Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRTAP5-11 Gene

Aliases for KRTAP5-11 Gene

  • Keratin Associated Protein 5-11 2 3 5
  • Ultrahigh Sulfur Keratin-Associated Protein 5.11 3 4
  • Keratin-Associated Protein 5.11 3 4
  • KRTAP5.11 3 4
  • Keratin Associated Protein 5-5 3
  • KRTAP5-5 3
  • KRTAP5-6 3
  • KAP5.11 4

External Ids for KRTAP5-11 Gene

Previous GeneCards Identifiers for KRTAP5-11 Gene

  • GC00U913948
  • GC11U900627
  • GC11M070971
  • GC11M071291
  • GC11M067586
  • GC11M071297

Summaries for KRTAP5-11 Gene

GeneCards Summary for KRTAP5-11 Gene

KRTAP5-11 (Keratin Associated Protein 5-11) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP5-11 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-11 Gene

Genomics for KRTAP5-11 Gene

Regulatory Elements for KRTAP5-11 Gene

Enhancers for KRTAP5-11 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRTAP5-11 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTAP5-11 Gene

Chromosome:
11
Start:
71,579,714 bp from pter
End:
71,603,353 bp from pter
Size:
23,640 bases
Orientation:
Minus strand

Genomic View for KRTAP5-11 Gene

Genes around KRTAP5-11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP5-11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP5-11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP5-11 Gene

Proteins for KRTAP5-11 Gene

  • Protein details for KRTAP5-11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6L8G4-KR511_HUMAN
    Recommended name:
    Keratin-associated protein 5-11
    Protein Accession:
    Q6L8G4

    Protein attributes for KRTAP5-11 Gene

    Size:
    156 amino acids
    Molecular mass:
    14610 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP5-11 Gene

Proteomics data for KRTAP5-11 Gene at MOPED

Post-translational modifications for KRTAP5-11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP5-11 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP5-11 Gene

Domains & Families for KRTAP5-11 Gene

Gene Families for KRTAP5-11 Gene

Protein Domains for KRTAP5-11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP5-11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6L8G4

UniProtKB/Swiss-Prot:

KR511_HUMAN :
  • Belongs to the KRTAP type 5 family.
Family:
  • Belongs to the KRTAP type 5 family.
genes like me logo Genes that share domains with KRTAP5-11: view

Function for KRTAP5-11 Gene

Molecular function for KRTAP5-11 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.
genes like me logo Genes that share phenotypes with KRTAP5-11: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP5-11 Gene

Localization for KRTAP5-11 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP5-11 Gene COMPARTMENTS Subcellular localization image for KRTAP5-11 gene
Compartment Confidence
extracellular 3
cytoskeleton 2
cytosol 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP5-11 Gene

Pathways & Interactions for KRTAP5-11 Gene

SuperPathways for KRTAP5-11 Gene

No Data Available

Interacting Proteins for KRTAP5-11 Gene

Gene Ontology (GO) - Biological Process for KRTAP5-11 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP5-11 Gene

Drugs & Compounds for KRTAP5-11 Gene

No Compound Related Data Available

Transcripts for KRTAP5-11 Gene

mRNA/cDNA for KRTAP5-11 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP5-11 Gene

Keratin associated protein 5-11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP5-11 Gene

No ASD Table

Relevant External Links for KRTAP5-11 Gene

GeneLoc Exon Structure for
KRTAP5-11
ECgene alternative splicing isoforms for
KRTAP5-11

Expression for KRTAP5-11 Gene

mRNA expression in normal human tissues for KRTAP5-11 Gene

mRNA expression in normal human tissues for KRTAP5-11 Gene

SOURCE GeneReport for Unigene cluster for KRTAP5-11 Gene Hs.679617

mRNA Expression by UniProt/SwissProt for KRTAP5-11 Gene

Q6L8G4-KR511_HUMAN
Tissue specificity: Restricted to hair root, not detected in any other tissues.
genes like me logo Genes that share expression patterns with KRTAP5-11: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for KRTAP5-11 Gene

Orthologs for KRTAP5-11 Gene

Evolution for KRTAP5-11 Gene

ENSEMBL:
Gene Tree for KRTAP5-11 (if available)
TreeFam:
Gene Tree for KRTAP5-11 (if available)

No data available for Orthologs for KRTAP5-11 Gene

Paralogs for KRTAP5-11 Gene

No data available for Paralogs for KRTAP5-11 Gene

Variants for KRTAP5-11 Gene

Sequence variations from dbSNP and Humsavar for KRTAP5-11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11821305 -- 71,584,410(+) aaaca(A/T)catcc upstream-variant-2KB
rs61888767 -- 71,583,828(+) GATCC(C/T)TTTTT upstream-variant-2KB
rs61888768 -- 71,584,580(+) CCCGC(C/T)TGCCT upstream-variant-2KB
rs61888769 -- 71,584,583(+) GCTTG(C/T)CTCCC upstream-variant-2KB
rs61888770 -- 71,584,585(+) TTGCC(C/T)CCCTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP5-11 Gene

Variant ID Type Subtype PubMed ID
nsv825988 CNV Loss 20364138

Variation tolerance for KRTAP5-11 Gene

Residual Variation Intolerance Score: 54.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTAP5-11 Gene

HapMap Linkage Disequilibrium report
KRTAP5-11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP5-11 Gene

Disorders for KRTAP5-11 Gene

Relevant External Links for KRTAP5-11

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP5-11

No disorders were found for KRTAP5-11 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP5-11 Gene

Publications for KRTAP5-11 Gene

  1. Identification of two novel clusters of ultrahigh-sulfur keratin- associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S. … Shimizu N. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP5-11 Gene

Sources for KRTAP5-11 Gene

Content