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KY Gene

protein-coding   GIFtS: 43
GCID: GC03M134318

Kyphoscoliosis Peptidase

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Kyphoscoliosis Peptidase1 2
EC 3.4.-.-3

External Ids:    HGNC: 265761   Entrez Gene: 3398552   Ensembl: ENSG000001746117   OMIM: 6057395   UniProtKB: Q8NBH23   

Export aliases for KY gene to outside databases

Previous GC identifers: GC03M135644 GC03M135804 GC03M131695


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KY Gene:
KY (kyphoscoliosis peptidase) is a protein-coding gene. Diseases associated with KY include muscular dystrophy. GO annotations related to this gene include peptidase activity.

UniProtKB/Swiss-Prot: KY_HUMAN, Q8NBH2
Function: Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function,
maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as
FLNC (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NT_005612.17  NC_018914.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the KY gene promoter:
         Bach1   AP-1   Tal-1   JunB   MyoD   MIF-1   E47   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKY promoter sequence
   Search Chromatin IP Primers for KY

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KY


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q22.2   Ensembl cytogenetic band:  3q22.2   HGNC cytogenetic band: 3q22.1

KY Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KY gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M134318:  view genomic region     (about GC identifiers)

Start:
134,318,765 bp from pter      End:
134,370,478 bp from pter
Size:
51,714 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: KY_HUMAN, Q8NBH2 (See protein sequence)
Recommended Name: Kyphoscoliosis peptidase  
Size: 561 amino acids; 63855 Da
Subunit: Interacts with IGFN1 and FLNC
Secondary accessions: B7Z1S4 Q6ZT15
Alternative splicing: 4 isoforms:  Q8NBH2-1   Q8NBH2-2   Q8NBH2-3   Q8NBH2-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KY: NX_Q8NBH2

Explore proteomics data for KY at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KY Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_848649.3  
    ENSEMBL proteins: 
     ENSP00000421297   ENSP00000397598   ENSP00000426777  

    KY Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for KY

    KY Assay Products:

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    Cloud-Clone Corp. ELISAs for KY
    Cloud-Clone Corp. CLIAs for KY


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002931 Transglutaminase-like

    Graphical View of Domain Structure for InterPro Entry Q8NBH2

    ProtoNet protein and cluster: Q8NBH2

    UniProtKB/Swiss-Prot: KY_HUMAN, Q8NBH2
    Similarity: Belongs to the transglutaminase-like superfamily


    KY for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KY_HUMAN, Q8NBH2
    Function: Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function,
    maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as
    FLNC (By similarity)

         Enzyme Number (IUBMB): EC 3.4.-.-1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008233peptidase activity IEA--
         
    KY for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ky):
     behavior/neurological  growth/size/body  homeostasis/metabolism  muscle  nervous system 
     reproductive system  respiratory system  skeleton 

    KY for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for KY
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for KY

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KY
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KY

    miRNA
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    Block miRNA regulation of human, mouse, rat KY using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KY (see all 51):
    hsa-miR-21* hsa-miR-15a hsa-miR-29a hsa-miR-578 hsa-miR-500a hsa-miR-3167 hsa-miR-4267 hsa-miR-424
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KY
    Predesigned siRNA for gene silencing in human, mouse, rat KY

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for KY

    Clone
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    OriGene ORF clones in mouse, rat for KY
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KY
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KY

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KY


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KY_HUMAN, Q8NBH2: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    cytosol2
    mitochondrion2
    nucleus1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005856cytoskeleton IEA--
    GO:0030018Z disc ISS--

    KY for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KY
    Interactions:

        Search GeneGlobe Interaction Network for KY

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for KY (Q8NBH23 ENSP000003975984) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FLNCQ143153, ENSP000003271454I2D: score=1 STRING: ENSP00000327145
    IGFN1Q86VF23, ENSP000003347144I2D: score=1 STRING: ENSP00000334714
    PEF1ENSP000003628074STRING: ENSP00000362807
    PSTPIP1ENSP000003689144STRING: ENSP00000368914
    PSTPIP2ENSP000003872614STRING: ENSP00000387261
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0007517muscle organ development IEA--
    GO:0007528neuromuscular junction development IEA--

    KY for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KY



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for KY gene: 
    NM_178554.4  

    Unigene Cluster for KY:

    Kyphoscoliosis peptidase
    Hs.146730  [show with all ESTs]
    Unigene Representative Sequence: NM_178554
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000508956(uc010hty.3 uc011blw.2 uc011blx.2) ENST00000423778
    ENST00000503669 ENST00000506319(uc003eqr.1 uc003eqs.1) ENST00000508041

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat KY using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate KY (see all 51):
    hsa-miR-21* hsa-miR-15a hsa-miR-29a hsa-miR-578 hsa-miR-500a hsa-miR-3167 hsa-miR-4267 hsa-miR-424
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for KY
    Predesigned siRNA for gene silencing in human, mouse, rat KY
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    OriGene ORF clones in mouse, rat for KY
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript Custom all cDNA clones Services for KY
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for KY
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat KY
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for KY
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat KY
      QuantiTect SYBR Green Assays in human, mouse, rat KY
      QuantiFast Probe-based Assays in human, mouse, rat KY

