KRTAP9-2 Gene
protein-coding GIFtS: 38
GCID: GC17P039383
|
|
keratin associated protein 9-2
| |
Aliases
for KRTAP9-2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Keratin Associated Protein 9-21 2 | | KAP9.21 2 3 | | Keratin-Associated Protein 9.22 3 | | Ultrahigh Sulfur Keratin-Associated Protein 9.22 3 | | KRTAP9.22 3 | | Keratin-Associated Protein 9-22 |
| External Ids: | HGNC: 169261 | Entrez Gene: 838992 | Ensembl: ENSG000002398867 | UniProtKB: Q9BYQ43 | | ORGUL members: | |
|---|
| NONCODE:n335525 | |
Export aliases for KRTAP9-2 gene to outside databasesPrevious GC identifers: GC17U990250 GC17P041487 GC17P039291 GC17P039757 GC17P039722 GC17P036636 GC17P035157
|---|
Summaries
for KRTAP9-2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for KRTAP9-2:
This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratinintermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique,family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according toamino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is amember of the ultrahigh sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. (provided byRefSeq, Jul 2008)
UniProtKB/Swiss-Prot: KRA92_HUMAN, Q9BYQ4Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistanthair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. Thematrix proteins include the high-sulfur and high-glycine-tyrosine keratins
|
Genomic Views
for KRTAP9-2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the KRTAP9-2 gene promoter:
SREBP-1a SREBP-1c MyoD AP-4 Tal-1beta SREBP-1b E47
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRTAP9-2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRTAP9-2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q12-q21 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q12-q21KRTAP9-2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17P039383: view genomic region
(about GC identifiers)
Start:
|
39,382,900 bp from pter |
End:
|
39,383,904 bp from pter |
Size:
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1,005 bases |
Orientation:
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plus strand |
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Proteins
for KRTAP9-2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KRA92_HUMAN, Q9BYQ4 (See
protein sequence)Recommended Name: Keratin-associated protein 9-2 Size: 174 amino acids; 18287 Da
Subunit: Interacts with hair keratins
Secondary accessions: Q17RK8 Q2TB15Explore the universe of human proteins at neXtProt for KRTAP9-2: NX_Q9BYQ4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BYQ4
KRTAP9-2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_114167.2
ENSEMBL proteins: ENSP00000366950 ENSP00000398325
Human Recombinant Protein Products for KRTAP9-2:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045095 | keratin filament |
IEA | -- |
KRTAP9-2 for ontologies About GeneDecksing
KRTAP9-2 Antibody Products:
Assay Products for KRTAP9-2: |
Protein
Domains /
Families
for KRTAP9-2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRTAP9-2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BYQ4ProtoNet protein and cluster: Q9BYQ4 UniProtKB/Swiss-Prot: KRA92_HUMAN, Q9BYQ4Similarity: Belongs to the KRTAP type 9 family |
Function
for KRTAP9-2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: KRA92_HUMAN, Q9BYQ4Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistanthair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. Thematrix proteins include the high-sulfur and high-glycine-tyrosine keratinsAnimal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP9-2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP9-2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: KRTAP9-2 (NM_031961) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRTAP9-2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRTAP9-2 |
|
Pathways & Interactions
for KRTAP9-2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRTAP9-2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for KRTAP9-2 (Q9BYQ43 ENSP000003669504) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KRTAP9-2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRTAP9-2
Search CenterWatch for drugs/clinical trials and news about KRTAP9-2 / KRA92
|
Transcripts
for KRTAP9-2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRTAP9-2 gene: NM_031961.2 Unigene Cluster for KRTAP9-2: Keratin associated protein 9-2 Hs.307013 [show with all ESTs]Unigene Representative Sequence: AJ4069462 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000377721(uc002hwf.3) ENST00000455970
