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Aliases for L3HYPDH Gene

Aliases for L3HYPDH Gene

  • Trans-L-3-Hydroxyproline Dehydratase 2 3 4 5
  • L-3-Hydroxyproline Dehydratase (Trans-) 2 3
  • C14orf149 3 4
  • Trans-3-Hydroxyl-L-Proline Dehydratase 3
  • Trans-3-Hydroxy-L-Proline Dehydratase 3
  • Chromosome 14 Open Reading Frame 149 2
  • EC 4

External Ids for L3HYPDH Gene

Previous HGNC Symbols for L3HYPDH Gene

  • C14orf149

Previous GeneCards Identifiers for L3HYPDH Gene

  • GC14M059939
  • GC14M059928

Summaries for L3HYPDH Gene

Entrez Gene Summary for L3HYPDH Gene

  • The protein encoded by this gene is a dehydratase that converts trans-3-hydroxy-L-proline to delta(1)-pyrroline-2-carboxylate. This enzyme may function to degrade dietary proteins that contain trans-3-hydroxy-L-proline as well as other proteins such as collagen IV. The encoded protein can be converted to an epimerase by changing a threonine to a cysteine at a catalytic site. [provided by RefSeq, Sep 2016]

GeneCards Summary for L3HYPDH Gene

L3HYPDH (Trans-L-3-Hydroxyproline Dehydratase) is a Protein Coding gene. Among its related pathways are Arginine and proline metabolism. GO annotations related to this gene include hydro-lyase activity and trans-L-3-hydroxyproline dehydratase activity.

UniProtKB/Swiss-Prot for L3HYPDH Gene

  • Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for L3HYPDH Gene

Genomics for L3HYPDH Gene

Regulatory Elements for L3HYPDH Gene

Enhancers for L3HYPDH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F059405 1.3 FANTOM5 Ensembl ENCODE 29.9 +77.3 77252 2.6 SOX13 ELF3 TFAP4 JUN RAD21 GATA4 NCOR1 FOS CREM MAFK L3HYPDH JKAMP RTN1 DAAM1 RBM8B GC14P059386 PIR32681
GH14F059563 0.7 ENCODE 47.9 -81.1 -81088 3.2 PKNOX1 FEZF1 ZIC2 ZFP69B OSR2 ZNF692 SCRT2 ZNF341 ZNF600 FOXP2 L3HYPDH JKAMP RTN1 DAAM1 DHRS7 CCDC175 ENSG00000258782
GH14F059510 0.6 ENCODE 52.1 -27.2 -27225 2.4 CTCF ZNF654 HLF ZIC2 ZNF652 ZNF2 RAD21 L3HYPDH CCDC175 JKAMP ENSG00000258782
GH14F059453 0.6 ENCODE 50.3 +29.5 29519 2.1 JUND ATF4 ZBTB48 CEBPB CREB1 FOS L3HYPDH JKAMP DAAM1 PIR32681 GC14P059386
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around L3HYPDH on UCSC Golden Path with GeneCards custom track

Promoters for L3HYPDH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for L3HYPDH Gene

59,460,363 bp from pter
59,484,438 bp from pter
24,076 bases
Minus strand

Genomic View for L3HYPDH Gene

Genes around L3HYPDH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
L3HYPDH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for L3HYPDH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for L3HYPDH Gene

Proteins for L3HYPDH Gene

  • Protein details for L3HYPDH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Trans-3-hydroxy-L-proline dehydratase
    Protein Accession:
    Secondary Accessions:
    • Q96LJ5

    Protein attributes for L3HYPDH Gene

    354 amino acids
    Molecular mass:
    38138 Da
    Quaternary structure:
    • Homodimer.
    • In contrast to the T.cruzi proline racemase enzyme, lacks the conserved Cys at position 273 which is replaced by a Thr residue, transforming the racemase activity into dehydratase activity.

neXtProt entry for L3HYPDH Gene

Post-translational modifications for L3HYPDH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for L3HYPDH Gene

Domains & Families for L3HYPDH Gene

Protein Domains for L3HYPDH Gene


Suggested Antigen Peptide Sequences for L3HYPDH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the proline racemase family.
  • Belongs to the proline racemase family.
genes like me logo Genes that share domains with L3HYPDH: view

No data available for Gene Families for L3HYPDH Gene

Function for L3HYPDH Gene

Molecular function for L3HYPDH Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=7.23 mM for trans-3-hydroxy-L-proline {ECO:0000269 PubMed:22528483}; Vmax=39.5 umol/min/mg enzyme {ECO:0000269 PubMed:22528483}; pH dependence: Optimum pH is 8.0. {ECO:0000269 PubMed:22528483};
UniProtKB/Swiss-Prot CatalyticActivity:
Trans-3-hydroxy-L-proline = 1-pyrroline 2-carboxylate + H(2)O.
UniProtKB/Swiss-Prot Function:
Catalyzes the dehydration of trans-3-hydroxy-L-proline to Delta(1)-pyrroline-2-carboxylate (Pyr2C). May be required to degrade trans-3-hydroxy-L-proline from the diet and originating from the degradation of proteins such as collagen-IV that contain it.

