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Aliases for KRTAP5-9 Gene

Aliases for KRTAP5-9 Gene

  • Keratin Associated Protein 5-9 2 3 5
  • Ultrahigh Sulfur Keratin-Associated Protein 5.9 3 4
  • Keratin, Ultra High-Sulfur Matrix Protein A 3 4
  • Keratin, Cuticle, Ultrahigh Sulfur 1 3 4
  • Keratin-Associated Protein 5.9 3 4
  • UHS Keratin A 3 4
  • KRTAP5.9 3 4
  • UHS KerA 3 4
  • KRN1 3 4
  • Keratin, Cuticle, Ultrahigh Sulphur 1 3
  • Keratin-Associated Protein 5-9 3
  • KRTAP5-1 3
  • KAP5.9 4
  • UHSK1 4

External Ids for KRTAP5-9 Gene

Previous HGNC Symbols for KRTAP5-9 Gene

  • KRN1

Previous GeneCards Identifiers for KRTAP5-9 Gene

  • GC00U913946
  • GC11P070938
  • GC11P071259

Summaries for KRTAP5-9 Gene

GeneCards Summary for KRTAP5-9 Gene

KRTAP5-9 (Keratin Associated Protein 5-9) is a Protein Coding gene. Among its related pathways are Developmental Biology.

UniProtKB/Swiss-Prot for KRTAP5-9 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-9 Gene

Genomics for KRTAP5-9 Gene

Regulatory Elements for KRTAP5-9 Gene

Enhancers for KRTAP5-9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F071534 0.9 ENCODE 10.8 -13.2 -13219 2.0 ELF3 HDAC1 MLX ARID4B DMAP1 ZNF48 ZSCAN9 RARA MIXL1 THAP11 KRTAP5-9 KRTAP5-8 KRTAP5-7
GH11F071479 0.9 ENCODE 10.5 -67.2 -67210 3.1 PKNOX1 SIN3A ZBTB40 RAD21 SCRT2 ZNF207 RCOR1 FOS HCFC1 ZHX2 ENSG00000254682 NADSYN1 ENSG00000248671 DHCR7 KRTAP5-9 ALG1L9P MIR6754 GC11M071490
GH11F071487 0.8 ENCODE 11.1 -59.6 -59575 2.4 HDGF PKNOX1 RAD21 RELA GATA3 CTBP1 POLR2A SCRT2 EED FOS ENSG00000254682 NADSYN1 DHCR7 KRTAP5-9 KRTAP5-8 GC11M071490 MIR6754
GH11F071504 0.7 ENCODE 11.6 -43.0 -42999 2.6 GTF2F1 ZNF687 PKNOX1 NFIA ZHX2 DPF2 REST RAD21 CTBP1 RCOR1 NADSYN1 ENSG00000254682 KRTAP5-9 DHCR7 GC11M071508 GC11M071490
GH11F071500 0.7 ENCODE 11.3 -47.6 -47629 0.2 ZNF687 PKNOX1 MAX REST RAD21 NR2F2 ZKSCAN1 MBD2 GATA3 CTBP1 KRTAP5-9 DHCR7 NADSYN1 ENSG00000254682 GC11M071490 GC11M071508
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRTAP5-9 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTAP5-9 Gene

Chromosome:
11
Start:
71,548,418 bp from pter
End:
71,549,607 bp from pter
Size:
1,190 bases
Orientation:
Plus strand

Genomic View for KRTAP5-9 Gene

Genes around KRTAP5-9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP5-9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP5-9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP5-9 Gene

Proteins for KRTAP5-9 Gene

  • Protein details for KRTAP5-9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P26371-KRA59_HUMAN
    Recommended name:
    Keratin-associated protein 5-9
    Protein Accession:
    P26371
    Secondary Accessions:
    • Q14564
    • Q3MIP8

    Protein attributes for KRTAP5-9 Gene

    Size:
    169 amino acids
    Molecular mass:
    16276 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP5-9 Gene

Post-translational modifications for KRTAP5-9 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP5-9 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP5-9 Gene

Domains & Families for KRTAP5-9 Gene

Gene Families for KRTAP5-9 Gene

Protein Domains for KRTAP5-9 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP5-9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P26371

UniProtKB/Swiss-Prot:

