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Aliases for KTI12 Gene

Aliases for KTI12 Gene

  • KTI12 Chromatin Associated Homolog 2 3 5
  • KTI12 Homolog, Chromatin Associated (S. Cerevisiae) 2
  • KTI12 Homolog, Chromatin Associated 3
  • SBBI81 3
  • TOT4 3

External Ids for KTI12 Gene

Previous GeneCards Identifiers for KTI12 Gene

  • GC01M052210
  • GC01M052497
  • GC01M050615

Summaries for KTI12 Gene

GeneCards Summary for KTI12 Gene

KTI12 (KTI12 Chromatin Associated Homolog) is a Protein Coding gene. Diseases associated with KTI12 include Ostertagiasis and Trichostrongyloidiasis.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KTI12 Gene

Genomics for KTI12 Gene

Regulatory Elements for KTI12 Gene

Enhancers for KTI12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KTI12 on UCSC Golden Path with GeneCards custom track

Promoters for KTI12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KTI12 on UCSC Golden Path with GeneCards custom track

Genomic Location for KTI12 Gene

Chromosome:
1
Start:
52,032,103 bp from pter
End:
52,033,816 bp from pter
Size:
1,714 bases
Orientation:
Minus strand

Genomic View for KTI12 Gene

Genes around KTI12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KTI12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KTI12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KTI12 Gene

Proteins for KTI12 Gene

  • Protein details for KTI12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96EK9-KTI12_HUMAN
    Recommended name:
    Protein KTI12 homolog
    Protein Accession:
    Q96EK9

    Protein attributes for KTI12 Gene

    Size:
    354 amino acids
    Molecular mass:
    38616 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KTI12 Gene

Proteomics data for KTI12 Gene at MOPED

Post-translational modifications for KTI12 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KTI12 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KTI12 Gene

Domains & Families for KTI12 Gene

Protein Domains for KTI12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KTI12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96EK9

UniProtKB/Swiss-Prot:

KTI12_HUMAN :
  • Belongs to the KTI12 family.
Family:
  • Belongs to the KTI12 family.
genes like me logo Genes that share domains with KTI12: view

No data available for Gene Families for KTI12 Gene

Function for KTI12 Gene

Gene Ontology (GO) - Molecular Function for KTI12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KTI12: view

Phenotypes for KTI12 Gene

GenomeRNAi human phenotypes for KTI12:
genes like me logo Genes that share phenotypes with KTI12: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KTI12 Gene

Localization for KTI12 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KTI12 Gene COMPARTMENTS Subcellular localization image for KTI12 gene
Compartment Confidence
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KTI12 Gene

Pathways & Interactions for KTI12 Gene

SuperPathways for KTI12 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KTI12 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KTI12 Gene

Drugs & Compounds for KTI12 Gene

No Compound Related Data Available

Transcripts for KTI12 Gene

mRNA/cDNA for KTI12 Gene

(1) REFSEQ mRNAs :
(129) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KTI12 Gene

No ASD Table

Relevant External Links for KTI12 Gene

GeneLoc Exon Structure for
KTI12
ECgene alternative splicing isoforms for
KTI12

Expression for KTI12 Gene

mRNA expression in normal human tissues for KTI12 Gene

Protein differential expression in normal tissues from HIPED for KTI12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (38.3) and Blymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for KTI12 Gene



genes like me logo Genes that share expression patterns with KTI12: view

Protein tissue co-expression partners for KTI12 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for KTI12 Gene

Orthologs for KTI12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for KTI12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KTI12 35
  • 83.9 (n)
  • 84.75 (a)
dog
(Canis familiaris)
Mammalia KTI12 35
  • 82.75 (n)
  • 83.33 (a)
KTI12 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Kti12 35
  • 77.68 (n)
  • 77.21 (a)
Kti12 16
Kti12 36
  • 76 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KTI12 35
  • 99.34 (n)
  • 99.15 (a)
rat
(Rattus norvegicus)
Mammalia Kti12 35
  • 78.48 (n)
  • 76.86 (a)
chicken
(Gallus gallus)
Aves TXNDC12 35
  • 66.81 (n)
  • 63.71 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia kti12 35
  • 60.02 (n)
  • 57.56 (a)
zebrafish
(Danio rerio)
Actinopterygii kti12 35
  • 57.14 (n)
  • 57.89 (a)
kti12 36
  • 56 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005190 35
  • 49.3 (n)
  • 37.64 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG3587 35
  • 48.43 (n)
  • 36.58 (a)
CG3587 36
  • 33 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_Y57G11C.43 35
  • 46.01 (n)
  • 38.82 (a)
Y57G11C.43 36
  • 31 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ABL049C 35
  • 47.69 (n)
  • 36.76 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F02926g 35
  • 43.31 (n)
  • 35.43 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KTI12 35
  • 42.86 (n)
  • 34.36 (a)
KTI12 36
  • 28 (a)
OneToOne
KTI12 38
thale cress
(Arabidopsis thaliana)
eudicotyledons DRL1 35
  • 42.08 (n)
  • 35.36 (a)
rice
(Oryza sativa)
Liliopsida Os11g0312782 35
  • 45.27 (n)
  • 35.8 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU00178 35
  • 44.08 (n)
  • 33.43 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC30.02c 35
  • 44.23 (n)
  • 38.4 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5241 36
  • 39 (a)
OneToOne
Species with no ortholog for KTI12:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KTI12 Gene

ENSEMBL:
Gene Tree for KTI12 (if available)
TreeFam:
Gene Tree for KTI12 (if available)

Paralogs for KTI12 Gene

No data available for Paralogs for KTI12 Gene

Variants for KTI12 Gene

Sequence variations from dbSNP and Humsavar for KTI12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_032046 -

Structural Variations from Database of Genomic Variants (DGV) for KTI12 Gene

Variant ID Type Subtype PubMed ID
nsv829848 CNV Loss 17160897

Variation tolerance for KTI12 Gene

Residual Variation Intolerance Score: 74.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.19; 69.73% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KTI12 Gene

Disorders for KTI12 Gene

MalaCards: The human disease database

(2) MalaCards diseases for KTI12 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ostertagiasis
trichostrongyloidiasis
- elite association - COSMIC cancer census association via MalaCards
Search KTI12 in MalaCards View complete list of genes associated with diseases

Relevant External Links for KTI12

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KTI12
genes like me logo Genes that share disorders with KTI12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for KTI12 Gene

Publications for KTI12 Gene

  1. Molecular analysis of KTI12/TOT4, a Saccharomyces cerevisiae gene required for Kluyveromyces lactis zymocin action. (PMID: 11929532) Fichtner L. … Schaffrath R. (Mol. Microbiol. 2002) 2 3 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KTI12 Gene

Sources for KTI12 Gene

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