Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KSR1 Gene

Aliases for KSR1 Gene

  • Kinase Suppressor Of Ras 1 2 3 5
  • KSR 3 4
  • Kinase Suppressor Of Ras 2
  • RSU2 3

External Ids for KSR1 Gene

Previous HGNC Symbols for KSR1 Gene

  • KSR

Previous GeneCards Identifiers for KSR1 Gene

  • GC17P022899
  • GC17P025799
  • GC17P022092
  • GC17P025783

Summaries for KSR1 Gene

GeneCards Summary for KSR1 Gene

KSR1 (Kinase Suppressor Of Ras 1) is a Protein Coding gene. Among its related pathways are RET signaling and Oncogenic MAPK signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is KSR2.

UniProtKB/Swiss-Prot for KSR1 Gene

  • Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.

Gene Wiki entry for KSR1 Gene

Additional gene information for KSR1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KSR1 Gene

Genomics for KSR1 Gene

Regulatory Elements for KSR1 Gene

Enhancers for KSR1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17H027528 2 FANTOM5 Ensembl ENCODE dbSUPER 24 +76.3 76280 9 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 ZNF766 FOS ZHX2 KSR1 LGALS9 WSB1 PIR50901 LOC100420848
GH17H027543 1.3 ENCODE dbSUPER 36.1 +89.2 89231 3 PKNOX1 ATF1 ARNT FEZF1 TCF12 ZNF121 GLIS2 GATA2 FOS ATF7 KSR1 TMEM199 NOS2 LGALS9 PIR50901 PIR39350
GH17H027538 1.4 Ensembl ENCODE dbSUPER 23.7 +83.9 83923 4 PKNOX1 INSM2 ZNF76 KLF17 SIN3A RAD21 BRCA1 RFX5 ELK1 SCRT2 KSR1 PIR50901 PIR39350
GH17H027526 1.4 Ensembl ENCODE dbSUPER 22.6 +70.3 70324 1 HDAC1 ATF1 SIN3A ZBTB40 ZNF366 SCRT2 ATF7 CREM CEBPB ELF1 KSR1 GC17M027527 PIR42403
GH17H027493 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.1 +39.8 39809 5 ARID4B SIN3A FEZF1 DMAP1 YY1 TCF12 GATA2 ZNF143 RUNX3 MXD4 KSR1 GC17M027476 PIR42403
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KSR1 on UCSC Golden Path with GeneCards custom track

Promoters for KSR1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000092587 536 2401 ATF1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF766 GLIS2 ZNF143 ATF7

Genomic Location for KSR1 Gene

Chromosome:
17
Start:
27,456,464 bp from pter
End:
27,626,441 bp from pter
Size:
169,978 bases
Orientation:
Plus strand

Genomic View for KSR1 Gene

Genes around KSR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KSR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KSR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KSR1 Gene

Proteins for KSR1 Gene

  • Protein details for KSR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IVT5-KSR1_HUMAN
    Recommended name:
    Kinase suppressor of Ras 1
    Protein Accession:
    Q8IVT5
    Secondary Accessions:
    • F8WEA9
    • H7BYU0
    • Q13476

    Protein attributes for KSR1 Gene

    Size:
    923 amino acids
    Molecular mass:
    102160 Da
    Quaternary structure:
    • Interacts with HSP90AA1/HSP90, YWHAE/14-3-3, CDC37, MAP2K1/MEK-1 and MAP2K2/MEK-2 (PubMed:10409742). Interacts with MARK3, PPP2R1A and PPP2CA. Also interacts with RAF and MAPK/ERK, in a Ras-dependent manner. The binding of 14-3-3 proteins to phosphorylated KSR prevents the membrane localization (By similarity). Interacts with isoform 1 of VRK2 (PubMed:20679487). Interacts with AKAP13 and BRAF (PubMed:21102438). Identified in a complex with AKAP13, MAP2K1 and BRAF (By similarity).

    Alternative splice isoforms for KSR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KSR1 Gene

Post-translational modifications for KSR1 Gene

  • Phosphorylated on Ser-311 and, to a higher extent, on Ser-406 by MARK3. Dephosphorylated on Ser-406 by PPP2CA. In resting cells, phosphorylated KSR1 is cytoplasmic and in stimulated cells, dephosphorylated KSR1 is membrane-associated. Phosphorylated by PKA at Ser-888. Phosphorylation at Ser-888 is required for cAMP-dependent activation of MAPK1 and/or MAPK3 (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for KSR1 Gene

Domains & Families for KSR1 Gene

Gene Families for KSR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for KSR1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8IVT5

UniProtKB/Swiss-Prot:

KSR1_HUMAN :
  • The protein kinase domain is predicted to be catalytically inactive. The domain is sufficient for KSR1 and KSR1-mediated MAP2K1 and MAP2K2 membrane localization. The domain is required but not sufficient for MAP kinase-mediated inhibition of ELK1 phosphorylation (PubMed:10409742).
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
Domain:
  • The protein kinase domain is predicted to be catalytically inactive. The domain is sufficient for KSR1 and KSR1-mediated MAP2K1 and MAP2K2 membrane localization. The domain is required but not sufficient for MAP kinase-mediated inhibition of ELK1 phosphorylation (PubMed:10409742).
  • The protein kinase domain is predicted to be catalytically inactive. The domain is sufficient for KSR1 and KSR1-mediated MAP2K1 and MAP2K2 membrane localization. The domain is required but not sufficient for MAP kinase-mediated inhibition of ELK1 phosphorylation.
  • The N-terminal region mediates interaction with BRAF and with membranes.
Family:
  • Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.
genes like me logo Genes that share domains with KSR1: view

Function for KSR1 Gene

Molecular function for KSR1 Gene

UniProtKB/Swiss-Prot Function:
Scaffolding protein that is part of a multiprotein signaling complex. Promotes phosphorylation of Raf family members and activation of downstream MAP kinases. Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP. Does not have kinase activity by itself.

Phenotypes From GWAS Catalog for KSR1 Gene

Gene Ontology (GO) - Molecular Function for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity NAS,IBA 8521512
GO:0004871 signal transducer activity IBA --
GO:0005078 MAP-kinase scaffold activity ISS --
GO:0005515 protein binding IPI 11909642
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with KSR1: view
genes like me logo Genes that share phenotypes with KSR1: view

Animal Models for KSR1 Gene

MGI Knock Outs for KSR1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KSR1
  • Applied Biological Materials Clones for KSR1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for KSR1 Gene

Localization for KSR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KSR1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Cell membrane; Peripheral membrane protein. Cell projection, ruffle membrane. Endoplasmic reticulum membrane. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery. {ECO:0000305 PubMed:12007434}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KSR1 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 5
plasma membrane 4
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005783 endoplasmic reticulum IDA 22572157
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with KSR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for KSR1 Gene

Pathways & Interactions for KSR1 Gene

SuperPathway Contained pathways
1 RET signaling
2 Signaling by moderate kinase activity BRAF mutants
3 Developmental Biology
4 Cytokine Signaling in Immune system
5 HIV Life Cycle
.45
genes like me logo Genes that share pathways with KSR1: view

SIGNOR curated interactions for KSR1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for KSR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0006468 protein phosphorylation IBA --
GO:0007265 Ras protein signal transduction NAS,IBA 8521512
GO:0019933 cAMP-mediated signaling ISS --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with KSR1: view

Drugs & Compounds for KSR1 Gene

(4) Additional Compounds for KSR1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-behenoyl-sn-glycerol
  • 1-Tetradecanoyl-3-docosanoyl-sn-glycerol
  • DAG(14:0/0:0/22:0)
  • DAG(36:0)
  • DG(36:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with KSR1: view

Transcripts for KSR1 Gene

Unigene Clusters for KSR1 Gene

Kinase suppressor of ras 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for KSR1
  • Applied Biological Materials Clones for KSR1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KSR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16 ^ 17a · 17b · 17c ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^
SP1: - - -
SP2: - -
SP3: - - -
SP4: -
SP5: - - -
SP6:
SP7: - -

ExUns: 22a · 22b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:

Relevant External Links for KSR1 Gene

GeneLoc Exon Structure for
KSR1
ECgene alternative splicing isoforms for
KSR1

Expression for KSR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KSR1 Gene

mRNA differential expression in normal tissues according to GTEx for KSR1 Gene

This gene is overexpressed in Pancreas (x6.5).