    Additional mRNA sequence: 

    AF086360.1 AK090526.1 AK126993.1 AK293840.1 AK294500.1 BC024014.1 BC037842.2 BC136349.1 

    8 DOTS entries:

    DT.430606  DT.99999815  DT.421502  DT.101979700  DT.86843623  DT.95202243  DT.120876683  DT.40115370 

    18 AceView cDNA sequences:

    AW297228 F30423 BM768793 W75935 BM768817 NM_178554 AX746495 F35670 
    AK090526 AK126993 AF086360 AI275028 BC024014 BG723082 BM856161 AI567821 
    BI025527 W73871 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for KY    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12
    SP1:                                                                          -                 -         
    SP2:        -           -                       -     -     -                 -                           
    SP3:                                                                                                      


    ECgene alternative splicing isoforms for KY

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KY expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    KY Expression
    About this image

    KY Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KY Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.146730
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KY

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KY gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ky1 , 5 kyphoscoliosis peptidase1, 5 87.64(n)1
    90.47(a)1
      9 (54.54 cM)5
    167161  NM_024291.31  NP_077253.31 
     1025061385 
    chicken
    (Gallus gallus)
    Aves KY1 kyphoscoliosis peptidase 66.3(n)
    56.9(a)
      429137  XM_426693.4  XP_426693.3 
    lizard
    (Anolis carolinensis)
    Reptilia KY6
    kyphoscoliosis peptidase
    58(a)
    1 ↔ 1
    3(31500331-31540989)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004946961 kyphoscoliosis peptidase-like 57.33(n)
    47.09(a)
      100494696  XM_002935077.2  XP_002935123.2 
    zebrafish
    (Danio rerio)
    Actinopterygii ky6
    kyphoscoliosis peptidase
    21(a)
    1 ↔ 1
    13(13604215-13617398) ENSDARG00000074036
    fruit fly
    (Drosophila melanogaster)
    Insecta Hil6
    Hillarin
    18(a)
    1 ↔ 1
    2R(16494386-16505719)
    worm
    (Caenorhabditis elegans)
    Secernentea ltd-16
    Protein LTD-1 (ltd-1) mRNA, complete cds
    18(a)
    1 ↔ 1
    II(8088494-8092754) WBGene00003089


    ENSEMBL Gene Tree for KY (if available)
    TreeFam Gene Tree for KY (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KY (see all 1022)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1919994651,2
    Cuntested1134339675(+) CAGTTC/TGTCTA 2 K E mis10--------
    rs350847721,2
    C--134311932(+) TGTGT-/G/GT/GT
    GT
    /GTGTGT
    TGCCT
    2 -- int1 cds10--------
    rs45961891,2
    C,H--134318577(+) AACCTA/GATTAT 1 -- int113Minor allele frequency- G:0.01NA WA CSA EA 380
    rs1410680761,2
    --134318625(+) CCATTC/TGCATC 1 -- int10--------
    rs1925481851,2
    --134318636(+) TCACCA/GTCGCA 1 -- int10--------
    rs1448797651,2
    --134318824(+) AGAAAG/TCATAC 1 -- ut310--------
    rs1474601021,2
    C--134318842(+) CCACCA/GGCCCA 1 -- ut310--------
    rs747257031,2
    C,F--134318849(+) CCCACA/GCAACT 1 -- ut311Minor allele frequency- G:0.13EA 120
    rs1398355341,2
    --134318897(+) TTGCCG/TACTAC 1 -- ut310--------
    rs1841851471,2
    --134318993(+) GCAAAC/TGATGT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for KY (134318765 - 134370478 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for KY:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2669745CNV Deletion23128226
    nsv829730CNV Loss17160897
    dgv5259n71CNV Loss21882294
    nsv520371CNV Loss19592680
    nsv877510CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing KY
    DNA2.0 Custom Variant and Variant Library Synthesis for KY

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605739    OMIM disorders: --

    1 disease for KY:    
    About MalaCards
    muscular dystrophy


    KY for disorders           About GeneDecksing

    Genetic Association Database (GAD): KY
    Human Genome Epidemiology (HuGE) Navigator: KY (303 documents)

    Export disorders for KY gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KY gene integrated from 10 sources:
    (articles sorted by number of sources associating them with KY)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Filamin C interacts with the muscular dystrophy KY protein and is abnormally distributed in mouse KY deficient muscle fibres. (PubMed id 15385448)1, 2 Beatham J....Blanco G. (Hum. Mol. Genet. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 339855 HGNC: 26576 AceView: KY Ensembl:ENSG00000174611 euGenes: HUgn339855
    ECgene: KY H-InvDB: KY

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KY Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KY gene:
    Search GeneIP for patents involving KY

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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