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Aliases for KRTCAP2 Gene

Aliases for KRTCAP2 Gene

  • Keratinocyte Associated Protein 2 2 3 5
  • KCP-2 3 4
  • KCP2 3 4
  • Keratinocytes Associated Protein 2 3
  • Keratinocyte-Associated Protein 2 3

External Ids for KRTCAP2 Gene

Previous GeneCards Identifiers for KRTCAP2 Gene

  • GC01M152358
  • GC01M151954
  • GC01M153408
  • GC01M126504

Summaries for KRTCAP2 Gene

GeneCards Summary for KRTCAP2 Gene

KRTCAP2 (Keratinocyte Associated Protein 2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTCAP2 Gene

  • Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient substrate-specific N-glycosylation probably involving the STT3A-containing OST complex. May be involved in N-glycosylation of APP (beta-amyloid precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTCAP2 Gene

Genomics for KRTCAP2 Gene

Regulatory Elements for KRTCAP2 Gene

Enhancers for KRTCAP2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G155242 1.5 ENCODE dbSUPER 26.5 -70.8 -70768 2.9 CREB3L1 FEZF1 YBX1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21 KIAA0907 ENSG00000271267 RUSC1-AS1 MSTO2P ASH1L THBS3 PYGO2 LOC101928120 GBA BGLAP
GH01G154998 1.9 FANTOM5 ENCODE dbSUPER 14.9 +169.0 169024 11.3 MLX CREB3L1 AGO1 ZFP64 YBX1 DMAP1 FEZF1 YY1 SLC30A9 ZNF416 KIAA0907 THBS3 ENSG00000271267 RUSC1-AS1 ZBTB7B EFNA4 ASH1L-AS1 DCST1 KRTCAP2 DPM3
GH01G155042 1.7 Ensembl ENCODE dbSUPER 14.9 +129.3 129347 3.0 HDGF FOXA2 PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 FEZF1 KIAA0907 ENSG00000271267 THBS3 RUSC1-AS1 KRTCAP2 LOC101928120 SSR2 DCST1 EFNA4 RIT1
GH01G155015 1.7 Ensembl ENCODE dbSUPER 14.9 +156.2 156161 3.2 CREB3L1 AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ADAM15 ZBTB7B KRTCAP2 KIAA0907 ENSG00000271267 THBS3 DCST1-AS1 LENEP FLAD1 PYGO2
GH01G154351 1.7 Ensembl ENCODE dbSUPER 14.8 +820.3 820292 3.5 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 MEF2D SSRP1 CHTOP RUSC1-AS1 SLC27A3 THBS3 INTS3 EFNA4 ENSG00000272030 KRTCAP2 ENSG00000238279 DPM3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRTCAP2 on UCSC Golden Path with GeneCards custom track

Promoters for KRTCAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000254614 175 1401 HDGF MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9
ENSR00000014036 -1125 401 KLF1 KLF17 RBBP5 BMI1 ZIC2 ETS1 GLIS2 POLR2A PATZ1 ZNF600

Transcription factor binding sites by QIAGEN in the KRTCAP2 gene promoter:

Genomic Location for KRTCAP2 Gene

Chromosome:
1
Start:
155,169,408 bp from pter
End:
155,173,475 bp from pter
Size:
4,068 bases
Orientation:
Minus strand

Genomic View for KRTCAP2 Gene

Genes around KRTCAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTCAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTCAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTCAP2 Gene

Proteins for KRTCAP2 Gene

  • Protein details for KRTCAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6L1-KTAP2_HUMAN
    Recommended name:
    Keratinocyte-associated protein 2
    Protein Accession:
    Q8N6L1
    Secondary Accessions:
    • B2R4Q1
    • Q6PG45
    • Q86XW2
    • Q8IWS4

    Protein attributes for KRTCAP2 Gene

    Size:
    136 amino acids
    Molecular mass:
    14679 Da
    Quaternary structure:
    • Accessory component of the STT3A-containing form of the oligosaccharyltransferase (OST) complex. OST exists in two different complex forms which contain common core subunits RPN1, RPN2, OST48, OST4, DAD1 and TMEM258, either STT3A or STT3B as catalytic subunits, and form-specific accessory subunits. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes. Interacts with PSEN1 and NCSTN; indicative for an association with the gamma-secretase complex.

    Alternative splice isoforms for KRTCAP2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRTCAP2 Gene

Post-translational modifications for KRTCAP2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTCAP2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTCAP2 Gene

Domains & Families for KRTCAP2 Gene

Gene Families for KRTCAP2 Gene

Protein Domains for KRTCAP2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTCAP2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N6L1

UniProtKB/Swiss-Prot:

KTAP2_HUMAN :
  • Belongs to the KRTCAP2 family.
Family:
  • Belongs to the KRTCAP2 family.
genes like me logo Genes that share domains with KRTCAP2: view

Function for KRTCAP2 Gene

Molecular function for KRTCAP2 Gene

UniProtKB/Swiss-Prot Function:
Acts as accessory component of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for efficient substrate-specific N-glycosylation probably involving the STT3A-containing OST complex. May be involved in N-glycosylation of APP (beta-amyloid precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1.

