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L3MBTL Gene

protein-coding GIFtS: 54

GC20P041576

l(3)mbt-like (Drosophila)
(Previous name: l(3)mbt (Drosophila)-like )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DKFZp586P1522 ^¹, ²
FLJ41181 ^²
H-L(3)MBT ^², ³
KIAA0681 ^¹, ², ³
L(3)mbt-like ^³
L3MBT ^³
L3MBTL1 ^¹, ², ³
OTTHUMP00000031024 ^²
dJ138B7.3 ^¹, ²
l(3)mbt-like ^²

Descriptions
H-l(3)mbt protein ^³
L(3)mbt protein homolog ^³
l(3)mbt (Drosophila)-like ^¹
l(3)mbt-like (Drosophila) ^²
lethal (3) malignant brain tumor l(3) ^²

External Ids
HGNC: 15905¹
Entrez Gene: 26013²
UniProtKB: Q9Y468³
Ensembl: ENSG00000185513⁷

Search outside databases for aliases for L3MBTL gene

Previous GC identifers: GC20M003219 GC20P041831 GC20P042781 GC20P042828

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for L3MBTL:

This gene encodes the homolog of a protein identified in Drosophila as a suppressor of malignant

transformation of neuroblasts and ganglion-mother cells in the optic centers of the brain. This

gene product is localized to condensed chromosomes in mitotic cells. Overexpression of this gene

in a glioma cell line results in improper nuclear segregation and cytokinesis producing

multinucleated cells. Alternatively spliced transcript variants encoding different isoforms have

been identified. [provided by RefSeq]

UniProtKB/Swiss-Prot: LMBL1_HUMAN, Q9Y468

Function: Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive

state of genes, probably via a modification of chromatin, rendering it heritably changed in its

expressibility. Participates in the ETV6-mediated repression. Probably plays a role in cell

proliferation. Overexpression induces multinucleated cells, suggesting that it is required to

accomplish normal mitosis

Gene Wiki entry for L3MBTL

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the L3MBTL gene

Entrez Gene cytogenetic band: 20q13.12 Ensembl cytogenetic band: 20q13.11 HGNC cytogenetic band: 20q13.12

L3MBTL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 20 GeneLoc Exon Structure

GeneLoc location for GC20P041576: (about GC identifiers)

Start:	41,576,467 bp from pter
End:	41,603,949 bp from pter
Size:	27,483 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000020.9 NT_011362.9

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LMBL1_HUMAN, Q9Y468 (See protein sequence)

Recommended Name: Lethal(3)malignant brain tumor-like protein

Size: 772 amino acids; 85917 Da

Subunit: Homodimer. Interacts with ETV6

Subcellular location: Nucleus. Note=Excluded from the nucleolus. Does not colocalizes with the PcG

protein BMI1, suggesting that these two proteins do not belong to the same complex

Developmental stage: In interphase cells, it is scattered throughout the nucleoplasm. In mitotic

cells, it strongly associates with condensed chromosomes from the prophase to telophase

Sequence caution: Sequence=CAC18508.1; Type=Erroneous gene model prediction;

PDB structures from and Proteopedia :

1OYX (3D)

1OZ2 (3D)

1OZ3 (3D)

2PQW (3D)

2RHI (3D)

2RHU (3D)

2RHX (3D)

2RHY (3D)

2RHZ (3D)

2RI2 (3D)

2RI3 (3D)

2RI5 (3D)

2RJC (3D)

2RJD (3D)

2RJE (3D)

2RJF (3D)

Secondary accessions: Q5H8Y8 Q8IUV7 Q9H1E6 Q9H1G5 Q9UG06 Q9UJB9 Q9Y4C9

Alternative splicing: 4 isoforms: Q9Y468-1 Q9Y468-2 Q9Y468-3 Q9Y468-4

REFSEQ proteins (2 alternative transcripts):

NP_056293.4 NP_115479.3

ENSEMBL proteins:

ENSP00000362227 ENSP00000362226 ENSP00000362225

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (L3MBTL1)
	Human Recombinant Proteins from Abnova (L3MBTL)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

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Antibodies for L3MBTL:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for L3MBTL
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (L3MBTL1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (L3MBTL)
	Novus Biologicals Antibody for L3MBTL

