Aliases for KYNU Gene
External Ids for KYNU Gene
Previous GeneCards Identifiers for KYNU Gene
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
GeneCards Summary for KYNU Gene
KYNU (Kynureninase) is a Protein Coding gene. Diseases associated with KYNU include hydroxykynureninuria and encephalopathy due to hydroxykynureninuria. Among its related pathways are Metabolism and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include protein homodimerization activity and kynureninase activity.
UniProtKB/Swiss-Prot for KYNU Gene
Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity