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Aliases for KSR2 Gene

Aliases for KSR2 Gene

  • Kinase Suppressor Of Ras 2 2 3 5
  • EC 2.7.11.1 4
  • HKSR2 4

External Ids for KSR2 Gene

Previous GeneCards Identifiers for KSR2 Gene

  • GC12M117738
  • GC12M116367
  • GC12M116316
  • GC12M116370
  • GC12M117890
  • GC12M114899

Summaries for KSR2 Gene

GeneCards Summary for KSR2 Gene

KSR2 (Kinase Suppressor Of Ras 2) is a Protein Coding gene. Among its related pathways are RET signaling and Immune System. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is KSR1.

UniProtKB/Swiss-Prot for KSR2 Gene

  • Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KSR2 Gene

Genomics for KSR2 Gene

Regulatory Elements for KSR2 Gene

Enhancers for KSR2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F117911 0.5 FANTOM5 11.2 +57.6 57599 0.3 RAD51 RBAK NFYB TRIM28 KSR2 ENSG00000256071
GH12F118187 1.1 FANTOM5 ENCODE 8 -220.2 -220196 3.4 TAL1 JUN ZNF384 EBF1 POLR2A GATA2 NCOR1 TRIM24 RFX1 MTA2 KSR2 VSIG10 GC12P118191 GC12M118176
GH12F117968 0.2 ENCODE 0.8 -0.2 -186 1.4 PKNOX1 FEZF1 ZNF2 GLIS2 ZNF263 SP3 YY2 TSHZ1 REST ZNF518A ENSG00000256071 LOC105370016 LOC105370013 LOC105370014 ENSG00000256149 SUDS3 RFC5 VSIG10 KSR2
GH12F117985 0.2 ENCODE 0.3 -17.9 -17891 2.0 ARID1B NCOR1 RNF2 MTA2 TAL1 IKZF1 HMBOX1 PRDM10 TCF7L2 KSR2 RFC5
GH12F117907 0.5 ENCODE 0.2 +61.6 61593 0.2 HDGF CBX3 PKNOX1 ARNT ZNF644 CHAMP1 GATA3 GATA2 SCRT2 TRIM24 ENSG00000256071 KSR2
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around KSR2 on UCSC Golden Path with GeneCards custom track

Promoters for KSR2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000437881 102 1200 PKNOX1 FEZF1 ZNF2 GLIS2 ZNF263 SP3 YY2 TSHZ1 REST ZNF518A

Genomic Location for KSR2 Gene

Chromosome:
12
Start:
117,453,012 bp from pter
End:
117,969,103 bp from pter
Size:
516,092 bases
Orientation:
Minus strand

Genomic View for KSR2 Gene

Genes around KSR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KSR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KSR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KSR2 Gene

Proteins for KSR2 Gene

  • Protein details for KSR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VAB6-KSR2_HUMAN
    Recommended name:
    Kinase suppressor of Ras 2
    Protein Accession:
    Q6VAB6
    Secondary Accessions:
    • A0PJT2
    • Q3B828
    • Q8N775

    Protein attributes for KSR2 Gene

    Size:
    950 amino acids
    Molecular mass:
    107632 Da
    Quaternary structure:
    • Interacts with MAP2K1, forming a heterodimer that can dimerize to form a heterotetramer. Interacts with MAP3K8, MAPK, RAS and RAF. Interacts with BRAF; this increases the low intrinsic protein kinase activity of KSR2.

    Three dimensional structures from OCA and Proteopedia for KSR2 Gene

    Alternative splice isoforms for KSR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KSR2 Gene

Post-translational modifications for KSR2 Gene

No data available for DME Specific Peptides for KSR2 Gene

Domains & Families for KSR2 Gene

Gene Families for KSR2 Gene

Suggested Antigen Peptide Sequences for KSR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6VAB6

UniProtKB/Swiss-Prot:

KSR2_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive and seems to have very low intrinsic kinase activity. This low kinase activity can be increased by interaction with BRAF.
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
  • Contains 1 phorbol-ester/DAG-type zinc finger.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive and seems to have very low intrinsic kinase activity. This low kinase activity can be increased by interaction with BRAF.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Similarity:
  • Contains 1 phorbol-ester/DAG-type zinc finger.
genes like me logo Genes that share domains with KSR2: view

