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Aliases for KRTCAP3 Gene

Aliases for KRTCAP3 Gene

  • Keratinocyte Associated Protein 3 2 3 5
  • KCP3 3 4
  • Keratinocytes Associated Protein 3 3
  • Keratinocyte-Associated Protein 3 3
  • KCP-3 4

External Ids for KRTCAP3 Gene

Previous GeneCards Identifiers for KRTCAP3 Gene

  • GC02P027639
  • GC02P027576
  • GC02P027518
  • GC02P027665

Summaries for KRTCAP3 Gene

GeneCards Summary for KRTCAP3 Gene

KRTCAP3 (Keratinocyte Associated Protein 3) is a Protein Coding gene. An important paralog of this gene is TMEM54.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTCAP3 Gene

Genomics for KRTCAP3 Gene

Regulatory Elements for KRTCAP3 Gene

Enhancers for KRTCAP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KRTCAP3 on UCSC Golden Path with GeneCards custom track

Promoters for KRTCAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around KRTCAP3 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTCAP3 Gene

Chromosome:
2
Start:
27,442,351 bp from pter
End:
27,446,481 bp from pter
Size:
4,131 bases
Orientation:
Plus strand

Genomic View for KRTCAP3 Gene

Genes around KRTCAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTCAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTCAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTCAP3 Gene

Proteins for KRTCAP3 Gene

  • Protein details for KRTCAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53RY4-KCP3_HUMAN
    Recommended name:
    Keratinocyte-associated protein 3
    Protein Accession:
    Q53RY4
    Secondary Accessions:
    • B7ZL49
    • Q6UW42
    • Q8IWS5

    Protein attributes for KRTCAP3 Gene

    Size:
    240 amino acids
    Molecular mass:
    25627 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRTCAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRTCAP3 Gene

Post-translational modifications for KRTCAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTCAP3 Gene

No data available for DME Specific Peptides for KRTCAP3 Gene

Domains & Families for KRTCAP3 Gene

Protein Domains for KRTCAP3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTCAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53RY4

UniProtKB/Swiss-Prot:

KCP3_HUMAN :
  • Belongs to the TMEM54 family.
Family:
  • Belongs to the TMEM54 family.
genes like me logo Genes that share domains with KRTCAP3: view

No data available for Gene Families for KRTCAP3 Gene

Function for KRTCAP3 Gene

Phenotypes for KRTCAP3 Gene

GenomeRNAi human phenotypes for KRTCAP3:
genes like me logo Genes that share phenotypes with KRTCAP3: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTCAP3 Gene

Localization for KRTCAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRTCAP3 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTCAP3 Gene COMPARTMENTS Subcellular localization image for KRTCAP3 gene
Compartment Confidence
plasma membrane 3
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KRTCAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KRTCAP3: view

Pathways & Interactions for KRTCAP3 Gene

SuperPathways for KRTCAP3 Gene

No Data Available

Interacting Proteins for KRTCAP3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000288873%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000288873 for KRTCAP3 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for KRTCAP3 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTCAP3 Gene

Drugs & Compounds for KRTCAP3 Gene

No Compound Related Data Available

Transcripts for KRTCAP3 Gene

Unigene Clusters for KRTCAP3 Gene

Keratinocyte associated protein 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTCAP3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP2:
SP3: - - -
SP4:

Relevant External Links for KRTCAP3 Gene

GeneLoc Exon Structure for
KRTCAP3
ECgene alternative splicing isoforms for
KRTCAP3

Expression for KRTCAP3 Gene

mRNA expression in normal human tissues for KRTCAP3 Gene

mRNA differential expression in normal tissues according to GTEx for KRTCAP3 Gene

This gene is overexpressed in Colon - Transverse (x6.8), Pancreas (x5.5), Stomach (x4.9), and Minor Salivary Gland (x4.0).

Protein differential expression in normal tissues from HIPED for KRTCAP3 Gene

This gene is overexpressed in Colon (23.9), Prostate (11.6), Islet of Langerhans (9.7), Pancreas (9.2), and Rectum (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for KRTCAP3 Gene



Protein tissue co-expression partners for KRTCAP3 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRTCAP3 Gene:

KRTCAP3

SOURCE GeneReport for Unigene cluster for KRTCAP3 Gene:

Hs.59509

mRNA Expression by UniProt/SwissProt for KRTCAP3 Gene:

Q53RY4-KCP3_HUMAN
Tissue specificity: Expressed in skin, pancreas and keratinocytes.
genes like me logo Genes that share expression patterns with KRTCAP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRTCAP3 Gene

Orthologs for KRTCAP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRTCAP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRTCAP3 34
  • 88.75 (n)
  • 89.17 (a)
KRTCAP3 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRTCAP3 34
  • 87.45 (n)
  • 87.45 (a)
KRTCAP3 35
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krtcap3 34
  • 84.72 (n)
  • 85.83 (a)
Krtcap3 16
Krtcap3 35
  • 85 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KRTCAP3 34
  • 99.03 (n)
  • 99.17 (a)
KRTCAP3 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krtcap3 34
  • 84.58 (n)
  • 84.17 (a)
oppossum
(Monodelphis domestica)
Mammalia KRTCAP3 35
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KRTCAP3 35
  • 59 (a)
OneToOne
chicken
(Gallus gallus)
Aves KRTCAP3 34
  • 62.11 (n)
  • 58.95 (a)
KRTCAP3 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6595 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.21819 34
zebrafish
(Danio rerio)
Actinopterygii LOC100538219 34
  • 53.93 (n)
  • 48.11 (a)
CU462878.1 35
  • 44 (a)
OneToOne
Species where no ortholog for KRTCAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRTCAP3 Gene

ENSEMBL:
Gene Tree for KRTCAP3 (if available)
TreeFam:
Gene Tree for KRTCAP3 (if available)

Paralogs for KRTCAP3 Gene

Paralogs for KRTCAP3 Gene

(1) SIMAP similar genes for KRTCAP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KRTCAP3: view

Variants for KRTCAP3 Gene

Sequence variations from dbSNP and Humsavar for KRTCAP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs780113 -- 27,443,142(+) CTCCT(C/T)CTTGC reference, synonymous-codon
rs61732551 -- 27,442,800(+) GGGCT(A/C/T)CCGGA intron-variant
rs139722862 -- 27,443,439(+) ATGTC(C/T)GCAGG reference, synonymous-codon
rs145181670 -- 27,443,517(+) AAGGA(A/C/T)GGACT reference, synonymous-codon, missense
rs145201619 -- 27,443,106(+) GTGAA(A/C/T)CTGCT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for KRTCAP3 Gene

Variant ID Type Subtype PubMed ID
nsv581244 CNV loss 21841781
nsv817684 CNV gain 17921354
nsv833614 CNV gain 17160897

Variation tolerance for KRTCAP3 Gene

Residual Variation Intolerance Score: 35.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTCAP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTCAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTCAP3 Gene

Disorders for KRTCAP3 Gene

Relevant External Links for KRTCAP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTCAP3

No disorders were found for KRTCAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTCAP3 Gene

Publications for KRTCAP3 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. (PMID: 12752121) Bonkobara M. … Ariizumi K. (Br. J. Dermatol. 2003) 3 4 65
  3. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D. … Pajukanta P. (J. Med. Genet. 2013) 3 65
  4. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 3 65
  5. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3 65

Products for KRTCAP3 Gene

Sources for KRTCAP3 Gene

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