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Aliases for KTI12 Gene

Aliases for KTI12 Gene

  • KTI12 Chromatin Associated Homolog 2 3 5
  • KTI12 Homolog, Chromatin Associated (S. Cerevisiae) 2
  • KTI12 Homolog, Chromatin Associated 3
  • Protein KTI12 Homolog 3
  • SBBI81 3
  • TOT4 3

External Ids for KTI12 Gene

Previous GeneCards Identifiers for KTI12 Gene

  • GC01M052210
  • GC01M052497
  • GC01M050615

Summaries for KTI12 Gene

GeneCards Summary for KTI12 Gene

KTI12 (KTI12 Chromatin Associated Homolog) is a Protein Coding gene. Diseases associated with KTI12 include Ostertagiasis and Trichostrongyloidiasis.

Additional gene information for KTI12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KTI12 Gene

Genomics for KTI12 Gene

Regulatory Elements for KTI12 Gene

Enhancers for KTI12 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H051513 1.4 ENCODE dbSUPER 13.9 +516.0 516018 7.7 DMAP1 YY1 ZNF416 SP3 ZC3H11A ZNF610 GLIS1 RCOR2 NBN NR2C1 ENSG00000266993 PRPF38A KTI12 FAF1 LOC100190934 ORC1 EPS15 ENSG00000227070 LOC105378720
GH01H051874 1.7 FANTOM5 ENCODE dbSUPER 9.8 +156.4 156350 5.3 MLX DMAP1 YY1 ZNF143 ZNF548 SP3 NFYC ZNF610 GLIS1 NBN ENSG00000266993 ZCCHC11 PRPF38A GAPDHP51 SLC25A6P3 TXNDC12-AS1 CC2D1B TXNDC12 NRDC CFL1P2
GH01H052032 1.1 ENCODE 14.6 +0.4 421 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 PAF1 ZHX2 ZCCHC11 PRPF38A CC2D1B KTI12 BTF3L4 TXNDC12 ENSG00000266993 ORC1 LOC100190934 ENSG00000223390
GH01H052697 1.1 ENCODE 13.9 -664.3 -664334 2.2 HDGF FOXA2 PKNOX1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ENSG00000228838 ZCCHC11 MAGOH LOC100652967 TXNDC12-AS1 ENSG00000226938 SLC25A6P3 GAPDHP51 KTI12 PRPF38A
GH01H052053 1.2 ENCODE 12 -22.0 -22013 4.4 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 LOC100190934 ENSG00000230953 ZCCHC11 KTI12 ENSG00000223390 ZFYVE9 TXNDC12 TTC39A GC01M052055 TXNDC12-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KTI12 on UCSC Golden Path with GeneCards custom track

Promoters for KTI12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000251857 416 1601 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 PAF1 ZHX2
ENSR00000006360 1716 201 EBF1 BATF

Genomic Locations for KTI12 Gene

Genomic Locations for KTI12 Gene
chr1:52,032,103-52,033,816
(GRCh38/hg38)
Size:
1,714 bases
Orientation:
Minus strand
chr1:52,497,775-52,499,488
(GRCh37/hg19)

Genomic View for KTI12 Gene

Genes around KTI12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KTI12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KTI12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KTI12 Gene

Proteins for KTI12 Gene

  • Protein details for KTI12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EK9-KTI12_HUMAN
    Recommended name:
    Protein KTI12 homolog
    Protein Accession:
    Q96EK9

    Protein attributes for KTI12 Gene

    Size:
    354 amino acids
    Molecular mass:
    38616 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KTI12 Gene

Post-translational modifications for KTI12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KTI12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KTI12 Gene

Domains & Families for KTI12 Gene

Gene Families for KTI12 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KTI12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KTI12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96EK9

UniProtKB/Swiss-Prot:

KTI12_HUMAN :
  • Belongs to the KTI12 family.
Family:
  • Belongs to the KTI12 family.
genes like me logo Genes that share domains with KTI12: view

Function for KTI12 Gene

Gene Ontology (GO) - Molecular Function for KTI12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KTI12: view

