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Aliases for KRTAP9-1 Gene

Aliases for KRTAP9-1 Gene

  • Keratin Associated Protein 9-1 2 3
  • Keratin Associated Protein 9-Like 3 2 3
  • KAP9.1 3 4
  • Putative Keratin-Associated Protein 9-2-Like 3 3
  • Keratin-Associated Protein 9-1 3
  • KRTAP9L3 3
  • KRTAP9.1 4

External Ids for KRTAP9-1 Gene

Previous Symbols for KRTAP9-1 Gene

  • KRTAP9L3

Summaries for KRTAP9-1 Gene

GeneCards Summary for KRTAP9-1 Gene

KRTAP9-1 (Keratin Associated Protein 9-1) is a Protein Coding gene. An important paralog of this gene is KRTAP4-4.

UniProtKB/Swiss-Prot for KRTAP9-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP9-1 Gene

Genomics for KRTAP9-1 Gene

Genomic Location for KRTAP9-1 Gene

Start:
41,189,887 bp from pter
End:
41,190,639 bp from pter
Size:
753 bases
Orientation:
Plus strand

Genomic View for KRTAP9-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP9-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP9-1 Gene

No data available for Regulatory Elements for KRTAP9-1 Gene

Proteins for KRTAP9-1 Gene

  • Protein details for KRTAP9-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MXZ3-KRA91_HUMAN
    Recommended name:
    Keratin-associated protein 9-1
    Protein Accession:
    A8MXZ3
    Secondary Accessions:

    Protein attributes for KRTAP9-1 Gene

    Size:
    250 amino acids
    Molecular mass:
    26333 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP9-1 Gene

Proteomics data for KRTAP9-1 Gene at MOPED

Post-translational modifications for KRTAP9-1 Gene

No Post-translational modifications

Other Protein References for KRTAP9-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP9-1 Gene

Domains for KRTAP9-1 Gene

Gene Families for KRTAP9-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP9-1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KRA91_HUMAN
Family:
  • Belongs to the KRTAP type 9 family.:
    • A8MXZ3
genes like me logo Genes that share domains with KRTAP9-1: view

Function for KRTAP9-1 Gene

Molecular function for KRTAP9-1 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP9-1 Gene

Localization for KRTAP9-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP9-1 Gene COMPARTMENTS Subcellular localization image for KRTAP9-1 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
extracellular 2
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRTAP9-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP9-1: view

Pathways for KRTAP9-1 Gene

SuperPathways for KRTAP9-1 Gene

No Data Available

Interacting Proteins for KRTAP9-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP9-1 Gene

None

No data available for Pathways by source for KRTAP9-1 Gene

Transcripts for KRTAP9-1 Gene

mRNA/cDNA for KRTAP9-1 Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP9-1 Gene

No ASD Table

Relevant External Links for KRTAP9-1 Gene

GeneLoc Exon Structure for
KRTAP9-1
ECgene alternative splicing isoforms for
KRTAP9-1

Expression for KRTAP9-1 Gene

mRNA expression in normal human tissues for KRTAP9-1 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP9-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (37.5), Colon - Transverse (7.8), and Skin - Sun Exposed (Lower leg) (7.7).

SOURCE GeneReport for Unigene cluster for KRTAP9-1 Gene Hs.727478

genes like me logo Genes that share expressions with KRTAP9-1: view

Orthologs for KRTAP9-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP9-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP9-1 37
  • 98 (a)
OneToOne
LOC100613989 36
  • 98.83 (n)
  • 97.37 (a)
cow
(Bos Taurus)
Mammalia -- 37
  • 48 (a)
ManyToMany
KRTAP9-1 37
  • 43 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Gm11559 37
  • 57 (a)
ManyToMany
Gm11567 37
  • 55 (a)
ManyToMany
Gm11568 37
  • 52 (a)
ManyToMany
Krtap9-1 37
  • 59 (a)
ManyToMany
Krtap9-5 36
  • 68.71 (n)
  • 57.65 (a)
Krtap9-5 16
rat
(Rattus norvegicus)
Mammalia LOC100364862 36
  • 71.09 (n)
  • 61.06 (a)
Species with no ortholog for KRTAP9-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP9-1 Gene

ENSEMBL:
Gene Tree for KRTAP9-1 (if available)
TreeFam:
Gene Tree for KRTAP9-1 (if available)

Paralogs for KRTAP9-1 Gene

Selected SIMAP similar genes for KRTAP9-1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with KRTAP9-1: view

Variants for KRTAP9-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP9-1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs238824 -- 41,190,266(-) AGCAG(A/G)TAGTT missense, reference
rs238825 -- 41,188,051(-) caacc(A/C)ccgct upstream-variant-2KB
rs420206 -- 41,188,713(-) gtttc(A/C)ccgtg upstream-variant-2KB
rs976092 -- 41,189,154(-) TAATT(C/T)TAATA upstream-variant-2KB
rs976093 -- 41,188,910(-) TGTGT(G/T)TTTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP9-1 Gene

Variant ID Type Subtype PubMed ID
nsv908232 CNV Loss 21882294
nsv833446 CNV Gain 17160897
dgv961e1 CNV Complex 17122850

Relevant External Links for KRTAP9-1 Gene

HapMap Linkage Disequilibrium report
KRTAP9-1

Disorders for KRTAP9-1 Gene

No disorders were found for KRTAP9-1 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP9-1 Gene

Publications for KRTAP9-1 Gene

  1. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  2. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 3

Products for KRTAP9-1 Gene

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP9-1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP9-1
    • Block miRNA regulation of KRTAP9-1 using miScript Target Protectors

    Sources for KRTAP9-1 Gene

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