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Aliases for L1TD1 Gene

Aliases for L1TD1 Gene

  • LINE-1 Type Transposase Domain Containing 1 2 3 5
  • ES Cell-Associated Protein 11 3 4
  • ECAT11 3 4

External Ids for L1TD1 Gene

Previous GeneCards Identifiers for L1TD1 Gene

  • GC01P062434
  • GC01P062660
  • GC01P060773

Summaries for L1TD1 Gene

GeneCards Summary for L1TD1 Gene

L1TD1 (LINE-1 Type Transposase Domain Containing 1) is a Protein Coding gene. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and signal transducer activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for L1TD1 Gene

Genomics for L1TD1 Gene

Regulatory Elements for L1TD1 Gene

Enhancers for L1TD1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around L1TD1 on UCSC Golden Path with GeneCards custom track

Promoters for L1TD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around L1TD1 on UCSC Golden Path with GeneCards custom track

Genomic Location for L1TD1 Gene

Chromosome:
1
Start:
62,194,802 bp from pter
End:
62,212,328 bp from pter
Size:
17,527 bases
Orientation:
Plus strand

Genomic View for L1TD1 Gene

Genes around L1TD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
L1TD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for L1TD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for L1TD1 Gene

Proteins for L1TD1 Gene

  • Protein details for L1TD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7N2-LITD1_HUMAN
    Recommended name:
    LINE-1 type transposase domain-containing protein 1
    Protein Accession:
    Q5T7N2
    Secondary Accessions:
    • Q8NDA1
    • Q9NUV8
    • Q9NV78

    Protein attributes for L1TD1 Gene

    Size:
    865 amino acids
    Molecular mass:
    98850 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA91878.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91878.1; Type=Erroneous termination; Positions=555; Note=Translated as Leu.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for L1TD1 Gene

neXtProt entry for L1TD1 Gene

Proteomics data for L1TD1 Gene at MOPED

Post-translational modifications for L1TD1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for L1TD1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for L1TD1 Gene

Domains & Families for L1TD1 Gene

Protein Domains for L1TD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for L1TD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T7N2

UniProtKB/Swiss-Prot:

LITD1_HUMAN :
  • Belongs to the transposase 22 family.
Family:
  • Belongs to the transposase 22 family.
genes like me logo Genes that share domains with L1TD1: view

No data available for Gene Families for L1TD1 Gene

Function for L1TD1 Gene

genes like me logo Genes that share phenotypes with L1TD1: view

Animal Model Products

miRNA for L1TD1 Gene

miRTarBase miRNAs that target L1TD1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for L1TD1 Gene

Localization for L1TD1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for L1TD1 Gene COMPARTMENTS Subcellular localization image for L1TD1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for L1TD1 Gene

Pathways & Interactions for L1TD1 Gene

SuperPathways for L1TD1 Gene

No Data Available

Interacting Proteins for L1TD1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000419901%0d%0a9606.ENSP00000259915%0d%0a
Selected Interacting proteins: Q5T7N2-LITD1_HUMAN ENSP00000419901 for L1TD1 Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for L1TD1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for L1TD1 Gene

Drugs & Compounds for L1TD1 Gene

No Compound Related Data Available

Transcripts for L1TD1 Gene

mRNA/cDNA for L1TD1 Gene

Unigene Clusters for L1TD1 Gene

LINE-1 type transposase domain containing 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for L1TD1 Gene

No ASD Table

Relevant External Links for L1TD1 Gene

GeneLoc Exon Structure for
L1TD1
ECgene alternative splicing isoforms for
L1TD1

Expression for L1TD1 Gene

mRNA expression in normal human tissues for L1TD1 Gene

mRNA differential expression in normal tissues according to GTEx for L1TD1 Gene

This gene is overexpressed in Testis (x12.1), Colon - Transverse (x10.7), and Nerve - Tibial (x4.3).

Protein differential expression in normal tissues from HIPED for L1TD1 Gene

This gene is overexpressed in Cervix (27.4), Prostate (12.3), Testis (10.5), and Plasma (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for L1TD1 Gene



SOURCE GeneReport for Unigene cluster for L1TD1 Gene Hs.685462

genes like me logo Genes that share expression patterns with L1TD1: view

Protein tissue co-expression partners for L1TD1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for L1TD1 Gene

Orthologs for L1TD1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for L1TD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia L1TD1 35
  • 99.03 (n)
  • 98.15 (a)
L1TD1 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 22 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 15 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 21 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 17 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 27 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 28 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 24 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 25 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 30 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
-- 36
  • 26 (a)
OneToMany
mouse
(Mus musculus)
Mammalia L1td1 36
  • 48 (a)
OneToOne
Species with no ortholog for L1TD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for L1TD1 Gene

ENSEMBL:
Gene Tree for L1TD1 (if available)
TreeFam:
Gene Tree for L1TD1 (if available)

Paralogs for L1TD1 Gene

(1) SIMAP similar genes for L1TD1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for L1TD1 Gene

genes like me logo Genes that share paralogs with L1TD1: view

No data available for Paralogs for L1TD1 Gene

Variants for L1TD1 Gene

Sequence variations from dbSNP and Humsavar for L1TD1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs7552335 - 62,206,709(+) aaaag(A/T)gagca reference, missense
rs7542665 - 62,207,365(+) cctgg(C/T)agccg reference, missense
rs7533274 - 62,207,553(+) cttct(A/G)tgaaa reference, missense
rs2457828 - 62,207,615(-) ccata(G/T)tttct reference, missense
rs11207933 - 62,210,419(+) GCACA(A/C)CCTGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for L1TD1 Gene

Variant ID Type Subtype PubMed ID
nsv870842 CNV Gain 21882294

Variation tolerance for L1TD1 Gene

Gene Damage Index Score: 6.21; 76.06% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for L1TD1 Gene

HapMap Linkage Disequilibrium report
L1TD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for L1TD1 Gene

Disorders for L1TD1 Gene

Relevant External Links for L1TD1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
L1TD1

No disorders were found for L1TD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for L1TD1 Gene

Publications for L1TD1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The L1TD1 protein interactome reveals the importance of post-transcriptional regulation in human pluripotency. (PMID: 25702638) Emani M.R. … Lahesmaa R. (Stem Cell Reports 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. DNA methylation levels of SOCS1 and LINE-1 in oral epithelial cells from aggressive periodontitis patients. (PMID: 24769218) Baptista N.B. … Andia D.C. (Arch. Oral Biol. 2014) 3

Products for L1TD1 Gene

Sources for L1TD1 Gene

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