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Aliases for KSR2 Gene

Aliases for KSR2 Gene

  • Kinase Suppressor Of Ras 2 2 3
  • EC 2.7.11.1 4
  • HKSR2 4

External Ids for KSR2 Gene

Summaries for KSR2 Gene

GeneCards Summary for KSR2 Gene

KSR2 (Kinase Suppressor Of Ras 2) is a Protein Coding gene. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is MAP3K9.

UniProtKB/Swiss-Prot for KSR2 Gene

  • Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KSR2 Gene

Genomics for KSR2 Gene

Genomic Location for KSR2 Gene

Start:
117,453,012 bp from pter
End:
117,968,983 bp from pter
Size:
515,972 bases
Orientation:
Minus strand

Genomic View for KSR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KSR2 Gene

Regulatory Elements for KSR2 Gene

Proteins for KSR2 Gene

  • Protein details for KSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VAB6-KSR2_HUMAN
    Recommended name:
    Kinase suppressor of Ras 2
    Protein Accession:
    Q6VAB6
    Secondary Accessions:
    • A0PJT2
    • Q3B828
    • Q8N775

    Protein attributes for KSR2 Gene

    Size:
    950 amino acids
    Molecular mass:
    107632 Da
    Quaternary structure:
    • Interacts with MAP2K1, forming a heterodimer that can dimerize to form a heterotetramer. Interacts with MAP3K8, MAPK, RAS and RAF. Interacts with BRAF; this increases the low intrinsic protein kinase activity of KSR2.

    Three dimensional structures from OCA and Proteopedia for KSR2 Gene

    Alternative splice isoforms for KSR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KSR2 Gene

Proteomics data for KSR2 Gene at MOPED

Post-translational modifications for KSR2 Gene

Other Protein References for KSR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KSR2 Gene

Domains for KSR2 Gene

Gene Families for KSR2 Gene

UniProtKB/Swiss-Prot:

KSR2_HUMAN
Domain:
  • The protein kinase domain is predicted to be catalytically inactive and seems to have very low intrinsic kinase activity. This low kinase activity can be increased by interaction with BRAF:
    • Q6VAB6
  • Contains 1 protein kinase domain.:
    • Q6VAB6
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.:
    • Q6VAB6
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.:
    • Q6VAB6
genes like me logo Genes that share domains with KSR2: view

Function for KSR2 Gene

Molecular function for KSR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation: Kinase activity is inhibited by ASC24.
UniProtKB/Swiss-Prot Function: Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Enzyme Numbers (IUBMB) for KSR2 Gene

Gene Ontology (GO) - Molecular Function for KSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005078 MAP-kinase scaffold activity --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with KSR2: view
genes like me logo Genes that share phenotypes with KSR2: view

Animal Models for KSR2 Gene

MGI Knock Outs for KSR2:

miRNA for KSR2 Gene

miRTarBase miRNAs that target KSR2

No data available for Transcription Factor Targeting and HOMER Transcription for KSR2 Gene

Localization for KSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KSR2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KSR2 Gene COMPARTMENTS Subcellular localization image for KSR2 gene
Compartment Confidence
cytosol 3
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for KSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol --
GO:0005886 plasma membrane --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KSR2: view

Pathways for KSR2 Gene

SuperPathways for KSR2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0019722 calcium-mediated signaling --
GO:0035556 intracellular signal transduction IEA --
GO:0043410 positive regulation of MAPK cascade --
genes like me logo Genes that share ontologies with KSR2: view

No data available for Pathways by source for KSR2 Gene

Compounds for KSR2 Gene

(843) HMDB Compounds for KSR2 Gene

Compound Synonyms Cas Number PubMed IDs
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available
DG(14:0/16:1(9Z)/0:0)
  • DG(30:1)
Not Available
genes like me logo Genes that share compounds with KSR2: view

Transcripts for KSR2 Gene

mRNA/cDNA for KSR2 Gene

(8) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KSR2 Gene

Kinase suppressor of ras 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KSR2 Gene

No ASD Table

Relevant External Links for KSR2 Gene

GeneLoc Exon Structure for
KSR2
ECgene alternative splicing isoforms for
KSR2

Expression for KSR2 Gene

mRNA expression in normal human tissues for KSR2 Gene

mRNA differential expression in normal tissues according to GTEx for KSR2 Gene

This gene is overexpressed in Pituitary (9.2), Brain - Cerebellum (5.5), Brain - Cerebellar Hemisphere (5.0), and Brain - Cortex (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KSR2 Gene

