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Aliases for KYAT3 Gene

Aliases for KYAT3 Gene

  • Kynurenine Aminotransferase 3 2 3
  • CCBL2 3 4 5
  • Kynurenine--Oxoglutarate Transaminase III 3 4
  • Kynurenine--Glyoxylate Transaminase 3 4
  • Cysteine-S-Conjugate Beta-Lyase 2 3 4
  • Cysteine Conjugate Beta Lyase 2 2 3
  • Kynurenine Aminotransferase III 3 4
  • Cysteine Conjugate-Beta Lyase 2 3 5
  • KATIII 3 4
  • KAT3 3 4
  • Kynurenine--Oxoglutarate Transaminase 3 2
  • Kynurenine-Oxoglutarate Transaminase 3 3
  • RP11-82K18.3 3
  • EC 4.4.1.13 4
  • EC 2.6.1.63 4
  • EC 2.6.1.7 4

External Ids for KYAT3 Gene

Previous HGNC Symbols for KYAT3 Gene

  • CCBL2

Summaries for KYAT3 Gene

Entrez Gene Summary for KYAT3 Gene

  • This gene encodes an aminotransferase that transaminates kynurenine to form kynurenic acid. Kynurenic acid is a metabolite of tryptophan. Multiple alternatively spliced transcript variants that encode different proteins have been described for this gene. This gene shares 5' exon structure with the RNA binding motif protein, X-linked-like 1 locus on chromosome 1, but the coding sequences are non-overlapping. [provided by RefSeq, Jun 2009]

GeneCards Summary for KYAT3 Gene

KYAT3 (Kynurenine Aminotransferase 3) is a Protein Coding gene. Among its related pathways are Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism and Selenocompound metabolism. An important paralog of this gene is TAT.

UniProtKB/Swiss-Prot for KYAT3 Gene

  • Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KYAT3 Gene

Genomics for KYAT3 Gene

Regulatory Elements for KYAT3 Gene

Enhancers for KYAT3 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KYAT3 on UCSC Golden Path with GeneCards custom track

Promoters for KYAT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KYAT3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KYAT3 Gene

Chromosome:
1
Start:
88,935,773 bp from pter
End:
88,992,960 bp from pter
Size:
57,188 bases
Orientation:
Minus strand

Genomic View for KYAT3 Gene

Genes around KYAT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KYAT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KYAT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KYAT3 Gene

Proteins for KYAT3 Gene

  • Protein details for KYAT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6YP21-KAT3_HUMAN
    Recommended name:
    Kynurenine--oxoglutarate transaminase 3
    Protein Accession:
    Q6YP21
    Secondary Accessions:
    • B3KQ13
    • O95335
    • Q5JS27
    • Q5T9T7
    • Q5T9T8
    • Q6AI27
    • Q6ICW1
    • Q9BVY5

    Protein attributes for KYAT3 Gene

    Size:
    454 amino acids
    Molecular mass:
    51400 Da
    Cofactor:
    Name=pyridoxal 5-phosphate; Xref=ChEBI:CHEBI:597326;
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=AAC72959.1; Type=Frameshift; Positions=336; Evidence={ECO:0000305}; Sequence=AAH00819.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAG29278.1; Type=Frameshift; Positions=336; Evidence={ECO:0000305}; Sequence=CAI21695.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI21696.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41339.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI41340.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for KYAT3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KYAT3 Gene

Proteomics data for KYAT3 Gene at MOPED

Post-translational modifications for KYAT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KYAT3 Gene

No data available for DME Specific Peptides for KYAT3 Gene

Domains & Families for KYAT3 Gene

Graphical View of Domain Structure for InterPro Entry

Q6YP21

UniProtKB/Swiss-Prot:

KAT3_HUMAN :
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
Family:
  • Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.
genes like me logo Genes that share domains with KYAT3: view

No data available for Gene Families for KYAT3 Gene

Function for KYAT3 Gene

Molecular function for KYAT3 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
UniProtKB/Swiss-Prot CatalyticActivity:
An L-cysteine-S-conjugate + H(2)O = RSH + NH(3) + pyruvate.
UniProtKB/Swiss-Prot CatalyticActivity:
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.
UniProtKB/Swiss-Prot Function:
Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).

Enzyme Numbers (IUBMB) for KYAT3 Gene

Gene Ontology (GO) - Molecular Function for KYAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016212 kynurenine-oxoglutarate transaminase activity IEA,ISS --
GO:0030170 pyridoxal phosphate binding IEA --
genes like me logo Genes that share ontologies with KYAT3: view
genes like me logo Genes that share phenotypes with KYAT3: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KYAT3 Gene

Localization for KYAT3 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for KYAT3 Gene

Pathways & Interactions for KYAT3 Gene

genes like me logo Genes that share pathways with KYAT3: view

Gene Ontology (GO) - Biological Process for KYAT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006520 cellular amino acid metabolic process IEA,ISS --
GO:0006569 tryptophan catabolic process TAS --
GO:0009058 biosynthetic process IEA --
GO:0097052 L-kynurenine metabolic process IEA,ISS --
genes like me logo Genes that share ontologies with KYAT3: view

No data available for SIGNOR curated interactions for KYAT3 Gene

Drugs & Compounds for KYAT3 Gene

(7) Drugs for KYAT3 Gene - From: DrugBank and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Glycine Approved Nutra Full agonist, Agonist Endogenous potentiator, co-transmitter 197
L-Methionine Approved Nutra 0
Pyruvic acid Approved Nutra 0
Glyoxylic acid Experimental Pharma 0
L-Glutamic Acid Nutra Full agonist, Agonist, Target 0

