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Aliases for KRTAP5-3 Gene

Aliases for KRTAP5-3 Gene

  • Keratin Associated Protein 5-3 2 3
  • Ultrahigh Sulfur Keratin-Associated Protein 5.3 3 4
  • Keratin-Associated Protein 5.3 3 4
  • Keratin-Associated Protein 5-9 3 4
  • Keratin-Associated Protein 5.9 3 4
  • KRTAP5.3 3 4
  • KRTAP5-9 3 4
  • Keratin-Associated Protein 5-3 3
  • UHS KerB-Like 4
  • KRTAP5.9 4
  • KAP5.3 4
  • KAP5-9 4

External Ids for KRTAP5-3 Gene

Summaries for KRTAP5-3 Gene

GeneCards Summary for KRTAP5-3 Gene

KRTAP5-3 (Keratin Associated Protein 5-3) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP5-3 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-3 Gene

Genomics for KRTAP5-3 Gene

Genomic Location for KRTAP5-3 Gene

Start:
1,607,565 bp from pter
End:
1,608,463 bp from pter
Size:
899 bases
Orientation:
Minus strand

Genomic View for KRTAP5-3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP5-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP5-3 Gene

Regulatory Elements for KRTAP5-3 Gene

Proteins for KRTAP5-3 Gene

  • Protein details for KRTAP5-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6L8H2-KRA53_HUMAN
    Recommended name:
    Keratin-associated protein 5-3
    Protein Accession:
    Q6L8H2
    Secondary Accessions:
    • Q6PL44
    • Q701N3

    Protein attributes for KRTAP5-3 Gene

    Size:
    238 amino acids
    Molecular mass:
    22106 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP5-3 Gene

Proteomics data for KRTAP5-3 Gene at MOPED

Post-translational modifications for KRTAP5-3 Gene

No Post-translational modifications

Other Protein References for KRTAP5-3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP5-3 Gene

Domains for KRTAP5-3 Gene

Gene Families for KRTAP5-3 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP5-3 Gene

Blocks:
InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KRA53_HUMAN
Family:
  • Belongs to the KRTAP type 5 family.:
    • Q6L8H2
genes like me logo Genes that share domains with KRTAP5-3: view

Function for KRTAP5-3 Gene

Molecular function for KRTAP5-3 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

miRNA for KRTAP5-3 Gene

miRTarBase miRNAs that target KRTAP5-3

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRTAP5-3 Gene

Localization for KRTAP5-3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP5-3 Gene COMPARTMENTS Subcellular localization image for KRTAP5-3 gene
Compartment Confidence
extracellular 3
cytoskeleton 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP5-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP5-3: view

Pathways for KRTAP5-3 Gene

SuperPathways for KRTAP5-3 Gene

No Data Available

Interacting Proteins for KRTAP5-3 Gene

Gene Ontology (GO) - Biological Process for KRTAP5-3 Gene

None

No data available for Pathways by source for KRTAP5-3 Gene

Compounds for KRTAP5-3 Gene

(1) Drugbank Compounds for KRTAP5-3 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Beta-D-Glucose
50-99-7 target
genes like me logo Genes that share compounds with KRTAP5-3: view

Transcripts for KRTAP5-3 Gene

mRNA/cDNA for KRTAP5-3 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP5-3 Gene

No ASD Table

Relevant External Links for KRTAP5-3 Gene

GeneLoc Exon Structure for
KRTAP5-3
ECgene alternative splicing isoforms for
KRTAP5-3

Expression for KRTAP5-3 Gene

mRNA expression in normal human tissues for KRTAP5-3 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP5-3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (47.7) and Skin - Sun Exposed (Lower leg) (4.2).

SOURCE GeneReport for Unigene cluster for KRTAP5-3 Gene Hs.532471

mRNA Expression by UniProt/SwissProt for KRTAP5-3 Gene

Q6L8H2-KRA53_HUMAN
Tissue specificity: Restricted to hair root, not detected in any other tissues.
genes like me logo Genes that share expressions with KRTAP5-3: view

Orthologs for KRTAP5-3 Gene

Evolution for KRTAP5-3 Gene

ENSEMBL:
Gene Tree for KRTAP5-3 (if available)
TreeFam:
Gene Tree for KRTAP5-3 (if available)

No data available for Orthologs for KRTAP5-3 Gene

Paralogs for KRTAP5-3 Gene

No data available for Paralogs for KRTAP5-3 Gene

Variants for KRTAP5-3 Gene

Sequence variations from dbSNP and Humsavar for KRTAP5-3 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1989591 -- 1,607,284(+) GCAGG(A/G)TGAAG downstream-variant-500B
rs1989592 -- 1,607,614(+) CTGCA(A/G)TCATT utr-variant-3-prime
rs2130414 -- 1,609,599(-) aggga(C/G)actca upstream-variant-2KB
rs7101385 -- 1,608,179(+) CCACA(A/G)GAGCC synonymous-codon, reference
rs7103788 -- 1,610,082(+) ttcgc(C/T)gcctt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP5-3 Gene

Variant ID Type Subtype PubMed ID
dgv968n71 CNV Loss 21882294
esv2743946 CNV Deletion 23290073
esv991273 CNV Deletion 20482838

Relevant External Links for KRTAP5-3 Gene

HapMap Linkage Disequilibrium report
KRTAP5-3

Disorders for KRTAP5-3 Gene

No disorders were found for KRTAP5-3 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP5-3 Gene

Publications for KRTAP5-3 Gene

  1. Identification of two novel clusters of ultrahigh-sulfur keratin- associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S. … Shimizu N. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25

Products for KRTAP5-3 Gene

Sources for KRTAP5-3 Gene

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