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Aliases for KRTAP5-10 Gene

Aliases for KRTAP5-10 Gene

  • Keratin Associated Protein 5-10 2 3 5
  • Ultrahigh Sulfur Keratin-Associated Protein 5.10 3 4
  • Keratin-Associated Protein 5.10 3 4
  • KRTAP5.10 3 4
  • Keratin-Associated Protein 5-10 3
  • KAP5.10 4

External Ids for KRTAP5-10 Gene

Previous GeneCards Identifiers for KRTAP5-10 Gene

  • GC00U913947
  • GC11U900660
  • GC11P070955
  • GC11P071239
  • GC11P067556
  • GC11P071276
  • GC11P071530
  • GC11P071537

Summaries for KRTAP5-10 Gene

GeneCards Summary for KRTAP5-10 Gene

KRTAP5-10 (Keratin Associated Protein 5-10) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology.

UniProtKB/Swiss-Prot for KRTAP5-10 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Additional gene information for KRTAP5-10 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-10 Gene

Genomics for KRTAP5-10 Gene

Regulatory Elements for KRTAP5-10 Gene

Enhancers for KRTAP5-10 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H071587 0.6 ENCODE 12 +23.0 22972 1 SOX13 CTCF PKNOX1 RB1 HLF TRIM22 ZEB2 ATF2 CTBP1 ZNF143 KRTAP5-10 OR7E87P KRTAP5-14P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around KRTAP5-10 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTAP5-10 Gene

Chromosome:
11
Start:
71,565,563 bp from pter
End:
71,566,738 bp from pter
Size:
1,176 bases
Orientation:
Plus strand

Genomic View for KRTAP5-10 Gene

Genes around KRTAP5-10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP5-10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP5-10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP5-10 Gene

Proteins for KRTAP5-10 Gene

  • Protein details for KRTAP5-10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6L8G5-KR510_HUMAN
    Recommended name:
    Keratin-associated protein 5-10
    Protein Accession:
    Q6L8G5
    Secondary Accessions:
    • B9EHA4

    Protein attributes for KRTAP5-10 Gene

    Size:
    202 amino acids
    Molecular mass:
    17984 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP5-10 Gene

Post-translational modifications for KRTAP5-10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP5-10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP5-10 Gene

Domains & Families for KRTAP5-10 Gene

Gene Families for KRTAP5-10 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for KRTAP5-10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP5-10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6L8G5

UniProtKB/Swiss-Prot:

KR510_HUMAN :
  • Belongs to the KRTAP type 5 family.
Family:
  • Belongs to the KRTAP type 5 family.
genes like me logo Genes that share domains with KRTAP5-10: view

Function for KRTAP5-10 Gene

Molecular function for KRTAP5-10 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Phenotypes for KRTAP5-10 Gene

GenomeRNAi human phenotypes for KRTAP5-10:
genes like me logo Genes that share phenotypes with KRTAP5-10: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for KRTAP5-10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP5-10 Gene

Localization for KRTAP5-10 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTAP5-10 gene
Compartment Confidence
cytosol 5
extracellular 3
cytoskeleton 2
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP5-10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP5-10: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for KRTAP5-10 Gene

Pathways & Interactions for KRTAP5-10 Gene

SuperPathways for KRTAP5-10 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRTAP5-10: view

Pathways by source for KRTAP5-10 Gene

2 Reactome pathways for KRTAP5-10 Gene

Interacting Proteins for KRTAP5-10 Gene

Gene Ontology (GO) - Biological Process for KRTAP5-10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
genes like me logo Genes that share ontologies with KRTAP5-10: view

No data available for SIGNOR curated interactions for KRTAP5-10 Gene

Drugs & Compounds for KRTAP5-10 Gene

No Compound Related Data Available

Transcripts for KRTAP5-10 Gene

mRNA/cDNA for KRTAP5-10 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP5-10 Gene

Keratin associated protein 5-10:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for KRTAP5-10
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP5-10 Gene

No ASD Table

Relevant External Links for KRTAP5-10 Gene

GeneLoc Exon Structure for
KRTAP5-10
ECgene alternative splicing isoforms for
KRTAP5-10

Expression for KRTAP5-10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTAP5-10 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP5-10 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x31.3).

Protein differential expression in normal tissues from HIPED for KRTAP5-10 Gene

This gene is overexpressed in Brain (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for KRTAP5-10 Gene



Protein tissue co-expression partners for KRTAP5-10 Gene

- Elite partner

SOURCE GeneReport for Unigene cluster for KRTAP5-10 Gene:

Hs.661887

mRNA Expression by UniProt/SwissProt for KRTAP5-10 Gene:

Q6L8G5-KR510_HUMAN
Tissue specificity: Expressed in hair root but not in skin. Expressed also in brain and skeletal muscle.

Evidence on tissue expression from TISSUES for KRTAP5-10 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with KRTAP5-10: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP5-10 Gene

Orthologs for KRTAP5-10 Gene

This gene was present in the common ancestor of human and mouse.

Orthologs for KRTAP5-10 Gene

Organism Taxonomy Gene Similarity Type Details
mouse
(Mus musculus)
Mammalia Gm7579 34
  • 55 (a)
OneToMany
Species where no ortholog for KRTAP5-10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP5-10 Gene

ENSEMBL:
Gene Tree for KRTAP5-10 (if available)
TreeFam:
Gene Tree for KRTAP5-10 (if available)

Paralogs for KRTAP5-10 Gene

No data available for Paralogs for KRTAP5-10 Gene

Variants for KRTAP5-10 Gene

Sequence variations from dbSNP and Humsavar for KRTAP5-10 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1002822159 -- 71,566,695(+) AGTAA(C/T)GAATG downstream-variant-500B
rs1006482098 -- 71,563,801(+) TTTCT(A/G)CAACT upstream-variant-2KB
rs1006672005 -- 71,566,941(+) GGAGG(A/T)TTCAG downstream-variant-500B
rs1006983508 -- 71,566,800(+) CGTTC(C/T)GATCT downstream-variant-500B
rs1010329335 -- 71,564,235(+) CTTGC(A/C)TCTTG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP5-10 Gene

Variant ID Type Subtype PubMed ID
nsv555402 CNV gain 21841781
nsv825988 CNV loss 20364138
nsv975200 CNV duplication 23825009
nsv983039 CNV duplication 23825009

Variation tolerance for KRTAP5-10 Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.97; 96.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTAP5-10 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTAP5-10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP5-10 Gene

Disorders for KRTAP5-10 Gene

Relevant External Links for KRTAP5-10

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP5-10

No disorders were found for KRTAP5-10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP5-10 Gene

Publications for KRTAP5-10 Gene

  1. Identification of two novel clusters of ultrahigh-sulfur keratin-associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S … Shimizu N (Biochemical and biophysical research communications 2004) 2 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for KRTAP5-10 Gene

Sources for KRTAP5-10 Gene

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