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Aliases for KRTAP5-10 Gene

Aliases for KRTAP5-10 Gene

  • Keratin Associated Protein 5-10 2 3 5
  • Ultrahigh Sulfur Keratin-Associated Protein 5.10 3 4
  • Keratin-Associated Protein 5.10 3 4
  • KRTAP5.10 3 4
  • Keratin-Associated Protein 5-10 3
  • KAP5.10 4

External Ids for KRTAP5-10 Gene

Previous GeneCards Identifiers for KRTAP5-10 Gene

  • GC00U913947
  • GC11U900660
  • GC11P070955
  • GC11P071239
  • GC11P067556
  • GC11P071276
  • GC11P071530
  • GC11P071537

Summaries for KRTAP5-10 Gene

GeneCards Summary for KRTAP5-10 Gene

KRTAP5-10 (Keratin Associated Protein 5-10) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology.

UniProtKB/Swiss-Prot for KRTAP5-10 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Additional gene information for KRTAP5-10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-10 Gene

Genomics for KRTAP5-10 Gene

GeneHancer (GH) Regulatory Elements for KRTAP5-10 Gene

Promoters and enhancers for KRTAP5-10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I071565 Promoter 0.5 EPDnew 550.8 -0.1 -78 0.1 KRTAP5-10 GC11M071543
GH11I071587 Enhancer 0.6 ENCODE 12 +23.0 22971 1.3 CTCF SOX13 PKNOX1 RB1 HLF TRIM22 ZEB2 ATF2 CTBP1 ZNF143 KRTAP5-10 OR7E87P KRTAP5-14P KRTAP5-11
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around KRTAP5-10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the KRTAP5-10 gene promoter:

Genomic Locations for KRTAP5-10 Gene

Genomic Locations for KRTAP5-10 Gene
chr11:71,565,563-71,566,738
(GRCh38/hg38)
Size:
1,176 bases
Orientation:
Plus strand
chr11:71,276,609-71,279,980
(GRCh37/hg19)

Genomic View for KRTAP5-10 Gene

Genes around KRTAP5-10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP5-10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP5-10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP5-10 Gene

Proteins for KRTAP5-10 Gene

  • Protein details for KRTAP5-10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6L8G5-KR510_HUMAN
    Recommended name:
    Keratin-associated protein 5-10
    Protein Accession:
    Q6L8G5
    Secondary Accessions:
    • B9EHA4

    Protein attributes for KRTAP5-10 Gene

    Size:
    202 amino acids
    Molecular mass:
    17984 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP5-10 Gene

Post-translational modifications for KRTAP5-10 Gene

No Post-translational modifications

Other Protein References for KRTAP5-10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP5-10 Gene

Domains & Families for KRTAP5-10 Gene

Gene Families for KRTAP5-10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRTAP5-10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP5-10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6L8G5

UniProtKB/Swiss-Prot:

KR510_HUMAN :
  • Belongs to the KRTAP type 5 family.
Family:
  • Belongs to the KRTAP type 5 family.
genes like me logo Genes that share domains with KRTAP5-10: view

Function for KRTAP5-10 Gene

Molecular function for KRTAP5-10 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes for KRTAP5-10 Gene

GenomeRNAi human phenotypes for KRTAP5-10:
genes like me logo Genes that share phenotypes with KRTAP5-10: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP5-10 Gene

Localization for KRTAP5-10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTAP5-10 gene
Compartment Confidence
cytosol 5
extracellular 3
cytoskeleton 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP5-10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP5-10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP5-10 Gene

Pathways & Interactions for KRTAP5-10 Gene

SuperPathways for KRTAP5-10 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRTAP5-10: view

Pathways by source for KRTAP5-10 Gene

2 Reactome pathways for KRTAP5-10 Gene

Interacting Proteins for KRTAP5-10 Gene

Gene Ontology (GO) - Biological Process for KRTAP5-10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
genes like me logo Genes that share ontologies with KRTAP5-10: view

No data available for SIGNOR curated interactions for KRTAP5-10 Gene

Drugs & Compounds for KRTAP5-10 Gene

No Compound Related Data Available

Transcripts for KRTAP5-10 Gene

mRNA/cDNA for KRTAP5-10 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP5-10 Gene

Keratin associated protein 5-10:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP5-10 Gene

No ASD Table

Relevant External Links for KRTAP5-10 Gene

GeneLoc Exon Structure for
KRTAP5-10
ECgene alternative splicing isoforms for
KRTAP5-10

Expression for KRTAP5-10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTAP5-10 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP5-10 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x31.3).

Protein differential expression in normal tissues from HIPED for KRTAP5-10 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRTAP5-10 Gene



Protein tissue co-expression partners for KRTAP5-10 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for KRTAP5-10 Gene:

Hs.661887

mRNA Expression by UniProt/SwissProt for KRTAP5-10 Gene:

Q6L8G5-KR510_HUMAN
Tissue specificity: Expressed in hair root but not in skin. Expressed also in brain and skeletal muscle.

Evidence on tissue expression from TISSUES for KRTAP5-10 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with KRTAP5-10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP5-10 Gene

Orthologs for KRTAP5-10 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for KRTAP5-10 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gm7579 34
  • 55 (a)
OneToMany
Species where no ortholog for KRTAP5-10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP5-10 Gene

ENSEMBL:
Gene Tree for KRTAP5-10 (if available)
TreeFam:
Gene Tree for KRTAP5-10 (if available)

Paralogs for KRTAP5-10 Gene

No data available for Paralogs for KRTAP5-10 Gene

Variants for KRTAP5-10 Gene

Sequence variations from dbSNP and Humsavar for KRTAP5-10 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1002822159 -- 71,566,695(+) T/C downstream_transcript_variant
rs1006482098 -- 71,563,801(+) A/G upstream_transcript_variant
rs1006672005 -- 71,566,941(+) A/T downstream_transcript_variant
rs1006983508 -- 71,566,800(+) T/C downstream_transcript_variant
rs1010329335 -- 71,564,235(+) A/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for KRTAP5-10 Gene

Variant ID Type Subtype PubMed ID
nsv555402 CNV gain 21841781
nsv825988 CNV loss 20364138
nsv975200 CNV duplication 23825009
nsv983039 CNV duplication 23825009

Variation tolerance for KRTAP5-10 Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.97; 96.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for KRTAP5-10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTAP5-10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP5-10 Gene

Disorders for KRTAP5-10 Gene

Additional Disease Information for KRTAP5-10

No disorders were found for KRTAP5-10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP5-10 Gene

Publications for KRTAP5-10 Gene

  1. Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S … Shimizu N (Biochemical and biophysical research communications 2004) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for KRTAP5-10 Gene

Sources for KRTAP5-10 Gene

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