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Aliases for KTN1 Gene

Aliases for KTN1 Gene

  • Kinectin 1 2 3 5
  • Kinectin 1 (Kinesin Receptor) 2 3
  • Kinesin Receptor 3 4
  • CG-1 Antigen 3 4
  • CG1 3 4
  • MU-RMS-40.19 3
  • KIAA0004 4
  • KNT 3

External Ids for KTN1 Gene

Previous GeneCards Identifiers for KTN1 Gene

  • GC14P053370
  • GC14P049842
  • GC14P054037
  • GC14P055116
  • GC14P056046
  • GC14P036232

Summaries for KTN1 Gene

Entrez Gene Summary for KTN1 Gene

  • This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for KTN1 Gene

KTN1 (Kinectin 1) is a Protein Coding gene. Among its related pathways are Signaling by Rho GTPases and RHO GTPases activate KTN1. GO annotations related to this gene include poly(A) RNA binding and kinesin binding. An important paralog of this gene is RRBP1.

UniProtKB/Swiss-Prot for KTN1 Gene

  • Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.

Gene Wiki entry for KTN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KTN1 Gene

Genomics for KTN1 Gene

Regulatory Elements for KTN1 Gene

Enhancers for KTN1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KTN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KTN1 Gene

Chromosome:
14
Start:
55,559,072 bp from pter
End:
55,701,526 bp from pter
Size:
142,455 bases
Orientation:
Plus strand

Genomic View for KTN1 Gene

Genes around KTN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KTN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KTN1 Gene

Proteins for KTN1 Gene

  • Protein details for KTN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UP2-KTN1_HUMAN
    Recommended name:
    Kinectin
    Protein Accession:
    Q86UP2
    Secondary Accessions:
    • B4DZ88
    • Q13999
    • Q14707
    • Q15387
    • Q17RZ5
    • Q5GGW3
    • Q86W57

    Protein attributes for KTN1 Gene

    Size:
    1357 amino acids
    Molecular mass:
    156275 Da
    Quaternary structure:
    • Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.
    SequenceCaution:
    • Sequence=AAH50555.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA02794.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KTN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KTN1 Gene

Proteomics data for KTN1 Gene at MOPED

Post-translational modifications for KTN1 Gene

  • Ubiquitination at Lys 285, Lys 309, and Lys 1296
  • Glycosylation at Asn 172, Asn 435, Asn 772, Asn 904, Asn 1055, Asn 1088, Asn 1263, and Asn 1329
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for KTN1 (KTN1)

No data available for DME Specific Peptides for KTN1 Gene

Domains & Families for KTN1 Gene

Protein Domains for KTN1 Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86UP2

UniProtKB/Swiss-Prot:

KTN1_HUMAN :
  • Belongs to the kinectin family.
Family:
  • Belongs to the kinectin family.
genes like me logo Genes that share domains with KTN1: view

No data available for Gene Families for KTN1 Gene

Function for KTN1 Gene

Molecular function for KTN1 Gene

GENATLAS Biochemistry:
kinectin 1,156kDa,vesicle membrane protein of the endoplasmic reticulum,binding vesicles to kinesin and promoting vesicle motility,expressed in diverse tissues
UniProtKB/Swiss-Prot Function:
Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
genes like me logo Genes that share phenotypes with KTN1: view

Animal Model Products

miRNA for KTN1 Gene

miRTarBase miRNAs that target KTN1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KTN1 Gene

Localization for KTN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KTN1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Vesicle membrane protein anchored to the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KTN1 Gene COMPARTMENTS Subcellular localization image for KTN1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
cytoskeleton 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7787243
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane TAS 7787244
GO:0030176 integral component of endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with KTN1: view

Pathways & Interactions for KTN1 Gene

genes like me logo Genes that share pathways with KTN1: view

Pathways by source for KTN1 Gene

1 Cell Signaling Technology pathway for KTN1 Gene
1 BioSystems pathway for KTN1 Gene
1 Qiagen pathway for KTN1 Gene

SIGNOR curated interactions for KTN1 Gene

Activates:

Gene Ontology (GO) - Biological Process for KTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with KTN1: view

Drugs & Compounds for KTN1 Gene

(2) Drugs for KTN1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with KTN1: view

