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Aliases for KRTAP5-5 Gene

Aliases for KRTAP5-5 Gene

  • Keratin Associated Protein 5-5 2 3
  • Ultrahigh Sulfur Keratin-Associated Protein 5.5 3 4
  • Keratin-Associated Protein 5-11 3 4
  • Keratin-Associated Protein 5.11 3 4
  • Keratin-Associated Protein 5.5 3 4
  • KRTAP5-11 3 4
  • KRTAP5.5 3 4
  • Keratin Associated Protein 5-11 3
  • Keratin-Associated Protein 5-5 3
  • KRTAP5.11 4
  • KAP5-11 4
  • KAP5.5 4

External Ids for KRTAP5-5 Gene

Previous GeneCards Identifiers for KRTAP5-5 Gene

  • GC00U913942
  • GC11P001609
  • GC11P001444

Summaries for KRTAP5-5 Gene

GeneCards Summary for KRTAP5-5 Gene

KRTAP5-5 (Keratin Associated Protein 5-5) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP5-5 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-5 Gene

Genomics for KRTAP5-5 Gene

Regulatory Elements for KRTAP5-5 Gene

Genomic Location for KRTAP5-5 Gene

Start:
1,629,775 bp from pter
End:
1,630,930 bp from pter
Size:
1,156 bases
Orientation:
Plus strand

Genomic View for KRTAP5-5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP5-5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP5-5 Gene

Proteins for KRTAP5-5 Gene

  • Protein details for KRTAP5-5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q701N2-KRA55_HUMAN
    Recommended name:
    Keratin-associated protein 5-5
    Protein Accession:
    Q701N2
    Secondary Accessions:
    • A8MWN2

    Protein attributes for KRTAP5-5 Gene

    Size:
    237 amino acids
    Molecular mass:
    21409 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP5-5 Gene

Proteomics data for KRTAP5-5 Gene at MOPED

Post-translational modifications for KRTAP5-5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP5-5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP5-5 Gene

Domains for KRTAP5-5 Gene

Gene Families for KRTAP5-5 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP5-5 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP5-5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q701N2

UniProtKB/Swiss-Prot:

KRA55_HUMAN :
  • Q701N2
Family:
  • Belongs to the KRTAP type 5 family.
genes like me logo Genes that share domains with KRTAP5-5: view

Function for KRTAP5-5 Gene

Molecular function for KRTAP5-5 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP5-5 Gene

Localization for KRTAP5-5 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP5-5 Gene COMPARTMENTS Subcellular localization image for KRTAP5-5 gene
Compartment Confidence
cytoskeleton 2
extracellular 2
mitochondrion 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KRTAP5-5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP5-5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP5-5 Gene

Pathways for KRTAP5-5 Gene

SuperPathways for KRTAP5-5 Gene

No Data Available

Interacting Proteins for KRTAP5-5 Gene

Gene Ontology (GO) - Biological Process for KRTAP5-5 Gene

None

No data available for Pathways by source for KRTAP5-5 Gene

Transcripts for KRTAP5-5 Gene

mRNA/cDNA for KRTAP5-5 Gene

(1) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP5-5 Gene

Keratin associated protein 5-5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP5-5

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP5-5 Gene

No ASD Table

Relevant External Links for KRTAP5-5 Gene

GeneLoc Exon Structure for
KRTAP5-5
ECgene alternative splicing isoforms for
KRTAP5-5

Expression for KRTAP5-5 Gene

mRNA expression in normal human tissues for KRTAP5-5 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP5-5 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (44.8) and Skin - Sun Exposed (Lower leg) (4.1).

Protein differential expression in normal tissues for KRTAP5-5 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTAP5-5 Gene

SOURCE GeneReport for Unigene cluster for KRTAP5-5 Gene Hs.653467

mRNA Expression by UniProt/SwissProt for KRTAP5-5 Gene

Q701N2-KRA55_HUMAN
Tissue specificity: Restricted to hair root, not detected in any other tissues.
genes like me logo Genes that share expressions with KRTAP5-5: view

Expression partners for KRTAP5-5 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRTAP5-5 Gene

Orthologs for KRTAP5-5 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for KRTAP5-5 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Krtap5-5 16
chimpanzee
(Pan troglodytes)
Mammalia KRTAP5-5 36
  • 94 (a)
OneToOne
Species with no ortholog for KRTAP5-5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP5-5 Gene

ENSEMBL:
Gene Tree for KRTAP5-5 (if available)
TreeFam:
Gene Tree for KRTAP5-5 (if available)

Paralogs for KRTAP5-5 Gene

No data available for Paralogs for KRTAP5-5 Gene

Variants for KRTAP5-5 Gene

Sequence variations from dbSNP and Humsavar for KRTAP5-5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1021342 -- 1,629,034(-) GGGTC(A/G)GGACC upstream-variant-2KB
rs1021343 -- 1,628,926(-) ACAGC(C/G)GCACA upstream-variant-2KB
rs1021344 -- 1,628,849(-) GCTCC(A/G)GGTCC upstream-variant-2KB
rs1021345 -- 1,628,817(-) CAACT(A/G)CATTC upstream-variant-2KB
rs4752769 -- 1,630,687(-) TTCGG(A/G)AGCAC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KRTAP5-5 Gene

Variant ID Type Subtype PubMed ID
dgv968n71 CNV Loss 21882294
dgv979n71 CNV Loss 21882294
dgv980n71 CNV Loss 21882294
dgv981n71 CNV Loss 21882294
nsv467644 CNV Loss 19166990
dgv982n71 CNV Loss 21882294
esv2743949 CNV Deletion 23290073

Relevant External Links for KRTAP5-5 Gene

HapMap Linkage Disequilibrium report
KRTAP5-5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP5-5 Gene

Disorders for KRTAP5-5 Gene

No disorders were found for KRTAP5-5 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KRTAP5-5 Gene

Publications for KRTAP5-5 Gene

  1. Identification of two novel clusters of ultrahigh-sulfur keratin- associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S. … Shimizu N. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for KRTAP5-5 Gene

Sources for KRTAP5-5 Gene

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