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Aliases for KRTAP5-8 Gene

Aliases for KRTAP5-8 Gene

  • Keratin Associated Protein 5-8 2 3 5
  • Ultrahigh Sulfur Keratin-Associated Protein 5.8 3 4
  • Keratin, Ultra High-Sulfur Matrix Protein B 3 4
  • Keratin-Associated Protein 5.8 3 4
  • UHS Keratin B 3 4
  • KRTAP5.8 3 4
  • UHS KerB 3 4
  • Keratin, Ultrahigh Sulfur, B 3
  • UHS KERB-Like Protein 3
  • KRTAP5-2 3
  • UHSKerB 3
  • KAP5.8 4
  • UHSKB 4

External Ids for KRTAP5-8 Gene

Previous GeneCards Identifiers for KRTAP5-8 Gene

  • GC00U913944
  • GC11P070918
  • GC11M001587
  • GC11P070927
  • GC11P071249
  • GC11P067542
  • GC11P071529

Summaries for KRTAP5-8 Gene

GeneCards Summary for KRTAP5-8 Gene

KRTAP5-8 (Keratin Associated Protein 5-8) is a Protein Coding gene. GO annotations related to this gene include structural constituent of epidermis.

UniProtKB/Swiss-Prot for KRTAP5-8 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-8 Gene

Genomics for KRTAP5-8 Gene

Regulatory Elements for KRTAP5-8 Gene

Enhancers for KRTAP5-8 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRTAP5-8 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTAP5-8 Gene

Chromosome:
11
Start:
71,538,025 bp from pter
End:
71,539,207 bp from pter
Size:
1,183 bases
Orientation:
Plus strand

Genomic View for KRTAP5-8 Gene

Genes around KRTAP5-8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP5-8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP5-8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP5-8 Gene

Proteins for KRTAP5-8 Gene

  • Protein details for KRTAP5-8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75690-KRA58_HUMAN
    Recommended name:
    Keratin-associated protein 5-8
    Protein Accession:
    O75690
    Secondary Accessions:
    • Q6L8G7
    • Q6UTX6

    Protein attributes for KRTAP5-8 Gene

    Size:
    187 amino acids
    Molecular mass:
    17519 Da
    Quaternary structure:
    No Data Available

neXtProt entry for KRTAP5-8 Gene

Proteomics data for KRTAP5-8 Gene at MOPED

Post-translational modifications for KRTAP5-8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP5-8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP5-8 Gene

Domains & Families for KRTAP5-8 Gene

Gene Families for KRTAP5-8 Gene

Protein Domains for KRTAP5-8 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP5-8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75690

UniProtKB/Swiss-Prot:

KRA58_HUMAN :
  • Belongs to the KRTAP type 5 family.
Family:
  • Belongs to the KRTAP type 5 family.
genes like me logo Genes that share domains with KRTAP5-8: view

Function for KRTAP5-8 Gene

Molecular function for KRTAP5-8 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes for KRTAP5-8 Gene

genes like me logo Genes that share phenotypes with KRTAP5-8: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP5-8 Gene

Localization for KRTAP5-8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP5-8 Gene COMPARTMENTS Subcellular localization image for KRTAP5-8 gene
Compartment Confidence
extracellular 3
cytoskeleton 2
cytosol 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP5-8 Gene

Pathways & Interactions for KRTAP5-8 Gene

SuperPathways for KRTAP5-8 Gene

No Data Available

Interacting Proteins for KRTAP5-8 Gene

Gene Ontology (GO) - Biological Process for KRTAP5-8 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP5-8 Gene

Drugs & Compounds for KRTAP5-8 Gene

No Compound Related Data Available

Transcripts for KRTAP5-8 Gene

mRNA/cDNA for KRTAP5-8 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP5-8 Gene

Keratin associated protein 5-8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP5-8 Gene

No ASD Table

Relevant External Links for KRTAP5-8 Gene

GeneLoc Exon Structure for
KRTAP5-8
ECgene alternative splicing isoforms for
KRTAP5-8

Expression for KRTAP5-8 Gene

mRNA expression in normal human tissues for KRTAP5-8 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP5-8 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x32.9).

SOURCE GeneReport for Unigene cluster for KRTAP5-8 Gene Hs.445245

mRNA Expression by UniProt/SwissProt for KRTAP5-8 Gene

O75690-KRA58_HUMAN
Tissue specificity: Restricted to hair root, not detected in any other tissues. Expressed in cuticle layers of differentiating hair follicles.
genes like me logo Genes that share expression patterns with KRTAP5-8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KRTAP5-8 Gene

Orthologs for KRTAP5-8 Gene

Evolution for KRTAP5-8 Gene

ENSEMBL:
Gene Tree for KRTAP5-8 (if available)
TreeFam:
Gene Tree for KRTAP5-8 (if available)

No data available for Orthologs for KRTAP5-8 Gene

Paralogs for KRTAP5-8 Gene

No data available for Paralogs for KRTAP5-8 Gene

Variants for KRTAP5-8 Gene

Sequence variations from dbSNP and Humsavar for KRTAP5-8 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs55921335 - 71,538,137(+) CTAGC(C/T)GCTGT reference, missense
rs11605448 -- 71,537,334(+) AGGAA(A/G)ACTTG upstream-variant-2KB
rs11827219 -- 71,539,282(+) GTCGC(A/G)CTCCC downstream-variant-500B
rs7926544 -- 71,536,297(+) actac(A/G)cgatg upstream-variant-2KB
rs7926656 -- 71,536,348(+) ctgta(A/G)tccca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP5-8 Gene

Variant ID Type Subtype PubMed ID
dgv1217n71 CNV Gain 21882294
esv2744750 CNV Deletion 23290073
esv2744751 CNV Deletion 23290073

Variation tolerance for KRTAP5-8 Gene

Residual Variation Intolerance Score: 90.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 18.26; 98.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for KRTAP5-8 Gene

Disorders for KRTAP5-8 Gene

Relevant External Links for KRTAP5-8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP5-8

No disorders were found for KRTAP5-8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP5-8 Gene

Publications for KRTAP5-8 Gene

  1. Identification of two novel clusters of ultrahigh-sulfur keratin- associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S. … Shimizu N. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. Genomic organization and promoter characterization of two human UHS keratin genes. (PMID: 10023043) Perez C. … Egly J.-M. (Gene 1999) 3

Products for KRTAP5-8 Gene

Sources for KRTAP5-8 Gene

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