Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRTAP8-1 Gene

Aliases for KRTAP8-1 Gene

  • Keratin Associated Protein 8-1 2 3 5
  • High Glycine-Tyrosine Keratin-Associated Protein 8.1 3 4
  • KAP8.1 3 4
  • KRTAP8.1 4

External Ids for KRTAP8-1 Gene

Previous GeneCards Identifiers for KRTAP8-1 Gene

  • GC21U900011
  • GC21M031105
  • GC21M031106
  • GC21M032185
  • GC21M017593

Summaries for KRTAP8-1 Gene

GeneCards Summary for KRTAP8-1 Gene

KRTAP8-1 (Keratin Associated Protein 8-1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP8-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP8-1 Gene

Genomics for KRTAP8-1 Gene

Regulatory Elements for KRTAP8-1 Gene


Genomic Location for KRTAP8-1 Gene

Chromosome:
21
Start:
30,812,697 bp from pter
End:
30,813,252 bp from pter
Size:
556 bases
Orientation:
Minus strand

Genomic View for KRTAP8-1 Gene

Genes around KRTAP8-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP8-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP8-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP8-1 Gene

Proteins for KRTAP8-1 Gene

  • Protein details for KRTAP8-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUC2-KRA81_HUMAN
    Recommended name:
    Keratin-associated protein 8-1
    Protein Accession:
    Q8IUC2
    Secondary Accessions:
    • Q3LI57

    Protein attributes for KRTAP8-1 Gene

    Size:
    63 amino acids
    Molecular mass:
    6826 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP8-1 Gene

Proteomics data for KRTAP8-1 Gene at MOPED

Post-translational modifications for KRTAP8-1 Gene

No Post-translational modifications

Other Protein References for KRTAP8-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP8-1 Gene

Domains & Families for KRTAP8-1 Gene

Gene Families for KRTAP8-1 Gene

Protein Domains for KRTAP8-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP8-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IUC2

UniProtKB/Swiss-Prot:

KRA81_HUMAN :
  • Belongs to the KRTAP type 8 family.
Family:
  • Belongs to the KRTAP type 8 family.
genes like me logo Genes that share domains with KRTAP8-1: view

Function for KRTAP8-1 Gene

Molecular function for KRTAP8-1 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes for KRTAP8-1 Gene

GenomeRNAi human phenotypes for KRTAP8-1:
genes like me logo Genes that share phenotypes with KRTAP8-1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP8-1 Gene

Localization for KRTAP8-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP8-1 Gene COMPARTMENTS Subcellular localization image for KRTAP8-1 gene
Compartment Confidence
cytoskeleton 3
extracellular 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP8-1 Gene

Pathways & Interactions for KRTAP8-1 Gene

SuperPathways for KRTAP8-1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRTAP8-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP8-1 Gene

Drugs & Compounds for KRTAP8-1 Gene

No Compound Related Data Available

Transcripts for KRTAP8-1 Gene

mRNA/cDNA for KRTAP8-1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP8-1 Gene

Keratin associated protein 8-1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP8-1 Gene

No ASD Table

Relevant External Links for KRTAP8-1 Gene

GeneLoc Exon Structure for
KRTAP8-1
ECgene alternative splicing isoforms for
KRTAP8-1

Expression for KRTAP8-1 Gene

mRNA expression in normal human tissues for KRTAP8-1 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP8-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x47.8) and Skin - Sun Exposed (Lower leg) (x4.7).

SOURCE GeneReport for Unigene cluster for KRTAP8-1 Gene Hs.407655

mRNA Expression by UniProt/SwissProt for KRTAP8-1 Gene

Q8IUC2-KRA81_HUMAN
Tissue specificity: Is essentially restricted to only one vertical half of the hair forming compartment and in beard hairs is absent from the central medulla.
genes like me logo Genes that share expression patterns with KRTAP8-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KRTAP8-1 Gene

Orthologs for KRTAP8-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP8-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP8-1 35
  • 100 (n)
  • 100 (a)
KRTAP8-1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRTAP8-1 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRTAP8-1 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krtap8-1 36
  • 84 (a)
OneToOne
Species with no ortholog for KRTAP8-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP8-1 Gene

ENSEMBL:
Gene Tree for KRTAP8-1 (if available)
TreeFam:
Gene Tree for KRTAP8-1 (if available)

Paralogs for KRTAP8-1 Gene

No data available for Paralogs for KRTAP8-1 Gene

Variants for KRTAP8-1 Gene

Structural Variations from Database of Genomic Variants (DGV) for KRTAP8-1 Gene

Variant ID Type Subtype PubMed ID
nsv459237 CNV Gain 19166990
nsv834077 CNV Gain 17160897

Variation tolerance for KRTAP8-1 Gene

Residual Variation Intolerance Score: 61% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.51; 29.38% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for KRTAP8-1 Gene

Disorders for KRTAP8-1 Gene

Relevant External Links for KRTAP8-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP8-1

No disorders were found for KRTAP8-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP8-1 Gene

Publications for KRTAP8-1 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3 4 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Bidirectional binding property of high glycine-tyrosine keratin-associated protein contributes to the mechanical strength and shape of hair. (PMID: 23791804) Matsunaga R. … Tsumoto K. (J. Struct. Biol. 2013) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3

Products for KRTAP8-1 Gene

Sources for KRTAP8-1 Gene

Content