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Aliases for KRTAP5-2 Gene

Aliases for KRTAP5-2 Gene

  • Keratin Associated Protein 5-2 2 3
  • Ultrahigh Sulfur Keratin-Associated Protein 5.2 3 4
  • Keratin-Associated Protein 5-8 3 4
  • Keratin-Associated Protein 5.8 3 4
  • Keratin-Associated Protein 5.2 3 4
  • KRTAP5-8 3 4
  • KRTAP5.2 3 4
  • Keratin-Associated Protein 5-2 3
  • KRTAP5.8 4
  • KAP5-8 4
  • KAP5.2 4

External Ids for KRTAP5-2 Gene

Summaries for KRTAP5-2 Gene

GeneCards Summary for KRTAP5-2 Gene

KRTAP5-2 (Keratin Associated Protein 5-2) is a Protein Coding gene. An important paralog of this gene is KRTAP5-10.

UniProtKB/Swiss-Prot for KRTAP5-2 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-2 Gene

Genomics for KRTAP5-2 Gene

Genomic Location for KRTAP5-2 Gene

Start:
1,597,177 bp from pter
End:
1,598,294 bp from pter
Size:
1,118 bases
Orientation:
Minus strand

Genomic View for KRTAP5-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP5-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP5-2 Gene

Regulatory Elements for KRTAP5-2 Gene

Proteins for KRTAP5-2 Gene

  • Protein details for KRTAP5-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q701N4-KRA52_HUMAN
    Recommended name:
    Keratin-associated protein 5-2
    Protein Accession:
    Q701N4
    Secondary Accessions:
    • A9JTZ1

    Protein attributes for KRTAP5-2 Gene

    Size:
    177 amino acids
    Molecular mass:
    16271 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP5-2 Gene

Proteomics data for KRTAP5-2 Gene at MOPED

Post-translational modifications for KRTAP5-2 Gene

No Post-translational modifications

Other Protein References for KRTAP5-2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP5-2 Gene

Domains for KRTAP5-2 Gene

Gene Families for KRTAP5-2 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP5-2 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KRA52_HUMAN
Family:
  • Belongs to the KRTAP type 5 family.:
    • Q701N4
genes like me logo Genes that share domains with KRTAP5-2: view

Function for KRTAP5-2 Gene

Molecular function for KRTAP5-2 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP5-2 Gene

Localization for KRTAP5-2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP5-2 Gene COMPARTMENTS Subcellular localization image for KRTAP5-2 gene
Compartment Confidence
cytoskeleton 2
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP5-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP5-2: view

Pathways for KRTAP5-2 Gene

SuperPathways for KRTAP5-2 Gene

No Data Available

Interacting Proteins for KRTAP5-2 Gene

Gene Ontology (GO) - Biological Process for KRTAP5-2 Gene

None

No data available for Pathways by source for KRTAP5-2 Gene

Compounds for KRTAP5-2 Gene

(2) Drugbank Compounds for KRTAP5-2 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Beta-D-Glucose
50-99-7 target
Pyroglutamic Acid
98-79-3 target
genes like me logo Genes that share compounds with KRTAP5-2: view

Transcripts for KRTAP5-2 Gene

mRNA/cDNA for KRTAP5-2 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP5-2 Gene

Keratin associated protein 5-2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP5-2 Gene

No ASD Table

Relevant External Links for KRTAP5-2 Gene

GeneLoc Exon Structure for
KRTAP5-2
ECgene alternative splicing isoforms for
KRTAP5-2

Expression for KRTAP5-2 Gene

mRNA expression in normal human tissues for KRTAP5-2 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP5-2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (14.5), Brain - Cerebellar Hemisphere (5.9), and Brain - Cerebellum (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTAP5-2 Gene

SOURCE GeneReport for Unigene cluster for KRTAP5-2 Gene Hs.673618

mRNA Expression by UniProt/SwissProt for KRTAP5-2 Gene

Q701N4-KRA52_HUMAN
Tissue specificity: Restricted to hair root, not detected in any other tissues.
genes like me logo Genes that share expressions with KRTAP5-2: view

Orthologs for KRTAP5-2 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for KRTAP5-2 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gm7579 37
  • 50 (a)
OneToMany
Krtap5-2 16
Species with no ortholog for KRTAP5-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP5-2 Gene

ENSEMBL:
Gene Tree for KRTAP5-2 (if available)
TreeFam:
Gene Tree for KRTAP5-2 (if available)

Paralogs for KRTAP5-2 Gene

Paralogs for KRTAP5-2 Gene

genes like me logo Genes that share paralogs with KRTAP5-2: view

Variants for KRTAP5-2 Gene

Sequence variations from dbSNP and Humsavar for KRTAP5-2 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs59223848 -- 1,599,814(+) GGTAC(C/T)ACAGT upstream-variant-2KB
rs113047533 -- 1,599,826(+) ACTAT(G/T)TTGGT upstream-variant-2KB
rs113574170 -- 1,599,900(+) ATGTA(C/G)TGCCT upstream-variant-2KB
rs117788562 -- 1,600,133(+) CACAC(C/T)GAATC upstream-variant-2KB
rs150820557 -- 1,599,834(+) GGTGA(C/T)GGATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP5-2 Gene

Variant ID Type Subtype PubMed ID
dgv968n71 CNV Loss 21882294

Relevant External Links for KRTAP5-2 Gene

HapMap Linkage Disequilibrium report
KRTAP5-2

Disorders for KRTAP5-2 Gene

No disorders were found for KRTAP5-2 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP5-2 Gene

Publications for KRTAP5-2 Gene

  1. Identification of two novel clusters of ultrahigh-sulfur keratin- associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S. … Shimizu N. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
  2. Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma. (PMID: 23590728) Clarke L.E. … Helm K.F. (J. Cutan. Pathol. 2013) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. The Protein Data Bank. (PMID: 10592235) Berman H.M. … Bourne P.E. (Nucleic Acids Res. 2000) 25
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP5-2 Gene

Sources for KRTAP5-2 Gene

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