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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

KRTDAP Gene

protein-coding GIFtS: 38
GCID: GC19M035978

keratinocyte differentiation-associated protein

Search for KRTDAP
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Keratinocyte Differentiation-Associated Protein¹ ²
KDAP¹ ² ³
UNQ467¹ ²
KIPV467²

External Ids:	HGNC: 16313¹	Entrez Gene: 388533²	Ensembl: ENSG00000188508⁷	UniProtKB: P60985³

Export aliases for KRTDAP gene to outside databases

Previous GC identifers: GC19U990285 GC19M040654 GC19M040671 GC19M032483

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRTDAP:

This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance of

stratified epithelia. Multiple transcript variants encoding different isoforms have been found for this gene.

(provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: KTDAP_HUMAN, P60985

Function: May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin

morphogenesis

Gene Wiki entry for KRTDAP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the KRTDAP gene promoter:
SRF C/EBPbeta SRF (504 AA) POU3F1 Brachyury Olf-1 MZF-1 PPAR-gamma1 PPAR-gamma2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: KRTDAP promoter sequence

Search SABiosciences Chromatin IP Primers for KRTDAP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRTDAP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12 Ensembl cytogenetic band: 19q13.12 HGNC chromosome: 19

KRTDAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRTDAP gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M035978: view genomic region (about GC identifiers)

Start:	35,978,226 bp from pter	End:	35,986,460 bp from pter
Size:	8,235 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: KTDAP_HUMAN, P60985 (See protein sequence)

Recommended Name: Keratinocyte differentiation-associated protein precursor

Size: 99 amino acids; 11050 Da

Subcellular location: Secreted

Secondary accessions: A1L4D7

Alternative splicing: 2 isoforms: P60985-1 P60985-2

Explore the universe of human proteins at neXtProt for KRTDAP: NX_P60985

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P60985

KRTDAP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001231776.1 NP_997275.1

ENSEMBL proteins:

ENSP00000339251

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

KRTDAP for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: P60985

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: KTDAP_HUMAN, P60985

Function: May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic skin

morphogenesis

Induction: Up-regulated in situ in psoriatic skin (at protein level)

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1 GenomeRNAi human phenotype for KRTDAP:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for KRTDAP

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030154	cell differentiation	IEA	--

KRTDAP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for KRTDAP gene (2 alternative transcripts):

NM_001244847.1 NM_207392.2

Unigene Cluster for KRTDAP:

Keratinocyte differentiation-associated protein

Hs.112457 [show with all ESTs]

Unigene Representative Sequence: AJ293408

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000484218 ENST00000479340 ENST00000338897(uc002nzh.3 uc021uso.1)

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Additional cDNA sequence:

AJ293408.1 AY359007.1 BC130501.1

4 DOTS entries:

DT.442838 DT.70103174 DT.95211912 DT.121430402

24/30 AceView cDNA sequences (see all 30):

W60320 AA398638 W69108 BE466728 BX112106 AA778414 AI140605 AA776980

AA584333 AA582988 BX476814 AY359007 BG150312 AA595989 W69233 AI217565

AA586846 AA722694 NM_207392 AI217587 W52030 AA297512 W60268 AA393296

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for KRTDAP About this scheme

ExUns:	1	^	2	^	3	^	4	^	5	^	6
SP1:
SP2:					-

ECgene alternative splicing isoforms for KRTDAP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KRTDAP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCTCCACTG

About this image

KRTDAP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Testis

Seminiferous Tubules

Sertoli cells

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See KRTDAP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRTDAP

SOURCE GeneReport for Unigene cluster: Hs.112457

UniProtKB/Swiss-Prot: KTDAP_HUMAN, P60985

Tissue specificity: Highly expressed in skin and detected at lower levels in thymus. In skin, found exclusively in

lamellar granules of granular keratinocytes and in the intracellular space of the stratum corneum. Also highly

expressed in oral mucosa, tongue, esophagus, and stomach, and at much lower levels in bladder and uterus. Not detected

in gastrointestinal mucosa

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for KRTDAP gene from 1/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Krtdap^{1 , 5}	keratinocyte differentiation associated protein^{1, 5}	69.7(n)¹ 56.57(a)¹		7 (19.24 cM)⁵ 64661¹ NM_001033131.3¹ NP_001028303.1¹ 30787905⁵

ENSEMBL Gene Tree for KRTDAP (if available)
TreeFam Gene Tree for KRTDAP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs74917167^1,2	F,	--	32483253(+)	`TCCCCG/AGCATT`	2	--	ds500¹		1		WA	118
rs12610255^1,2	A,H	--	32483388(+)	`TATCGT/ATGCTT`	2	--	ds500¹		4		NS EA	420
rs17638216^1,2	C,F,H,	--	32483978(+)	`GGTGTG/AAGTTC`	2	--	int¹		19		NA NS EA WA	2286
rs10407971^1,2	C,F,H,	--	32484984(+)	`GAGAAG/AGTGAA`	2	--	int¹		16		NS EA NA WA CSA	1896
rs73928205^1,2	C,	--	32485721(+)	`TGGAGG/ATTCCA`	2	--	int¹		3		WA NA	240
rs75688166^1,2	F,	--	32485810(+)	`AGCCCG/ACAGGC`	2	--	int¹		1		EA	120
rs73043062^1,2	C,	--	32487100(+)	`TCTTCA/GTGCAG`	2	--	us2k¹		0	--	--	--	--
rs7253910^1,2	C,F,A,H,	--	32487388(+)	`GGCACG/ACATCA`	2	--	us2k¹		10		NS NA WA CSA	469
rs79332038^1,2	F,	--	32487872(+)	`TGCCCA/TGTCCT`	2	--	us2k¹		1		WA	118
rs76512835^1,2	F,	--	32488175(+)	`TGCCCG/ATCTTT`	2	--	us2k¹		1		EA	120

HapMap Linkage Disequilibrium report for KRTDAP (35978226 - 35986460 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRTDAP: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for KRTDAP gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRTDAP)

Utopia: connect your pdf to the dynamic
world of online information

Characterization of Kdap, a protein secreted by keratinocytes. (PubMed id 15140226)^{1, 2} Tsuchida S.... Ariizumi K. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Kdap, a novel gene associated with the stratification of the epithelium. (PubMed id 11054531)^{1, 3} Oomizu S....Yoshizato K. (2000)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)¹ Hartley J.L....Brasch M.A. (2000)
Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)¹ Adams M.D....White O. (1995)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 388533	HGNC: 16313	AceView: UNQ467	Ensembl:ENSG00000188508	euGenes: HUgn388533
ECgene: KRTDAP	H-InvDB: KRTDAP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for KRTDAP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for KRTDAP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for KRTDAP gene:
Search GeneIP for patents involving KRTDAP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRTDAP

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes KRTDAP gene at Home site.

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KRTDAP Gene

keratinocyte differentiation-associated protein

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KRTDAP Gene

keratinocyte differentiation-associated protein

Aliasesfor KRTDAP gene

Summariesfor KRTDAP gene

Genomic Viewsfor KRTDAP gene

Proteinsfor KRTDAP gene

Protein Domains /Familiesfor KRTDAP gene

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Aliases
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Summaries
for KRTDAP gene

Genomic Views
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for KRTDAP gene

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for KRTDAP gene

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for KRTDAP gene

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for KRTDAP gene

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for KRTDAP gene

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for KRTDAP gene

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for KRTDAP gene

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