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Aliases for L3HYPDH Gene

Aliases for L3HYPDH Gene

  • L-3-Hydroxyproline Dehydratase (Trans-) 2 3
  • Trans-L-3-Hydroxyproline Dehydratase 2 3 4
  • C14orf149 3 4 6
  • Trans-3-Hydroxyl-L-Proline Dehydratase 3
  • Trans-3-Hydroxy-L-Proline Dehydratase 3
  • Chromosome 14 Open Reading Frame 149 2
  • Probable Proline Racemase 3
  • EC 4

External Ids for L3HYPDH Gene

Previous HGNC Symbols for L3HYPDH Gene

  • C14orf149

Previous GeneCards Identifiers for L3HYPDH Gene

  • GC14M059939
  • GC14M059928

Summaries for L3HYPDH Gene

GeneCards Summary for L3HYPDH Gene

L3HYPDH (L-3-Hydroxyproline Dehydratase (Trans-)) is a Protein Coding gene. GO annotations related to this gene include hydro-lyase activity and trans-L-3-hydroxyproline dehydratase activity.

UniProtKB/Swiss-Prot for L3HYPDH Gene

  • Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for L3HYPDH Gene

Genomics for L3HYPDH Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for L3HYPDH Gene

59,458,966 bp from pter
59,484,473 bp from pter
25,508 bases
Minus strand

Genomic View for L3HYPDH Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for L3HYPDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for L3HYPDH Gene

No data available for Regulatory Elements for L3HYPDH Gene

Proteins for L3HYPDH Gene

  • Protein details for L3HYPDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trans-3-hydroxy-L-proline dehydratase
    Protein Accession:
    Secondary Accessions:
    • Q96LJ5

    Protein attributes for L3HYPDH Gene

    354 amino acids
    Molecular mass:
    38138 Da
    Quaternary structure:
    • Homodimer.
    • In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity.

neXtProt entry for L3HYPDH Gene

Proteomics data for L3HYPDH Gene at MOPED

Post-translational modifications for L3HYPDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for L3HYPDH Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for L3HYPDH Gene

Domains for L3HYPDH Gene

Protein Domains for L3HYPDH Gene


Graphical View of Domain Structure for InterPro Entry



  • Q96EM0
  • Belongs to the proline racemase family.
genes like me logo Genes that share domains with L3HYPDH: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for L3HYPDH Gene

Function for L3HYPDH Gene

Molecular function for L3HYPDH Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=7.23 mM for trans-3-hydroxy-L-proline {ECO:0000269 PubMed:22528483}; Vmax=39.5 umol/min/mg enzyme {ECO:0000269 PubMed:22528483}; pH dependence: Optimum pH is 8.0. {ECO:0000269 PubMed:22528483};
UniProtKB/Swiss-Prot CatalyticActivity: Trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H(2)O.
UniProtKB/Swiss-Prot Function: Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.

Enzyme Numbers (IUBMB) for L3HYPDH Gene

Gene Ontology (GO) - Molecular Function for L3HYPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016836 hydro-lyase activity IDA 22528483
GO:0018112 NOT proline racemase activity IDA 22528483
GO:0050346 trans-L-3-hydroxyproline dehydratase activity IEA --
genes like me logo Genes that share ontologies with L3HYPDH: view

Phenotypes for L3HYPDH Gene

genes like me logo Genes that share phenotypes with L3HYPDH: view

Animal Model Products

CRISPR Products

miRNA for L3HYPDH Gene

miRTarBase miRNAs that target L3HYPDH

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for L3HYPDH

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for L3HYPDH Gene

Localization for L3HYPDH Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for L3HYPDH Gene

Pathways for L3HYPDH Gene

SuperPathways for L3HYPDH Gene

No Data Available

Interacting Proteins for L3HYPDH Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000247194 for L3HYPDH Gene via STRING

Gene Ontology (GO) - Biological Process for L3HYPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IDA 22528483
genes like me logo Genes that share ontologies with L3HYPDH: view

No data available for Pathways by source for L3HYPDH Gene

Transcripts for L3HYPDH Gene

Unigene Clusters for L3HYPDH Gene

L-3-hydroxyproline dehydratase (trans-):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for L3HYPDH

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for L3HYPDH Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - -
SP4: -

Relevant External Links for L3HYPDH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for L3HYPDH Gene

mRNA expression in normal human tissues for L3HYPDH Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for L3HYPDH Gene

SOURCE GeneReport for Unigene cluster for L3HYPDH Gene Hs.729061

mRNA Expression by UniProt/SwissProt for L3HYPDH Gene

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expressions with L3HYPDH: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for L3HYPDH Gene

Orthologs for L3HYPDH Gene

This gene was present in the common ancestor of chordates.

Orthologs for L3HYPDH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C14ORF149 36
  • 99 (a)
  • 99.25 (n)
  • 99.04 (a)
(Bos Taurus)
Mammalia L3HYPDH 35
  • 88.79 (n)
  • 90.4 (a)
  • 90 (a)
(Canis familiaris)
Mammalia L3HYPDH 35
  • 90.3 (n)
  • 92.37 (a)
  • 86 (a)
(Mus musculus)
Mammalia L3hypdh 35
  • 83.71 (n)
  • 88.98 (a)
L3hypdh 16
L3hypdh 36
  • 89 (a)
(Monodelphis domestica)
Mammalia L3HYPDH 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia L3HYPDH 36
  • 72 (a)
(Rattus norvegicus)
Mammalia L3hypdh 35
  • 84.56 (n)
  • 89.83 (a)
(Gallus gallus)
Aves C14ORF149 35
  • 68.6 (n)
  • 68.9 (a)
  • 64 (a)
(Anolis carolinensis)
Reptilia L3HYPDH 36
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia l3hypdh 35
  • 70.46 (n)
  • 71.72 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4463 35
(Danio rerio)
Actinopterygii CABZ01039235.1 36
  • 71 (a)
LOC565785 35
  • 66.76 (n)
  • 71.3 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 40 (a)
-- 36
  • 50 (a)
Species with no ortholog for L3HYPDH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for L3HYPDH Gene

Gene Tree for L3HYPDH (if available)
Gene Tree for L3HYPDH (if available)

Paralogs for L3HYPDH Gene

No data available for Paralogs for L3HYPDH Gene

Variants for L3HYPDH Gene

Sequence variations from dbSNP and Humsavar for L3HYPDH Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs8660 - 59,473,009(-) TTATA(A/G)TAGAA reference, missense, intron-variant
rs10148 -- 59,472,963(+) GAAGA(A/T)GTCAC utr-variant-3-prime, intron-variant
rs723873 -- 59,481,633(-) ctcgt(A/C)tcttc intron-variant
rs1034028 -- 59,478,330(+) AGGCC(A/G)AGCTG intron-variant
rs1046689 -- 59,476,187(-) GTGAA(G/T)ACCTT reference, missense, nc-transcript-variant

Relevant External Links for L3HYPDH Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for L3HYPDH Gene

Disorders for L3HYPDH Gene

No disorders were found for L3HYPDH Gene.

No data available for UniProtKB/Swiss-Prot for L3HYPDH Gene

Publications for L3HYPDH Gene

  1. Identification of a human trans-3-Hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes. (PMID: 22528483) Visser W.F. … de Koning T.J. (J. Biol. Chem. 2012) 2 3 4
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for L3HYPDH Gene

Sources for L3HYPDH Gene

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