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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KTN1 Gene

protein-coding   GIFtS: 60
GCID: GC14P056046

Kinectin 1 (Kinesin Receptor)

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinectin 1 (Kinesin Receptor)1 2     KNT2
CG12 3 5     MU-RMS-40.192
Kinesin Receptor2 3     kinectin2
CG-1 Antigen2 3     KIAA00043

External Ids:    HGNC: 64671   Entrez Gene: 38952   Ensembl: ENSG000001267777   OMIM: 6003815   UniProtKB: Q86UP23   

Export aliases for KTN1 gene to outside databases

Previous GC identifers: GC14P053370 GC14P049842 GC14P054037 GC14P055116 GC14P036232


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KTN1 Gene:
This gene encodes an integral membrane protein that is a member of the kinectin protein family. The encoded
protein is primarily localized to the endoplasmic reticulum membrane. This protein binds kinesin and may be
involved in intracellular organelle motility. This protein also binds translation elongation factor-delta and may
be involved in the assembly of the elongation factor-1 complex. Alternate splicing results in multiple transcript
variants of this gene. (provided by RefSeq, Aug 2012)

GeneCards Summary for KTN1 Gene: 
KTN1 (kinectin 1 (kinesin receptor)) is a protein-coding gene. Diseases associated with KTN1 include giant cell tumor, and aplastic anemia, and among its related super-pathways are Actin Nucleation by ARP-WASP Complex. GO annotations related to this gene include molecular_function and kinesin binding. An important paralog of this gene is RRBP1.

UniProtKB/Swiss-Prot: KTN1_HUMAN, Q86UP2
Function: Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based
adhesion complexes (IAC) upon integrin aggregation by fibronectin

Gene Wiki entry for KTN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KTN1 gene promoter:
         SRF   Max1   AML1a   SRF (504 AA)   CUTL1   Roaz   MEF-2A   aMEF-2   Pax-4a   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for KTN1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KTN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.3   HGNC cytogenetic band: 14q22.1

KTN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KTN1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P056046:  view genomic region     (about GC identifiers)

Start:
56,025,790 bp from pter      End:
56,168,244 bp from pter
Size:
142,455 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KTN1_HUMAN, Q86UP2 (See protein sequence)
Recommended Name: Kinectin  
Size: 1357 amino acids; 156275 Da
Subunit: Parallel homodimers formed between the membrane-bound and the cytosolic form, and also between 2
cytosolic forms (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Note=Vesicle membrane
protein anchored to the endoplasmic reticulum
Sequence caution: Sequence=AAH50555.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence; Sequence=BAA02794.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q13999 Q14707 Q15387 Q17RZ5 Q86W57
Alternative splicing: 3 isoforms:  Q86UP2-1   Q86UP2-2   Q86UP2-3   

Explore the universe of human proteins at neXtProt for KTN1: NX_Q86UP2

Explore proteomics data for KTN1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86UP2

  • KTN1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KTN1 Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001257943.1  NP_004977.2  NP_001072989.1  NP_001072990.1  

    ENSEMBL proteins: 
     ENSP00000451641   ENSP00000452459   ENSP00000451878   ENSP00000391964   ENSP00000378725  
     ENSP00000432149   ENSP00000378719   ENSP00000378722   ENSP00000452576   ENSP00000452073  
     ENSP00000452337   ENSP00000452205   ENSP00000452445   ENSP00000451698   ENSP00000451876  
     ENSP00000451139   ENSP00000394992   ENSP00000378720   ENSP00000388807  

    Human Recombinant Protein Products for KTN1: 
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    Cloud-Clone Corp. Proteins for KTN1 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum IDA--
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005887integral to plasma membrane TAS7787243
    GO:0016020membrane TAS7787243
    GO:0016021integral to membrane TAS7787244

    KTN1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR024854 Kinectin

    Graphical View of Domain Structure for InterPro Entry Q86UP2

    ProtoNet protein and cluster: Q86UP2

    1 Blocks protein domain: IPB002017 Spectrin repeat

    UniProtKB/Swiss-Prot: KTN1_HUMAN, Q86UP2
    Similarity: Belongs to the kinectin family


    KTN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KTN1_HUMAN, Q86UP2
    Function: Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based
    adhesion complexes (IAC) upon integrin aggregation by fibronectin

         Genatlas biochemistry entry for KTN1:
    kinectin 1,156kDa,vesicle membrane protein of the endoplasmic reticulum,binding vesicles to kinesin and promoting
    vesicle motility,expressed in diverse tissues

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0019894kinesin binding IEA--
         
    KTN1 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Ktn1):
     no phenotypic analysis  normal 

