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Aliases for KRTAP7-1 Gene

Aliases for KRTAP7-1 Gene

  • Keratin Associated Protein 7-1 (Gene/Pseudogene) 2 3
  • High Tyrosine-Glycine Keratin-Associated Protein 7.1 3 4
  • KAP7.1 3 4
  • Keratin Associated Protein 7-1 2
  • Keratin-Associated Protein 7-1 3
  • KRTAP7.1 4

External Ids for KRTAP7-1 Gene

Summaries for KRTAP7-1 Gene

GeneCards Summary for KRTAP7-1 Gene

KRTAP7-1 (Keratin Associated Protein 7-1 (Gene/Pseudogene)) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP7-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP7-1 Gene

Genomics for KRTAP7-1 Gene

Genomic Location for KRTAP7-1 Gene

Start:
30,829,039 bp from pter
End:
30,829,759 bp from pter
Size:
721 bases
Orientation:
Minus strand

Genomic View for KRTAP7-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP7-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP7-1 Gene

Regulatory Elements for KRTAP7-1 Gene

Proteins for KRTAP7-1 Gene

  • Protein details for KRTAP7-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IUC3-KRA71_HUMAN
    Recommended name:
    Keratin-associated protein 7-1
    Protein Accession:
    Q8IUC3
    Secondary Accessions:
    • Q3LI56

    Protein attributes for KRTAP7-1 Gene

    Size:
    87 amino acids
    Molecular mass:
    9288 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP7-1 Gene

Proteomics data for KRTAP7-1 Gene at MOPED

Post-translational modifications for KRTAP7-1 Gene

No Post-translational modifications

Other Protein References for KRTAP7-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP7-1 Gene

Domains for KRTAP7-1 Gene

Gene Families for KRTAP7-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP7-1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KRA71_HUMAN
Family:
  • Belongs to the KRTAP type 7 family.:
    • Q8IUC3
genes like me logo Genes that share domains with KRTAP7-1: view

Function for KRTAP7-1 Gene

Molecular function for KRTAP7-1 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP7-1 Gene

Localization for KRTAP7-1 Gene

Gene Ontology (GO) - Cellular Components for KRTAP7-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP7-1: view

Pathways for KRTAP7-1 Gene

SuperPathways for KRTAP7-1 Gene

No Data Available

Interacting Proteins for KRTAP7-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP7-1 Gene

None

No data available for Pathways by source for KRTAP7-1 Gene

Transcripts for KRTAP7-1 Gene

mRNA/cDNA for KRTAP7-1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP7-1 Gene

No ASD Table

Relevant External Links for KRTAP7-1 Gene

GeneLoc Exon Structure for
KRTAP7-1
ECgene alternative splicing isoforms for
KRTAP7-1

Expression for KRTAP7-1 Gene

mRNA expression in normal human tissues for KRTAP7-1 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTAP7-1 Gene

SOURCE GeneReport for Unigene cluster for KRTAP7-1 Gene Hs.407656

mRNA Expression by UniProt/SwissProt for KRTAP7-1 Gene

Q8IUC3-KRA71_HUMAN
Tissue specificity: Expressed in the upper portion of the hair cortex
genes like me logo Genes that share expressions with KRTAP7-1: view

Orthologs for KRTAP7-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP7-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP7-1 36
  • 98.85 (n)
  • 97.7 (a)
cow
(Bos Taurus)
Mammalia KRTAP7-1 36
  • 88.51 (n)
  • 88.51 (a)
dog
(Canis familiaris)
Mammalia KRTAP7-1 36
  • 88.51 (n)
  • 88.51 (a)
mouse
(Mus musculus)
Mammalia Krtap7-1 36
  • 82.95 (n)
  • 80.23 (a)
Krtap7-1 16
rat
(Rattus norvegicus)
Mammalia Krtap7-1 36
  • 82.95 (n)
  • 80.23 (a)
Species with no ortholog for KRTAP7-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP7-1 Gene

ENSEMBL:
Gene Tree for KRTAP7-1 (if available)
TreeFam:
Gene Tree for KRTAP7-1 (if available)

Paralogs for KRTAP7-1 Gene

No data available for Paralogs for KRTAP7-1 Gene

Variants for KRTAP7-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP7-1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs2252751 -- 30,830,955(+) AATCA(C/T)AGAGT upstream-variant-2KB
rs2833117 -- 30,828,654(+) ACAAC(A/C)TGAGG downstream-variant-500B
rs2833118 -- 30,829,787(+) CTTTT(A/T)ATACC upstream-variant-2KB
rs9305443 -- 30,829,153(+) CAGAG(A/C)AACCA utr-variant-3-prime
rs9647139 -- 30,829,990(+) CCCAT(A/G)GTTTA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP7-1 Gene

Variant ID Type Subtype PubMed ID
nsv459237 CNV Gain 19166990
nsv834077 CNV Gain 17160897

Relevant External Links for KRTAP7-1 Gene

HapMap Linkage Disequilibrium report
KRTAP7-1

Disorders for KRTAP7-1 Gene

Relevant External Links for KRTAP7-1

Genetic Association Database (GAD)
KRTAP7-1
genes like me logo Genes that share disorders with KRTAP7-1: view

No data available for UniProtKB/Swiss-Prot for KRTAP7-1 Gene

Publications for KRTAP7-1 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3 4
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3 4
  3. Whole genome association scan for genetic polymorphisms influencing information processing speed. (PMID: 21130836) Luciano M. … Deary I.J. (Biol Psychol 2011) 49

Products for KRTAP7-1 Gene

Sources for KRTAP7-1 Gene

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