Assays for L3MBTL:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q9Y468

ProtoNet protein and cluster: Q9Y468

UniProtKB/Swiss-Prot: LMBL1_HUMAN, Q9Y468

Similarity: Contains 1 C2HC-type zinc finger

Similarity: Contains 3 MBT repeats

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (L3MBTL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (L3MBTL)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015478

Applied Biosystems Silencer® siRNAs for L3MBTL

Sigma-Aldrich siRNA for L3MBTL

Sigma-Aldrich shRNA for L3MBTL

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for L3MBTL
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_015478
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_015478
untagged cDNA clones in CMV expression vector (see all 3): NM_015478

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_015478

UniProtKB/Swiss-Prot: LMBL1_HUMAN, Q9Y468

Function: Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive

state of genes, probably via a modification of chromatin, rendering it heritably changed in its

expressibility. Participates in the ETV6-mediated repression. Probably plays a role in cell

proliferation. Overexpression induces multinucleated cells, suggesting that it is required to

accomplish normal mitosis

4 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	transcription factor activity	IEA	--
GO:0005515	protein binding	IPI	17540172
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for L3MBTL

5/28 Interacting proteins for L3MBTL (ENSP00000362227³ Q9Y468^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 28 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4F	P62805¹^,²	STRING (score=.865) EBI-1265089, EBI-302023 MINT-2830429
HIST1H1E	P10412¹	STRING (score=.899) EBI-1265089, EBI-358163
HIST1H4B	P62805¹^,²	EBI-1265089, EBI-302023 MINT-2830429
HIST1H4C	P62805¹^,²	EBI-1265089, EBI-302023 MINT-2830429
HIST1H4D	P62805¹^,²	EBI-1265089, EBI-302023 MINT-2830429
HIST1H4E	P62805¹^,²	EBI-1265089, EBI-302023 MINT-2830429

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2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0016568	chromatin modification	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for L3MBTL

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (L3MBTL)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (L3MBTL)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_015478

Sigma-Aldrich siRNA for L3MBTL

Sigma-Aldrich shRNA for L3MBTL

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_015478 NM_032107

REFSEQ mRNAs for L3MBTL gene (2 alternative transcripts):

NM_015478.5 NM_032107.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_015478 NM_032107

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_015478
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_015478
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_015478

Additional cDNA sequence:

AB014581.1 AK299199.1 AK308334.1 AK310345.1 BC034398.1 BC039820.1 CR596734.1 CR622260.1

11 DOTS entries:

DT.454846 DT.97787327 DT.108537 DT.40188435 DT.91759018 DT.97798646 DT.108538 DT.40308245

DT.86842861 DT.446663 DT.86846672

24/83 AceView cDNA sequences (see all 83 ):

AI223099 T24783 BU741824 BU690058 CR596734 AA907142 AA814378 NM_032107

AK123176 CR622260 BU609129 AA505406 AA778664 BM729294 BE394474 BC039820

BU849880 AI539731 NM_015478 AL110279 AA764969 AW207373 AW592566 AA584868

highest scoring ESTs for L3MBTL:

U89358 AB014581 AL110279 AW236679 BU741824 AK123176 BX435633 DB298192 AA764969 AA814378

Unigene Cluster for L3MBTL:

L(3)mbt-like (Drosophila)

Hs.709356 [show with all ESTs]

Unigene Representative Sequence: AB014581

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for L3MBTL (see all 9 )

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6	^	7	^	8a	·	8b	^	9a	·	9b	^	10	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16a	·
SP1:																	-				-												-												-
SP2:																																	-		-										-
SP3:
SP4:																	-		-		-
SP5:																											-		-		-		-		-		-

ExUns:	16b	^	17	^	18a	·	18b	^	19	^	20a	·	20b
SP1:					-
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for L3MBTL

3 Ensembl transcripts including schematic representations:

ENST00000373135 ENST00000373134 ENST00000373133

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

L3MBTL expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for L3MBTL

¹ / ² / ³

13 probe-sets matching L3MBTL gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
34244_r_at²^{, 3}	U95-A	1	1.00	1.00	0.61	0.41	U89358	0.80	0.88	0.84	1
34243_i_at²^{, 3}	U95-A	1	1.00	1.00	0.96	0.72	U89358	0.80	0.88	0.84	1
34242_at²^{, 3}	U95-A	1	1.00	1.00	0.93	1.30	AB014581	0.80	0.70	0.75	1
206822_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_015478	0.40	0.50	0.45	1
216077_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW445040	0.20	0.25	0.23	2
213837_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
210306_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U89358	0.80	0.88	0.84	1
206823_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_015478	0.40	0.50	0.45	1
206822_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
216077_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
213837_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210306_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
206823_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks L3MBTL for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCACAGGCAA

SOURCE GeneReport for Unigene cluster: Hs.709356
Expression variation in blood from EXPOLDB for L3MBTL
UniProtKB/Swiss-Prot: LMBL1_HUMAN, Q9Y468
Tissue specificity: Widely expressed. Expression is reduced in colorectal cancer cell line SW480
and promyelocytic leukemia cell line HL-60

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for L3MBTL gene from 5/6 species (see all 6 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	L3MBTL¹	--	l(3)mbt-like (Drosophila)	90.45(n) 91.69(a)	477231 XM_534423.2 XP_534423.2
chimpanzee (Pan troglodytes)	L3MBTL¹	--	l(3)mbt-like (Drosophila)	99.16(n) 98.81(a)	469947 XM_001148788.1 XP_001148788.1
rat (Rattus norvegicus)	L3mbtl¹	--	l(3)mbt-like (Drosophila)	85.14(n) 84.64(a)	311613 XM_230849.4 XP_230849.4
mouse (Mus musculus)	L3mbtl^{1, 5}	2⁵	l(3)mbt-like (Drosophila)^{1, 5}	85.26(n)¹ 84.86(a)¹	241764¹ NM_001081338.1¹ NP_001074807.1¹ AJ875399⁵ AJ875400⁵ (see all 13)
chicken (Gallus gallus)	L3MBTL¹	--	l(3)mbt-like (Drosophila)	73.2(n) 74.55(a)	419115 XM_417302.2 XP_417302.2

About this table Species with no ortholog for L3MBTL

ENSEMBL Gene Tree for L3MBTL

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for L3MBTL gene

L3MBTL4² L3MBTL3²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/193 NCBI SNPs in L3MBTL are shown (see all 193 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 91)

AB	SNP ID	Valid	Chr 20 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs6017097^1,2	A,C,F,H	41575379(+)	`AGACAC/ACCTAC`	2	--	ng5¹		7	EU EA WA NA	560
	rs1062943^1,2	C,F,H,O	41603741(+)	`TGTATC/TAGGTT`	2	--	ut3¹ ese³		17	NA EA MN EU WA	1656
	rs6017096^1,2	A,C,F,H	41574789(+)	`ATAGAT/CATTAA`	2	--	ng5¹ tfbs³		8	EU EA WA NA	774
	rs6017104^1,2	C,F,H	41596445(+)	`CGGATA/GAAGGT`	2	I/M	mis¹ ese³		9	EU EA WA NA	914
	rs6030948^1,2	C,F,H	41603139(+)	`CACTCA/GTTTGC`	2	H/R	mis¹ ut3¹ ese³		9	EU EA WA NA	916
--	rs17857202^1,2	C,F,H	41576744(+)	`CCCGAG/CCCCCG`	2	T/S	mis¹ ese³		8	EU EA WA	810
	rs2072978^1,2	C,F,H	41576238(-)	`GCCCAC/TCCCTA`	2	--	ng5¹		9	EA NA MN EU WA	832
	rs6030930^1,2	H	41575680(+)	`ACTGCC/TTTCAT`	2	--	ng5¹		4	EU EA WA	420
	rs6093849^1,2	H	41575308(+)	`CCATCC/TTTACA`	2	--	ng5¹ tfbs³		4	EU EA WA	416
	rs6124572^1,2	H	41603271(+)	`GGATCC/TTAACA`	2	--	ut3¹ ese³		4	EU EA WA	420

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HapMap Linkage Disequilibrium images for L3MBTL (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 608802

4 Novoseek disease relationships for L3MBTL gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
brain tumors	65.99	6	12588862 (2), 18256536 (2), 15334543 (1)
myeloid leukemia	61.06	3	15334543 (2)
leukemia	24.43	3	15334543 (1), 12588862 (1)
tumors	9.42	2	12588862 (1)

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/20 PubMed articles for L3MBTL gene (see all 20 ):

