2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_031488
Applied Biosystems Silencer® siRNAs for L3MBTL2
Sigma-Aldrich siRNA for L3MBTL2  Sigma-Aldrich shRNA for L3MBTL2  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_031488                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_031488                                  untagged cDNA clones in CMV expression vector (see all 3): NM_001003689 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_031488
UniProtKB/Swiss-Prot: LMBL2_HUMAN, Q969R5Function: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis3 Gene Ontology (GO) molecular function terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003714 | transcription corepressor activity |
NAS | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0046872 | metal ion binding |
IEA | -- | About this table | Pathways & Interactions for L3MBTL2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
2 Interacting proteins for L3MBTL2 (Q969R52) via UniProtKB, MINT, and/or STRINGAbout this table
2 Gene Ontology (GO) biological process terms (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0016568 | chromatin modification |
NAS | -- | About this table
|
Drugs & Compounds for L3MBTL2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for L3MBTL2
|
Transcripts for L3MBTL2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_031488
Sigma-Aldrich siRNA for L3MBTL2  Sigma-Aldrich shRNA for L3MBTL2  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_031488 REFSEQ mRNAs for L3MBTL2 gene: NM_031488.4
Applied Biosystems TaqMan ® Gene Expression Assays: NM_031488               OriGene GFP tagged cDNA clone in CMV expression vector: NM_031488                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_031488                                  untagged cDNA clones in CMV expression vector (see all 3): NM_001003689  Additional cDNA sequence: AJ305226.1 AK056443.1 AK057177.1 AK097052.1 AK307763.1 AL136564.1 BC017191.2 BC102006.1 BC103626.1 CR456482.1 CR594826.1 14 DOTS entries: DT.92430829 DT.91888833 DT.100822812 DT.424974 DT.100028061 DT.100829578 DT.100028062 DT.100822815 DT.95218869 DT.95218874 DT.100831188 DT.100652993 DT.100653666 DT.120647809 13 AceView cDNA sequences:AW410406 N63530 BQ437709 BU838420 AI351341 BF307973 AK057177 N94850 AW410405 BG002228 N95732 BI038667 AA355743
highest scoring ESTs for L3MBTL2:AA026761 AA233695 AA280121 AA281766 AA351589 AA351643 AA353188 AA356192 AA630686 AA634292 Unigene Cluster for L3MBTL2: L(3)mbt-like 2 (Drosophila) Hs.517641 [show with all ESTs]Unigene Representative Sequence: BC017191
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for L3MBTL2 (see all 8
)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | ^ | |
| SP1: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | - |   | - |   | |   | - |   | - |   | - |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP5: | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 17a | · | 17b | |
| SP1: | |   | |   | |
| SP2: | |   | |   | |
| SP3: | |   | |   | |
| SP4: | |   | |   | |
| SP5: | |   | |   |
About this scheme
ECgene alternative splicing isoforms for L3MBTL2
1 Ensembl transcript including schematic representation: ENST00000216237
|
Expression for L3MBTL2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| L3MBTL2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for L3MBTL2
1 / 2 / 3 5 probe-sets matching L3MBTL2 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: CCTGGAGGGG
SOURCE GeneReport for Unigene cluster: Hs.517641
|
Orthologs for L3MBTL2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for L3MBTL2 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for L3MBTL2
ENSEMBL Gene Tree for L3MBTL2 | Paralogs for L3MBTL2(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for L3MBTL2 gene
- MBTD12
|
SNPs/Variants for L3MBTL2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for L3MBTL2 (up to first 250kb)
|
Disorders & Mutations for L3MBTL2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 611865
|
Medical News for L3MBTL2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for L3MBTL2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/15 PubMed articles for L3MBTL2 gene (see all 15
):- Molecular characterization of h-l(3)mbt-like: a new member of the human mbt family. (PubMed id 11682070)2, 3, 4 Wismar J. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)3, 4 Collins J.E.... Dunham I. (2004)
- A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. (PubMed id 12004135)3, 4 Ogawa H....Nakatani Y. (2002)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)3, 4 Wiemann S.... Poustka A. (2001)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)3, 4 Dunham I....O'Brien K.P. (1999)
- Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. (PubMed id 18220336)4 Cantin G.T....Yates J.R. III (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)4 Dephoure N.... Gygi S.P. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
|
Search for L3MBTL2
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing L3MBTL2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing L3MBTL2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing L3MBTL2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for L3MBTL2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for L3MBTL2:

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Incremental update: 13 Oct 2009
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