Protein differential expression in normal tissues from HIPED for KSR1 Gene

This gene is overexpressed in Heart (25.0), Plasma (15.5), and Peripheral blood mononuclear cells (13.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KSR1 Gene



Protein tissue co-expression partners for KSR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of KSR1 Gene:

KSR1

SOURCE GeneReport for Unigene cluster for KSR1 Gene:

Hs.133534

Evidence on tissue expression from TISSUES for KSR1 Gene

  • Nervous system(4.4)
  • Blood(4.1)
  • Kidney(2.3)
  • Intestine(2.1)
  • Liver(2.1)
  • Stomach(2.1)
genes like me logo Genes that share expression patterns with KSR1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for KSR1 Gene

Orthologs for KSR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for KSR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KSR1 33
  • 97.68 (n)
cow
(Bos Taurus)
Mammalia KSR1 33 34
  • 90.59 (n)
dog
(Canis familiaris)
Mammalia KSR1 33 34
  • 90.12 (n)
rat
(Rattus norvegicus)
Mammalia Ksr1 33
  • 88.35 (n)
mouse
(Mus musculus)
Mammalia Ksr1 33 16 34
  • 87 (n)
oppossum
(Monodelphis domestica)
Mammalia KSR1 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KSR1 34
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves KSR1 33 34
  • 70.98 (n)
lizard
(Anolis carolinensis)
Reptilia KSR1 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ksr1 33
  • 69.55 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.16325 33
zebrafish
(Danio rerio)
Actinopterygii si:dkey-174l22.2 33
  • 67.43 (n)
KSR1 (2 of 2) 34
  • 48 (a)
OneToMany
KSR1 (1 of 2) 34
  • 47 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta ksr 34
  • 27 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ksr-2 34
  • 27 (a)
ManyToMany
ksr-1 34
  • 25 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 41 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11620 33
Species where no ortholog for KSR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for KSR1 Gene

ENSEMBL:
Gene Tree for KSR1 (if available)
TreeFam:
Gene Tree for KSR1 (if available)

Paralogs for KSR1 Gene

Paralogs for KSR1 Gene

genes like me logo Genes that share paralogs with KSR1: view

Variants for KSR1 Gene

Sequence variations from dbSNP and Humsavar for KSR1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1000001193 -- 27,476,453(+) GCTGC(C/T)GGTGA intron-variant
rs1000011290 -- 27,607,068(+) CTGAG(G/T)TGATC intron-variant
rs1000014899 -- 27,514,432(+) GATAG(A/G)TGGAT intron-variant
rs1000016382 -- 27,526,130(+) CTTGT(A/G)TGAAT intron-variant
rs1000023980 -- 27,557,906(+) TTTGT(A/G)TGCAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KSR1 Gene

Variant ID Type Subtype PubMed ID
esv2422193 CNV duplication 17116639
esv2758683 CNV gain 17122850
esv6766 CNV gain 19470904
nsv474126 CNV novel sequence insertion 20440878
nsv475286 CNV novel sequence insertion 20440878
nsv478552 CNV novel sequence insertion 20440878

Variation tolerance for KSR1 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.27; 70.29% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KSR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KSR1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KSR1 Gene

Disorders for KSR1 Gene

Relevant External Links for KSR1

Genetic Association Database (GAD)
KSR1
Human Genome Epidemiology (HuGE) Navigator
KSR1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KSR1

No disorders were found for KSR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KSR1 Gene

Publications for KSR1 Gene

  1. KSR, a novel protein kinase required for RAS signal transduction. (PMID: 8521512) Therrien M … Rubin GM (Cell 1995) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. VRK2 inhibits mitogen-activated protein kinase signaling and inversely correlates with ErbB2 in human breast cancer. (PMID: 20679487) Fernández IF … Lazo PA (Molecular and cellular biology 2010) 3 4 60
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 3 4 60
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 60

Products for KSR1 Gene

  • Addgene plasmids for KSR1

Sources for KSR1 Gene

Content
Loading form....