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Aliases for KRTAP3-1 Gene

Aliases for KRTAP3-1 Gene

  • Keratin Associated Protein 3-1 2 3
  • High Sulfur Keratin-Associated Protein 3.1 3 4
  • Keratin-Associated Protein 3.1 3 4
  • KRTAP3.1 3 4
  • KAP3.1 3 4
  • Keratin-Associated Protein 3-1 3

External Ids for KRTAP3-1 Gene

Previous GeneCards Identifiers for KRTAP3-1 Gene

  • GC17M038665
  • GC17M041340
  • GC17M039073
  • GC17M039538
  • GC17M039539
  • GC17P9W0119
  • GC17M036419
  • GC17M039164
  • GC17M034959

Summaries for KRTAP3-1 Gene

Entrez Gene Summary for KRTAP3-1 Gene

  • This protein is a member of the keratin-associated protein (KAP) family. The KAP proteins form a matrix of keratin intermediate filaments which contribute to the structure of hair fibers. KAP family members appear to have unique, family-specific amino- and carboxyl-terminal regions and are subdivided into three multi-gene families according to amino acid composition: the high sulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs. This protein is a member of the high sulfur KAP family and the gene is localized to a cluster of KAPs at 17q12-q21. [provided by RefSeq, Jul 2008]

GeneCards Summary for KRTAP3-1 Gene

KRTAP3-1 (Keratin Associated Protein 3-1) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity. An important paralog of this gene is KRTAP3-3.

UniProtKB/Swiss-Prot for KRTAP3-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP3-1 Gene

Genomics for KRTAP3-1 Gene

Regulatory Elements for KRTAP3-1 Gene

Genomic Location for KRTAP3-1 Gene

Start:
41,008,521 bp from pter
End:
41,019,324 bp from pter
Size:
10,804 bases
Orientation:
Minus strand

Genomic View for KRTAP3-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP3-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP3-1 Gene

Proteins for KRTAP3-1 Gene

  • Protein details for KRTAP3-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYR8-KRA31_HUMAN
    Recommended name:
    Keratin-associated protein 3-1
    Protein Accession:
    Q9BYR8
    Secondary Accessions:
    • Q14DM4

    Protein attributes for KRTAP3-1 Gene

    Size:
    98 amino acids
    Molecular mass:
    10539 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP3-1 Gene

Proteomics data for KRTAP3-1 Gene at MOPED

Post-translational modifications for KRTAP3-1 Gene

No Post-translational modifications

Other Protein References for KRTAP3-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP3-1 Gene

Domains for KRTAP3-1 Gene

Gene Families for KRTAP3-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP3-1 Gene

Suggested Antigen Peptide Sequences for KRTAP3-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYR8

UniProtKB/Swiss-Prot:

KRA31_HUMAN :
  • Q9BYR8
Family:
  • Belongs to the KRTAP type 3 family.
genes like me logo Genes that share domains with KRTAP3-1: view

Function for KRTAP3-1 Gene

Molecular function for KRTAP3-1 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP3-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with KRTAP3-1: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP3-1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP3-1 Gene

Localization for KRTAP3-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP3-1 Gene COMPARTMENTS Subcellular localization image for KRTAP3-1 gene
Compartment Confidence
extracellular 3
cytoskeleton 2
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for KRTAP3-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP3-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP3-1 Gene

Pathways for KRTAP3-1 Gene

SuperPathways for KRTAP3-1 Gene

No Data Available

Interacting Proteins for KRTAP3-1 Gene

Selected Interacting proteins: Q9BYR8-KRA31_HUMAN for KRTAP3-1 Gene via UniProtKB

Symbol External ID(s) Details
NOTCH2NL

Gene Ontology (GO) - Biological Process for KRTAP3-1 Gene

None

No data available for Pathways by source for KRTAP3-1 Gene

Transcripts for KRTAP3-1 Gene

mRNA/cDNA for KRTAP3-1 Gene

(3) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP3-1 Gene

Keratin associated protein 3-1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP3-1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP3-1 Gene

No ASD Table

Relevant External Links for KRTAP3-1 Gene

GeneLoc Exon Structure for
KRTAP3-1
ECgene alternative splicing isoforms for
KRTAP3-1

Expression for KRTAP3-1 Gene

mRNA expression in normal human tissues for KRTAP3-1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for KRTAP3-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (48.4) and Skin - Sun Exposed (Lower leg) (4.4).

Protein differential expression in normal tissues for KRTAP3-1 Gene

This gene is overexpressed in Hair follicle (68.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTAP3-1 Gene

SOURCE GeneReport for Unigene cluster for KRTAP3-1 Gene Hs.307027

genes like me logo Genes that share expressions with KRTAP3-1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for KRTAP3-1 Gene

Orthologs for KRTAP3-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP3-1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KRTAP3-1 35
  • 85.71 (n)
  • 82.65 (a)
KRTAP3-1 36
  • 84 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC102151669 35
  • 89.02 (n)
  • 87.5 (a)
KRTAP3-1 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krtap3-1 35
  • 86.73 (n)
  • 86.73 (a)
Krtap3-1 16
Krtap3-1 36
  • 87 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KRTAP3-1 35
  • 98.98 (n)
  • 97.96 (a)
KRTAP3-1 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krtap3-1 35
  • 85.71 (n)
  • 85.71 (a)
oppossum
(Monodelphis domestica)
Mammalia KRTAP3-1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KRTAP3-1 36
  • 68 (a)
OneToOne
Species with no ortholog for KRTAP3-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP3-1 Gene

ENSEMBL:
Gene Tree for KRTAP3-1 (if available)
TreeFam:
Gene Tree for KRTAP3-1 (if available)

Paralogs for KRTAP3-1 Gene

Paralogs for KRTAP3-1 Gene

Selected SIMAP similar genes for KRTAP3-1 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for KRTAP3-1 Gene

genes like me logo Genes that share paralogs with KRTAP3-1: view

Variants for KRTAP3-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP3-1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs937980 -- 41,009,901(-) TGTTC(A/G)TGGAA upstream-variant-2KB
rs3841252 -- 41,009,248(+) TACTT(-/AAGT)GTTTA upstream-variant-2KB
rs9891464 -- 41,008,754(+) CCTCA(A/C)GGAAC utr-variant-3-prime
rs9891631 -- 41,008,504(+) AATAA(A/G)TAATC downstream-variant-500B
rs9904456 -- 41,010,404(+) TTTCC(G/T)AGTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP3-1 Gene

Variant ID Type Subtype PubMed ID
nsv9550 CNV Loss 18304495
nsv908230 CNV Loss 21882294

Relevant External Links for KRTAP3-1 Gene

HapMap Linkage Disequilibrium report
KRTAP3-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP3-1 Gene

Disorders for KRTAP3-1 Gene

No disorders were found for KRTAP3-1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for KRTAP3-1 Gene

Publications for KRTAP3-1 Gene

  1. Characterization of a cluster of human high/ultrahigh sulfur keratin- associated protein genes embedded in the type I keratin gene domain on chromosome 17q12-21. (PMID: 11279113) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2001) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for KRTAP3-1 Gene

Sources for KRTAP3-1 Gene

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