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Aliases for KRTAP9-9 Gene

Aliases for KRTAP9-9 Gene

  • Keratin Associated Protein 9-9 2 3 5
  • Ultrahigh Sulfur Keratin-Associated Protein 9.9 3 4
  • Keratin-Associated Protein 9-5 3 4
  • Keratin-Associated Protein 9.5 3 4
  • KRTAP9-5 3 4
  • KRTAP9.9 3 4
  • KAP9.5 3 4
  • KAP9.9 3 4
  • Keratin Associated Protein 9-5 2
  • Keratin-Associated Protein 9.9 4
  • KRTAP9.5 4

External Ids for KRTAP9-9 Gene

Previous HGNC Symbols for KRTAP9-9 Gene

  • KRTAP9-5

Previous GeneCards Identifiers for KRTAP9-9 Gene

  • GC17P038967
  • GC17P041499
  • GC17P039294
  • GC17P039767
  • GC17P039721
  • GC17P036659
  • GC17U900598
  • GC17P036637
  • GC17P039382
  • GC17P035175
  • GC17P039406

Summaries for KRTAP9-9 Gene

Entrez Gene Summary for KRTAP9-9 Gene

  • This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. Alternative haplotypes of this gene are represented in the GRCh38 reference genome assembly. [provided by RefSeq, Dec 2015]

GeneCards Summary for KRTAP9-9 Gene

KRTAP9-9 (Keratin Associated Protein 9-9) is a Protein Coding gene. An important paralog of this gene is KRTAP9-8.

UniProtKB/Swiss-Prot for KRTAP9-9 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP9-9 Gene

Genomics for KRTAP9-9 Gene

Regulatory Elements for KRTAP9-9 Gene

Enhancers for KRTAP9-9 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRTAP9-9 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTAP9-9 Gene

Chromosome:
17
Start:
41,226,653 bp from pter
End:
41,256,364 bp from pter
Size:
29,712 bases
Orientation:
Plus strand

Genomic View for KRTAP9-9 Gene

Genes around KRTAP9-9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP9-9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP9-9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP9-9 Gene

Proteins for KRTAP9-9 Gene

  • Protein details for KRTAP9-9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYP9-KRA99_HUMAN
    Recommended name:
    Keratin-associated protein 9-9
    Protein Accession:
    Q9BYP9
    Secondary Accessions:
    • B5MDD6
    • Q9BYQ1

    Protein attributes for KRTAP9-9 Gene

    Size:
    154 amino acids
    Molecular mass:
    16266 Da
    Quaternary structure:
    • Interacts with hair keratins.

    Alternative splice isoforms for KRTAP9-9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for KRTAP9-9 Gene

Proteomics data for KRTAP9-9 Gene at MOPED

Post-translational modifications for KRTAP9-9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP9-9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP9-9 Gene

Domains & Families for KRTAP9-9 Gene

Gene Families for KRTAP9-9 Gene

Protein Domains for KRTAP9-9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP9-9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYP9

UniProtKB/Swiss-Prot:

KRA99_HUMAN :
  • Belongs to the KRTAP type 9 family.
Family:
  • Belongs to the KRTAP type 9 family.
genes like me logo Genes that share domains with KRTAP9-9: view

Function for KRTAP9-9 Gene

Molecular function for KRTAP9-9 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP9-9 Gene

Localization for KRTAP9-9 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP9-9 Gene COMPARTMENTS Subcellular localization image for KRTAP9-9 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
extracellular 2
nucleus 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP9-9 Gene

Pathways & Interactions for KRTAP9-9 Gene

SuperPathways for KRTAP9-9 Gene

No Data Available

Interacting Proteins for KRTAP9-9 Gene

Gene Ontology (GO) - Biological Process for KRTAP9-9 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP9-9 Gene

Drugs & Compounds for KRTAP9-9 Gene

No Compound Related Data Available

Transcripts for KRTAP9-9 Gene

mRNA/cDNA for KRTAP9-9 Gene

(2) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP9-9 Gene

No ASD Table

Relevant External Links for KRTAP9-9 Gene

GeneLoc Exon Structure for
KRTAP9-9
ECgene alternative splicing isoforms for
KRTAP9-9

Expression for KRTAP9-9 Gene

mRNA expression in normal human tissues for KRTAP9-9 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP9-9 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x49.6).

SOURCE GeneReport for Unigene cluster for KRTAP9-9 Gene Hs.722077

genes like me logo Genes that share expression patterns with KRTAP9-9: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KRTAP9-9 Gene

Orthologs for KRTAP9-9 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP9-9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP9-2 35
  • 94.14 (n)
  • 91.52 (a)
KRTAP9-9 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 46 (a)
ManyToMany
KRTAP9-1 36
  • 41 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm11559 36
  • 51 (a)
ManyToMany
Gm11567 36
  • 49 (a)
ManyToMany
Gm11568 36
  • 46 (a)
ManyToMany
Krtap9-1 36
  • 53 (a)
ManyToMany
Species with no ortholog for KRTAP9-9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP9-9 Gene

ENSEMBL:
Gene Tree for KRTAP9-9 (if available)
TreeFam:
Gene Tree for KRTAP9-9 (if available)

Paralogs for KRTAP9-9 Gene

Paralogs for KRTAP9-9 Gene

(9) SIMAP similar genes for KRTAP9-9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with KRTAP9-9: view

Variants for KRTAP9-9 Gene

Sequence variations from dbSNP and Humsavar for KRTAP9-9 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_060047 -
VAR_060048 -

Structural Variations from Database of Genomic Variants (DGV) for KRTAP9-9 Gene

Variant ID Type Subtype PubMed ID
dgv961e1 CNV Complex 17122850
nsv510710 CNV Loss 20534489
nsv9551 CNV Loss 18304495
dgv454e201 CNV Deletion 23290073

Variation tolerance for KRTAP9-9 Gene

Residual Variation Intolerance Score: 91.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.75; 97.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTAP9-9 Gene

HapMap Linkage Disequilibrium report
KRTAP9-9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP9-9 Gene

Disorders for KRTAP9-9 Gene

Relevant External Links for KRTAP9-9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP9-9

No disorders were found for KRTAP9-9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP9-9 Gene

Publications for KRTAP9-9 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 2 3 4 67
  2. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. (PMID: 25963833) Drissi R. … Boisvert F.M. (Mol. Cell Proteomics 2015) 3

Products for KRTAP9-9 Gene

Sources for KRTAP9-9 Gene

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