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Aliases for KTI12 Gene

Aliases for KTI12 Gene

  • KTI12 Chromatin Associated Homolog 2 3 5
  • KTI12 Homolog, Chromatin Associated (S. Cerevisiae) 2
  • KTI12 Homolog, Chromatin Associated 3
  • Protein KTI12 Homolog 3
  • SBBI81 3
  • TOT4 3

External Ids for KTI12 Gene

Previous GeneCards Identifiers for KTI12 Gene

  • GC01M052210
  • GC01M052497
  • GC01M050615

Summaries for KTI12 Gene

GeneCards Summary for KTI12 Gene

KTI12 (KTI12 Chromatin Associated Homolog) is a Protein Coding gene. Diseases associated with KTI12 include Ostertagiasis and Trichostrongyloidiasis.

Additional gene information for KTI12 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KTI12 Gene

Genomics for KTI12 Gene

GeneHancer (GH) Regulatory Elements for KTI12 Gene

Promoters and enhancers for KTI12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I052032 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 564.6 +0.4 420 2.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF213 KTI12 ENSG00000223390 ZCCHC11 ENSG00000266993 CC2D1B BTF3L4 TXNDC12 ORC1 LOC100190934
GH01I052033 Promoter 0.7 Ensembl 550.8 +1.7 1715 0.2 POLR2A EBF1 ENSG00000223390 KTI12 TXNDC12 GC01M051997 GC01M051996
GH01I052402 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 17.9 -370.5 -370466 3.2 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 PRPF38A ORC1 MAGOH KTI12 ENSG00000266993 TXNDC12 PLA2G12AP1
GH01I051513 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 13.9 +516.0 516018 7.7 DMAP1 YY1 ZNF213 E2F8 ZNF416 SP3 ZNF610 GLIS1 RCOR2 NBN EPS15 ENSG00000227070 LOC105378720 ENSG00000266993 KTI12 FAF1 LOC100190934 ORC1
GH01I052697 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13.9 -664.3 -664333 2.2 HDGF FOXA2 PKNOX1 CLOCK SMAD1 MLX ARNT ARID4B SIN3A DMAP1 COA7 GC01P052696 ZCCHC11 MAGOH KTI12 PRPF38A ENSG00000230953 ENSG00000272100 ENSG00000266993 ZFYVE9
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KTI12 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KTI12 gene promoter:

Genomic Locations for KTI12 Gene

Genomic Locations for KTI12 Gene
chr1:52,032,103-52,033,816
(GRCh38/hg38)
Size:
1,714 bases
Orientation:
Minus strand
chr1:52,497,775-52,499,488
(GRCh37/hg19)

Genomic View for KTI12 Gene

Genes around KTI12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KTI12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KTI12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KTI12 Gene

Proteins for KTI12 Gene

  • Protein details for KTI12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EK9-KTI12_HUMAN
    Recommended name:
    Protein KTI12 homolog
    Protein Accession:
    Q96EK9

    Protein attributes for KTI12 Gene

    Size:
    354 amino acids
    Molecular mass:
    38616 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KTI12 Gene

Post-translational modifications for KTI12 Gene

No Post-translational modifications

Other Protein References for KTI12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KTI12 Gene

Domains & Families for KTI12 Gene

Gene Families for KTI12 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KTI12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KTI12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96EK9

UniProtKB/Swiss-Prot:

KTI12_HUMAN :
  • Belongs to the KTI12 family.
Family:
  • Belongs to the KTI12 family.
genes like me logo Genes that share domains with KTI12: view

Function for KTI12 Gene

Gene Ontology (GO) - Molecular Function for KTI12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KTI12: view

Phenotypes for KTI12 Gene

GenomeRNAi human phenotypes for KTI12:
genes like me logo Genes that share phenotypes with KTI12: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KTI12 Gene