Function for KSR2 Gene

Molecular function for KSR2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Kinase activity is inhibited by ASC24.
UniProtKB/Swiss-Prot Function:
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Enzyme Numbers (IUBMB) for KSR2 Gene

Gene Ontology (GO) - Molecular Function for KSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IEA,IBA --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004871 signal transducer activity IBA --
GO:0005524 ATP binding IEA --
GO:0016301 kinase activity IEA --
genes like me logo Genes that share ontologies with KSR2: view
genes like me logo Genes that share phenotypes with KSR2: view

Animal Models for KSR2 Gene

MGI Knock Outs for KSR2:

Animal Model Products

  • Taconic Biosciences Mouse Models for KSR2

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KSR2

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KSR2 Gene

Localization for KSR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KSR2 Gene

Cytoplasm. Membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KSR2 Gene COMPARTMENTS Subcellular localization image for KSR2 gene
Compartment Confidence
cytosol 3
nucleus 2

Gene Ontology (GO) - Cellular Components for KSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IBA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KSR2: view

Pathways & Interactions for KSR2 Gene

SuperPathways for KSR2 Gene

SuperPathway Contained pathways
1 RET signaling
2 MAPK-Erk Pathway
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with KSR2: view

Pathways by source for KSR2 Gene

2 Sino Biological pathways for KSR2 Gene
1 BioSystems pathway for KSR2 Gene

Gene Ontology (GO) - Biological Process for KSR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IBA --
GO:0007265 NOT Ras protein signal transduction IBA --
GO:0016310 phosphorylation IEA --
GO:0019722 calcium-mediated signaling IBA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with KSR2: view

No data available for SIGNOR curated interactions for KSR2 Gene

Drugs & Compounds for KSR2 Gene

(4) Additional Compounds for KSR2 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with KSR2: view

Transcripts for KSR2 Gene

mRNA/cDNA for KSR2 Gene

(9) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KSR2 Gene

Kinase suppressor of ras 2:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KSR2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KSR2 Gene

No ASD Table

Relevant External Links for KSR2 Gene

GeneLoc Exon Structure for
KSR2
ECgene alternative splicing isoforms for
KSR2

Expression for KSR2 Gene

mRNA expression in normal human tissues for KSR2 Gene

mRNA differential expression in normal tissues according to GTEx for KSR2 Gene

This gene is overexpressed in Pituitary (x9.2), Brain - Cerebellum (x5.5), Brain - Cerebellar Hemisphere (x5.0), and Brain - Cortex (x4.4).

Protein differential expression in normal tissues from HIPED for KSR2 Gene

This gene is overexpressed in Plasma (47.3), Pancreatic juice (12.6), and Skin (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KSR2 Gene



Protein tissue co-expression partners for KSR2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of KSR2 Gene:

KSR2

SOURCE GeneReport for Unigene cluster for KSR2 Gene:

Hs.375836

mRNA Expression by UniProt/SwissProt for KSR2 Gene:

Q6VAB6-KSR2_HUMAN
Tissue specificity: Mainly expressed in brain and kidney.
genes like me logo Genes that share expression patterns with KSR2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KSR2 Gene

Orthologs for KSR2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KSR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KSR2 34 35
  • 99.71 (n)
oppossum
(Monodelphis domestica)
Mammalia KSR2 35
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
OneToMany
-- 35
  • 92 (a)
OneToMany
cow
(Bos Taurus)
Mammalia KSR2 34 35
  • 93.59 (n)
dog
(Canis familiaris)
Mammalia KSR2 34 35
  • 92.93 (n)
mouse
(Mus musculus)
Mammalia Ksr2 34 16 35
  • 88.78 (n)
rat
(Rattus norvegicus)
Mammalia Ksr2 34
  • 88.53 (n)
chicken
(Gallus gallus)
Aves KSR2 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KSR2 35
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ksr2 34
  • 78.87 (n)
zebrafish
(Danio rerio)
Actinopterygii ksr2 34 35
  • 76.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta ksr 35
  • 32 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ksr-2 35
  • 27 (a)
ManyToMany
ksr-1 35
  • 26 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
OneToMany
Species where no ortholog for KSR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KSR2 Gene