Enzyme Numbers (IUBMB) for L3HYPDH Gene

Gene Ontology (GO) - Molecular Function for L3HYPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016829 lyase activity IEA --
GO:0016836 hydro-lyase activity IDA 22528483
GO:0018112 NOT proline racemase activity IDA 22528483
GO:0050346 trans-L-3-hydroxyproline dehydratase activity IEA --
genes like me logo Genes that share ontologies with L3HYPDH: view
genes like me logo Genes that share phenotypes with L3HYPDH: view

Animal Model Products

miRNA for L3HYPDH Gene

miRTarBase miRNAs that target L3HYPDH

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for L3HYPDH Gene

Localization for L3HYPDH Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for L3HYPDH gene
Compartment Confidence
nucleus 3
peroxisome 2
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for L3HYPDH Gene

Pathways & Interactions for L3HYPDH Gene

genes like me logo Genes that share pathways with L3HYPDH: view

Pathways by source for L3HYPDH Gene

1 KEGG pathway for L3HYPDH Gene

Interacting Proteins for L3HYPDH Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000247194 Q96EM0-T3HPD_HUMAN for L3HYPDH Gene via STRING IID

Gene Ontology (GO) - Biological Process for L3HYPDH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IDA 22528483
genes like me logo Genes that share ontologies with L3HYPDH: view

No data available for SIGNOR curated interactions for L3HYPDH Gene

Drugs & Compounds for L3HYPDH Gene

(3) Drugs for L3HYPDH Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target 0
Water Approved Pharma 0
D-Proline Experimental Pharma 0

(1) Additional Compounds for L3HYPDH Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with L3HYPDH: view

Transcripts for L3HYPDH Gene

Unigene Clusters for L3HYPDH Gene

L-3-hydroxyproline dehydratase (trans-):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for L3HYPDH Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - - - - - -
SP2: - -
SP4: -

Relevant External Links for L3HYPDH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for L3HYPDH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for L3HYPDH Gene

Protein differential expression in normal tissues from HIPED for L3HYPDH Gene

This gene is overexpressed in Nasopharynx (8.4), Uterus (6.9), and Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for L3HYPDH Gene

NURSA nuclear receptor signaling pathways regulating expression of L3HYPDH Gene:


SOURCE GeneReport for Unigene cluster for L3HYPDH Gene:


mRNA Expression by UniProt/SwissProt for L3HYPDH Gene:

Tissue specificity: Ubiquitously expressed.
genes like me logo Genes that share expression patterns with L3HYPDH: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for L3HYPDH Gene

Orthologs for L3HYPDH Gene

This gene was present in the common ancestor of chordates.

Orthologs for L3HYPDH Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia L3HYPDH 34
  • 99.25 (n)
C14ORF149 35
  • 99 (a)
(Canis familiaris)
Mammalia L3HYPDH 34 35
  • 90.3 (n)
(Bos Taurus)
Mammalia L3HYPDH 34 35
  • 88.79 (n)
(Rattus norvegicus)
Mammalia L3hypdh 34
  • 84.56 (n)
(Mus musculus)
Mammalia L3hypdh 34 16 35
  • 83.71 (n)
(Monodelphis domestica)
Mammalia L3HYPDH 35
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia L3HYPDH 35
  • 72 (a)
(Gallus gallus)
Aves C14ORF149 34
  • 68.6 (n)
  • 64 (a)
(Anolis carolinensis)
Reptilia L3HYPDH 35
  • 59 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia l3hypdh 34
  • 70.46 (n)
(Danio rerio)
Actinopterygii CABZ01039235.1 35
  • 71 (a)
LOC565785 34
  • 66.76 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4463 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
-- 35
  • 40 (a)
Species where no ortholog for L3HYPDH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for L3HYPDH Gene

Gene Tree for L3HYPDH (if available)
Gene Tree for L3HYPDH (if available)

Paralogs for L3HYPDH Gene

No data available for Paralogs for L3HYPDH Gene

Variants for L3HYPDH Gene

Sequence variations from dbSNP and Humsavar for L3HYPDH Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10134140 -- 59,477,325(+) ATTTA(C/T)ATTAA intron-variant
rs10139134 -- 59,483,223(+) GGTTG(A/C)ACAGC intron-variant, upstream-variant-2KB
rs10140007 -- 59,484,560(+) TCTAG(C/T)GCTTC upstream-variant-2KB, utr-variant-5-prime
rs10144789 -- 59,481,153(+) ctgag(A/T)ttcag intron-variant
rs10147234 -- 59,483,295(+) ACATT(A/C)GTATC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for L3HYPDH Gene

Variant ID Type Subtype PubMed ID
nsv832810 CNV loss 17160897

Variation tolerance for L3HYPDH Gene

Residual Variation Intolerance Score: 80% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.04; 68.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for L3HYPDH Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for L3HYPDH Gene

Disorders for L3HYPDH Gene

Relevant External Links for L3HYPDH

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for L3HYPDH Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for L3HYPDH Gene

Publications for L3HYPDH Gene

  1. Identification of a human trans-3-Hydroxy-L-proline dehydratase, the first characterized member of a novel family of proline racemase-like enzymes. (PMID: 22528483) Visser W.F. … de Koning T.J. (J. Biol. Chem. 2012) 2 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. Identification and characterization of trans-3-hydroxy-L-proline dehydratase and Delta(1)-pyrroline-2-carboxylate reductase involved in trans-3-hydroxy-L-proline metabolism of bacteria. (PMID: 24649405) Watanabe S. … Watanabe Y. (FEBS Open Bio 2014) 4 64
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  5. Initial characterization of the human central proteome. (PMID: 21269460) Burkard T.R. … Colinge J. (BMC Syst. Biol. 2011) 4 64

Products for L3HYPDH Gene

Sources for L3HYPDH Gene

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