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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRTCAP2 Gene

protein-coding   GIFtS: 44
GCID: GC01M155141

Keratinocyte Associated Protein 2

  Search for KRTCAP2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratinocyte Associated Protein 21 2
KCP-22 3
KCP22 3
Keratinocyte-Associated Protein 22
Keratinocytes Associated Protein 22

External Ids:    HGNC: 289421   Entrez Gene: 2001852   Ensembl: ENSG000001634637   UniProtKB: Q8N6L13   

Export aliases for KRTCAP2 gene to outside databases

Previous GC identifers: GC01M152358 GC01M151954 GC01M153408 GC01M126504


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KRTCAP2 Gene: 
KRTCAP2 (keratinocyte associated protein 2) is a protein-coding gene. GO annotations related to this gene include molecular_function.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the KRTCAP2 gene promoter:
         AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRTCAP2 promoter sequence
   Search SABiosciences Chromatin IP Primers for KRTCAP2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRTCAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

KRTCAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRTCAP2 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M155141:  view genomic region     (about GC identifiers)

Start:
155,141,884 bp from pter      End:
155,159,747 bp from pter
Size:
17,864 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: KTAP2_HUMAN, Q8N6L1 (See protein sequence)
Recommended Name: Keratinocyte-associated protein 2  
Size: 162 amino acids; 17595 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which
contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes
with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity)
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Caution: It is uncertain whether Met-1 or Met-27 is the initiator
Sequence caution: Sequence=AAO13161.2; Type=Erroneous initiation;
Secondary accessions: B2R4Q1 Q6PG45 Q86XW2 Q8IWS4

Explore the universe of human proteins at neXtProt for KRTCAP2: NX_Q8N6L1

Explore proteomics data for KRTCAP2 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N6L1

  • KRTCAP2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    KRTCAP2 Protein Expression
    REFSEQ proteins: NP_776251.1  
    ENSEMBL proteins: 
     ENSP00000295682  

    Human Recombinant Protein Products for KRTCAP2: 
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    Cloud-Clone Corp. Proteins for KRTCAP2 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0008250colocalizes with oligosaccharyltransferase complex ISS--
    GO:0016021integral to membrane IEA--

    KRTCAP2 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR018614 Uncharacterised_KRTCAP2

    Graphical View of Domain Structure for InterPro Entry Q8N6L1

    ProtoNet protein and cluster: Q8N6L1

    UniProtKB/Swiss-Prot: KTAP2_HUMAN, Q8N6L1
    Similarity: Belongs to the KRTCAP2 family


    KRTCAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    KRTCAP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for KRTCAP2:
     Increased HPV18 LCR reporter a 

         1 MGI phenotypic allele for Krtcap2 (no phenotypes)

    KRTCAP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for KRTCAP2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for KRTCAP2 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRTCAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 12)

    5/14 Interacting proteins for KRTCAP2 (Q8N6L13 ENSP000002956824) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C20orf24Q9BUV83, ENSP000003412134I2D: score=1 STRING: ENSP00000341213
    TSC22D1Q157143, ENSP000003974354I2D: score=1 STRING: ENSP00000397435
    CREB3O438893I2D: score=1 
    VHLP403373I2D: score=1 
    DAD1ENSP000002504984STRING: ENSP00000250498
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    KRTCAP2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for KRTCAP2 (KTAP2)

    Search CenterWatch for drugs/clinical trials and news about KRTCAP2 / KTAP2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for KRTCAP2 gene: 
    NM_173852.3  

    Unigene Clusters for KRTCAP2:

    Keratinocyte associated protein 2
    Hs.516671  [show with all ESTs], Hs.704676  [show with all ESTs]
    Unigene Representative Sequences: AK024167, BX647396
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000463527 ENST00000487350 ENST00000497317 ENST00000480091(uc001fhp.1)
    ENST00000295682(uc001fho.3) ENST00000491084 ENST00000471891 ENST00000482246
    ENST00000490672 ENST00000473363 ENST00000461136 ENST00000492892
    miRNA
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    hsa-miR-520d-5p hsa-miR-524-5p
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    Inhib. RNA
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRTCAP2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRTCAP2

    Additional mRNA sequence: BX647396.1 

    14 DOTS entries:

    DT.100826678  DT.101961664  DT.85104603  DT.121335507  DT.92430605  DT.100826682  DT.121335529  DT.100826681 
    DT.121335525  DT.121335542  DT.100826684  DT.121005707  DT.95188826  DT.100826677 