ENSEMBL:
Gene Tree for KSR2 (if available)
TreeFam:
Gene Tree for KSR2 (if available)

Paralogs for KSR2 Gene

(1) SIMAP similar genes for KSR2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KSR2: view

Variants for KSR2 Gene

Sequence variations from dbSNP and Humsavar for KSR2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_040659 A lung adenocarcinoma sample
rs1001426 -- 117,703,787(+) ATACG(C/T)CCTCC intron-variant
rs1002231 -- 117,671,747(+) AGAGC(A/G)CTTGG intron-variant
rs10035406 -- 117,625,952(-) gataa(A/G)ttcct intron-variant
rs10037378 -- 117,625,627(-) CAATG(C/T)GAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KSR2 Gene

Variant ID Type Subtype PubMed ID
dgv879n106 CNV duplication 24896259
dgv89e215 CNV deletion 23714750
dgv923e59 CNV duplication 20981092
esv1001837 CNV insertion 20482838
esv1951791 CNV deletion 18987734
esv2661492 CNV deletion 23128226
esv2667163 CNV deletion 23128226
esv2674921 CNV deletion 23128226
esv2746440 CNV deletion 23290073
esv2746442 CNV deletion 23290073
esv2746443 CNV deletion 23290073
esv2746444 CNV deletion 23290073
esv2746445 CNV deletion 23290073
esv2746446 CNV deletion 23290073
esv2746447 CNV deletion 23290073
esv2746448 CNV deletion 23290073
esv2746449 CNV deletion 23290073
esv2746450 CNV deletion 23290073
esv3303451 CNV mobile element insertion 20981092
esv3372967 CNV insertion 20981092
esv3423992 CNV insertion 20981092
esv3580493 CNV loss 25503493
esv3580495 CNV loss 25503493
esv3580496 CNV loss 25503493
esv3581916 CNV gain 25503493
esv3630872 CNV loss 21293372
esv3630873 CNV gain 21293372
esv3630874 CNV loss 21293372
esv3630875 CNV loss 21293372
esv3630877 CNV loss 21293372
esv988370 CNV deletion 20482838
nsv1045538 CNV loss 25217958
nsv1075849 CNV duplication 25765185
nsv1122771 CNV deletion 24896259
nsv1127296 CNV deletion 24896259
nsv1127297 CNV deletion 24896259
nsv1138173 CNV deletion 24896259
nsv1138174 CNV deletion 24896259
nsv1145629 CNV deletion 24896259
nsv1150302 CNV deletion 26484159
nsv1160064 CNV deletion 26073780
nsv442289 CNV loss 18776908
nsv509481 CNV insertion 20534489
nsv517825 CNV loss 19592680
nsv519555 CNV gain+loss 19592680
nsv528755 CNV loss 19592680
nsv53849 CNV deletion 16902084
nsv560386 CNV gain 21841781
nsv560387 CNV loss 21841781
nsv560388 CNV loss 21841781
nsv832527 CNV gain 17160897

Variation tolerance for KSR2 Gene

Residual Variation Intolerance Score: 4.66% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.94; 49.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KSR2 Gene

Human Gene Mutation Database (HGMD)
KSR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
KSR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KSR2 Gene

Disorders for KSR2 Gene

Relevant External Links for KSR2

Genetic Association Database (GAD)
KSR2
Human Genome Epidemiology (HuGE) Navigator
KSR2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KSR2

No disorders were found for KSR2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KSR2 Gene

Publications for KSR2 Gene

  1. hKSR-2 inhibits MEKK3-activated MAP kinase and NF-kappaB pathways in inflammation. (PMID: 16039990) Channavajhala P.L. … Zhang Y.G. (Biochem. Biophys. Res. Commun. 2005) 3 4 22 64
  2. Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. (PMID: 12975377) Channavajhala P.L. … Zhang Y. (J. Biol. Chem. 2003) 3 4 22 64
  3. A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK. (PMID: 21441910) Brennan D.F. … Barford D. (Nature 2011) 3 4 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64

Products for KSR2 Gene