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KRTCAP2 Gene

protein-coding   GIFtS: 45
GCID: GC01M155141

Keratinocyte Associated Protein 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Keratinocyte Associated Protein 21 2
KCP-22 3
KCP22 3
Keratinocyte-Associated Protein 22
Keratinocytes Associated Protein 22

External Ids:    HGNC: 289421   Entrez Gene: 2001852   Ensembl: ENSG000001634637   UniProtKB: Q8N6L13   

Export aliases for KRTCAP2 gene to outside databases

Previous GC identifers: GC01M152358 GC01M151954 GC01M153408 GC01M126504


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for KRTCAP2 Gene:
KRTCAP2 (keratinocyte associated protein 2) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the KRTCAP2 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRTCAP2 promoter sequence
   Search Chromatin IP Primers for KRTCAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat KRTCAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

KRTCAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRTCAP2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155141:  view genomic region     (about GC identifiers)

Start:
155,141,884 bp from pter      End:
155,145,951 bp from pter
Size:
4,068 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: KTAP2_HUMAN, Q8N6L1 (See protein sequence)
Recommended Name: Keratinocyte-associated protein 2  
Size: 136 amino acids; 14679 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which
contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes
with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with STT3A
Secondary accessions: B2R4Q1 Q6PG45 Q86XW2 Q8IWS4
Alternative initiation: 2 isoforms:  Q8N6L1-1   Q8N6L1-2   (Produced at low levels due to suboptimal Kozak context)

Explore the universe of human proteins at neXtProt for KRTCAP2: NX_Q8N6L1

Explore proteomics data for KRTCAP2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See KRTCAP2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_776251.1  
    ENSEMBL proteins: 
     ENSP00000295682  

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    antibodies-online antibodies for KRTCAP2 (9 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR018614 Uncharacterised_KRTCAP2

    Graphical View of Domain Structure for InterPro Entry Q8N6L1

    ProtoNet protein and cluster: Q8N6L1

    UniProtKB/Swiss-Prot: KTAP2_HUMAN, Q8N6L1
    Similarity: Belongs to the KRTCAP2 family


    Find genes that share domains with KRTCAP2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    Find genes that share ontologies with KRTCAP2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for KRTCAP2:
     Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Krtcap2 (no phenotypes)

    Find genes that share phenotypes with KRTCAP2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for KRTCAP2

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    KTAP2_HUMAN, Q8N6L1: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    endoplasmic reticulum2
    extracellular2
    mitochondrion1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0008250colocalizes with oligosaccharyltransferase complex ISS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with KRTCAP2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for KRTCAP2
    Interactions:

        Search GeneGlobe Interaction Network for KRTCAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    Selected Interacting proteins for KRTCAP2 (Q8N6L13 ENSP000002956824) via UniProtKB, MINT, STRING, and/or I2D (see all 19)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C20orf24Q9BUV83, ENSP000003412134I2D: score=1 STRING: ENSP00000341213
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    CREB3O438893I2D: score=1 
    VHLP403373I2D: score=1 
    RTN3ENSP000003441064STRING: ENSP00000344106
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    Find genes that share ontologies with KRTCAP2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for KRTCAP2 (KTAP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for KRTCAP2 gene: 
    NM_173852.3  

    Unigene Cluster for KRTCAP2:

    Keratinocyte associated protein 2
    Hs.516671  [show with all ESTs]
    Unigene Representative Sequence: AK024167
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463527 ENST00000487350 ENST00000497317 ENST00000295682(uc001fho.3)
    ENST00000491084 ENST00000471891 ENST00000482246 ENST00000490672 ENST00000461136
    ENST00000492892
    miRNA
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    hsa-miR-520d-5p hsa-miR-524-5p
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      QuantiFast Probe-based Assays in human, mouse, rat KRTCAP2

    Additional mRNA sequence: 

    AK024167.1 AK311907.1 AY157577.1 BC029806.1 BC048205.1 BC057233.1 

    14 DOTS entries:

    DT.100826678  DT.101961664  DT.121335507  DT.92430605  DT.100826682  DT.121335529  DT.85104603  DT.100826681 
    DT.121335525  DT.121335542  DT.100826684  DT.121005707  DT.95188826  DT.100826677 

