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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KSR1 Gene

protein-coding   GIFtS: 61
GCID: GC17P025783

Kinase Suppressor Of Ras 1

(Previous name: kinase suppressor of ras)
(Previous symbol: KSR)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Kinase Suppressor Of Ras 11 2
KSR1 2 3 5
Kinase Suppressor Of Ras1
RSU22

External Ids:    HGNC: 64651   Entrez Gene: 88442   Ensembl: ENSG000001410687   OMIM: 6011325   UniProtKB: Q8IVT53   

Export aliases for KSR1 gene to outside databases

Previous GC identifers: GC17P022899 GC17P025799 GC17P022092


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KSR1 Gene: 
KSR1 (kinase suppressor of ras 1) is a protein-coding gene. Diseases associated with KSR1 include bronchopneumonia, and scarlet fever, and among its related super-pathways are Inflammasome Activation Pathways. GO annotations related to this gene include protein serine/threonine kinase activity and protein kinase activity. An important paralog of this gene is FPGT-TNNI3K.

UniProtKB/Swiss-Prot: KSR1_HUMAN, Q8IVT5
Function: Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and
activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity

Gene Wiki entry for KSR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000017.10  NC_018928.2  NT_010799.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KSR1 gene promoter:
         USF1   Tal-1   MyoD   NF-kappaB   RORalpha1   USF-1   HSF2   SEF-1 (1)   NF-kappaB1   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKSR1 promoter sequence
   Search SABiosciences Chromatin IP Primers for KSR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KSR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q11.2   Ensembl cytogenetic band:  17q11.1   HGNC cytogenetic band: 17q11.2

KSR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KSR1 gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P025783:  view genomic region     (about GC identifiers)

Start:
25,783,670 bp from pter      End:
25,953,461 bp from pter
Size:
169,792 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KSR1_HUMAN, Q8IVT5 (See protein sequence)
Recommended Name: Kinase suppressor of Ras 1  
Size: 921 amino acids; 102032 Da
Subunit: Interacts with HSPCA/HSP90, YWHAB/14-3-3, CDC37, MAP2K/MEK, MARK3, PPP2R1A and PPP2CA. Also interacts
with RAF and MAPK/ERK, in a Ras-dependent manner (By similarity). The binding of 14-3-3 proteins to
phosphorylated KSR prevents the membrane localization. Interacts with isoform 1 of VRK2
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein (By similarity). Endoplasmic reticulum
membrane. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration
in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and
it moves from the cytoplasm to the cell periphery (By similarity)
Secondary accessions: Q13476
Alternative splicing: 3 isoforms:  Q8IVT5-1   Q8IVT5-2   Q8IVT5-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for KSR1: NX_Q8IVT5

Explore proteomics data for KSR1 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on Ser-309 and, to a higher extent, on Ser-404 by MARK3. Dephosphorylated on Ser-404 by PPP2CA. In
    resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is
    membrane-associated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8IVT5

  • KSR1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KSR1 Protein Expression
    REFSEQ proteins: NP_055053.1  
    ENSEMBL proteins: 
     ENSP00000463204   ENSP00000464081   ENSP00000381958   ENSP00000381952   ENSP00000463554  
     ENSP00000464680   ENSP00000463790   ENSP00000463779   ENSP00000323178   ENSP00000438795  
     ENSP00000268763  

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    Cloud-Clone Corp. Proteins for KSR1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular NAS--
    GO:0005789endoplasmic reticulum membrane IEA--

    KSR1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for KSR1 
    Cloud-Clone Corp. CLIAs for KSR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: kinase suppressor of ras 1 
    RAF family

    5/6 InterPro protein domains (see all 6):
     IPR001245 Ser-Thr/Tyr_kinase_cat_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR002219 Prot_Kinase_C-like_PE/DAG-bd
     IPR025561 KSR_SAM-like_dom

    Graphical View of Domain Structure for InterPro Entry Q8IVT5

    ProtoNet protein and cluster: Q8IVT5

    UniProtKB/Swiss-Prot: KSR1_HUMAN, Q8IVT5
    Domain: The protein kinase domain is predicted to be catalytically inactive
    Similarity: Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family
    Similarity: Contains 1 phorbol-ester/DAG-type zinc finger
    Similarity: Contains 1 protein kinase domain


    KSR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KSR1_HUMAN, Q8IVT5
    Function: Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and
    activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity

         Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004672protein kinase activity NAS8521512
    GO:0004674protein serine/threonine kinase activity IEA--
    GO:0004713protein tyrosine kinase activity ----
    GO:0005078MAP-kinase scaffold activity ----
    GO:0005515protein binding IPI--
         
    KSR1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for KSR1:
     Decreased substrate adherent c  Decreased viability 

         10 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Ksr1):
     adipose tissue  behavior/neurological  cellular  hematopoietic system  homeostasis/metabolism 
     immune system  integument  nervous system  skeleton  tumorigenesis 