KRA59_HUMAN :
  • Belongs to the KRTAP type 5 family.
Family:
  • Belongs to the KRTAP type 5 family.
genes like me logo Genes that share domains with KRTAP5-9: view

Function for KRTAP5-9 Gene

Molecular function for KRTAP5-9 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Gene Ontology (GO) - Molecular Function for KRTAP5-9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 21516116
genes like me logo Genes that share ontologies with KRTAP5-9: view
genes like me logo Genes that share phenotypes with KRTAP5-9: view

Animal Model Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for KRTAP5-9 Gene

Localization for KRTAP5-9 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTAP5-9 gene
Compartment Confidence
cytosol 4
cytoskeleton 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for KRTAP5-9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP5-9: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP5-9 Gene

Pathways & Interactions for KRTAP5-9 Gene

SuperPathways for KRTAP5-9 Gene

SuperPathway Contained pathways
1 Developmental Biology
genes like me logo Genes that share pathways with KRTAP5-9: view

Pathways by source for KRTAP5-9 Gene

1 Reactome pathway for KRTAP5-9 Gene

Gene Ontology (GO) - Biological Process for KRTAP5-9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008544 epidermis development TAS 1703541
genes like me logo Genes that share ontologies with KRTAP5-9: view

No data available for SIGNOR curated interactions for KRTAP5-9 Gene

Transcripts for KRTAP5-9 Gene

mRNA/cDNA for KRTAP5-9 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP5-9 Gene

Keratin associated protein 5-9:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP5-9 Gene

No ASD Table

Relevant External Links for KRTAP5-9 Gene

GeneLoc Exon Structure for
KRTAP5-9
ECgene alternative splicing isoforms for
KRTAP5-9

Expression for KRTAP5-9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for KRTAP5-9 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP5-9 Gene

This gene is overexpressed in Testis (x5.3).

SOURCE GeneReport for Unigene cluster for KRTAP5-9 Gene:

Hs.709220

mRNA Expression by UniProt/SwissProt for KRTAP5-9 Gene:

P26371-KRA59_HUMAN
Tissue specificity: Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles.
genes like me logo Genes that share expression patterns with KRTAP5-9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KRTAP5-9 Gene

Orthologs for KRTAP5-9 Gene

Evolution for KRTAP5-9 Gene

ENSEMBL:
Gene Tree for KRTAP5-9 (if available)
TreeFam:
Gene Tree for KRTAP5-9 (if available)

No data available for Orthologs for KRTAP5-9 Gene

Paralogs for KRTAP5-9 Gene

No data available for Paralogs for KRTAP5-9 Gene

Variants for KRTAP5-9 Gene

Sequence variations from dbSNP and Humsavar for KRTAP5-9 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10751114 -- 71,547,952(+) CAGGA(A/G)TAGGG upstream-variant-2KB
rs10792769 -- 71,548,776(+) CGTCT(A/G)CTGCT reference, missense
rs10792770 -- 71,549,802(+) GAAGA(C/T)GAGGA downstream-variant-500B
rs10898282 -- 71,546,526(+) AGCCC(A/G)CAGCA upstream-variant-2KB
rs111841817 -- 71,546,549(+) TAAAG(C/G/T)GCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP5-9 Gene

Variant ID Type Subtype PubMed ID
nsv555402 CNV gain 21841781
esv3626782 CNV gain 21293372
esv3626781 CNV gain 21293372
esv2744750 CNV deletion 23290073

Variation tolerance for KRTAP5-9 Gene

Residual Variation Intolerance Score: 93.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.78; 86.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTAP5-9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTAP5-9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP5-9 Gene

Disorders for KRTAP5-9 Gene

Relevant External Links for KRTAP5-9

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP5-9

No disorders were found for KRTAP5-9 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP5-9 Gene

Publications for KRTAP5-9 Gene

  1. Identification of two novel clusters of ultrahigh-sulfur keratin- associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S. … Shimizu N. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Genomic organization and promoter characterization of two human UHS keratin genes. (PMID: 10023043) Perez C. … Egly J.-M. (Gene 1999) 3 4 64
  4. Structure and expression of genes for a class of cysteine-rich proteins of the cuticle layers of differentiating wool and hair follicles. (PMID: 1703541) McKinnon P.J. … Rogers G.E. (J. Cell Biol. 1990) 3 4 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for KRTAP5-9 Gene

Sources for KRTAP5-9 Gene

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