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Aliases for KRTCAP2 Gene

Aliases for KRTCAP2 Gene

  • Keratinocyte Associated Protein 2 2 3 5
  • KCP-2 3 4
  • KCP2 3 4
  • Keratinocytes Associated Protein 2 3
  • Keratinocyte-Associated Protein 2 3

External Ids for KRTCAP2 Gene

Previous GeneCards Identifiers for KRTCAP2 Gene

  • GC01M152358
  • GC01M151954
  • GC01M153408
  • GC01M126504

Summaries for KRTCAP2 Gene

GeneCards Summary for KRTCAP2 Gene

KRTCAP2 (Keratinocyte Associated Protein 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTCAP2 Gene

Genomics for KRTCAP2 Gene

Regulatory Elements for KRTCAP2 Gene

Enhancers for KRTCAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around KRTCAP2 on UCSC Golden Path with GeneCards custom track

Promoters for KRTCAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the KRTCAP2 gene promoter:

Genomic Location for KRTCAP2 Gene

155,169,408 bp from pter
155,173,475 bp from pter
4,068 bases
Minus strand

Genomic View for KRTCAP2 Gene

Genes around KRTCAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTCAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTCAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTCAP2 Gene

Proteins for KRTCAP2 Gene

  • Protein details for KRTCAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Keratinocyte-associated protein 2
    Protein Accession:
    Secondary Accessions:
    • B2R4Q1
    • Q6PG45
    • Q86XW2
    • Q8IWS4

    Protein attributes for KRTCAP2 Gene

    136 amino acids
    Molecular mass:
    14679 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with STT3A.

    Alternative splice isoforms for KRTCAP2 Gene


neXtProt entry for KRTCAP2 Gene

Post-translational modifications for KRTCAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTCAP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTCAP2 Gene

Domains & Families for KRTCAP2 Gene

Gene Families for KRTCAP2 Gene

Protein Domains for KRTCAP2 Gene


Suggested Antigen Peptide Sequences for KRTCAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the KRTCAP2 family.
  • Belongs to the KRTCAP2 family.
genes like me logo Genes that share domains with KRTCAP2: view

Function for KRTCAP2 Gene

Gene Ontology (GO) - Molecular Function for KRTCAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with KRTCAP2: view
genes like me logo Genes that share phenotypes with KRTCAP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KRTCAP2

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTCAP2 Gene

Localization for KRTCAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRTCAP2 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for KRTCAP2 Gene COMPARTMENTS Subcellular localization image for KRTCAP2 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 3
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KRTCAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0008250 colocalizes_with oligosaccharyltransferase complex IEA,ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with KRTCAP2: view

Pathways & Interactions for KRTCAP2 Gene

SuperPathways for KRTCAP2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRTCAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KRTCAP2: view

No data available for Pathways by source and SIGNOR curated interactions for KRTCAP2 Gene

Drugs & Compounds for KRTCAP2 Gene

No Compound Related Data Available

Transcripts for KRTCAP2 Gene

Unigene Clusters for KRTCAP2 Gene

Keratinocyte associated protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTCAP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -

Relevant External Links for KRTCAP2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for KRTCAP2 Gene

mRNA expression in normal human tissues for KRTCAP2 Gene

Protein differential expression in normal tissues from HIPED for KRTCAP2 Gene

This gene is overexpressed in Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KRTCAP2 Gene

Protein tissue co-expression partners for KRTCAP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRTCAP2 Gene:


SOURCE GeneReport for Unigene cluster for KRTCAP2 Gene:


mRNA Expression by UniProt/SwissProt for KRTCAP2 Gene:

Tissue specificity: Expressed in skin, heart, placental, liver, skeletal muscle, kidney, pancreas, keratinocytes and dermal fibroblasts.
genes like me logo Genes that share expression patterns with KRTCAP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for KRTCAP2 Gene

Orthologs for KRTCAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KRTCAP2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia KRTCAP2 34
  • 93.87 (n)
  • 98.53 (a)
  • 99 (a)
(Canis familiaris)
Mammalia KRTCAP2 34
  • 91.18 (n)
  • 97.79 (a)
  • 55 (a)
(Mus musculus)
Mammalia Krtcap2 34
  • 89.46 (n)
  • 97.06 (a)
Krtcap2 16
Krtcap2 35
  • 97 (a)
(Pan troglodytes)
Mammalia KRTCAP2 34
  • 99.59 (n)
  • 99.38 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Krtcap2 34
  • 90.64 (n)
  • 97.37 (a)
(Monodelphis domestica)
Mammalia KRTCAP2 35
  • 78 (a)
(Anolis carolinensis)
Reptilia KRTCAP2 35
  • 79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.22211 34
(Danio rerio)
Actinopterygii Dr.17589 34
krtcap2 34
  • 71.6 (n)
  • 75.56 (a)
krtcap2 35
  • 76 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10836 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003126 34
  • 59.09 (n)
  • 55.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31460 34
  • 52.61 (n)
  • 44.12 (a)
CG31460 35
  • 40 (a)
Species where no ortholog for KRTCAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRTCAP2 Gene

Gene Tree for KRTCAP2 (if available)
Gene Tree for KRTCAP2 (if available)

Paralogs for KRTCAP2 Gene Pseudogenes for KRTCAP2 Gene

genes like me logo Genes that share paralogs with KRTCAP2: view

No data available for Paralogs for KRTCAP2 Gene

Variants for KRTCAP2 Gene

Sequence variations from dbSNP and Humsavar for KRTCAP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
VAR_025531 -
rs4421576 -- 155,169,734(+) CAGTA(A/G)GATCC intron-variant
rs4276914 -- 155,169,753(+) AAAAC(A/G)GAATG intron-variant
rs4971088 -- 155,170,407(+) CCCCA(A/T)ATCTC intron-variant
rs4971089 -- 155,170,451(+) AAAGG(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for KRTCAP2 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv2758971 CNV gain 17122850
esv3587615 CNV gain 21293372
nsv1010146 CNV gain 25217958
nsv464084 CNV loss 19166990
nsv470741 CNV loss 18288195
nsv547961 CNV loss 21841781
nsv8447 CNV gain 18304495

Variation tolerance for KRTCAP2 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTCAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTCAP2 Gene

Disorders for KRTCAP2 Gene

Relevant External Links for KRTCAP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for KRTCAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTCAP2 Gene

Publications for KRTCAP2 Gene

  1. Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase. (PMID: 22266900) Roboti P. … High S. (J. Cell. Sci. 2012) 2 3 4 65
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 65
  3. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PMID: 15835887) Shibatani T. … Skach W.R. (Biochemistry 2005) 2 3 65
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65

Products for KRTCAP2 Gene

Sources for KRTCAP2 Gene

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