    KSR1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for KSR1: Ksr1tm1Shaw Ksr1tm1Kole

       inGenious Targeting Laboratory - Custom generated mouse model solutions for KSR1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for KSR1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KSR1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for KSR1 

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    SwitchGear 3'UTR luciferase reporter plasmidKSR1 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KSR1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for KSR1 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Toll-Like receptor Signaling Pathways
    Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways0.31
    2Tuberculosis
    Tuberculosis
    3MAP Kinase Signaling
    MAP Kinase Signaling
    4ErbB1 downstream signaling
    ErbB1 downstream signaling
    5BDNF signaling pathway
    BDNF signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for KSR1
        Pathogen or Damage-activated C-Type Lectin Receptor Signaling Pathways


    1 Cell Signaling Technology (CST) Pathway for KSR1
        MAP Kinase Signaling

    3 BioSystems Pathways for KSR1
        BDNF signaling pathway
    Ceramide signaling pathway
    ErbB1 downstream signaling


    1         Kegg Pathway  (Kegg details for KSR1):
        Tuberculosis


    KSR1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for KSR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/39 Interacting proteins for KSR1 (Q8IVT51, 2, 3 ENSP000002687634) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678703I2D: score=1 
    ENSG00000206406P678703I2D: score=1 
    ENSG00000224398P678703I2D: score=1 
    ENSG00000224774P678703I2D: score=1 
    ENSG00000228875P678703I2D: score=1 
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation NAS--
    GO:0007265Ras protein signal transduction NAS8521512
    GO:0035556intracellular signal transduction ----
    GO:0043410positive regulation of MAPK cascade ----

    KSR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KSR1

    10/843 HMDB Compounds for KSR1 (see all 843)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----
    DG(14:0/18:2(9Z,12Z)/0:0)DAG(14:0/18:2n6) (see all 15)----
    DG(14:0/18:3(6Z,9Z,12Z)/0:0)Diacylglycerol(14:0/18:3n6) (see all 16)----

    Search CenterWatch for drugs/clinical trials and news about KSR1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KSR1 gene: 
    NM_014238.1  

    Unigene Cluster for KSR1:

    Kinase suppressor of ras 1
    Hs.133534  [show with all ESTs]
    Unigene Representative Sequence: NM_014238
    18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):
    ENST00000580163 ENST00000579309 ENST00000583370 ENST00000398988(uc010crg.3 uc002gzm.3)
    ENST00000582311 ENST00000398985(uc002gzl.1) ENST00000579399 ENST00000398982
    ENST00000577823 ENST00000581975 ENST00000580822 ENST00000579961 ENST00000583525
    ENST00000582410(uc002gzn.3) ENST00000580430 ENST00000583998 ENST00000578981
    ENST00000319524
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Additional mRNA sequence: 

    AK095721.1 AK124344.1 AK130719.1 BC035488.1 BC037586.1 BC042106.1 U43586.1 

    11 DOTS entries:

    DT.75101380  DT.40118322  DT.95378650  DT.100786396  DT.95218803  DT.101972616  DT.100758649  DT.99946344 
    DT.102824541  DT.120966531  DT.91818885 

    24/85 AceView cDNA sequences (see all 85):

    CA942123 C02393 BX092902 AI536645 AI809969 CB268574 BC037586 BM989782 
    AI458861 BX108666 AI184584 AI925520 BX327146 BX952294 BF512794 AK095721 
    AI123553 BI829205 AW027596 AK130719 BF528425 AI698440 BF115266 H88142 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for KSR1 (see all 7)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
    SP1:                                                                    -                                         -                             -               
    SP2:              -     -                                                                                                                                       
    SP3:                    -                                         -     -                                                                                       
    SP4:                                                                                                                                            -               
    SP5:                                                                                                                                            -     -     -   

    ExUns: 22a · 22b
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for KSR1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KSR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCTGTGC
    KSR1 Expression
    About this image


    See KSR1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KSR1

    SOURCE GeneReport for Unigene cluster: Hs.133534
        SABiosciences Expression via Pathway-Focused PCR Array including KSR1: 
              MAP Kinase (MAPK) Signaling Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KSR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KSR1 gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ksr11 , 5 kinase suppressor of ras 11, 5 87.19(n)1
    91.3(a)1
      11 (46.74 cM)5
    167061  NM_013571.21  NP_038599.11 
     790134405 
    chicken
    (Gallus gallus)
    Aves KSR11 kinase suppressor of ras 1 71.62(n)
    77.79(a)
      427839  XM_425413.3  XP_425413.3 
    lizard
    (Anolis carolinensis)
    Reptilia KSR16
    Uncharacterized protein
    72(a)
    1 ↔ 1
    GL343543.1(410399-438715)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.163252 Xenopus laevis transcribed sequence with weak similarity more 76.06(n)    BX848684.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ksr21 kinase suppressor of ras 2 67.94(n)
    67.85(a)
      100150814  XM_001919014.2  XP_001919049.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta ksr6
    kinase suppressor of ras
    26(a)
    1 → many
    3R(1305871-1309607)
    worm
    (Caenorhabditis elegans)
    Secernentea ksr-26
    ksr-16
    Protein KSR-1
    25(a)
    24(a)
    many ↔ many
    many ↔ many
    I(12047340-12059800)
    X(8275158-8283320)