(10) Additional Compounds for KYAT3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2-Oxo-4-methylthiobutanoic acid
  • 2-Keto-4-methylthiobutyrate
  • 2-Keto-4-methylthiobutyric acid
  • 2-Ketomethiobutyrate
  • 2-Oxo-4-methylthiobutanoate
  • 2-Oxo-4-methylthiobutanoic acid
583-92-6
4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
  • 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoate
  • 4-(2-Amino-3-hydroxyphenyl)-2,4-dioxobutanoic acid
4-(2-Aminophenyl)-2,4-dioxobutanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoate
  • 4-(2-Aminophenyl)-2,4-dioxo-butanoic acid
  • 4-(2-Aminophenyl)-2,4-dioxobutanoate
  • 4-(2-Aminophenyl)-2,4-dioxobutanoic acid
Ammonia
  • Ammonia anhydrous
  • Ammonia inhalant
  • Ammonia solution strong [usan]
  • Ammonia water
  • Ammoniak
7664-41-7
L-3-Hydroxykynurenine
  • 3-(2-Amino-3-hydroxybenzoyl)-L-alanine
  • 3-(3-Hydroxyanthraniloyl)-L-alanine
  • 3-Hydroxy-L-kynurenine
  • L-3-HK
606-14-4
genes like me logo Genes that share compounds with KYAT3: view

Transcripts for KYAT3 Gene

Unigene Clusters for KYAT3 Gene

Cysteine conjugate-beta lyase 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KYAT3 Gene

No ASD Table

Relevant External Links for KYAT3 Gene

GeneLoc Exon Structure for
KYAT3
ECgene alternative splicing isoforms for
KYAT3

Expression for KYAT3 Gene

SOURCE GeneReport for Unigene cluster for KYAT3 Gene Hs.481898

No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KYAT3 Gene

Orthologs for KYAT3 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KYAT3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCBL2 35
  • 91.56 (n)
  • 88.77 (a)
CCBL2 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCBL2 35
  • 91.69 (n)
  • 91.17 (a)
CCBL2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccbl2 35
  • 84.21 (n)
  • 85 (a)
Ccbl2 16
Ccbl2 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCBL2 35
  • 99.41 (n)
  • 98.9 (a)
CCBL2 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Kat3 35
  • 81.35 (n)
  • 81.28 (a)
oppossum
(Monodelphis domestica)
Mammalia CCBL2 36
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCBL2 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCBL2 35
  • 73.44 (n)
  • 72.41 (a)
CCBL2 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCBL2 36
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch73-97h19.2 35
  • 66.75 (n)
  • 67.47 (a)
ccbl2 36
  • 62 (a)
OneToMany
ccbl2 36
  • 62 (a)
OneToMany
CCBL2 (3 of 4) 36
  • 63 (a)
OneToMany
CCBL2 (4 of 4) 36
  • 52 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011158 35
  • 52.61 (n)
  • 53.29 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG6950 35
  • 53.53 (n)
  • 55.05 (a)
CG6950 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nkat-1 35
  • 53.08 (n)
  • 47.09 (a)
nkat-1 36
  • 41 (a)
ManyToMany
nkat-3 36
  • 41 (a)
ManyToMany
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F01617g 35
  • 47.57 (n)
  • 34.48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BNA3 35
  • 48.94 (n)
  • 34.84 (a)
BNA3 36
  • 31 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G77670 35
  • 50.62 (n)
  • 41.71 (a)
rice
(Oryza sativa)
Liliopsida Os09g0453800 35
  • 51.6 (n)
  • 40.91 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03347 35
  • 44.88 (n)
  • 35.63 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC6B12.04c 35
  • 46.9 (n)
  • 36.13 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 62 (a)
ManyToMany
CSA.3659 36
  • 48 (a)
ManyToMany
Species with no ortholog for KYAT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for KYAT3 Gene

ENSEMBL:
Gene Tree for KYAT3 (if available)
TreeFam:
Gene Tree for KYAT3 (if available)

Paralogs for KYAT3 Gene

Paralogs for KYAT3 Gene

genes like me logo Genes that share paralogs with KYAT3: view

Variants for KYAT3 Gene

Sequence variations from dbSNP and Humsavar for KYAT3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs14490 -- 88,935,930(-) AAGAA(A/C)TGTGA utr-variant-3-prime
rs1059370 -- 88,961,431(-) TTAAT(C/T)CCAAA reference, missense
rs1325921 -- 88,956,216(+) TGCTT(A/G)TAGTG intron-variant
rs1325922 -- 88,961,770(+) AAATG(A/G)AAAAA intron-variant
rs1325923 -- 88,949,893(+) AAGTA(C/T)AGTGG intron-variant

Variation tolerance for KYAT3 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.31; 53.31% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for KYAT3 Gene

Disorders for KYAT3 Gene

Relevant External Links for KYAT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KYAT3

No disorders were found for KYAT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KYAT3 Gene

Publications for KYAT3 Gene

  1. Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family. (PMID: 16376499) Yu P. … Cai T. (Gene 2006) 2 3 4 23 67
  2. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  3. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3

Products for KYAT3 Gene

Sources for KYAT3 Gene

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