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Aliases for KRTAP5-6 Gene

Aliases for KRTAP5-6 Gene

  • Keratin Associated Protein 5-6 2 3
  • Ultrahigh Sulfur Keratin-Associated Protein 5.6 3 4
  • Keratin-Associated Protein 5.6 3 4
  • KRTAP5.6 3 4
  • Keratin-Associated Protein 5-6 3
  • KAP5.6 4

External Ids for KRTAP5-6 Gene

Previous GeneCards Identifiers for KRTAP5-6 Gene

  • GC00U913941
  • GC11P001675
  • GC11P001509

Summaries for KRTAP5-6 Gene

GeneCards Summary for KRTAP5-6 Gene

KRTAP5-6 (Keratin Associated Protein 5-6) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP5-6 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-6 Gene

Genomics for KRTAP5-6 Gene

Regulatory Elements for KRTAP5-6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for KRTAP5-6 Gene

Start:
1,697,195 bp from pter
End:
1,697,755 bp from pter
Size:
561 bases
Orientation:
Plus strand

Genomic View for KRTAP5-6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP5-6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP5-6 Gene

Proteins for KRTAP5-6 Gene

  • Protein details for KRTAP5-6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6L8G9-KRA56_HUMAN
    Recommended name:
    Keratin-associated protein 5-6
    Protein Accession:
    Q6L8G9
    Secondary Accessions:
    • A1L452

    Protein attributes for KRTAP5-6 Gene

    Size:
    129 amino acids
    Molecular mass:
    11784 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP5-6 Gene

Proteomics data for KRTAP5-6 Gene at MOPED

Post-translational modifications for KRTAP5-6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP5-6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP5-6 Gene

Domains for KRTAP5-6 Gene

Gene Families for KRTAP5-6 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP5-6 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP5-6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6L8G9

UniProtKB/Swiss-Prot:

KRA56_HUMAN :
  • Q6L8G9
Family:
  • Belongs to the KRTAP type 5 family.
genes like me logo Genes that share domains with KRTAP5-6: view

Function for KRTAP5-6 Gene

Molecular function for KRTAP5-6 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP5-6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP5-6: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP5-6

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP5-6 Gene

Localization for KRTAP5-6 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP5-6 Gene COMPARTMENTS Subcellular localization image for KRTAP5-6 gene
Compartment Confidence
extracellular 3
cytoskeleton 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KRTAP5-6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP5-6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP5-6 Gene

Pathways for KRTAP5-6 Gene

SuperPathways for KRTAP5-6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for KRTAP5-6 Gene

None

No data available for Pathways by source for KRTAP5-6 Gene

Transcripts for KRTAP5-6 Gene

mRNA/cDNA for KRTAP5-6 Gene

(1) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP5-6

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTAP5-6
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP5-6 Gene

No ASD Table

Relevant External Links for KRTAP5-6 Gene

GeneLoc Exon Structure for
KRTAP5-6
ECgene alternative splicing isoforms for
KRTAP5-6

Expression for KRTAP5-6 Gene

mRNA expression in normal human tissues for KRTAP5-6 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP5-6 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (33.7) and Liver (13.0).

SOURCE GeneReport for Unigene cluster for KRTAP5-6 Gene Hs.534863

mRNA Expression by UniProt/SwissProt for KRTAP5-6 Gene

Q6L8G9-KRA56_HUMAN
Tissue specificity: Expressed in hair root and not in skin. Expressed also in liver and skeletal muscle.
genes like me logo Genes that share expressions with KRTAP5-6: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for KRTAP5-6 Gene

Orthologs for KRTAP5-6 Gene

Evolution for KRTAP5-6 Gene

ENSEMBL:
Gene Tree for KRTAP5-6 (if available)
TreeFam:
Gene Tree for KRTAP5-6 (if available)

No data available for Orthologs for KRTAP5-6 Gene

Paralogs for KRTAP5-6 Gene

No data available for Paralogs for KRTAP5-6 Gene

Variants for KRTAP5-6 Gene

Sequence variations from dbSNP and Humsavar for KRTAP5-6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs518555 -- 1,696,961(+) ACACA(A/G)AAGGA upstream-variant-2KB
rs557220 -- 1,698,072(-) TCTCA(G/T)GTCCT downstream-variant-500B
rs4752743 -- 1,696,347(+) ACCCA(C/T)GGGTG upstream-variant-2KB
rs4752744 -- 1,697,036(+) ACTAT(A/G)TACAC upstream-variant-2KB
rs4752745 -- 1,697,237(+) AATCC(A/T)CCAGA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for KRTAP5-6 Gene

Variant ID Type Subtype PubMed ID
dgv980n71 CNV Loss 21882294
nsv896727 CNV Gain 21882294
nsv896728 CNV Gain 21882294
nsv832049 CNV Loss 17160897
nsv896729 CNV Loss 21882294
nsv896730 CNV Loss 21882294
nsv896731 CNV Loss 21882294
nsv896732 CNV Loss 21882294

Relevant External Links for KRTAP5-6 Gene

HapMap Linkage Disequilibrium report
KRTAP5-6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP5-6 Gene

Disorders for KRTAP5-6 Gene

Relevant External Links for KRTAP5-6

Genetic Association Database (GAD)
KRTAP5-6
genes like me logo Genes that share disorders with KRTAP5-6: view

No data available for UniProtKB/Swiss-Prot for KRTAP5-6 Gene

Publications for KRTAP5-6 Gene

  1. Identification of two novel clusters of ultrahigh-sulfur keratin- associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S. … Shimizu N. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP5-6 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP5-6
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP5-6
    • Block miRNA regulation of KRTAP5-6 using miScript Target Protectors

    Sources for KRTAP5-6 Gene

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