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Aliases for KRTAP3-2 Gene

Aliases for KRTAP3-2 Gene

  • Keratin Associated Protein 3-2 2 3
  • High Sulfur Keratin-Associated Protein 3.2 3 4
  • Keratin-Associated Protein 3.2 3 4
  • KRTAP3.2 3 4
  • KAP3.2 3 4
  • Keratin Associated Protein 3.2 3
  • Keratin-Associated Protein 3-2 3

External Ids for KRTAP3-2 Gene

Previous GeneCards Identifiers for KRTAP3-2 Gene

  • GC17M038655
  • GC17M041331
  • GC17M039064
  • GC17M039528
  • GC17P9W0128
  • GC17M036408
  • GC17M039155
  • GC17M034950

Summaries for KRTAP3-2 Gene

Entrez Gene Summary for KRTAP3-2 Gene

  • This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRTAP3-2 Gene

KRTAP3-2 (Keratin Associated Protein 3-2) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRTAP3-1.

UniProtKB/Swiss-Prot for KRTAP3-2 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP3-2 Gene

Genomics for KRTAP3-2 Gene

Regulatory Elements for KRTAP3-2 Gene

Genomic Location for KRTAP3-2 Gene

Start:
40,999,193 bp from pter
End:
40,999,894 bp from pter
Size:
702 bases
Orientation:
Minus strand

Genomic View for KRTAP3-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP3-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP3-2 Gene

Proteins for KRTAP3-2 Gene

  • Protein details for KRTAP3-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYR7-KRA32_HUMAN
    Recommended name:
    Keratin-associated protein 3-2
    Protein Accession:
    Q9BYR7
    Secondary Accessions:

    Protein attributes for KRTAP3-2 Gene

    Size:
    98 amino acids
    Molecular mass:
    10407 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP3-2 Gene

Proteomics data for KRTAP3-2 Gene at MOPED

Post-translational modifications for KRTAP3-2 Gene

No Post-translational modifications

Other Protein References for KRTAP3-2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP3-2 Gene

Domains for KRTAP3-2 Gene

Gene Families for KRTAP3-2 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP3-2 Gene

Suggested Antigen Peptide Sequences for KRTAP3-2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYR7

UniProtKB/Swiss-Prot:

KRA32_HUMAN :
  • Q9BYR7
Family:
  • Belongs to the KRTAP type 3 family.
genes like me logo Genes that share domains with KRTAP3-2: view

Function for KRTAP3-2 Gene

Molecular function for KRTAP3-2 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP3-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 23088713
genes like me logo Genes that share ontologies with KRTAP3-2: view

Animal Model Products

CRISPR Products

miRNA for KRTAP3-2 Gene

miRTarBase miRNAs that target KRTAP3-2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP3-2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for KRTAP3-2 Gene

Localization for KRTAP3-2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP3-2 Gene COMPARTMENTS Subcellular localization image for KRTAP3-2 gene
Compartment Confidence
extracellular 3
cytoskeleton 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRTAP3-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP3-2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP3-2 Gene

Pathways for KRTAP3-2 Gene

SuperPathways for KRTAP3-2 Gene

No Data Available

Interacting Proteins for KRTAP3-2 Gene

Gene Ontology (GO) - Biological Process for KRTAP3-2 Gene

None

No data available for Pathways by source for KRTAP3-2 Gene

Transcripts for KRTAP3-2 Gene

mRNA/cDNA for KRTAP3-2 Gene

(2) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP3-2 Gene

Keratin associated protein 3-2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP3-2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTAP3-2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP3-2 Gene

No ASD Table

Relevant External Links for KRTAP3-2 Gene

GeneLoc Exon Structure for
KRTAP3-2
ECgene alternative splicing isoforms for
KRTAP3-2

Expression for KRTAP3-2 Gene

mRNA expression in normal human tissues for KRTAP3-2 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP3-2 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (47.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRTAP3-2 Gene

SOURCE GeneReport for Unigene cluster for KRTAP3-2 Gene Hs.307026

genes like me logo Genes that share expressions with KRTAP3-2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for KRTAP3-2 Gene

Orthologs for KRTAP3-2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP3-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 98 (a)
ManyToMany
KRTAP3-2 35
  • 98.3 (n)
  • 97.96 (a)
cow
(Bos Taurus)
Mammalia -- 36
  • 84 (a)
ManyToMany
KRTAP3-3 36
  • 84 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Krtap3-2 16
Krtap3-2 36
  • 82 (a)
ManyToMany
Krtap3-3 36
  • 82 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
ManyToMany
-- 36
  • 75 (a)
ManyToMany
Species with no ortholog for KRTAP3-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP3-2 Gene

ENSEMBL:
Gene Tree for KRTAP3-2 (if available)
TreeFam:
Gene Tree for KRTAP3-2 (if available)

Paralogs for KRTAP3-2 Gene

Paralogs for KRTAP3-2 Gene

Selected SIMAP similar genes for KRTAP3-2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with KRTAP3-2: view

Variants for KRTAP3-2 Gene

Sequence variations from dbSNP and Humsavar for KRTAP3-2 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs906980 -- 41,001,420(-) attta(G/T)ctacc upstream-variant-2KB
rs2160436 -- 41,001,515(-) gttat(C/T)tttcc upstream-variant-2KB
rs3067653 -- 41,001,759(+) CCAAA(-/CAAA)GAATT upstream-variant-2KB
rs3813047 -- 40,999,506(+) TGAAG(A/G)GACAG utr-variant-3-prime
rs3813048 -- 40,999,629(+) AGGCC(C/T)GGAGT synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for KRTAP3-2 Gene

Variant ID Type Subtype PubMed ID
nsv9550 CNV Loss 18304495
nsv908230 CNV Loss 21882294
esv2666089 CNV Deletion 23128226
esv2190143 CNV Deletion 18987734
esv28462 CNV Loss 19812545

Relevant External Links for KRTAP3-2 Gene

HapMap Linkage Disequilibrium report
KRTAP3-2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP3-2 Gene

Disorders for KRTAP3-2 Gene

Relevant External Links for KRTAP3-2

Genetic Association Database (GAD)
KRTAP3-2
genes like me logo Genes that share disorders with KRTAP3-2: view

No data available for UniProtKB/Swiss-Prot for KRTAP3-2 Gene

Publications for KRTAP3-2 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  4. Protein interactions of the transcription factor Hoxa1. (PMID: 23088713) Lambert B. … Rezsohazy R. (BMC Dev. Biol. 2012) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for KRTAP3-2 Gene

Sources for KRTAP3-2 Gene

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