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Aliases for KRTCAP3 Gene

Aliases for KRTCAP3 Gene

  • Keratinocyte Associated Protein 3 2 3
  • KCP-3 3 4
  • KCP3 3 4
  • Keratinocytes Associated Protein 3 3
  • PRO9898 3
  • MRV222 3

External Ids for KRTCAP3 Gene

Previous GeneCards Identifiers for KRTCAP3 Gene

  • GC02P027639
  • GC02P027576
  • GC02P027518
  • GC02P027665

Summaries for KRTCAP3 Gene

GeneCards Summary for KRTCAP3 Gene

KRTCAP3 (Keratinocyte Associated Protein 3) is a Protein Coding gene. An important paralog of this gene is TMEM54.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTCAP3 Gene

Genomics for KRTCAP3 Gene

Regulatory Elements for KRTCAP3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KRTCAP3 Gene

27,442,351 bp from pter
27,446,481 bp from pter
4,131 bases
Plus strand

Genomic View for KRTCAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTCAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTCAP3 Gene

Proteins for KRTCAP3 Gene

  • Protein details for KRTCAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratinocyte-associated protein 3
    Protein Accession:
    Secondary Accessions:
    • B7ZL49
    • Q6UW42
    • Q8IWS5

    Protein attributes for KRTCAP3 Gene

    240 amino acids
    Molecular mass:
    25627 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for KRTCAP3 Gene


neXtProt entry for KRTCAP3 Gene

Proteomics data for KRTCAP3 Gene at MOPED

Post-translational modifications for KRTCAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTCAP3 Gene

No data available for DME Specific Peptides for KRTCAP3 Gene

Domains & Families for KRTCAP3 Gene

Protein Domains for KRTCAP3 Gene


Suggested Antigen Peptide Sequences for KRTCAP3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM54 family.
  • Belongs to the TMEM54 family.
genes like me logo Genes that share domains with KRTCAP3: view

No data available for Gene Families for KRTCAP3 Gene

Function for KRTCAP3 Gene

Phenotypes for KRTCAP3 Gene

GenomeRNAi human phenotypes for KRTCAP3:
genes like me logo Genes that share phenotypes with KRTCAP3: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTCAP3

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTCAP3 Gene

Localization for KRTCAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRTCAP3 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for KRTCAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KRTCAP3: view

No data available for Subcellular locations from COMPARTMENTS for KRTCAP3 Gene

Pathways & Interactions for KRTCAP3 Gene

SuperPathways for KRTCAP3 Gene

No Data Available

Interacting Proteins for KRTCAP3 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000288873 for KRTCAP3 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for KRTCAP3 Gene


No data available for Pathways by source and SIGNOR curated interactions for KRTCAP3 Gene

Drugs & Compounds for KRTCAP3 Gene

No Compound Related Data Available

Transcripts for KRTCAP3 Gene

Unigene Clusters for KRTCAP3 Gene

Keratinocyte associated protein 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTCAP3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTCAP3 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b
SP1: -
SP3: - - -

Relevant External Links for KRTCAP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRTCAP3 Gene

mRNA expression in normal human tissues for KRTCAP3 Gene

mRNA differential expression in normal tissues according to GTEx for KRTCAP3 Gene

This gene is overexpressed in Colon - Transverse (x6.8), Pancreas (x5.5), Stomach (x4.9), and Minor Salivary Gland (x4.0).

Protein differential expression in normal tissues from HIPED for KRTCAP3 Gene

This gene is overexpressed in Colon (23.9), Prostate (11.6), Islet of Langerhans (9.7), Pancreas (9.2), and Rectum (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for KRTCAP3 Gene

SOURCE GeneReport for Unigene cluster for KRTCAP3 Gene Hs.59509

mRNA Expression by UniProt/SwissProt for KRTCAP3 Gene

Tissue specificity: Expressed in skin, pancreas and keratinocytes.
genes like me logo Genes that share expression patterns with KRTCAP3: view

Protein tissue co-expression partners for KRTCAP3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRTCAP3 Gene

Orthologs for KRTCAP3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for KRTCAP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRTCAP3 35
  • 88.75 (n)
  • 89.17 (a)
  • 88 (a)
(Canis familiaris)
Mammalia KRTCAP3 35
  • 87.45 (n)
  • 87.45 (a)
  • 86 (a)
(Mus musculus)
Mammalia Krtcap3 35
  • 84.72 (n)
  • 85.83 (a)
Krtcap3 16
Krtcap3 36
  • 85 (a)
(Pan troglodytes)
Mammalia KRTCAP3 35
  • 99.03 (n)
  • 99.17 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Krtcap3 35
  • 84.58 (n)
  • 84.17 (a)
(Monodelphis domestica)
Mammalia KRTCAP3 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia KRTCAP3 36
  • 59 (a)
(Gallus gallus)
Aves KRTCAP3 35
  • 62.11 (n)
  • 58.95 (a)
  • 50 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.6595 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.21819 35
(Danio rerio)
Actinopterygii LOC100538219 35
  • 53.93 (n)
  • 48.11 (a)
CU462878.1 36
  • 44 (a)
Species with no ortholog for KRTCAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRTCAP3 Gene

Gene Tree for KRTCAP3 (if available)
Gene Tree for KRTCAP3 (if available)

Paralogs for KRTCAP3 Gene

Paralogs for KRTCAP3 Gene

(1) SIMAP similar genes for KRTCAP3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KRTCAP3: view

Variants for KRTCAP3 Gene

Sequence variations from dbSNP and Humsavar for KRTCAP3 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs780113 -- 27,443,142(+) CTCCT(C/T)CTTGC synonymous-codon, reference
rs61732551 -- 27,442,800(+) GGGCT(A/C/T)CCGGA intron-variant
rs111682980 -- 27,443,871(+) GCTCC(A/G)TCACA intron-variant
rs112908126 -- 27,443,463(+) TCTGG(A/T)TACTG synonymous-codon, reference
rs114788910 -- 27,443,294(+) ATTCT(C/T)TTCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRTCAP3 Gene

Variant ID Type Subtype PubMed ID
nsv873754 CNV Loss 21882294
nsv833614 CNV Gain 17160897
nsv817684 CNV Gain 17921354

Variation tolerance for KRTCAP3 Gene

Residual Variation Intolerance Score: 35.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.55; 30.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTCAP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTCAP3 Gene

Disorders for KRTCAP3 Gene

Relevant External Links for KRTCAP3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with KRTCAP3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTCAP3 Gene

Publications for KRTCAP3 Gene

  1. Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. (PMID: 23505323) Weissglas-Volkov D. … Pajukanta P. (J. Med. Genet. 2013) 67
  2. Genome-scale RNAi screen for host factors required for HIV replication. (PMID: 18976975) Zhou H. … Espeseth A.S. (Cell Host Microbe 2008) 67
  3. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 67
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 67
  5. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh J.H. … Kim N.S. (Mamm. Genome 2005) 67

Products for KRTCAP3 Gene

Sources for KRTCAP3 Gene

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