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Aliases for KRTAP26-1 Gene

Aliases for KRTAP26-1 Gene

  • Keratin Associated Protein 26-1 2 3
  • KAP26.1 4

External Ids for KRTAP26-1 Gene

Previous GeneCards Identifiers for KRTAP26-1 Gene

  • GC21M030614
  • GC21M031691
  • GC21M017100

Summaries for KRTAP26-1 Gene

GeneCards Summary for KRTAP26-1 Gene

KRTAP26-1 (Keratin Associated Protein 26-1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP26-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP26-1 Gene

Genomics for KRTAP26-1 Gene

Genomic Location for KRTAP26-1 Gene

Start:
30,319,124 bp from pter
End:
30,320,316 bp from pter
Size:
1,193 bases
Orientation:
Minus strand

Genomic View for KRTAP26-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP26-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP26-1 Gene

No data available for Regulatory Elements for KRTAP26-1 Gene

Proteins for KRTAP26-1 Gene

  • Protein details for KRTAP26-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PEX3-KR261_HUMAN
    Recommended name:
    Keratin-associated protein 26-1
    Protein Accession:
    Q6PEX3
    Secondary Accessions:
    • B0RZD3

    Protein attributes for KRTAP26-1 Gene

    Size:
    210 amino acids
    Molecular mass:
    22554 Da
    Quaternary structure:
    • Interacts with hair keratins

neXtProt entry for KRTAP26-1 Gene

Proteomics data for KRTAP26-1 Gene at MOPED

Post-translational modifications for KRTAP26-1 Gene

No Post-translational modifications

Other Protein References for KRTAP26-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP26-1 Gene

Domains for KRTAP26-1 Gene

Gene Families for KRTAP26-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP26-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP26-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PEX3

UniProtKB/Swiss-Prot:

KR261_HUMAN :
  • Q6PEX3
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP26-1: view

Function for KRTAP26-1 Gene

Molecular function for KRTAP26-1 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP26-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22458338
genes like me logo Genes that share ontologies with KRTAP26-1: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP26-1
    • Block miRNA regulation of KRTAP26-1 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP26-1

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP26-1 Gene

    Localization for KRTAP26-1 Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for KRTAP26-1 Gene COMPARTMENTS Subcellular localization image for KRTAP26-1 gene
    Compartment Confidence
    cytoskeleton 3
    extracellular 2
    cytosol 1
    mitochondrion 1
    nucleus 1
    plasma membrane 1

    Gene Ontology (GO) - Cellular Components for KRTAP26-1 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005882 intermediate filament IEA --
    genes like me logo Genes that share ontologies with KRTAP26-1: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP26-1 Gene

    Pathways for KRTAP26-1 Gene

    SuperPathways for KRTAP26-1 Gene

    No Data Available

    Gene Ontology (GO) - Biological Process for KRTAP26-1 Gene

    None

    No data available for Pathways by source for KRTAP26-1 Gene

    Transcripts for KRTAP26-1 Gene

    mRNA/cDNA for KRTAP26-1 Gene

    (3) Additional mRNA sequences :
    (14) Selected AceView cDNA sequences:
    (1) REFSEQ mRNAs :
    (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    Unigene Clusters for KRTAP26-1 Gene

    Keratin associated protein 26-1:
    Representative Sequences:

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP26-1
      • Block miRNA regulation of KRTAP26-1 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP26-1

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP26-1 Gene

      No ASD Table

      Relevant External Links for KRTAP26-1 Gene

      GeneLoc Exon Structure for
      KRTAP26-1
      ECgene alternative splicing isoforms for
      KRTAP26-1

      Expression for KRTAP26-1 Gene

      mRNA expression in normal human tissues for KRTAP26-1 Gene

      mRNA differential expression in normal tissues according to GTEx for KRTAP26-1 Gene

      This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (43.5) and Skin - Sun Exposed (Lower leg) (8.2).

      Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for KRTAP26-1 Gene

      SOURCE GeneReport for Unigene cluster for KRTAP26-1 Gene Hs.28704

      mRNA Expression by UniProt/SwissProt for KRTAP26-1 Gene

      Q6PEX3-KR261_HUMAN
      Tissue specificity: Localized high up in the well differentiated portion of the hair follicle cuticle (about 10-15 cell layers above the apex of the dermal papilla).
      genes like me logo Genes that share expressions with KRTAP26-1: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for KRTAP26-1 Gene

      Orthologs for KRTAP26-1 Gene

      This gene was present in the common ancestor of mammals.

      Orthologs for KRTAP26-1 Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia KRTAP26-1 36
      • 100 (a)
      OneToOne
      LOC100613423 35
      • 99.68 (n)
      • 99.52 (a)
      cow
      (Bos Taurus)
      Mammalia KRTAP26-1 35
      • 71.19 (n)
      • 57.63 (a)
      dog
      (Canis familiaris)
      Mammalia KRTAP26-1 35
      • 79.4 (n)
      • 65.17 (a)
      KRTAP26-1 36
      • 64 (a)
      OneToOne
      mouse
      (Mus musculus)
      Mammalia Krtap26-1 35
      • 69.68 (n)
      • 57.29 (a)
      Krtap26-1 16
      Krtap26-1 36
      • 54 (a)
      OneToOne
      platypus
      (Ornithorhynchus anatinus)
      Mammalia KRTAP26-1 36
      • 19 (a)
      OneToOne
      rat
      (Rattus norvegicus)
      Mammalia Krtap26-1 35
      • 69.24 (n)
      • 55.07 (a)
      Species with no ortholog for KRTAP26-1:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • rainbow trout (Oncorhynchus mykiss)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for KRTAP26-1 Gene

      ENSEMBL:
      Gene Tree for KRTAP26-1 (if available)
      TreeFam:
      Gene Tree for KRTAP26-1 (if available)

      Paralogs for KRTAP26-1 Gene

      No data available for Paralogs for KRTAP26-1 Gene

      Variants for KRTAP26-1 Gene

      Sequence variations from dbSNP and Humsavar for KRTAP26-1 Gene

      SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
      rs2212505 -- 30,319,070(+) TTGAC(A/G)TTGGT downstream-variant-500B
      rs2226642 -- 30,318,908(+) TTTTC(A/C)AAACA downstream-variant-500B
      rs2236427 -- 30,319,253(+) TAAAA(A/C)ATGCG utr-variant-3-prime
      rs2409367 -- 30,318,890(+) ATCAC(C/T)CCTAA downstream-variant-500B
      rs2832792 -- 30,321,073(+) TAGTA(C/T)TTTAA upstream-variant-2KB

      Structural Variations from Database of Genomic Variants (DGV) for KRTAP26-1 Gene

      Variant ID Type Subtype PubMed ID
      nsv834076 CNV Gain 17160897

      Relevant External Links for KRTAP26-1 Gene

      HapMap Linkage Disequilibrium report
      KRTAP26-1

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP26-1 Gene

      Disorders for KRTAP26-1 Gene

      No disorders were found for KRTAP26-1 Gene.

      No data available for UniProtKB/Swiss-Prot for KRTAP26-1 Gene

      Publications for KRTAP26-1 Gene

      1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
      2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
      3. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N. … Twizere J.C. (Retrovirology 2012) 3
      4. Protein interactions of the transcription factor Hoxa1. (PMID: 23088713) Lambert B. … Rezsohazy R. (BMC Dev. Biol. 2012) 3
      5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

      Products for KRTAP26-1 Gene

      Sources for KRTAP26-1 Gene

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