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Aliases for KRTAP5-10 Gene

Aliases for KRTAP5-10 Gene

  • Keratin Associated Protein 5-10 2 3
  • Ultrahigh Sulfur Keratin-Associated Protein 5.10 3 4
  • Keratin-Associated Protein 5.10 3 4
  • KRTAP5.10 3 4
  • Keratin-Associated Protein 5-10 3
  • KAP5.10 4

External Ids for KRTAP5-10 Gene

Previous GeneCards Identifiers for KRTAP5-10 Gene

  • GC00U913947
  • GC11U900660
  • GC11P070955
  • GC11P071239
  • GC11P067556
  • GC11P071276

Summaries for KRTAP5-10 Gene

GeneCards Summary for KRTAP5-10 Gene

KRTAP5-10 (Keratin Associated Protein 5-10) is a Protein Coding gene. An important paralog of this gene is KRTAP5-2.

UniProtKB/Swiss-Prot for KRTAP5-10 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP5-10 Gene

Genomics for KRTAP5-10 Gene

Regulatory Elements for KRTAP5-10 Gene

Genomic Location for KRTAP5-10 Gene

Start:
71,527,278 bp from pter
End:
71,568,934 bp from pter
Size:
41,657 bases
Orientation:
Plus strand

Genomic View for KRTAP5-10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP5-10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP5-10 Gene

Proteins for KRTAP5-10 Gene

  • Protein details for KRTAP5-10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6L8G5-KR510_HUMAN
    Recommended name:
    Keratin-associated protein 5-10
    Protein Accession:
    Q6L8G5
    Secondary Accessions:
    • B9EHA4

    Protein attributes for KRTAP5-10 Gene

    Size:
    202 amino acids
    Molecular mass:
    17984 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP5-10 Gene

Proteomics data for KRTAP5-10 Gene at MOPED

Post-translational modifications for KRTAP5-10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP5-10 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP5-10 Gene

Domains for KRTAP5-10 Gene

Gene Families for KRTAP5-10 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP5-10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP5-10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6L8G5

UniProtKB/Swiss-Prot:

KR510_HUMAN :
  • Q6L8G5
Family:
  • Belongs to the KRTAP type 5 family.
genes like me logo Genes that share domains with KRTAP5-10: view

Function for KRTAP5-10 Gene

Molecular function for KRTAP5-10 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated protein (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Phenotypes for KRTAP5-10 Gene

GenomeRNAi human phenotypes for KRTAP5-10:
genes like me logo Genes that share phenotypes with KRTAP5-10: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP5-10
    • Block miRNA regulation of KRTAP5-10 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP5-10

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP5-10 Gene

    Localization for KRTAP5-10 Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for KRTAP5-10 Gene COMPARTMENTS Subcellular localization image for KRTAP5-10 gene
    Compartment Confidence
    extracellular 3
    cytoskeleton 2
    cytosol 1
    mitochondrion 1
    nucleus 1

    Gene Ontology (GO) - Cellular Components for KRTAP5-10 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0045095 keratin filament IEA --
    genes like me logo Genes that share ontologies with KRTAP5-10: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP5-10 Gene

    Pathways for KRTAP5-10 Gene

    SuperPathways for KRTAP5-10 Gene

    No Data Available

    Interacting Proteins for KRTAP5-10 Gene

    Gene Ontology (GO) - Biological Process for KRTAP5-10 Gene

    None

    No data available for Pathways by source for KRTAP5-10 Gene

    Transcripts for KRTAP5-10 Gene

    mRNA/cDNA for KRTAP5-10 Gene

    (3) Additional mRNA sequences :
    (1) REFSEQ mRNAs :
    (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    Unigene Clusters for KRTAP5-10 Gene

    Keratin associated protein 5-10:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP5-10
      • Block miRNA regulation of KRTAP5-10 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP5-10

      Primer Products

      • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTAP5-10
      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP5-10 Gene

      No ASD Table

      Relevant External Links for KRTAP5-10 Gene

      GeneLoc Exon Structure for
      KRTAP5-10
      ECgene alternative splicing isoforms for
      KRTAP5-10

      Expression for KRTAP5-10 Gene

      mRNA expression in normal human tissues for KRTAP5-10 Gene

      mRNA differential expression in normal tissues according to GTEx for KRTAP5-10 Gene

      This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (31.3).

      Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTAP5-10 Gene

      SOURCE GeneReport for Unigene cluster for KRTAP5-10 Gene Hs.661887

      mRNA Expression by UniProt/SwissProt for KRTAP5-10 Gene

      Q6L8G5-KR510_HUMAN
      Tissue specificity: Expressed in hair root but not in skin. Expressed also in brain and skeletal muscle.
      genes like me logo Genes that share expressions with KRTAP5-10: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRTAP5-10 Gene

      Orthologs for KRTAP5-10 Gene

      This gene was present in the common ancestor of human and mouse.

      Orthologs for KRTAP5-10 Gene

      Organism Taxonomy Gene Similarity Type Details
      mouse
      (Mus musculus)
      Mammalia Gm7579 36
      • 55 (a)
      OneToMany
      Species with no ortholog for KRTAP5-10:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • chimpanzee (Pan troglodytes)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • cow (Bos Taurus)
      • dog (Canis familiaris)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • platypus (Ornithorhynchus anatinus)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for KRTAP5-10 Gene

      ENSEMBL:
      Gene Tree for KRTAP5-10 (if available)
      TreeFam:
      Gene Tree for KRTAP5-10 (if available)

      Paralogs for KRTAP5-10 Gene

      Paralogs for KRTAP5-10 Gene

      genes like me logo Genes that share paralogs with KRTAP5-10: view

      Variants for KRTAP5-10 Gene

      Sequence variations from dbSNP and Humsavar for KRTAP5-10 Gene

      SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
      rs7120471 -- 71,566,552(+) TGATC(A/C)CTAAG utr-variant-3-prime
      rs7930212 -- 71,567,093(+) AGGTC(A/G)GAGGA downstream-variant-500B
      rs7930224 -- 71,567,116(+) GCACC(A/G)CTGAG downstream-variant-500B
      rs7930916 -- 71,567,000(+) CCTGA(C/T)GACCA downstream-variant-500B
      rs10792783 -- 71,563,625(+) GCTCT(C/T)GTTGG upstream-variant-2KB

      Structural Variations from Database of Genomic Variants (DGV) for KRTAP5-10 Gene

      Variant ID Type Subtype PubMed ID
      dgv1217n71 CNV Gain 21882294
      nsv825988 CNV Loss 20364138

      Relevant External Links for KRTAP5-10 Gene

      HapMap Linkage Disequilibrium report
      KRTAP5-10

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP5-10 Gene

      Disorders for KRTAP5-10 Gene

      No disorders were found for KRTAP5-10 Gene.

      No data available for UniProtKB/Swiss-Prot for KRTAP5-10 Gene

      Publications for KRTAP5-10 Gene

      1. Identification of two novel clusters of ultrahigh-sulfur keratin- associated protein genes on human chromosome 11. (PMID: 15144888) Yahagi S. … Shimizu N. (Biochem. Biophys. Res. Commun. 2004) 2 3 4
      2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
      3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

      Products for KRTAP5-10 Gene

      Sources for KRTAP5-10 Gene

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