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Aliases for KTN1 Gene

Aliases for KTN1 Gene

  • Kinectin 1 (Kinesin Receptor) 2 3
  • CG1 3 4 6
  • Kinesin Receptor 3 4
  • CG-1 Antigen 3 4
  • MU-RMS-40.19 3
  • Kinectin 3
  • KIAA0004 4
  • KNT 3

External Ids for KTN1 Gene

Previous GeneCards Identifiers for KTN1 Gene

  • GC14P053370
  • GC14P049842
  • GC14P054037
  • GC14P055116
  • GC14P056046
  • GC14P036232

Summaries for KTN1 Gene

Entrez Gene Summary for KTN1 Gene

  • This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Aug 2012]

GeneCards Summary for KTN1 Gene

KTN1 (Kinectin 1 (Kinesin Receptor)) is a Protein Coding gene. Among its related pathways are Actin Nucleation by ARP-WASP Complex and Cytoskeletal Signaling. GO annotations related to this gene include kinesin binding. An important paralog of this gene is RRBP1.

UniProtKB/Swiss-Prot for KTN1 Gene

  • Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin

Gene Wiki entry for KTN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KTN1 Gene

Genomics for KTN1 Gene

Regulatory Elements for KTN1 Gene

Genomic Location for KTN1 Gene

Start:
55,559,072 bp from pter
End:
55,701,526 bp from pter
Size:
142,455 bases
Orientation:
Plus strand

Genomic View for KTN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KTN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KTN1 Gene

Proteins for KTN1 Gene

  • Protein details for KTN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UP2-KTN1_HUMAN
    Recommended name:
    Kinectin
    Protein Accession:
    Q86UP2
    Secondary Accessions:
    • B4DZ88
    • Q13999
    • Q14707
    • Q15387
    • Q17RZ5
    • Q5GGW3
    • Q86W57

    Protein attributes for KTN1 Gene

    Size:
    1357 amino acids
    Molecular mass:
    156275 Da
    Quaternary structure:
    • Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2 cytosolic forms.
    SequenceCaution:
    • Sequence=AAH50555.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=BAA02794.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for KTN1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KTN1 Gene

Proteomics data for KTN1 Gene at MOPED

Post-translational modifications for KTN1 Gene

  • Ubiquitination at Lys285, Lys309, and Lys1296
  • Glycosylation at Asn172, Asn435, Asn772, Asn904, Asn1055, Asn1088, Asn1263, and Asn1329
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for KTN1 Gene

Domains for KTN1 Gene

Protein Domains for KTN1 Gene

Blocks:
InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q86UP2

UniProtKB/Swiss-Prot:

KTN1_HUMAN :
  • Q86UP2
Family:
  • Belongs to the kinectin family.
genes like me logo Genes that share domains with KTN1: view

No data available for Gene Families for KTN1 Gene

Function for KTN1 Gene

Molecular function for KTN1 Gene

GENATLAS Biochemistry: kinectin 1,156kDa,vesicle membrane protein of the endoplasmic reticulum,binding vesicles to kinesin and promoting vesicle motility,expressed in diverse tissues
UniProtKB/Swiss-Prot Function: Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin

Gene Ontology (GO) - Molecular Function for KTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0019894 kinesin binding IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with KTN1: view

Phenotypes for KTN1 Gene

genes like me logo Genes that share phenotypes with KTN1: view

Animal Models for KTN1 Gene

MGI Knock Outs for KTN1:

Animal Model Products

miRNA for KTN1 Gene

miRTarBase miRNAs that target KTN1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KTN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for KTN1 Gene

Localization for KTN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KTN1 Gene

Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Vesicle membrane protein anchored to the endoplasmic reticulum.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KTN1 Gene COMPARTMENTS Subcellular localization image for KTN1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 4
cytoskeleton 2
extracellular 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IDA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005887 integral component of plasma membrane TAS 7787243
GO:0016020 membrane IDA 19946888
GO:0016021 integral component of membrane TAS 7787244
genes like me logo Genes that share ontologies with KTN1: view

Pathways for KTN1 Gene

genes like me logo Genes that share pathways with KTN1: view

Pathways by source for KTN1 Gene

1 Qiagen pathway for KTN1 Gene
1 Cell Signaling Technology pathway for KTN1 Gene
1 BioSystems pathway for KTN1 Gene

Gene Ontology (GO) - Biological Process for KTN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007018 microtubule-based movement IEA --
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0015031 protein transport --
genes like me logo Genes that share ontologies with KTN1: view