SOURCE GeneReport for Unigene cluster for KSR2 Gene Hs.375836

mRNA Expression by UniProt/SwissProt for KSR2 Gene

Q6VAB6-KSR2_HUMAN
Tissue specificity: Mainly expressed in brain and kidney.
genes like me logo Genes that share expressions with KSR2: view

Orthologs for KSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KSR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KSR2 36
  • 99.71 (n)
  • 100 (a)
KSR2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KSR2 36
  • 93.59 (n)
  • 98.8 (a)
KSR2 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KSR2 36
  • 92.93 (n)
  • 98.59 (a)
KSR2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ksr2 36
  • 88.78 (n)
  • 96.42 (a)
Ksr2 16
Ksr2 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia KSR2 37
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 92 (a)
OneToMany
-- 37
  • 94 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ksr2 36
  • 88.53 (n)
  • 96.74 (a)
chicken
(Gallus gallus)
Aves KSR2 37
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KSR2 37
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ksr2 36
  • 78.87 (n)
  • 90.35 (a)
zebrafish
(Danio rerio)
Actinopterygii ksr2 36
  • 76.12 (n)
  • 83.44 (a)
ksr2 37
  • 87 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta ksr 37
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ksr-1 37
  • 26 (a)
ManyToMany
ksr-2 37
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 43 (a)
OneToMany
Species with no ortholog for KSR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KSR2 Gene

ENSEMBL:
Gene Tree for KSR2 (if available)
TreeFam:
Gene Tree for KSR2 (if available)

Paralogs for KSR2 Gene

Selected SIMAP similar genes for KSR2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KSR2: view

Variants for KSR2 Gene

Sequence variations from dbSNP and Humsavar for KSR2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs256902 -- 117,624,645(-) atcac(A/G)ctacc intron-variant
rs388980 -- 117,625,512(+) attga(A/T)ttgca intron-variant
rs471231 -- 117,749,532(+) ATAAG(A/G)GACTG intron-variant
rs472758 -- 117,819,190(+) GCTCA(A/G/T)TCAAG intron-variant
rs472932 -- 117,701,067(+) aatag(A/G)aggaa intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KSR2 Gene

Variant ID Type Subtype PubMed ID
nsv899543 CNV Gain 21882294
esv2746440 CNV Deletion 23290073
esv2746442 CNV Deletion 23290073
nsv832527 CNV Gain 17160897
nsv528755 CNV Loss 19592680
esv2746443 CNV Deletion 23290073
esv1951791 CNV Deletion 18987734
nsv517825 CNV Loss 19592680
nsv442289 CNV CNV 18776908
esv2661492 CNV Deletion 23128226
esv2667163 CNV Deletion 23128226
esv2746444 CNV Deletion 23290073
nsv519555 CNV Gain+Loss 19592680
nsv509481 CNV Insertion 20534489
esv2674921 CNV Deletion 23128226
nsv53849 CNV Loss 16902084
esv1001837 CNV Insertion 20482838
esv267730 CNV Insertion 20981092
nsv899544 CNV Loss 21882294
esv2746445 CNV Deletion 23290073
esv2746446 CNV Deletion 23290073
esv2746447 CNV Deletion 23290073
esv2746448 CNV Deletion 23290073
esv2746449 CNV Deletion 23290073
esv988370 CNV Deletion 20482838
esv2746450 CNV Deletion 23290073
nsv899545 CNV Gain 21882294

Relevant External Links for KSR2 Gene

HapMap Linkage Disequilibrium report
KSR2
Human Gene Mutation Database (HGMD)
KSR2

Disorders for KSR2 Gene

Relevant External Links for KSR2

Genetic Association Database (GAD)
KSR2
Human Genome Epidemiology (HuGE) Navigator
KSR2
genes like me logo Genes that share disorders with KSR2: view

No data available for UniProtKB/Swiss-Prot for KSR2 Gene

Publications for KSR2 Gene

  1. Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. (PMID: 12975377) Channavajhala P.L. … Zhang Y. (J. Biol. Chem. 2003) 3 4 23
  2. hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation. (PMID: 16039990) Channavajhala P.L. … Zhang Y.G. (Biochem. Biophys. Res. Commun. 2005) 3 4 23
  3. The protein kinase complement of the human genome. (PMID: 12471243) Manning G. … Sudarsanam S. (Science 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for KSR2 Gene

Sources for KSR2 Gene

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