    24/438 AceView cDNA sequences (see all 438):

    BI761034 AI521451 CD251366 CB134007 AI570806 BM982837 CB138615 BM831319 
    F28098 AA532648 CB138992 AI905191 BM852127 BM850782 BQ447959 CB124769 
    CR596859 AA568733 D63281 AW511845 AA425185 BX474593 AA586676 BM686872 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for KRTCAP2    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                          -                       -                     
    SP2:                          -                       -                     
    SP3:                                                  -                     
    SP4:                          -     -                 -                     
    SP5:                          -           -     -                           


    ECgene alternative splicing isoforms for KRTCAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    KRTCAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTGGTCTGT
    KRTCAP2 Expression
    About this image


    See KRTCAP2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for KRTCAP2

    SOURCE GeneReport for Unigene clusters: Hs.516671 Hs.704676

    UniProtKB/Swiss-Prot: KTAP2_HUMAN, Q8N6L1
    Tissue specificity: Expressed in skin, heart, placental, liver, skeletal muscle, kidney, pancreas, keratinocytes
    and dermal fibroblasts

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRTCAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for KRTCAP2 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Krtcap21 , 5 keratinocyte associated protein 21, 5 89.46(n)1
    97.06(a)1
      3 (39.03 cM)5
    660591  NM_025327.21  NP_079603.11 
     892459665 
    lizard
    (Anolis carolinensis)
    Reptilia KRTCAP26
    Uncharacterized protein
    79(a)
    1 ↔ 1
    AAWZ02041356(2450-5594)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.222112 Xenopus laevis transcribed sequence with moderate similarity more 76.52(n)    BX846847.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.175892 Transcribed sequence with moderate similarity to protein more 78.23(n)    AL920742.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG314601 CG31460 50.51(n)
    43.08(a)
      318747  NM_169227.1  NP_731253.1 


    ENSEMBL Gene Tree for KRTCAP2 (if available)
    TreeFam Gene Tree for KRTCAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for KRTCAP2 gene

    KRTCAP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for KRTCAP2
    PGOHUM00000240633


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/56 SNPs in KRTCAP2 are shown (see all 56)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0255314
    ----see VAR_0255312 G V mis40--------
    rs1171988991,2
    C,F--155141467(+) ACTTGC/TAGCAG 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1808879701,2
    --155141506(+) GGAGTC/GGCAAA 1 -- int10--------
    rs1380916421,2
    C--155141545(+) TAGGT-/AATACG 1 -- int10--------
    rs1859384041,2
    --155141549(+) GTATAC/TGGGAC 1 -- int10--------
    rs1920406531,2
    --155141667(+) ATTCAC/TGTACT 1 -- int10--------
    rs784194031,2
    --155141690(+) TGAGAC/TTCACA 1 -- int11Minor allele frequency- T:0.01EA 120
    rs1450145491,2
    --155141725(+) CTGACA/GGTATT 1 -- int10--------
    rs1448753961,2
    C,F--155141857(+) TGACAC/TCCACA 1 -- int11Minor allele frequency- T:0.01EU 1313
    rs44215761,2
    C,F,A,H--155142210(+) CAGTAG/AGATCC 1 -- int129Minor allele frequency- A:0.34NA EA NS WA CSA 2715

    HapMap Linkage Disequilibrium report for KRTCAP2 (155141884 - 155159747 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for KRTCAP2:    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv3n68CNV Loss17160897
    nsv470741CNV Loss18288195
    nsv464084CNV Loss19166990
    nsv872457CNV Loss21882294
    nsv8447CNV Gain18304495
    dgv132e1CNV Complex17122850

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for KRTCAP2 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with KRTCAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    2. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)1, 3 Shibatani T.... Skach W.R. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Identification of novel genes for secreted and membrane-anchored proteins in human keratinocytes. (PubMed id 12752121)1, 2 Bonkobara M.... Ariizumi K. (2003)
    6. Keratinocyte-associated protein 2 is a bona fide subun it of the mammalian oligosaccharyltransferase. (PubMed id 22266900)1 Roboti P. and High S. (2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    8. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    9. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 200185 HGNC: 28942 AceView: MUC1 Ensembl:ENSG00000163463 euGenes: HUgn200185
    ECgene: KRTCAP2 H-InvDB: KRTCAP2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for KRTCAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for KRTCAP2 gene:
    Search GeneIP for patents involving KRTCAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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