    ENSEMBL Gene Tree for KSR1 (if available)
    TreeFam Gene Tree for KSR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KSR1 gene
    FPGT-TNNI3K2  MAP3K122  MAP3K112  KIAA18042  RAF12  KSR22  MOS2  BRAF2  
    MAP3K92  MAP3K102  ARAF2  MAP3K72  TNNI3K2  ZAK2  MAP3K132  ILK2  
    12 SIMAP similar genes for KSR1 using alignment to 11 protein entries:     KSR1_HUMAN (see all proteins):
    PHKG2    STK25    KSR2    TNNI3K    STK36    BRAF
    MAP4K5    TYK2    TXK    CAMK1    DAPK3    ZAK

    KSR1 for paralogs           About GeneDecksing


    5/20 Pseudogenes.org Pseudogenes for KSR1 (see all 20)
    PGOHUM00000258466 PGOHUM00000258903 PGOHUM00000259050 PGOHUM00000259053 PGOHUM00000259055


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2670 SNPs in KSR1 are shown (see all 2670)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0460484
    ----see VAR_0460482 V A mis40--------
    VAR_0406584
    ----see VAR_0406582 S P mis40--------
    VAR_0460494
    ----see VAR_0460492 Q H mis40--------
    rs351367761,2
    --25797044(+) TGTGTG/ATGTGT 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs113410911,2
    C--25797087(+) TTTTT-/TGAGGC 1 -- us2k1 trp31Minor allele frequency- T:0.00CSA 2
    rs1813860241,2
    --25797249(+) GCTAAC/GTTTTG 1 -- us2k10--------
    rs1850209851,2
    --25797390(+) AGCCTC/TCTGAG 1 -- us2k10--------
    rs1891444871,2
    --25797411(+) TACACG/TTGCCC 1 -- us2k10--------
    rs1499863851,2
    C--25797424(+) CACCAC/TGCCCA 1 -- us2k10--------
    rs1442017001,2
    --25797491(+) TCAAAC/TCCCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for KSR1 (25783670 - 25953461 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for KSR1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2422193CNV Duplication17116639
    esv6766CNV Gain19470904
    dgv943e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 601132    OMIM disorders: --

    16 diseases for KSR1:    About MalaCards
    bronchopneumonia    scarlet fever    bronchitis    otitis media
    tonsillitis    diarrhea    endometrial carcinoma    inflammatory bowel disease
    acute myeloid leukemia    myeloid leukemia    pancreatic cancer    tuberculosis
    sarcoma    pancreatitis    leukemia    breast cancer

    4 diseases from the University of Copenhagen DISEASES database for KSR1:
    Tonsillitis     Pharyngitis     Scarlet fever     Bronchopneumonia

    KSR1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): KSR1
    Human Genome Epidemiology (HuGE) Navigator: KSR1 (1 document)

    Export disorders for KSR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KSR1 gene, integrated from 9 sources (see all 61):
    (articles sorted by number of sources associating them with KSR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. KSR, a novel protein kinase required for RAS signal transduction. (PubMed id 8521512)1, 2, 3 Therrien M....Rubin G.M. (1995)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)1, 2 Zody M.C.... Nusbaum C. (2006)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. MAP kinase module: the Ksr connection. (PubMed id 12007434)1, 2 Roy F. and Therrien M. (2002)
    7. Identification of constitutive and ras-inducible phosphorylation sites of KSR: implications for 14-3-3 binding, mitogen-activated protein kinase binding, and KSR overexpression. (PubMed id 9858547)1, 9 Cacace A.M....Morrison D.K. (1999)
    8. C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. (PubMed id 11741534)1, 9 Muller J....Morrison D.K. (2001)
    9. Leukocyte-specific protein 1 targets the ERK/MAP kinase scaffold protein KSR and MEK1 and ERK2 to the actin cytoskeleton. (PubMed id 15090600)1, 9 Harrison R.E....Jongstra J. (2004)
    10. Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. (PubMed id 14724641)1, 9 Matheny S.A....White M.A. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8844 HGNC: 6465 AceView: KSR Ensembl:ENSG00000141068 euGenes: HUgn8844
    ECgene: KSR1 Kegg: 8844 H-InvDB: KSR1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KSR1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for KSR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KSR1 gene:
    Search GeneIP for patents involving KSR1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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