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Aliases for KY Gene

Aliases for KY Gene

  • Kyphoscoliosis Peptidase 2 3
  • EC 3.4.-.- 4

External Ids for KY Gene

Previous GeneCards Identifiers for KY Gene

  • GC03M135644
  • GC03M135804
  • GC03M134318
  • GC03M131695

Summaries for KY Gene

GeneCards Summary for KY Gene

KY (Kyphoscoliosis Peptidase) is a Protein Coding gene. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot for KY Gene

  • Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KY Gene

Genomics for KY Gene

Regulatory Elements for KY Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KY Gene

Start:
134,599,923 bp from pter
End:
134,651,680 bp from pter
Size:
51,758 bases
Orientation:
Minus strand

Genomic View for KY Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KY Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KY Gene

Proteins for KY Gene

  • Protein details for KY Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NBH2-KY_HUMAN
    Recommended name:
    Kyphoscoliosis peptidase
    Protein Accession:
    Q8NBH2
    Secondary Accessions:
    • B7Z1S4
    • Q6ZT15

    Protein attributes for KY Gene

    Size:
    561 amino acids
    Molecular mass:
    63855 Da
    Quaternary structure:
    • Interacts with IGFN1 and FLNC.

    Alternative splice isoforms for KY Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KY Gene

Proteomics data for KY Gene at MOPED

Post-translational modifications for KY Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KY Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KY Gene

Domains for KY Gene

Protein Domains for KY Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KY Gene

Graphical View of Domain Structure for InterPro Entry

Q8NBH2

UniProtKB/Swiss-Prot:

KY_HUMAN :
  • Q8NBH2
Family:
  • Belongs to the transglutaminase-like superfamily.
genes like me logo Genes that share domains with KY: view

No data available for Gene Families for KY Gene

Function for KY Gene

Molecular function for KY Gene

UniProtKB/Swiss-Prot Function: Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity).

Enzyme Numbers (IUBMB) for KY Gene

Gene Ontology (GO) - Molecular Function for KY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008233 peptidase activity IEA --
genes like me logo Genes that share ontologies with KY: view
genes like me logo Genes that share phenotypes with KY: view

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KY Gene

Localization for KY Gene

Subcellular locations from UniProtKB/Swiss-Prot for KY Gene

Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KY Gene COMPARTMENTS Subcellular localization image for KY gene
Compartment Confidence
cytoskeleton 2
cytosol 2
mitochondrion 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
GO:0030018 Z disc ISS --
genes like me logo Genes that share ontologies with KY: view

Pathways for KY Gene

SuperPathways for KY Gene

No Data Available

Gene Ontology (GO) - Biological Process for KY Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis IEA --
GO:0007517 muscle organ development IEA --
GO:0007528 neuromuscular junction development IEA --
genes like me logo Genes that share ontologies with KY: view

No data available for Pathways by source for KY Gene

Transcripts for KY Gene

Unigene Clusters for KY Gene

Kyphoscoliosis peptidase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KY

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KY Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - -
SP2: - - - - - -
SP3:

Relevant External Links for KY Gene

GeneLoc Exon Structure for
KY
ECgene alternative splicing isoforms for
KY

Expression for KY Gene

mRNA expression in normal human tissues for KY Gene

mRNA differential expression in normal tissues according to GTEx for KY Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (4.9), Pituitary (4.6), and Skin - Sun Exposed (Lower leg) (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KY Gene

SOURCE GeneReport for Unigene cluster for KY Gene Hs.146730

genes like me logo Genes that share expressions with KY: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KY Gene

Orthologs for KY Gene

This gene was present in the common ancestor of animals.

Orthologs for KY Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KY 35
  • 99.6 (n)
  • 99.7 (a)
KY 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KY 35
  • 89.56 (n)
  • 90.77 (a)
KY 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ky 35
  • 87.64 (n)
  • 90.47 (a)
Ky 16
Ky 36
  • 90 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KY 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 67 (a)
OneToMany
-- 36
  • 78 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ky 35
  • 86.14 (n)
  • 88.25 (a)
chicken
(Gallus gallus)
Aves KY 35
  • 66.3 (n)
  • 56.9 (a)
KY 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KY 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494696 35
  • 57.33 (n)
  • 47.09 (a)
zebrafish
(Danio rerio)
Actinopterygii ky 36
  • 21 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Hil 36
  • 18 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea ltd-1 36
  • 18 (a)
OneToOne
Species with no ortholog for KY:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KY Gene

ENSEMBL:
Gene Tree for KY (if available)
TreeFam:
Gene Tree for KY (if available)

Paralogs for KY Gene

No data available for Paralogs for KY Gene

Variants for KY Gene

Structural Variations from Database of Genomic Variants (DGV) for KY Gene

Variant ID Type Subtype PubMed ID
nsv877510 CNV Gain 21882294
dgv5259n71 CNV Loss 21882294
nsv829730 CNV Loss 17160897
nsv520371 CNV Loss 19592680
esv2669745 CNV Deletion 23128226

Relevant External Links for KY Gene

HapMap Linkage Disequilibrium report
KY

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for KY Gene

Disorders for KY Gene

Relevant External Links for KY

Genetic Association Database (GAD)
KY
Human Genome Epidemiology (HuGE) Navigator
KY
genes like me logo Genes that share disorders with KY: view

No data available for UniProtKB/Swiss-Prot for KY Gene

Publications for KY Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres. (PMID: 15385448) Beatham J. … Blanco G. (Hum. Mol. Genet. 2004) 3 4
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. The DNA sequence, annotation and analysis of human chromosome 3. (PMID: 16641997) Muzny D.M. … Gibbs R.A. (Nature 2006) 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for KY Gene

Sources for KY Gene

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