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Aliases for KRTAP3-3 Gene

Aliases for KRTAP3-3 Gene

  • Keratin Associated Protein 3-3 2 3
  • High Sulfur Keratin-Associated Protein 3.3 3 4
  • Keratin-Associated Protein 3.3 3 4
  • KRTAP3.3 3 4
  • KAP3.3 3 4
  • Keratin-Associated Protein 3-3 3

External Ids for KRTAP3-3 Gene

Previous GeneCards Identifiers for KRTAP3-3 Gene

  • GC17M038649
  • GC17M041325
  • GC17M039058
  • GC17M039522
  • GC17P9W0134
  • GC17M036404
  • GC17M039149
  • GC17M034944

Summaries for KRTAP3-3 Gene

Entrez Gene Summary for KRTAP3-3 Gene

  • This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRTAP3-3 Gene

KRTAP3-3 (Keratin Associated Protein 3-3) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRTAP3-1.

UniProtKB/Swiss-Prot for KRTAP3-3 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP3-3 Gene

Genomics for KRTAP3-3 Gene

Regulatory Elements for KRTAP3-3 Gene

Genomic Location for KRTAP3-3 Gene

Start:
40,993,430 bp from pter
End:
40,994,133 bp from pter
Size:
704 bases
Orientation:
Minus strand

Genomic View for KRTAP3-3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP3-3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP3-3 Gene

Proteins for KRTAP3-3 Gene

  • Protein details for KRTAP3-3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYR6-KRA33_HUMAN
    Recommended name:
    Keratin-associated protein 3-3
    Protein Accession:
    Q9BYR6
    Secondary Accessions:
    • Q52LP0
    • Q6NTD4

    Protein attributes for KRTAP3-3 Gene

    Size:
    98 amino acids
    Molecular mass:
    10365 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP3-3 Gene

Proteomics data for KRTAP3-3 Gene at MOPED

Post-translational modifications for KRTAP3-3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for KRTAP3-3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP3-3 Gene

Domains for KRTAP3-3 Gene

Gene Families for KRTAP3-3 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP3-3 Gene

Suggested Antigen Peptide Sequences for KRTAP3-3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYR6

UniProtKB/Swiss-Prot:

KRA33_HUMAN :
  • Q9BYR6
Family:
  • Belongs to the KRTAP type 3 family.
genes like me logo Genes that share domains with KRTAP3-3: view

Function for KRTAP3-3 Gene

Molecular function for KRTAP3-3 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP3-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP3-3: view

miRNA for KRTAP3-3 Gene

miRTarBase miRNAs that target KRTAP3-3

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRTAP3-3 Gene

Localization for KRTAP3-3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP3-3 Gene COMPARTMENTS Subcellular localization image for KRTAP3-3 gene
Compartment Confidence
extracellular 3
cytoskeleton 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRTAP3-3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP3-3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP3-3 Gene

Pathways for KRTAP3-3 Gene

SuperPathways for KRTAP3-3 Gene

No Data Available

Interacting Proteins for KRTAP3-3 Gene

Selected Interacting proteins: Q9BYR6-KRA33_HUMAN for KRTAP3-3 Gene via UniProtKB

Gene Ontology (GO) - Biological Process for KRTAP3-3 Gene

None

No data available for Pathways by source for KRTAP3-3 Gene

Transcripts for KRTAP3-3 Gene

mRNA/cDNA for KRTAP3-3 Gene

(5) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP3-3 Gene

Keratin associated protein 3-3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP3-3 Gene

No ASD Table

Relevant External Links for KRTAP3-3 Gene

GeneLoc Exon Structure for
KRTAP3-3
ECgene alternative splicing isoforms for
KRTAP3-3

Expression for KRTAP3-3 Gene

mRNA expression in normal human tissues for KRTAP3-3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRTAP3-3 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (48.5) and Skin - Sun Exposed (Lower leg) (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTAP3-3 Gene

SOURCE GeneReport for Unigene cluster for KRTAP3-3 Gene Hs.662759

mRNA Expression by UniProt/SwissProt for KRTAP3-3 Gene

Q9BYR6-KRA33_HUMAN
Tissue specificity: Localized to the upper cortex of the hair shaft.
genes like me logo Genes that share expressions with KRTAP3-3: view

Orthologs for KRTAP3-3 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP3-3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP3-3 35
  • 99.66 (n)
  • 100 (a)
KRTAP3-3 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 36
  • 85 (a)
ManyToMany
KRTAP3-3 35
  • 88.44 (n)
  • 84.69 (a)
KRTAP3-3 36
  • 85 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 84 (a)
OneToMany
LOC102151752 35
  • 91.06 (n)
  • 91.46 (a)
mouse
(Mus musculus)
Mammalia Krtap3-2 36
  • 83 (a)
ManyToMany
Krtap3-3 35
  • 87.76 (n)
  • 84.69 (a)
Krtap3-3 16
Krtap3-3 36
  • 83 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 76 (a)
ManyToMany
-- 36
  • 76 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Krtap3-3 35
  • 88.1 (n)
  • 84.69 (a)
Species with no ortholog for KRTAP3-3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP3-3 Gene

ENSEMBL:
Gene Tree for KRTAP3-3 (if available)
TreeFam:
Gene Tree for KRTAP3-3 (if available)

Paralogs for KRTAP3-3 Gene

Paralogs for KRTAP3-3 Gene

Selected SIMAP similar genes for KRTAP3-3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP3-3: view

Variants for KRTAP3-3 Gene

Sequence variations from dbSNP and Humsavar for KRTAP3-3 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1989365 -- 40,994,105(-) GACTC(C/T)AATAG utr-variant-5-prime
rs2010201 -- 40,994,032(-) TCCTC(C/T)GACAA synonymous-codon, reference
rs2010209 -- 40,994,191(-) GGGTA(C/T)ATAAG upstream-variant-2KB
rs2010385 -- 40,994,337(-) AGCAA(C/T)GAACT upstream-variant-2KB
rs3813042 -- 40,994,360(+) ATTAC(C/G)CTTGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP3-3 Gene

Variant ID Type Subtype PubMed ID
nsv9550 CNV Loss 18304495
nsv908230 CNV Loss 21882294
esv2666089 CNV Deletion 23128226
esv2190143 CNV Deletion 18987734

Relevant External Links for KRTAP3-3 Gene

HapMap Linkage Disequilibrium report
KRTAP3-3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP3-3 Gene

Disorders for KRTAP3-3 Gene

No disorders were found for KRTAP3-3 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP3-3 Gene

Publications for KRTAP3-3 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Protein interactions of the transcription factor Hoxa1. (PMID: 23088713) Lambert B. … Rezsohazy R. (BMC Dev. Biol. 2012) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for KRTAP3-3 Gene

Sources for KRTAP3-3 Gene

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