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP9-2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP9-2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRTAP9-2 (NM_031961) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRTAP9-2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRTAP9-2 |
Additional cDNA sequence: AJ406946.1 BC069560.1 BC110619.2 BC117287.1 2 DOTS entries: DT.432733 DT.104971 8 AceView cDNA sequences: BX282351 AA010677 NM_031961 AJ406946 AJ406949 BC069560 BV174393 AA010884
GeneLoc Exon Structure
|
Expression
for KRTAP9-2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRTAP9-2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See KRTAP9-2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRTAP9-2
SOURCE GeneReport for Unigene cluster: Hs.307013
SABiosciences Custom PCR Arrays for KRTAP9-2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRTAP9-2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat KRTAP9-2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRTAP9-2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRTAP9-2 |
Orthologs
for KRTAP9-2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for KRTAP9-2 gene from 4/10 species (see all 10) About this table
ENSEMBL Gene Tree for KRTAP9-2 (if available)
TreeFam Gene Tree for KRTAP9-2 (if available) |
Paralogs
for KRTAP9-2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRTAP9-2 gene
- KRTAP4-42 KRTAP10-22 KRTAP9-32 KRTAP10-112 KRTAP5-102 KRTAP9-62 KRTAP4-72 KRTAP1-12
- KRTAP10-12 KRTAP5-42 KRTAP1-42 KRTAP9-72 KRTAP4-12 KRTAP4-122 KRTAP10-32 KRTAP9-92
- KRTAP10-122 KRTAP5-22 KRTAP2-22 KRTAP12-32 KRTAP5-72 KRTAP10-102 KRTAP10-82 KRTAP16-12
- KRTAP12-42 KRTAP5-12 KRTAP4-16P2 KRTAP5-32 KRTAP1-52 KRTAP4-112 KRTAP2-42 KRTAP10-62
- KRTAP9-12 KRTAP1-32 KRTAP10-72 KRTAP4-52 KRTAP2-12 KRTAP4-22 KRTAP9-42 KRTAP4-92
- KRTAP5-52 KRTAP5-62 KRTAP12-22 KRTAP29-12 KRTAP5-112 KRTAP10-92 KRTAP5-92 KRTAP10-52
- KRTAP4-82 KRTAP12-12 KRTAP5-82 KRTAP2-32 KRTAP9-82 KRTAP4-62 KRTAP10-42 KRTAP4-32
11 SIMAP similar genes for KRTAP9-2 using alignment to 4 protein entries: KRA92_HUMAN (see all proteins):KRTAP9-6 KRTAP9-7 KRTAP9-9 KRTAP9-8 KRTAP9-3 KRTAP9-4
KRTAP9-1 KRTAP4-2 KRTAP4-1 KRTAP12-3 KRTAP29-1
KRTAP9-2 for paralogs About GeneDecksing
|
Genomic Variants
for KRTAP9-2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRTAP9-2 (39382900 - 39383904 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for KRTAP9-2
15/18 CNVs (see all 18): 77604 88466 72928 35452 77601 77599 88465 32178 88462 4036 88461 22862 72929 77603 77602 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRTAP9-2 |
|
Disorders
/ Diseases
for KRTAP9-2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
KRTAP9-2 for disorders About GeneDecksing
1  disease for KRTAP9-2: About MalaCardsfraser syndrome
Export disorders for KRTAP9-2 gene to outside databases
|
Publications
for KRTAP9-2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRTAP9-2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with KRTAP9-2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PubMed id 11279113)1, 2, 3 Rogers M.A....Schweizer J. (2001)
- Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)1 Ewing R.M.... Figeys D. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for KRTAP9-2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRTAP9-2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRTAP9-2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRTAP9-2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRTAP9-2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRTAP9-2 gene:
Search GeneIP for patents involving KRTAP9-2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRTAP9-2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRTAP9-2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRTAP9-2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRTAP9-2 | | | OriGene Protein Over-expression Lysate for KRTAP9-2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRTAP9-2 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP9-2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP9-2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRTAP9-2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRTAP9-2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRTAP9-2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRTAP9-2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRTAP9-2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRTAP9-2 |
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 | | | KRTAP9-2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  |  | | | | Search ThermoFisher Antibodies for KRTAP9-2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRTAP9-2 |
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