Transcripts for KTN1 Gene

Unigene Clusters for KTN1 Gene

Kinectin 1 (kinesin receptor):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KTN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10: - -
SP11:
SP12:

ExUns: 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b · 35c ^ 36a · 36b ^ 37 ^ 38 ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44a · 44b ^ 45a · 45b ^
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6:
SP7:
SP8: - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 46 ^ 47
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for KTN1 Gene

GeneLoc Exon Structure for
KTN1
ECgene alternative splicing isoforms for
KTN1

Expression for KTN1 Gene

mRNA expression in normal human tissues for KTN1 Gene

mRNA differential expression in normal tissues according to GTEx for KTN1 Gene

This gene is overexpressed in Muscle - Skeletal (x4.4).

Protein differential expression in normal tissues from HIPED for KTN1 Gene

This gene is overexpressed in Lymph node (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KTN1 Gene



SOURCE GeneReport for Unigene cluster for KTN1 Gene Hs.509414

mRNA Expression by UniProt/SwissProt for KTN1 Gene

Q86UP2-KTN1_HUMAN
Tissue specificity: High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon.
genes like me logo Genes that share expression patterns with KTN1: view

Protein tissue co-expression partners for KTN1 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KTN1 Gene

Orthologs for KTN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KTN1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KTN1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KTN1 36
  • 94 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KTN1 36
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ktn1 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia KTN1 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves KTN1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KTN1 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11429 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.2481 35
zebrafish
(Danio rerio)
Actinopterygii ktn1 35
  • 52.29 (n)
  • 43.57 (a)
ktn1 36
  • 41 (a)
OneToOne
Species with no ortholog for KTN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KTN1 Gene

ENSEMBL:
Gene Tree for KTN1 (if available)
TreeFam:
Gene Tree for KTN1 (if available)

Paralogs for KTN1 Gene

Paralogs for KTN1 Gene

genes like me logo Genes that share paralogs with KTN1: view

Variants for KTN1 Gene

Sequence variations from dbSNP and Humsavar for KTN1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2274073 - 55,619,193(+) CTGAA(A/G)TGAAG nc-transcript-variant, reference, missense
VAR_035931 A breast cancer sample
VAR_035932 A breast cancer sample
rs11546 -- 55,679,639(+) CAGGC(A/G)GTAAA nc-transcript-variant, reference, synonymous-codon
rs7140434 -- 55,613,990(+) TCGCT(G/T)CATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KTN1 Gene

Variant ID Type Subtype PubMed ID
dgv1937n71 CNV Gain 21882294
nsv901965 CNV Gain 21882294
nsv832804 CNV Gain 17160897
nsv1283 CNV Loss 18451855

Variation tolerance for KTN1 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.12; 61.26% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KTN1 Gene

Disorders for KTN1 Gene

Relevant External Links for KTN1

Genetic Association Database (GAD)
KTN1
Human Genome Epidemiology (HuGE) Navigator
KTN1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KTN1

No disorders were found for KTN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KTN1 Gene

Publications for KTN1 Gene

  1. Molecular cloning and characterization of human kinectin. (PMID: 7787243) Fuetterer A. … Kroenke M. (Mol. Biol. Cell 1995) 3 4 23 67
  2. Assignment of the human kinectin gene (KTN1), encoding a kinesin-binding protein, to chromosome 14 band q22.1 by in situ hybridization. (PMID: 9605849) Rao P.N. … Sheetz M.P. (Cytogenet. Cell Genet. 1997) 2 3 23
  3. Candidate-gene testing for orphan limb-girdle muscular dystrophies. (PMID: 19472918) Aurino S. … Nigro V. (Acta Myol 2008) 3 23
  4. Kinectin participates in microtubule-dependent hormone secretion in pancreatic islet beta-cells. (PMID: 16890462) Bai J.Z. … Krissansen G.W. (Cell Biol. Int. 2006) 3 23
  5. Kinectin-dependent assembly of translation elongation factor-1 complex on endoplasmic reticulum regulates protein synthesis. (PMID: 16950774) Ong L.L. … Yu H. (J. Biol. Chem. 2006) 3 23

Products for KTN1 Gene

Sources for KTN1 Gene

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