Compounds for KTN1 Gene

(2) Novoseek inferred chemical compound relationships for KTN1 Gene

Compound -log(P) Hits PubMed IDs
leucine 14.4 1
tyrosine 9.29 3
genes like me logo Genes that share compounds with KTN1: view

Transcripts for KTN1 Gene

Unigene Clusters for KTN1 Gene

Kinectin 1 (kinesin receptor):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KTN1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KTN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KTN1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10: - -
SP11:
SP12:

ExUns: 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b · 35c ^ 36a · 36b ^ 37 ^ 38 ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44a · 44b ^ 45a · 45b ^
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: -
SP6:
SP7:
SP8: - -
SP9: -
SP10:
SP11:
SP12:

ExUns: 46 ^ 47
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for KTN1 Gene

GeneLoc Exon Structure for
KTN1
ECgene alternative splicing isoforms for
KTN1

Expression for KTN1 Gene

mRNA expression in normal human tissues for KTN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KTN1 Gene

This gene is overexpressed in Muscle - Skeletal (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for KTN1 Gene

SOURCE GeneReport for Unigene cluster for KTN1 Gene Hs.509414

mRNA Expression by UniProt/SwissProt for KTN1 Gene

Q86UP2-KTN1_HUMAN
Tissue specificity: High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus, prostate, small intestine and colon
genes like me logo Genes that share expressions with KTN1: view

In Situ Assay Products

Orthologs for KTN1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KTN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KTN1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KTN1 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KTN1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ktn1 16
Ktn1 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KTN1 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 66 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 77 (a)
OneToMany
chicken
(Gallus gallus)
Aves KTN1 36
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KTN1 36
  • 65 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.2481 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11429 35
zebrafish
(Danio rerio)
Actinopterygii ktn1 35
  • 52.29 (n)
  • 43.57 (a)
ktn1 36
  • 41 (a)
OneToOne
Species with no ortholog for KTN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KTN1 Gene

ENSEMBL:
Gene Tree for KTN1 (if available)
TreeFam:
Gene Tree for KTN1 (if available)

Paralogs for KTN1 Gene

Paralogs for KTN1 Gene

genes like me logo Genes that share paralogs with KTN1: view

Variants for KTN1 Gene

Sequence variations from dbSNP and Humsavar for KTN1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11546 -- 55,679,639(+) CAGGC(A/G)GTAAA synonymous-codon, reference, nc-transcript-variant
rs1138345 -- 55,612,021(+) TAGGT(G/T)TTATA utr-variant-5-prime, nc-transcript-variant
rs1951887 -- 55,638,225(+) GAACA(A/G)TATGG intron-variant
rs1951888 -- 55,638,760(+) TAGAG(A/C)ATGCT intron-variant
rs1951889 -- 55,639,493(+) ATGTG(A/G)AAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KTN1 Gene

Variant ID Type Subtype PubMed ID
dgv1937n71 CNV Gain 21882294
nsv901965 CNV Gain 21882294
nsv832804 CNV Gain 17160897
nsv1283 CNV Loss 18451855

Relevant External Links for KTN1 Gene

HapMap Linkage Disequilibrium report
KTN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KTN1 Gene

Disorders for KTN1 Gene

(2) Novoseek inferred disease relationships for KTN1 Gene

Disease -log(P) Hits PubMed IDs
autoimmune diseases 17 1
hepatocellular carcinoma 15.1 1

Relevant External Links for KTN1

Genetic Association Database (GAD)
KTN1
Human Genome Epidemiology (HuGE) Navigator
KTN1
genes like me logo Genes that share disorders with KTN1: view

No data available for UniProtKB/Swiss-Prot for KTN1 Gene

Publications for KTN1 Gene

  1. Molecular cloning and characterization of human kinectin. (PMID: 7787243) Fuetterer A. … Kroenke M. (Mol. Biol. Cell 1995) 3 4 23
  2. The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22. (PMID: 8575822) Print C.G. … Krissansen G.W. (Immunogenetics 1996) 3 4 23
  3. Assignment of the human kinectin gene (KTN1), encoding a kinesin-binding protein, to chromosome 14 band q22.1 by in situ hybridization. (PMID: 9605849) Rao P.N. … Sheetz M.P. (Cytogenet. Cell Genet. 1997) 2 3 23
  4. Integrin clustering induces kinectin accumulation. (PMID: 11973345) Tran H. … Yamada K.M. (J. Cell Sci. 2002) 3 4 23
  5. Candidate-gene testing for orphan limb-girdle muscular dystrophies. (PMID: 19472918) Aurino S. … Nigro V. (Acta Myol 2008) 3 23 48

Products for KTN1 Gene

Sources for KTN1 Gene

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