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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRTDAP Gene

protein-coding   GIFtS: 39
GCID: GC19M035978

Keratinocyte Differentiation-Associated Protein

  Search for KRTDAP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratinocyte Differentiation-Associated Protein1 2
KDAP2 3
KIPV4672
UNQ4672

External Ids:    HGNC: 163131   Entrez Gene: 3885332   Ensembl: ENSG000001885087   UniProtKB: P609853   

Export aliases for KRTDAP gene to outside databases

Previous GC identifers: GC19U990285 GC19M040654 GC19M040671 GC19M032483


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for KRTDAP Gene:
This gene encodes a protein which may function in the regulation of keratinocyte differentiation and maintenance
of stratified epithelia. Multiple transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Oct 2011)

GeneCards Summary for KRTDAP Gene: 
KRTDAP (keratinocyte differentiation-associated protein) is a protein-coding gene.

UniProtKB/Swiss-Prot: KTDAP_HUMAN, P60985
Function: May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic
skin morphogenesis

Gene Wiki entry for KRTDAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRTDAP gene promoter:
         SRF   C/EBPbeta   SRF (504 AA)   POU3F1   Brachyury   Olf-1   MZF-1   PPAR-gamma1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRTDAP promoter sequence
   Search SABiosciences Chromatin IP Primers for KRTDAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRTDAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.12   Ensembl cytogenetic band:  19q13.12   HGNC cytogenetic band: 19q13.12

KRTDAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRTDAP gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M035978:  view genomic region     (about GC identifiers)

Start:
35,978,226 bp from pter      End:
35,986,460 bp from pter
Size:
8,235 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KTDAP_HUMAN, P60985 (See protein sequence)
Recommended Name: Keratinocyte differentiation-associated protein precursor  
Size: 99 amino acids; 11050 Da
Subcellular location: Secreted
Secondary accessions: A1L4D7
Alternative splicing: 2 isoforms:  P60985-1   P60985-2   

Explore the universe of human proteins at neXtProt for KRTDAP: NX_P60985

Explore proteomics data for KRTDAP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P60985

  • KRTDAP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRTDAP Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001231776.1  NP_997275.1  

    ENSEMBL proteins: 
     ENSP00000470713   ENSP00000339251  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    KRTDAP for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: P60985


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: KTDAP_HUMAN, P60985
    Function: May act as a soluble regulator of keratinocyte differentiation. May play an important role in embryonic
    skin morphogenesis
    Induction: Up-regulated in situ in psoriatic skin (at protein level)

    Phenotypes:
         1 GenomeRNAi human phenotype for KRTDAP:

     Increased gamma-H2AX phosphory 

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRTDAP

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0030154cell differentiation IEA--

    KRTDAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
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    Search CenterWatch for drugs/clinical trials and news about KRTDAP / KTDAP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for KRTDAP gene (2 alternative transcripts): 
    NM_001244847.1  NM_207392.2  

    Unigene Cluster for KRTDAP:

    Keratinocyte differentiation-associated protein
    Hs.112457  [show with all ESTs]
    Unigene Representative Sequence: AJ293408
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484218 ENST00000479340 ENST00000338897(uc002nzh.3 uc021uso.1)

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    Additional mRNA sequence: 

    AJ293408.1 AY359007.1 BC130501.1 

    4 DOTS entries:

    DT.442838  DT.70103174  DT.95211912  DT.121430402 

    24/30 AceView cDNA sequences (see all 30):

    AA778414 AI140605 BX112106 W60320 W69108 AA776980 BE466728 AA398638 
    AA586846 BG150312 AY359007 AI217565 AA595989 AA582988 W69233 AA722694 
    AA584333 NM_207392 BX476814 AI217587 W52030 AA297512 W60268 AA393296 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for KRTDAP    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
    SP1:                                    
    SP2:              -                     


    ECgene alternative splicing isoforms for KRTDAP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRTDAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCTCCACTG
    KRTDAP Expression
    About this image


    See KRTDAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRTDAP

    SOURCE GeneReport for Unigene cluster: Hs.112457

    UniProtKB/Swiss-Prot: KTDAP_HUMAN, P60985
    Tissue specificity: Highly expressed in skin and detected at lower levels in thymus. In skin, found exclusively in
    lamellar granules of granular keratinocytes and in the intracellular space of the stratum corneum. Also highly
    expressed in oral mucosa, tongue, esophagus, and stomach, and at much lower levels in bladder and uterus. Not
    detected in gastrointestinal mucosa

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRTDAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for KRTDAP gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krtdap1 , 5 keratinocyte differentiation associated protein1, 5 69.7(n)1
    56.57(a)1
      7 (19.24 cM)5
    646611  NM_001033131.31  NP_001028303.11 
     307879055 


    ENSEMBL Gene Tree for KRTDAP (if available)
    TreeFam Gene Tree for KRTDAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/134 SNPs in KRTDAP are shown (see all 134)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs749171671,2
    C,F--35977733(+) TCCCCG/AGCATT 2 -- ds50011Minor allele frequency- A:0.13WA 118
    rs32153821,2
    C--35980962(+) CACTC-/TTGAGA 2 -- int12Minor allele frequency- T:0.17NA CSA 6
    rs558140371,2
    C--35981732(+) TTTTTT/-GACAG 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs1148771431,2
    C,F--36136829(+) TCTATC/TGTTGC 2 -- ds50011Minor allele frequency- T:0.07WA 118
    rs126102551,2
    A,H--36136831(+) TATCGT/ATGCTT 2 -- ds50014Minor allele frequency- A:0.00NS EA 420
    rs1834057721,2
    --36137160(+) CCCAGC/TAGGAG 2 -- ds50010--------
    rs79761,2
    C,F,O,H--36137262(-) CTAGCG/ATGAGC 2 -- ut31 ese323Minor allele frequency- A:0.16MN NA NS EA WA EU 3951
    rs1892526731,2
    --36137289(+) AGGTCA/TTGGTC 2 -- ut310--------
    rs176382161,2
    C,F,H--36137421(+) GGTGTG/AAGTTC 2 -- int119Minor allele frequency- A:0.14NA NS EA WA 2286
    rs1930646251,2
    --36137425(+) TGAGTA/TCCCGT 2 -- int10--------

    HapMap Linkage Disequilibrium report for KRTDAP (35978226 - 35986460 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for KRTDAP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv833811CNV Gain17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRTDAP gene integrated from 9 sources:
    (articles sorted by number of sources associating them with KRTDAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of Kdap, a protein secreted by keratinocytes. (PubMed id 15140226)1, 2 Tsuchida S.... Ariizumi K. (2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    3. Kdap, a novel gene associated with the stratification of the epithelium. (PubMed id 11054531)1, 3 Oomizu S....Yoshizato K. (2000)
    4. The LIFEdb database in 2006. (PubMed id 16381901)1 Mehrle A....Wiemann S. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)1 Wiemann S....Poustka A. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. DNA cloning using in vitro site-specific recombination. (PubMed id 11076863)1 Hartley J.L....Brasch M.A. (2000)
    9. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PubMed id 7566098)1 Adams M.D....White O. (1995)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388533 HGNC: 16313 AceView: UNQ467 Ensembl:ENSG00000188508 euGenes: HUgn388533
    ECgene: KRTDAP H-InvDB: KRTDAP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRTDAP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRTDAP gene:
    Search GeneIP for patents involving KRTDAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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