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L1TD1 Gene

protein-coding GIFtS: 41

GC01P062434

LINE-1 type transposase domain containing 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
ECAT11 ^¹, ², ³
FLJ10884 ^¹, ²
MGC133253 ^²
OTTHUMP00000010477 ^²
RP5-1155K23.3 ^²

Descriptions
ES cell-associated protein 11 ^³
LINE-1 type transposase domain containing 1 ^²

External Ids
HGNC: 25595¹
Entrez Gene: 54596²
UniProtKB: Q5T7N2³
Ensembl: ENSG00000162606⁷

Search outside databases for aliases for L1TD1 gene

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the L1TD1 gene

Entrez Gene cytogenetic band: 1p31.3 Ensembl cytogenetic band: 1p31.3 HGNC cytogenetic band: 1p31.3

L1TD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P062434: (about GC identifiers)

Start:	62,433,084 bp from pter
End:	62,450,588 bp from pter
Size:	17,505 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_032977.8

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: LITD1_HUMAN, Q5T7N2 (See protein sequence)

Recommended Name: LINE-1 type transposase domain-containing protein 1

Size: 865 amino acids; 98850 Da

Sequence caution: Sequence=BAA91878.1; Type=Erroneous initiation; Note=Translation N-terminally

extended; Sequence=BAA91878.1; Type=Erroneous termination; Positions=555; Note=Translated as Leu;

Secondary accessions: Q8NDA1 Q9NUV8 Q9NV78

REFSEQ proteins: NP_061952.3

ENSEMBL proteins:

ENSP00000360197

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich AQUA Peptides for L1TD1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

Antibodies for L1TD1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for L1TD1

Assays for L1TD1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q5T7N2

ProtoNet protein and cluster: Q5T7N2

UniProtKB/Swiss-Prot: LITD1_HUMAN, Q5T7N2

Similarity: Belongs to the transposase 22 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (L1TD1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019079

Applied Biosystems Silencer® siRNAs for L1TD1

Sigma-Aldrich siRNA for L1TD1

Sigma-Aldrich shRNA for L1TD1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_019079
Myc/DDK tagged cDNA clone in CMV expression vector: NM_019079
untagged cDNA clone in CMV expression vector: NM_019079

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_019079

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Interacting protein for L1TD1 (Q5T7N2²) via UniProtKB, MINT, and/or STRING
Interactant Interaction Details
GeneCard External ID(s)
ZNF512B Q96KM6² MINT-60792
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for L1TD1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (L1TD1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_019079

Sigma-Aldrich siRNA for L1TD1

Sigma-Aldrich shRNA for L1TD1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_019079

REFSEQ mRNAs for L1TD1 gene:

NM_019079.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_019079

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_019079
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_019079
                                 untagged cDNA clone in CMV expression vector: NM_019079

Additional cDNA sequence:

AB211065.1 AK001746.1 AK001973.1 AL834314.1 BC012555.1 BC060808.1 BC111559.1

2 DOTS entries:

DT.40126711 DT.102830386

24/57 AceView cDNA sequences (see all 57 ):

AA233497 AI203902 BE551580 AI699586 BF059643 AI337030 BF059639 AW025668

BX281360 BX382229 AW291177 NM_019079 AI918848 AI656788 CK141566 AU133378

AI656240 AI650468 AW590091 AL834314 CB988408 AA933744 CD642516 BE464080

highest scoring ESTs for L1TD1:

AI650468 AI306146 AI337030 AI341793 AI638202 AI656240 AI656788 AI699586 AI918848 AI964037

Unigene Cluster for L1TD1:

LINE-1 type transposase domain containing 1

Hs.685462 [show with all ESTs]

Unigene Representative Sequence: NM_019079

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for L1TD1

ExUns:	1a	·	1b	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	^	6
SP1:											-
SP2:
SP3:							-		-		-
SP4:

About this scheme

ECgene alternative splicing isoforms for L1TD1

1 Ensembl transcript including schematic representation:

ENST00000371155

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

L1TD1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for L1TD1

¹ / ² / ³

6 probe-sets matching L1TD1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
78907_at²^{, 3}	U95-D	1	1.00	1.00	1.00	1.00	AI203404	0.60	1.00	0.82	1
90544_at²^{, 3}	U95-E	1	1.00	1.00	0.29	0.20	AI650468	1.00	1.00	1.00	1
236894_at²^{, 3}	U133-B	1	1.00	1.00	--	--	AI203404	0.60	1.00	0.82	1
219955_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_019079	0.60	1.00	0.82	1
236894_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
219955_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.685462

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for L1TD1 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	L1TD1¹	--	LINE-1 type transposase domain containing 1	78.26(n) 62.65(a)	489563 XM_847457.1 XP_852550.1
rat (Rattus norvegicus)	L1td1¹	--	LINE-1 type transposase domain containing 1	63.9(n) 50.26(a)	685355 XM_001063462.1 XP_001063462.1
mouse (Mus musculus)	L1td1^{1, 5}	4⁵	LINE-1 type transposase domain containing 1^{1, 5}	62.37(n)¹ 50.06(a)¹	381591¹ NM_001081202.1¹ NP_001074671.1¹ AA546746⁵ AB211064⁵ (see all 10)