A human homolog of Drosophila lethal(3)malignant brain tumor (l(3)mbt) protein associates with condensed mitotic chromosomes. (PubMed id 10445843)^{1, 2, 3, 4} Koga H.... Saya H. (1999)
The human L(3)MBT Polycomb group protein is a transcriptional repressor and interacts physically and functionally with TEL (ETV6). (PubMed id 12588862)^{1, 3, 4} Boccuni P.... Nimer S.D. (2003)
L3MBTL1, a histone-methylation-dependent chromatin lock. (PubMed id 17540172)^{2, 3} Trojer P....Reinberg D. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Malignant brain tumor repeats: a three-leaved propeller architecture with ligand/peptide binding pockets. (PubMed id 12842041)^{3, 4} Wang W.K....Patel D.J. (2003)
The DNA sequence and comparative analysis of human chromosome 20. (PubMed id 11780052)^{3, 4} Deloukas P....Rogers J. (2001)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{3, 4} Ishikawa K....Ohara O. (1998)
Structural integrity and expression of the L3MBTL gene in normal and malignant hematopoietic cells. (PubMed id 15334543)^{1, 3} MacGrogan D....Nimer S.D. (2004)
Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1. (PubMed id 18408754)³ Kalakonda N....Nimer S.D. (2008)
Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger. (PubMed id 18042461)³ Li H....Patel D.J. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 26013	HGNC: 15905	AceView: L3MBTL	Ensembl:ENSG00000185513	euGenes: HUgn26013
ECgene: L3MBTL	H-InvDB: L3MBTL

(According to HUGE)
About This Section

HUGE: KIAA0681

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for L3MBTL
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for L3MBTL:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for L3MBTL-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for L3MBTL		Antibodies for L3MBTL
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for L3MBTL		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (L3MBTL)
	Antibodies (L3MBTL)
	Chimera RNAi (L3MBTL)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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	Recombinant Proteins (L3MBTL1)
	Antibodies (L3MBTL1)

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Antibodies for L3MBTL

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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L3MBTL Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for L3MBTL

Summaries
for L3MBTL

Genomic Location
for L3MBTL

Proteins
for L3MBTL

Protein Domains/
Families
for L3MBTL

Gene Function
for L3MBTL

Pathways & Interactions
for L3MBTL

Drugs & Compounds
for L3MBTL

Transcripts
for L3MBTL

Expression
for L3MBTL

Orthologs
for L3MBTL

Paralogs
for L3MBTL

SNPs/Variants
for L3MBTL

Disorders & Mutations
for L3MBTL

Medical News
for L3MBTL

Publications
for L3MBTL

Search for L3MBTL

Genome Databases showing L3MBTL

Other Databases showing L3MBTL

Specialized Databases showing L3MBTL

Licensable Technologies
for L3MBTL

Services
for L3MBTL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

L3MBTL Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor L3MBTL

Summariesfor L3MBTL

Genomic Locationfor L3MBTL

Proteinsfor L3MBTL

Protein Domains/Familiesfor L3MBTL

Gene Functionfor L3MBTL

Pathways & Interactionsfor L3MBTL

Drugs & Compoundsfor L3MBTL

Transcriptsfor L3MBTL

Expression for L3MBTL

Orthologsfor L3MBTL

Paralogsfor L3MBTL

SNPs/Variantsfor L3MBTL

Disorders & Mutationsfor L3MBTL

Medical Newsfor L3MBTL

Publicationsfor L3MBTL

Search for L3MBTL

Genome Databases showing L3MBTL

Other Databases showing L3MBTL

Specialized Databases showing L3MBTL

Licensable Technologiesfor L3MBTL

Servicesfor L3MBTL

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for L3MBTL

Summaries
for L3MBTL

Genomic Location
for L3MBTL

Proteins
for L3MBTL

Protein Domains/
Families
for L3MBTL

Gene Function
for L3MBTL

Pathways & Interactions
for L3MBTL

Drugs & Compounds
for L3MBTL

Transcripts
for L3MBTL

Expression
for L3MBTL

Orthologs
for L3MBTL

Paralogs
for L3MBTL

SNPs/Variants
for L3MBTL

Disorders & Mutations
for L3MBTL

Medical News
for L3MBTL

Publications
for L3MBTL

Licensable Technologies
for L3MBTL

Services
for L3MBTL