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Aliases for KRTAP4-3 Gene

Aliases for KRTAP4-3 Gene

  • Keratin Associated Protein 4-3 2 3
  • Ultrahigh Sulfur Keratin-Associated Protein 4.3 3 4
  • Keratin-Associated Protein 4.3 3 4
  • KAP4.3 3 4
  • Keratin-Associated Protein 4-3 3
  • KRTAP4.3 4

External Ids for KRTAP4-3 Gene

Summaries for KRTAP4-3 Gene

GeneCards Summary for KRTAP4-3 Gene

KRTAP4-3 (Keratin Associated Protein 4-3) is a Protein Coding gene. An important paralog of this gene is KRTAP4-4.

UniProtKB/Swiss-Prot for KRTAP4-3 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP4-3 Gene

Genomics for KRTAP4-3 Gene

Genomic Location for KRTAP4-3 Gene

Start:
41,167,231 bp from pter
End:
41,168,194 bp from pter
Size:
964 bases
Orientation:
Minus strand

Genomic View for KRTAP4-3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP4-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP4-3 Gene

Regulatory Elements for KRTAP4-3 Gene

Proteins for KRTAP4-3 Gene

  • Protein details for KRTAP4-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYR4-KRA43_HUMAN
    Recommended name:
    Keratin-associated protein 4-3
    Protein Accession:
    Q9BYR4
    Secondary Accessions:

    Protein attributes for KRTAP4-3 Gene

    Size:
    195 amino acids
    Molecular mass:
    20504 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP4-3 Gene

Proteomics data for KRTAP4-3 Gene at MOPED

Post-translational modifications for KRTAP4-3 Gene

No Post-translational modifications

Other Protein References for KRTAP4-3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP4-3 Gene

Domains for KRTAP4-3 Gene

Gene Families for KRTAP4-3 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP4-3 Gene

Blocks:
InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KRA43_HUMAN
Family:
  • Belongs to the KRTAP type 4 family.:
    • Q9BYR4
genes like me logo Genes that share domains with KRTAP4-3: view

Function for KRTAP4-3 Gene

Molecular function for KRTAP4-3 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP4-3 Gene

Localization for KRTAP4-3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP4-3 Gene COMPARTMENTS Subcellular localization image for KRTAP4-3 gene
Compartment Confidence
extracellular 3
cytoskeleton 2
cytosol 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP4-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP4-3: view

Pathways for KRTAP4-3 Gene

SuperPathways for KRTAP4-3 Gene

No Data Available

Interacting Proteins for KRTAP4-3 Gene

Gene Ontology (GO) - Biological Process for KRTAP4-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007568 aging IDA 21916889
GO:0042633 hair cycle IDA 21916889
genes like me logo Genes that share ontologies with KRTAP4-3: view

No data available for Pathways by source for KRTAP4-3 Gene

Transcripts for KRTAP4-3 Gene

mRNA/cDNA for KRTAP4-3 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP4-3 Gene

Keratin associated protein 4-3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP4-3 Gene

No ASD Table

Relevant External Links for KRTAP4-3 Gene

GeneLoc Exon Structure for
KRTAP4-3
ECgene alternative splicing isoforms for
KRTAP4-3

Expression for KRTAP4-3 Gene

mRNA expression in normal human tissues for KRTAP4-3 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP4-3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (47.2) and Skin - Sun Exposed (Lower leg) (5.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTAP4-3 Gene

SOURCE GeneReport for Unigene cluster for KRTAP4-3 Gene Hs.307023

mRNA Expression by UniProt/SwissProt for KRTAP4-3 Gene

Q9BYR4-KRA43_HUMAN
Tissue specificity: Expressed specifically in the middle/uper portions of the hair cortex. Not detected in the hair matrix or cuticle.
genes like me logo Genes that share expressions with KRTAP4-3: view

Orthologs for KRTAP4-3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP4-3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP4-3 36
  • 98.12 (n)
  • 96.41 (a)
KRTAP4-3 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 58 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia KRTAP4-3 37
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krtap4-16 36
  • 72.93 (n)
  • 66.06 (a)
Krtap4-16 16
Krtap5-5 37
  • 41 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Krtap4-3 36
  • 74.55 (n)
  • 72.73 (a)
Species with no ortholog for KRTAP4-3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP4-3 Gene

ENSEMBL:
Gene Tree for KRTAP4-3 (if available)
TreeFam:
Gene Tree for KRTAP4-3 (if available)

Paralogs for KRTAP4-3 Gene

Selected SIMAP similar genes for KRTAP4-3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP4-3: view

Variants for KRTAP4-3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP4-3 Gene

Q9BYR4-KRA43_HUMAN
Numerous size polymorphism are present in KRTAP4 gene family, which are mainly due to variations in the sequence encoding cysteine-rich repeat segments

Sequence variations from dbSNP and Humsavar for KRTAP4-3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs367293 -- 41,169,791(+) GAGTC(A/G)CAATG upstream-variant-2KB
rs375705 -- 41,167,368(+) AAAGA(A/G)TTCTA utr-variant-3-prime
rs398631 -- 41,169,129(+) gtttt(A/G)ataaa upstream-variant-2KB
rs401645 -- 41,167,023(+) GTTAG(G/T)TTCAA downstream-variant-500B
rs413638 -- 41,167,550(+) GTTGA(C/G)AGCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KRTAP4-3 Gene

Variant ID Type Subtype PubMed ID
nsv908232 CNV Loss 21882294
nsv833446 CNV Gain 17160897
dgv961e1 CNV Complex 17122850
esv2715919 CNV Deletion 23290073
esv2715920 CNV Deletion 23290073
esv1004287 CNV Deletion 20482838
esv1556857 CNV Deletion 17803354
nsv112381 CNV Insertion 16902084

Relevant External Links for KRTAP4-3 Gene

HapMap Linkage Disequilibrium report
KRTAP4-3

Disorders for KRTAP4-3 Gene

No disorders were found for KRTAP4-3 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP4-3 Gene

Publications for KRTAP4-3 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 3 4
  2. Hair greying is associated with active hair growth. (PMID: 21916889) Choi H.I. … Lee Y.H. (Br. J. Dermatol. 2011) 3
  3. Size polymorphisms in the human ultrahigh sulfur hair keratin- associated protein 4, KAP4, gene family. (PMID: 15955084) Kariya N. … Ito M. (J. Invest. Dermatol. 2005) 4
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody M.C. … Nusbaum C. (Nature 2006) 4

Products for KRTAP4-3 Gene

Sources for KRTAP4-3 Gene

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