Localization for KTI12 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KTI12 gene
Compartment Confidence
extracellular 2
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytoplasmic bodies (2)
  • Nuclear speckles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KTI12 Gene

Pathways & Interactions for KTI12 Gene

SuperPathways for KTI12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KTI12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KTI12 Gene

Drugs & Compounds for KTI12 Gene

No Compound Related Data Available

Transcripts for KTI12 Gene

mRNA/cDNA for KTI12 Gene

(1) REFSEQ mRNAs :
(129) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for KTI12 Gene

No ASD Table

Relevant External Links for KTI12 Gene

GeneLoc Exon Structure for
KTI12
ECgene alternative splicing isoforms for
KTI12

Expression for KTI12 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KTI12 Gene

Protein differential expression in normal tissues from HIPED for KTI12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.3) and Blymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KTI12 Gene



Protein tissue co-expression partners for KTI12 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KTI12 Gene:

KTI12

Evidence on tissue expression from TISSUES for KTI12 Gene

  • Skin(4.3)
genes like me logo Genes that share expression patterns with KTI12: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KTI12 Gene

Orthologs for KTI12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KTI12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KTI12 33
  • 99.34 (n)
cow
(Bos Taurus)
Mammalia KTI12 33
  • 83.9 (n)
dog
(Canis familiaris)
Mammalia KTI12 33 34
  • 82.75 (n)
rat
(Rattus norvegicus)
Mammalia Kti12 33
  • 78.48 (n)
mouse
(Mus musculus)
Mammalia Kti12 33 16 34
  • 77.68 (n)
chicken
(Gallus gallus)
Aves TXNDC12 33
  • 66.81 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia kti12 33
  • 60.02 (n)
zebrafish
(Danio rerio)
Actinopterygii kti12 33 34
  • 57.14 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005190 33
  • 49.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG3587 33 34
  • 48.43 (n)
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57G11C.43 33
  • 46.01 (n)
Y57G11C.43 34
  • 31 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL049C 33
  • 47.69 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02926g 33
  • 43.31 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KTI12 33 34 36
  • 42.86 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons DRL1 33
  • 42.08 (n)
rice
(Oryza sativa)
Liliopsida Os11g0312782 33
  • 45.27 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC30.02c 33
  • 44.23 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU00178 33
  • 44.08 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5241 34
  • 39 (a)
OneToOne
Species where no ortholog for KTI12 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KTI12 Gene

ENSEMBL:
Gene Tree for KTI12 (if available)
TreeFam:
Gene Tree for KTI12 (if available)

Paralogs for KTI12 Gene

No data available for Paralogs for KTI12 Gene

Variants for KTI12 Gene

Sequence variations from dbSNP and Humsavar for KTI12 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000969069 -- 52,033,560(-) G/A coding_sequence_variant, missense_variant
rs1001617907 -- 52,034,269(-) A/C upstream_transcript_variant
rs1001940561 -- 52,032,566(-) G/C 3_prime_UTR_variant
rs1001973064 -- 52,032,300(-) G/T 3_prime_UTR_variant
rs1003474049 -- 52,034,995(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KTI12 Gene

Variant ID Type Subtype PubMed ID
nsv1004103 CNV loss 25217958
nsv829848 CNV loss 17160897

Variation tolerance for KTI12 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KTI12 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KTI12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KTI12 Gene

Disorders for KTI12 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KTI12 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ostertagiasis
trichostrongyloidiasis
- elite association - COSMIC cancer census association via MalaCards
Search KTI12 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for KTI12

genes like me logo Genes that share disorders with KTI12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KTI12 Gene

Publications for KTI12 Gene

  1. Molecular analysis of KTI12/TOT4, a Saccharomyces cerevisiae gene required for Kluyveromyces lactis zymocin action. (PMID: 11929532) Fichtner L … Schaffrath R (Molecular microbiology 2002) 2 3 22 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for KTI12 Gene

Sources for KTI12 Gene

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