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Aliases for KRTAP6-1 Gene

Aliases for KRTAP6-1 Gene

  • Keratin Associated Protein 6-1 2 3
  • C21orf103 3 4
  • KAP6.1 3 4
  • Keratin-Associated Protein 6-1 3

External Ids for KRTAP6-1 Gene

Previous GeneCards Identifiers for KRTAP6-1 Gene

  • GC21U900016
  • GC21M030907
  • GC21M030908
  • GC21M031985
  • GC21M017394

Summaries for KRTAP6-1 Gene

GeneCards Summary for KRTAP6-1 Gene

KRTAP6-1 (Keratin Associated Protein 6-1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP6-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP6-1 Gene

Genomics for KRTAP6-1 Gene

Regulatory Elements for KRTAP6-1 Gene

Genomic Location for KRTAP6-1 Gene

Start:
30,613,431 bp from pter
End:
30,613,930 bp from pter
Size:
500 bases
Orientation:
Minus strand

Genomic View for KRTAP6-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP6-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP6-1 Gene

Proteins for KRTAP6-1 Gene

  • Protein details for KRTAP6-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI64-KRA61_HUMAN
    Recommended name:
    Keratin-associated protein 6-1
    Protein Accession:
    Q3LI64
    Secondary Accessions:

    Protein attributes for KRTAP6-1 Gene

    Size:
    71 amino acids
    Molecular mass:
    7279 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP6-1 Gene

Proteomics data for KRTAP6-1 Gene at MOPED

Post-translational modifications for KRTAP6-1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP6-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP6-1 Gene

Domains for KRTAP6-1 Gene

Gene Families for KRTAP6-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP6-1 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP6-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LI64

UniProtKB/Swiss-Prot:

KRA61_HUMAN :
  • Q3LI64
Family:
  • Belongs to the KRTAP type 6 family.
genes like me logo Genes that share domains with KRTAP6-1: view

Function for KRTAP6-1 Gene

Molecular function for KRTAP6-1 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP6-1 Gene

Localization for KRTAP6-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP6-1 Gene COMPARTMENTS Subcellular localization image for KRTAP6-1 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
extracellular 3
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP6-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 16780588
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP6-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP6-1 Gene

Pathways for KRTAP6-1 Gene

SuperPathways for KRTAP6-1 Gene

No Data Available

Interacting Proteins for KRTAP6-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP6-1 Gene

None

No data available for Pathways by source for KRTAP6-1 Gene

Transcripts for KRTAP6-1 Gene

mRNA/cDNA for KRTAP6-1 Gene

(1) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP6-1 Gene

No ASD Table

Relevant External Links for KRTAP6-1 Gene

GeneLoc Exon Structure for
KRTAP6-1
ECgene alternative splicing isoforms for
KRTAP6-1

Expression for KRTAP6-1 Gene

mRNA expression in normal human tissues for KRTAP6-1 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP6-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (44.5) and Skin - Sun Exposed (Lower leg) (8.2).

SOURCE GeneReport for Unigene cluster for KRTAP6-1 Gene Hs.553689

genes like me logo Genes that share expressions with KRTAP6-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for KRTAP6-1 Gene

Orthologs for KRTAP6-1 Gene

Evolution for KRTAP6-1 Gene

ENSEMBL:
Gene Tree for KRTAP6-1 (if available)
TreeFam:
Gene Tree for KRTAP6-1 (if available)

No data available for Orthologs for KRTAP6-1 Gene

Paralogs for KRTAP6-1 Gene

No data available for Paralogs for KRTAP6-1 Gene

Variants for KRTAP6-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP6-1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs13051929 -- 30,613,504(+) ATTTT(A/C)CCTTA downstream-variant-500B
rs13052785 -- 30,613,404(+) TGTGT(A/T)TATTA downstream-variant-500B
rs28567421 -- 30,613,744(+) GGGAG(C/T)GGGAG missense, reference
rs72099279 -- 30,614,387(+) AGGAA(-/TTC)TTCTC upstream-variant-2KB
rs73347566 -- 30,614,383(+) CTTTA(C/G)GAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP6-1 Gene

Variant ID Type Subtype PubMed ID
nsv913677 CNV Loss 21882294

Relevant External Links for KRTAP6-1 Gene

HapMap Linkage Disequilibrium report
KRTAP6-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP6-1 Gene

Disorders for KRTAP6-1 Gene

No disorders were found for KRTAP6-1 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP6-1 Gene

Publications for KRTAP6-1 Gene

  1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  3. Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins. (PMID: 16780588) Hu Y.H. … Janitz M. (BMC Genomics 2006) 3

Products for KRTAP6-1 Gene

Sources for KRTAP6-1 Gene

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