Phenotypes for KTI12 Gene

GenomeRNAi human phenotypes for KTI12:
genes like me logo Genes that share phenotypes with KTI12: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KTI12 Gene

Localization for KTI12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KTI12 gene
Compartment Confidence
extracellular 2
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for KTI12 Gene

Pathways & Interactions for KTI12 Gene

SuperPathways for KTI12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KTI12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KTI12 Gene

Drugs & Compounds for KTI12 Gene

No Compound Related Data Available

Transcripts for KTI12 Gene

mRNA/cDNA for KTI12 Gene

(1) REFSEQ mRNAs :
(129) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KTI12 Gene

No ASD Table

Relevant External Links for KTI12 Gene

GeneLoc Exon Structure for
KTI12
ECgene alternative splicing isoforms for
KTI12

Expression for KTI12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KTI12 Gene

Protein differential expression in normal tissues from HIPED for KTI12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.3) and Blymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KTI12 Gene



Protein tissue co-expression partners for KTI12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KTI12 Gene:

KTI12

Evidence on tissue expression from TISSUES for KTI12 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with KTI12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KTI12 Gene

Orthologs for KTI12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KTI12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KTI12 33
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia KTI12 33
  • 83.9 (n)
dog
(Canis familiaris)
Mammalia KTI12 33 34
  • 82.75 (n)
rat
(Rattus norvegicus)
Mammalia Kti12 33
  • 78.48 (n)
mouse
(Mus musculus)
Mammalia Kti12 33 16 34
  • 77.68 (n)
chicken
(Gallus gallus)
Aves TXNDC12 33
  • 66.81 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia kti12 33
  • 60.02 (n)
zebrafish
(Danio rerio)
Actinopterygii kti12 33 34
  • 57.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005190 33
  • 49.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3587 33 34
  • 48.43 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57G11C.43 33
  • 46.01 (n)
Y57G11C.43 34
  • 31 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL049C 33
  • 47.69 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02926g 33
  • 43.31 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KTI12 33 34 36
  • 42.86 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DRL1 33
  • 42.08 (n)
rice
(Oryza sativa)
Liliopsida Os11g0312782 33
  • 45.27 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC30.02c 33
  • 44.23 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00178 33
  • 44.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5241 34
  • 39 (a)
OneToOne
Species where no ortholog for KTI12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KTI12 Gene

ENSEMBL:
Gene Tree for KTI12 (if available)
TreeFam:
Gene Tree for KTI12 (if available)

Paralogs for KTI12 Gene

No data available for Paralogs for KTI12 Gene

Variants for KTI12 Gene

Sequence variations from dbSNP and Humsavar for KTI12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000969069 -- 52,033,560(+) GCGCC(A/G)TTCCA intron-variant, nc-transcript-variant, reference, missense
rs1001617907 -- 52,034,269(+) ATGGG(A/C)AGGAT intron-variant, upstream-variant-2KB
rs1001940561 -- 52,032,566(+) AGTTT(C/G)AGTGA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1001973064 -- 52,032,300(+) ATGTA(G/T)AACTG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1003474049 -- 52,034,995(+) CTGAC(C/T)CCAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KTI12 Gene

Variant ID Type Subtype PubMed ID
nsv829848 CNV loss 17160897
nsv1004103 CNV loss 25217958

Variation tolerance for KTI12 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KTI12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KTI12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KTI12 Gene

Disorders for KTI12 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KTI12 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ostertagiasis
trichostrongyloidiasis
- elite association - COSMIC cancer census association via MalaCards
Search KTI12 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KTI12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KTI12
genes like me logo Genes that share disorders with KTI12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KTI12 Gene

Publications for KTI12 Gene

  1. Molecular analysis of KTI12/TOT4, a Saccharomyces cerevisiae gene required for Kluyveromyces lactis zymocin action. (PMID: 11929532) Fichtner L … Schaffrath R (Molecular microbiology 2002) 2 3 22 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for KTI12 Gene

Sources for KTI12 Gene

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