    KTN1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ktn1tm1.2Kpf for KTN1

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KTN1 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KTN1 
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    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidKTN1 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KTN1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Actin Nucleation by ARP-WASP Complex
    RhoA Pathway0.35
    2Cytoskeletal Signaling
    Cytoskeletal Signaling
    3TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for KTN1
        RhoA Pathway

    1 Cell Signaling Technology (CST) Pathway for KTN1
        Cytoskeletal Signaling

    1 BioSystems Pathway for KTN1
        TNF-alpha/NF-kB Signaling Pathway



    KTN1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KTN1

    5/17 Interacting proteins for KTN1 (Q86UP22, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKEQ141642, 3MINT-48110 MINT-47964 I2D: score=4 
    PLEKHA5Q9HAU03I2D: score=3 
    PSMD7P516653I2D: score=2 
    RAC1P630003I2D: score=2 
    RHOAP615863I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007018microtubule-based movement IEA--
    GO:0015031protein transport ----

    KTN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    KTN1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KTN1

    2 Novoseek inferred chemical compound relationships for KTN1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    leucine 14.4 1 9169133 (1)
    tyrosine 9.29 3 16848005 (1), 16540262 (1), 16912993 (1)

    Search CenterWatch for drugs/clinical trials and news about KTN1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KTN1 gene (5 alternative transcripts): 
    NM_001271014.1  NM_004986.3  NM_182926.2  NM_001079521.1  NM_001079522.1  

    Unigene Cluster for KTN1:

    Kinectin 1 (kinesin receptor)
    Hs.509414  [show with all ESTs]
    Unigene Representative Sequence: NR_073129
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000557267 ENST00000554567 ENST00000555498 ENST00000438792 ENST00000395314(uc001xcc.3)
    ENST00000459737(uc001xcb.3 uc001xcd.3 uc010trb.2) ENST00000395308
    ENST00000395311 ENST00000553360 ENST00000554507 ENST00000554890 ENST00000555164
    ENST00000554306 ENST00000554570 ENST00000553624 ENST00000555573(uc010trc.2)
    ENST00000555172(uc001xcg.3) ENST00000334975
    miRNA
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    hsa-miR-199a-3p hsa-miR-16-1* hsa-miR-374a hsa-miR-570 hsa-miR-374c hsa-miR-3163 hsa-miR-222* hsa-miR-374b
    SwitchGear 3'UTR luciferase reporter plasmidKTN1 3' UTR sequence
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KTN1

    Additional mRNA sequence: 

    AJ270687.1 AK300703.1 AK302797.1 AK308272.1 AK309840.1 AY264265.1 AY536375.1 BC050555.1 
    BC058736.1 BC066337.1 BC104648.1 BC112337.1 BC117132.1 BC143720.1 D13629.1 L25616.1 
    NR_073128.1 NR_073129.1 Z22551.1 

    24/48 DOTS entries (see all 48):

    DT.85104713  DT.95375978  DT.91786580  DT.101957505  DT.97850477  DT.95376001  DT.120792524  DT.120792661 
    DT.99988670  DT.75110805  DT.100038614  DT.100667517  DT.100679485  DT.100679490  DT.120792595  DT.100655189 
    DT.100679488  DT.120792656  DT.92457122  DT.95225282  DT.97798810  DT.100866936  DT.95375997  DT.449614 

    24/582 AceView cDNA sequences (see all 582):

    CB130281 BC050555 AW955274 BM474776 CB132613 BU686030 AI916662 BU166798 
    AW449600 CB132380 BF061788 AA126979 AW470089 CB305829 AA804174 AW611644 
    AI023635 D13629 BF981444 AL048828 BU689400 AA262613 CA423639 BQ014936 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for KTN1 (see all 12)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25 ^ 26 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34 ^ 35a · 35b · 35c ^ 36a · 36b ^ 37 ^ 38 ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43a · 43b ^ 44a · 44b ^ 45a · 45b ^
    SP1:                                                  -     -           -                       -                                   -     -                 -   
    SP2:                                                  -     -           -     -                 -                             -     -     -                 -   
    SP3:                                                                                            -                             -     -     -                 -   
    SP4:                                                                                            -                             -     -     -                 -   
    SP5:                                                                                                                                                        -   

    ExUns: 46 ^ 47
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for KTN1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KTN1 expression in normal human tissues (normalized intensities)      KTN1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATCTTTTA
    KTN1 Expression
    About this image


    KTN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/33 selected tissues (see all 33) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See KTN1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KTN1

    SOURCE GeneReport for Unigene cluster: Hs.509414

    UniProtKB/Swiss-Prot: KTN1_HUMAN, Q86UP2
    Tissue specificity: High levels in peripheral blood lymphocytes, testis and ovary, lower levels in spleen, thymus,
    prostate, small intestine and colon