    Selected AceView cDNA sequences (see all 438):

    AI570806 BM982837 CB138615 BM831319 F28098 AA532648 CB138992 AI905191 
    C01735 AA643942 AA812821 BM829853 BM993267 BM673704 BQ941191 BC048205 
    BG698098 AW029340 BQ029112 AI886098 AI738961 BM852127 BM850782 BQ447959 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KRTCAP2    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                          -                       -                     
    SP2:                          -                       -                     
    SP3:                                                  -                     
    SP4:                          -     -                 -                     
    SP5:                          -           -     -                           


    ECgene alternative splicing isoforms for KRTCAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    KRTCAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGGTCTGT
    KRTCAP2 Expression
    About this image

    KRTCAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    KRTCAP2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516671

    UniProtKB/Swiss-Prot: KTAP2_HUMAN, Q8N6L1
    Tissue specificity: Expressed in skin, heart, placental, liver, skeletal muscle, kidney, pancreas, keratinocytes
    and dermal fibroblasts

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for KRTCAP2 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krtcap21 , 5 keratinocyte associated protein 21, 5 89.46(n)1
    97.06(a)1
      3 (39.03 cM)5
    660591  NM_025327.21  NP_079603.11 
     892459665 
    lizard
    (Anolis carolinensis)
    Reptilia KRTCAP26
    keratinocyte associated protein 2
    79(a)
    1 ↔ 1
    AAWZ02041356(2450-5594)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.222112 Xenopus laevis transcribed sequence with moderate similarity more 76.52(n)    BX846847.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.175892 Transcribed sequence with moderate similarity to protein more 78.23(n)    AL920742.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG314601 CG31460 52.61(n)
    44.12(a)
      318747  NM_169227.1  NP_731253.1 


    ENSEMBL Gene Tree for KRTCAP2 (if available)
    TreeFam Gene Tree for KRTCAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for KRTCAP2 gene

    Find genes that share paralogs with KRTCAP2           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for KRTCAP2
    PGOHUM00000240633


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for KRTCAP2 (see all 56)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1171988991,2
    C,F--155141467(+) ACTTGC/TAGCAG 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1808879701,2
    --155141506(+) GGAGTC/GGCAAA 1 -- int10--------
    rs1380916421,2
    C--155141545(+) TAGGT-/AATACG 1 -- int10--------
    rs1859384041,2
    --155141549(+) GTATAC/TGGGAC 1 -- int10--------
    rs1920406531,2
    --155141667(+) ATTCAC/TGTACT 1 -- int10--------
    rs784194031,2
    --155141690(+) TGAGAC/TTCACA 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1450145491,2
    --155141725(+) CTGACA/GGTATT 1 -- int10--------
    rs1448753961,2
    C,F--155141857(+) TGACAC/TCCACA 1 -- int11Minor allele frequency- T:0.01EU 1313
    rs44215761,2
    C,F,A,H--155142210(+) CAGTAG/AGATCC 1 -- int129Minor allele frequency- A:0.34NA EA NS WA CSA 2715
    rs42769141,2
    C,F,A--155142229(+) AAAACA/GGAATG 1 -- int118Minor allele frequency- G:0.37NA WA CSA EA 703

    HapMap Linkage Disequilibrium report for KRTCAP2 (155141884 - 155145951 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KRTCAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3n68CNV Loss17160897
    nsv470741CNV Loss18288195
    nsv464084CNV Loss19166990
    nsv872457CNV Loss21882294
    nsv8447CNV Gain18304495
    dgv132e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for KRTCAP2 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with KRTCAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase. (PubMed id 22266900)1, 2 Roboti P. and High S. (J. Cell. Sci. 2012)
    2. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    3. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)1, 3 Shibatani T.... Skach W.R. (Biochemistry 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. (PubMed id 12752121)1, 2 Bonkobara M.... Ariizumi K. (Br. J. Dermatol. 2003)
    7. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 200185 HGNC: 28942 AceView: MUC1 Ensembl:ENSG00000163463 euGenes: HUgn200185
    ECgene: KRTCAP2 H-InvDB: KRTCAP2

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for KRTCAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for KRTCAP2 gene:
    Search GeneIP for patents involving KRTCAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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