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Aliases for KRTAP5-8 Gene

Aliases for KRTAP5-8 Gene

  • Keratin Associated Protein 5-8 2 3
  • Ultrahigh Sulfur Keratin-Associated Protein 5.8 3 4
  • Keratin, Ultra High-Sulfur Matrix Protein B 3 4
  • Keratin-Associated Protein 5.8 3 4
  • UHS Keratin B 3 4
  • UHS KerB 3 4
  • KRTAP5.8 3 4
  • Keratin-Associated Protein 5-8 3
  • Keratin, Ultrahigh Sulfur, B 3
  • UHS KERB-Like Protein 3
  • KRTAP5-2 3
  • UHSKerB 3
  • KAP5.8 4
  • UHSKB 4

External Ids for KRTAP5-8 Gene

Previous GeneCards Identifiers for KRTAP5-8 Gene

  • GC00U913944
  • GC11P070918
  • GC11M001587
  • GC11P070927
  • GC11P071249
  • GC11P067542

Summaries for KRTAP5-8 Gene

GeneCards Summary for KRTAP5-8 Gene

KRTAP5-8 (Keratin Associated Protein 5-8) is a Protein Coding gene. GO annotations related to this gene include structural constituent of epidermis.

UniProtKB/Swiss-Prot for KRTAP5-8 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-8 Gene

Genomics for KRTAP5-8 Gene

Regulatory Elements for KRTAP5-8 Gene

Genomic Location for KRTAP5-8 Gene

Start:
71,527,301 bp from pter
End:
71,549,167 bp from pter
Size:
21,867 bases
Orientation:
Plus strand

Genomic View for KRTAP5-8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP5-8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP5-8 Gene

Proteins for KRTAP5-8 Gene

  • Protein details for KRTAP5-8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75690-KRA58_HUMAN
    Recommended name:
    Keratin-associated protein 5-8
    Protein Accession:
    O75690
    Secondary Accessions:
    • Q6L8G7
    • Q6UTX6

    Protein attributes for KRTAP5-8 Gene

    Size:
    187 amino acids
    Molecular mass:
    17519 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KRTAP5-8 Gene

Proteomics data for KRTAP5-8 Gene at MOPED

Post-translational modifications for KRTAP5-8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP5-8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP5-8 Gene

Domains for KRTAP5-8 Gene

Gene Families for KRTAP5-8 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP5-8 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP5-8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75690

UniProtKB/Swiss-Prot:

KRA58_HUMAN :
  • O75690
Family:
  • Belongs to the KRTAP type 5 family.
genes like me logo Genes that share domains with KRTAP5-8: view

Function for KRTAP5-8 Gene

Molecular function for KRTAP5-8 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP5-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030280 structural constituent of epidermis NAS 10023043
genes like me logo Genes that share ontologies with KRTAP5-8: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP5-8

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP5-8 Gene

Localization for KRTAP5-8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP5-8 Gene COMPARTMENTS Subcellular localization image for KRTAP5-8 gene
Compartment Confidence
extracellular 5
cytoskeleton 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP5-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP5-8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP5-8 Gene

Pathways for KRTAP5-8 Gene

SuperPathways for KRTAP5-8 Gene

No Data Available

Interacting Proteins for KRTAP5-8 Gene

Gene Ontology (GO) - Biological Process for KRTAP5-8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with KRTAP5-8: view

No data available for Pathways by source for KRTAP5-8 Gene

Transcripts for KRTAP5-8 Gene

mRNA/cDNA for KRTAP5-8 Gene

(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP5-8 Gene

Keratin associated protein 5-8:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP5-8

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTAP5-8
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP5-8 Gene

No ASD Table

Relevant External Links for KRTAP5-8 Gene

GeneLoc Exon Structure for
KRTAP5-8
ECgene alternative splicing isoforms for
KRTAP5-8

Expression for KRTAP5-8 Gene

mRNA expression in normal human tissues for KRTAP5-8 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP5-8 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (32.9).

SOURCE GeneReport for Unigene cluster for KRTAP5-8 Gene Hs.445245

mRNA Expression by UniProt/SwissProt for KRTAP5-8 Gene

O75690-KRA58_HUMAN
Tissue specificity: Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles.
genes like me logo Genes that share expressions with KRTAP5-8: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for KRTAP5-8 Gene

Orthologs for KRTAP5-8 Gene

Evolution for KRTAP5-8 Gene

ENSEMBL:
Gene Tree for KRTAP5-8 (if available)
TreeFam:
Gene Tree for KRTAP5-8 (if available)

No data available for Orthologs for KRTAP5-8 Gene

Paralogs for KRTAP5-8 Gene

No data available for Paralogs for KRTAP5-8 Gene

Variants for KRTAP5-8 Gene

Sequence variations from dbSNP and Humsavar for KRTAP5-8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs7101792 -- 71,538,340(+) TGCTG(C/T)TGCTC synonymous-codon, reference
rs7926544 -- 71,536,297(+) actac(A/G)cgatg upstream-variant-2KB
rs7926656 -- 71,536,348(+) ctgta(A/G)tccca upstream-variant-2KB
rs7930195 -- 71,536,971(+) ccaac(A/G)tggtg upstream-variant-2KB
rs7941700 -- 71,536,048(+) ggaga(A/G)gggaa upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP5-8 Gene

Variant ID Type Subtype PubMed ID
dgv1217n71 CNV Gain 21882294
esv2744750 CNV Deletion 23290073
esv2744751 CNV Deletion 23290073

Relevant External Links for KRTAP5-8 Gene

HapMap Linkage Disequilibrium report
KRTAP5-8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP5-8 Gene

Disorders for KRTAP5-8 Gene

No disorders were found for KRTAP5-8 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP5-8 Gene

Publications for KRTAP5-8 Gene

  1. Identification of two novel clusters of ultrahigh-sulfur keratin- associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S. … Shimizu N. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. Genomic organization and promoter characterization of two human UHS keratin genes. (PMID: 10023043) Perez C. … Egly J.-M. (Gene 1999) 3 4

Products for KRTAP5-8 Gene

Sources for KRTAP5-8 Gene

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