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Aliases for KRTAP8-1 Gene

Aliases for KRTAP8-1 Gene

  • Keratin Associated Protein 8-1 2 3
  • High Glycine-Tyrosine Keratin-Associated Protein 8.1 3 4
  • KAP8.1 3 4
  • Keratin-Associated Protein 8-1 3
  • KRTAP8.1 4

External Ids for KRTAP8-1 Gene

Summaries for KRTAP8-1 Gene

GeneCards Summary for KRTAP8-1 Gene

KRTAP8-1 (Keratin Associated Protein 8-1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP8-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP8-1 Gene

Genomics for KRTAP8-1 Gene

Genomic Location for KRTAP8-1 Gene

Start:
30,812,697 bp from pter
End:
30,813,252 bp from pter
Size:
556 bases
Orientation:
Minus strand

Genomic View for KRTAP8-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP8-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP8-1 Gene

Regulatory Elements for KRTAP8-1 Gene

Proteins for KRTAP8-1 Gene

  • Protein details for KRTAP8-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUC2-KRA81_HUMAN
    Recommended name:
    Keratin-associated protein 8-1
    Protein Accession:
    Q8IUC2
    Secondary Accessions:
    • Q3LI57

    Protein attributes for KRTAP8-1 Gene

    Size:
    63 amino acids
    Molecular mass:
    6826 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP8-1 Gene

Proteomics data for KRTAP8-1 Gene at MOPED

Post-translational modifications for KRTAP8-1 Gene

No Post-translational modifications

Other Protein References for KRTAP8-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP8-1 Gene

Domains for KRTAP8-1 Gene

Gene Families for KRTAP8-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP8-1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KRA81_HUMAN
Family:
  • Belongs to the KRTAP type 8 family.:
    • Q8IUC2
genes like me logo Genes that share domains with KRTAP8-1: view

Function for KRTAP8-1 Gene

Molecular function for KRTAP8-1 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP8-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP8-1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP8-1 Gene

Localization for KRTAP8-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP8-1 Gene COMPARTMENTS Subcellular localization image for KRTAP8-1 gene
Compartment Confidence
cytoskeleton 3
extracellular 3
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KRTAP8-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP8-1: view

Pathways for KRTAP8-1 Gene

SuperPathways for KRTAP8-1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRTAP8-1 Gene

None

No data available for Pathways by source for KRTAP8-1 Gene

Transcripts for KRTAP8-1 Gene

mRNA/cDNA for KRTAP8-1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP8-1 Gene

Keratin associated protein 8-1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP8-1 Gene

No ASD Table

Relevant External Links for KRTAP8-1 Gene

GeneLoc Exon Structure for
KRTAP8-1
ECgene alternative splicing isoforms for
KRTAP8-1

Expression for KRTAP8-1 Gene

mRNA expression in normal human tissues for KRTAP8-1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRTAP8-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (47.8) and Skin - Sun Exposed (Lower leg) (4.7).

SOURCE GeneReport for Unigene cluster for KRTAP8-1 Gene Hs.407655

mRNA Expression by UniProt/SwissProt for KRTAP8-1 Gene

Q8IUC2-KRA81_HUMAN
Tissue specificity: Is essentially restricted to only one vertical half of the hair forming compartment and in beard hairs is absent from the central medulla
genes like me logo Genes that share expressions with KRTAP8-1: view

Orthologs for KRTAP8-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP8-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP8-1 36
  • 100 (n)
  • 100 (a)
KRTAP8-1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRTAP8-1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRTAP8-1 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krtap8-1 16
Krtap8-1 37
  • 84 (a)
OneToOne
Species with no ortholog for KRTAP8-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP8-1 Gene

ENSEMBL:
Gene Tree for KRTAP8-1 (if available)
TreeFam:
Gene Tree for KRTAP8-1 (if available)

Paralogs for KRTAP8-1 Gene

No data available for Paralogs for KRTAP8-1 Gene

Variants for KRTAP8-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP8-1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs728174 -- 30,813,951(+) TAAAA(C/T)GGAGT upstream-variant-2KB
rs1892667 -- 30,812,787(+) GTAGC(G/T)CATGA utr-variant-3-prime
rs2833101 -- 30,812,770(+) TCATG(A/G)AAAAT utr-variant-3-prime
rs2833102 -- 30,813,543(+) GACCC(C/T)ATATA upstream-variant-2KB
rs2833103 -- 30,814,461(+) GATAT(A/G)TATTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP8-1 Gene

Variant ID Type Subtype PubMed ID
nsv459237 CNV Gain 19166990
nsv834077 CNV Gain 17160897

Relevant External Links for KRTAP8-1 Gene

HapMap Linkage Disequilibrium report
KRTAP8-1

Disorders for KRTAP8-1 Gene

No disorders were found for KRTAP8-1 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP8-1 Gene

Publications for KRTAP8-1 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3 4
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Bidirectional binding property of high glycine-tyrosine keratin-associated protein contributes to the mechanical strength and shape of hair. (PMID: 23791804) Matsunaga R. … Tsumoto K. (J. Struct. Biol. 2013) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for KRTAP8-1 Gene

Sources for KRTAP8-1 Gene

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