About this table Species with no ortholog for L1TD1

ENSEMBL Gene Tree for L1TD1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/209 NCBI SNPs in L1TD1 are shown (see all 209 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 44)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs7533274^1,2	A,C,F,H	62445813(+)	`cttctG/Atgaaa`	1	M/V	mis¹ ese³		8	EU EA WA	838
	rs7552335^1,2	A,C,F,H	62444969(+)	`aaaagA/Tgagca`	1	R/S	mis¹ trp³		11	EU EA WA NA	978
--	rs2886644^1,2	A,C,F,H	62448872(+)	`ggaaaC/Tagaag`	1	T/I	mis¹ ese³		8	EU EA WA	832
--	rs1056517^1,2	A,C,F,H	62449636(+)	`AGCACG/TCCAGG`	1	--	ut3¹ ese³		4	MN EU EA	446
	rs7542665^1,2	A,C,F,H	62445625(+)	`cctggT/Cagccg`	1	A/V	mis¹ ese³		8	EU EA WA	838
	rs11207936^1,2	A,C,F,H	62450311(+)	`GTCAAT/CGTAGT`	1	--	ut3¹		4	EU EA WA	420
	rs2457828^1,2	A,C,F,H	62445875(-)	`ccataT/Gtttct`	1	N/K	mis¹ trp³		11	EU EA WA NA	980
--	rs11207933^1,2	C,F,H	62448679(+)	`GCACAC/ACCTGT`	1	T/P	mis¹ ese³		8	EU EA WA	828
	rs12143736^1,2	C,F,H	62431368(+)	`tcttaG/Cgtttt`	1	--	ng5¹		8	EU EA WA	836
--	rs11207934^1,2	F,H	62449612(+)	`AATTAC/GTGGGG`	1	L/V	mis¹ ese³		4	EU EA WA	382

About this table

HapMap Linkage Disequilibrium images for L1TD1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

9 PubMed articles for L1TD1 gene:

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{3, 4} Ota T....Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{2, 3} Strausberg R.L....Marra M.A. (2002)
LINE-1 hypomethylation is associated with increased CpG island methylation in Helicobacter pylori-related enlarged-fold gastritis. (PubMed id 18842996)³ Yamamoto E....Shinomura Y. (2008)
The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)⁴ Bechtel S....Schupp I. (2007)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)⁴ Gregory S.G.... Bentley D.R. (2006)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)³ Brandenberger R.... Stanton L.W. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)³ Bonaldo M.F....Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 54596	HGNC: 25595	AceView: FLJ10884	Ensembl:ENSG00000162606	euGenes: HUgn54596
ECgene: L1TD1	H-InvDB: L1TD1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for L1TD1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for L1TD1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for L1TD1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for L1TD1		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Proteins for L1TD1
	Lentivirus-delivered shRNAs for L1TD1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Search for Chimera RNAi
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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Search OriGene for L1TD1

Search Tocris compounds for L1TD1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Search Novus for antibodies for L1TD1

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L1TD1 Gene

protein-coding GIFtS: 41

Aliases &
Descriptions
for L1TD1

Summaries
for L1TD1

Genomic Location
for L1TD1

Proteins
for L1TD1

Protein Domains/
Families
for L1TD1

Gene Function
for L1TD1

Pathways & Interactions
for L1TD1

Drugs & Compounds
for L1TD1

Transcripts
for L1TD1

Expression
for L1TD1

Orthologs
for L1TD1

Paralogs
for L1TD1

SNPs/Variants
for L1TD1

Disorders & Mutations
for L1TD1

Medical News
for L1TD1

Publications
for L1TD1

Search for L1TD1

Genome Databases showing L1TD1

Other Databases showing L1TD1

Specialized Databases showing L1TD1

Licensable Technologies
for L1TD1

Services
for L1TD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

L1TD1 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor L1TD1

Summariesfor L1TD1

Genomic Locationfor L1TD1

Proteinsfor L1TD1

Protein Domains/Familiesfor L1TD1

Gene Functionfor L1TD1

Pathways & Interactionsfor L1TD1

Drugs & Compoundsfor L1TD1

Transcriptsfor L1TD1

Expression for L1TD1

Orthologsfor L1TD1

Paralogsfor L1TD1

SNPs/Variantsfor L1TD1

Disorders & Mutationsfor L1TD1

Medical Newsfor L1TD1

Publicationsfor L1TD1

Search for L1TD1

Genome Databases showing L1TD1

Other Databases showing L1TD1

Specialized Databases showing L1TD1

Licensable Technologiesfor L1TD1

Servicesfor L1TD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for L1TD1

Summaries
for L1TD1

Genomic Location
for L1TD1

Proteins
for L1TD1

Protein Domains/
Families
for L1TD1

Gene Function
for L1TD1

Pathways & Interactions
for L1TD1

Drugs & Compounds
for L1TD1

Transcripts
for L1TD1

Expression
for L1TD1

Orthologs
for L1TD1

Paralogs
for L1TD1

SNPs/Variants
for L1TD1

Disorders & Mutations
for L1TD1

Medical News
for L1TD1

Publications
for L1TD1

Licensable Technologies
for L1TD1

Services
for L1TD1