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KTN1 gene from 6/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ktn11 , 5 kinectin 11, 5 85.77(n)1
    83.88(a)1
      14 (24.60 cM)5
    167091  NM_008477.21  NP_032503.21 
     476637565 
    chicken
    (Gallus gallus)
    Aves KTN11 kinectin 1 (kinesin receptor) 72.49(n)
    68.02(a)
      396335  NM_205376.1  NP_990707.1 
    lizard
    (Anolis carolinensis)
    Reptilia KTN16
    kinectin 1 (kinesin receptor)
    65(a)
    1 ↔ 1
    GL343459.1(138910-292165)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.24812 Xenopus laevis transcribed sequence with weak similarity more 81.8(n)    BJ052318.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ktn12 kinectin 1 74.39(n)   368207  BC044389.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta alt6
    aluminum tubes
    13(a)
    1 → many
    3R(13499903-13508234)


    ENSEMBL Gene Tree for KTN1 (if available)
    TreeFam Gene Tree for KTN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KTN1 gene
    RRBP12  
    1 SIMAP similar gene for KTN1 using alignment to 16 protein entries:     KTN1_HUMAN (see all proteins):
    RRBP1

    KTN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2421 SNPs in KTN1 are shown (see all 2421)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359314
    A breast cancer sample4--see VAR_0359312 P R mis40--------
    VAR_0359324
    A breast cancer sample4--see VAR_0359322 T P mis40--------
    rs348987341,2
    C--36289891(+) AGGAG-/TTTTTTTT 6 -- int10--------
    rs1478892561,2
    C--56049073(+) GAGATC/TGTTTT 6 -- int10--------
    rs101361551,2
    C,F,A--56049129(+) CCTAAG/AACGTG 6 -- int12Minor allele frequency- A:0.09WA NA 238
    rs1415337761,2
    --56049153(+) GACTTC/GTAAAG 6 -- int10--------
    rs101359831,2
    C--56049196(+) TCTTAA/CCTTGA 6 -- int10--------
    rs23418891,2
    C,F,A--56049204(+) TGAATT/GTTAAG 6 -- int112Minor allele frequency- G:0.26NA WA CSA EA 374
    rs1510576831,2
    C--56049338(+) AACTT-/GAATG 
            
    GAACA
    6 -- int10--------
    rs1895930611,2
    --56049453(+) AGTGGG/TTCTAG 6 -- int10--------

    HapMap Linkage Disequilibrium report for KTN1 (56025790 - 56168244 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for KTN1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1283CNV Loss18451855
    nsv832804CNV Gain17160897
    dgv1937n71CNV Gain21882294
    nsv901965CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600381    OMIM disorders: --

    12 diseases for KTN1:    About MalaCards
    giant cell tumor    aplastic anemia    connective tissue disease    behcet's disease
    papillary thyroid carcinoma    hepatocellular carcinoma    myopathy    thyroiditis
    anemia    melanoma    pancreatitis    prostatitis


    KTN1 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for KTN1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    autoimmune diseases 17 1 12947009 (1)
    hepatocellular carcinoma 15.1 1 15060627 (1)

    Genetic Association Database (GAD): KTN1
    Human Genome Epidemiology (HuGE) Navigator: KTN1 (3 documents)

    Export disorders for KTN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KTN1 gene, integrated from 9 sources (see all 88):
    (articles sorted by number of sources associating them with KTN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and characterization of human kinectin. (PubMed id 7787243)1, 2, 9 Fuetterer A.... Kroenke M. (1995)
    2. Integrin clustering induces kinectin accumulation. (PubMed id 11973345)1, 2, 9 Tran H.... Yamada K.M. (2002)
    3. The CG-1 gene, a member of the kinectin and ES/130 family, maps to human chromosome band 14q22. (PubMed id 8575822)1, 2, 9 Print C.G.... Krissansen G.W. (1996)
    4. Assignment of the human kinectin gene (KTN1), encoding a kinesin-binding protein, to chromosome 14 band q22.1 by in situ hybridization. (PubMed id 9605849)1, 3, 9 Rao P.N....Sheetz M.P. (1997)
    5. Candidate-gene testing for orphan limb-girdle muscula r dystrophies. (PubMed id 19472918)1, 4, 9 Aurino S....Nigro V. (2008)
    6. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    7. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (2007)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    10. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 3895 HGNC: 6467 AceView: KTN1 Ensembl:ENSG00000126777 euGenes: HUgn3895
    ECgene: KTN1 H-InvDB: KTN1

    (According to HUGE)
    About This Section
    HUGE: KIAA0004

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KTN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KTN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KTN1 gene:
    Search GeneIP for patents involving KTN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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