Gene Ontology (GO) - Molecular Function for KRTCAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with KRTCAP2: view
genes like me logo Genes that share phenotypes with KRTCAP2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KRTCAP2

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTCAP2 Gene

Localization for KRTCAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for KRTCAP2 Gene

Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTCAP2 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 3
extracellular 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KRTCAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0008250 colocalizes_with oligosaccharyltransferase complex IEA,ISS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with KRTCAP2: view

Pathways & Interactions for KRTCAP2 Gene

SuperPathways for KRTCAP2 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N6L1-KTAP2_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for KRTCAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0042543 protein N-linked glycosylation via arginine IMP 22467853
genes like me logo Genes that share ontologies with KRTCAP2: view

No data available for Pathways by source and SIGNOR curated interactions for KRTCAP2 Gene

Transcripts for KRTCAP2 Gene

Unigene Clusters for KRTCAP2 Gene

Keratinocyte associated protein 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTCAP2 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - -
SP3: -
SP4: - - -
SP5: - - -

Relevant External Links for KRTCAP2 Gene

GeneLoc Exon Structure for
KRTCAP2
ECgene alternative splicing isoforms for
KRTCAP2

Expression for KRTCAP2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTCAP2 Gene

Protein differential expression in normal tissues from HIPED for KRTCAP2 Gene

This gene is overexpressed in Liver (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for KRTCAP2 Gene



Protein tissue co-expression partners for KRTCAP2 Gene

NURSA nuclear receptor signaling pathways regulating expression of KRTCAP2 Gene:

KRTCAP2

SOURCE GeneReport for Unigene cluster for KRTCAP2 Gene:

Hs.516671

mRNA Expression by UniProt/SwissProt for KRTCAP2 Gene:

Q8N6L1-KTAP2_HUMAN
Tissue specificity: Expressed in skin, heart, placental, liver, skeletal muscle, kidney, pancreas, keratinocytes and dermal fibroblasts.

Evidence on tissue expression from TISSUES for KRTCAP2 Gene

  • Nervous system(4.6)
  • Stomach(4.5)
  • Intestine(4.4)
  • Kidney(4.4)
  • Skin(4.3)
  • Lung(4.1)
  • Liver(3)
  • Muscle(2.2)
  • Heart(2)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with KRTCAP2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTCAP2 Gene

Orthologs for KRTCAP2 Gene

This gene was present in the common ancestor of animals.

Orthologs for KRTCAP2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTCAP2 34 35
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia KRTCAP2 34 35
  • 93.87 (n)
dog
(Canis familiaris)
Mammalia KRTCAP2 34 35
  • 91.18 (n)
rat
(Rattus norvegicus)
Mammalia Krtcap2 34
  • 90.64 (n)
mouse
(Mus musculus)
Mammalia Krtcap2 34 16 35
  • 89.46 (n)
oppossum
(Monodelphis domestica)
Mammalia KRTCAP2 35
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KRTCAP2 35
  • 79 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.22211 34
zebrafish
(Danio rerio)
Actinopterygii krtcap2 34 35
  • 71.6 (n)
Dr.17589 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10836 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003126 34
  • 59.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31460 35 34
  • 52.61 (n)
OneToOne
Species where no ortholog for KRTCAP2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for KRTCAP2 Gene

ENSEMBL:
Gene Tree for KRTCAP2 (if available)
TreeFam:
Gene Tree for KRTCAP2 (if available)

Paralogs for KRTCAP2 Gene

Pseudogenes.org Pseudogenes for KRTCAP2 Gene

genes like me logo Genes that share paralogs with KRTCAP2: view

No data available for Paralogs for KRTCAP2 Gene

Variants for KRTCAP2 Gene

Sequence variations from dbSNP and Humsavar for KRTCAP2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000388388 -- 155,174,402(+) GGGAT(G/T)ATGTA intron-variant, upstream-variant-2KB
rs1000594297 -- 155,174,474(+) CCCCA(C/G)TCAGG intron-variant, upstream-variant-2KB
rs1000687791 -- 155,173,146(+) CGGGA(A/G)AGGAC intron-variant, upstream-variant-2KB
rs1001596146 -- 155,172,988(+) GCCGA(C/T)CCCCT intron-variant, upstream-variant-2KB
rs1002542742 -- 155,173,437(+) TGGTC(C/G)TCAGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTCAP2 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv2758971 CNV gain 17122850
esv3587615 CNV gain 21293372
nsv1010146 CNV gain 25217958
nsv464084 CNV loss 19166990
nsv470741 CNV loss 18288195
nsv547961 CNV loss 21841781
nsv8447 CNV gain 18304495

Variation tolerance for KRTCAP2 Gene

Residual Variation Intolerance Score: 37.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTCAP2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTCAP2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTCAP2 Gene

Disorders for KRTCAP2 Gene

Relevant External Links for KRTCAP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTCAP2

No disorders were found for KRTCAP2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTCAP2 Gene

Publications for KRTCAP2 Gene

  1. Keratinocyte-associated protein 2 is a bona fide subunit of the mammalian oligosaccharyltransferase. (PMID: 22266900) Roboti P. … High S. (J. Cell. Sci. 2012) 2 3 4 64
  2. The oligosaccharyltransferase subunits OST48, DAD1 and KCP2 function as ubiquitous and selective modulators of mammalian N-glycosylation. (PMID: 22467853) Roboti P. … High S. (J. Cell Sci. 2012) 3 4 64
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 64
  4. Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PMID: 15835887) Shibatani T. … Skach W.R. (Biochemistry 2005) 2 3 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for KRTCAP2 Gene

Sources for KRTCAP2 Gene

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