KRTAP26-1 Gene
protein-coding GIFtS: 36
GCID: GC21M031691
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|
keratin associated protein 26-1
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Aliases
for KRTAP26-1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Keratin Associated Protein 26-11 2 | | Keratin-Associated Protein 26-12 | | KAP26.13 |
Export aliases for KRTAP26-1 gene to outside databasesPrevious GC identifers: GC21M030614 GC21M017100 |
Summaries
for KRTAP26-1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KR261_HUMAN, Q6PEX3Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistanthair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. Thematrix proteins include the high-sulfur and high-glycine-tyrosine keratins
|
Genomic Views
for KRTAP26-1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000021.8 NC_018932.1 NT_011512.11
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for KRTAP26-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for KRTAP26-1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRTAP26-1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 21q22.11 Ensembl cytogenetic band: 21q22.11 HGNC cytogenetic band: 21q22.11KRTAP26-1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 21 GeneLoc Exon Structure GeneLoc location for GC21M031691: view genomic region
(about GC identifiers)
Start:
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31,691,449 bp from pter |
End:
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31,692,607 bp from pter |
Size:
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1,159 bases |
Orientation:
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minus strand |
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Proteins
for KRTAP26-1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KR261_HUMAN, Q6PEX3 (See
protein sequence)Recommended Name: Keratin-associated protein 26-1 Size: 210 amino acids; 22554 Da
Subunit: Interacts with hair keratins
Secondary accessions: B0RZD3Explore the universe of human proteins at neXtProt for KRTAP26-1: NX_Q6PEX3
KRTAP26-1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_981950.1
ENSEMBL proteins: ENSP00000353742
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005882 | intermediate filament |
IEA | -- |
KRTAP26-1 for ontologies About GeneDecksing
KRTAP26-1 Antibody Products:
Assay Products for KRTAP26-1: |
Protein
Domains /
Families
for KRTAP26-1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
KRTAP26-1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6PEX3ProtoNet protein and cluster: Q6PEX3 UniProtKB/Swiss-Prot: KR261_HUMAN, Q6PEX3Similarity: Belongs to the PMG family |
Function
for KRTAP26-1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KR261_HUMAN, Q6PEX3Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistanthair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. Thematrix proteins include the high-sulfur and high-glycine-tyrosine keratins
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP26-1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP26-1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRTAP26-1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
IPI | -- |
KRTAP26-1 for ontologies About GeneDecksing
|
Pathways & Interactions
for KRTAP26-1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRTAP26-1
1 Interacting protein for KRTAP26-1 (Q6PEX31) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for KRTAP26-1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for KRTAP26-1
Search CenterWatch for drugs/clinical trials and news about KRTAP26-1 / KR261
|
Transcripts
for KRTAP26-1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for KRTAP26-1 gene: NM_203405.1 Unigene Cluster for KRTAP26-1: Keratin associated protein 26-1 Hs.28704 [show with all ESTs]Unigene Representative Sequence: BC0578251 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000360542(uc002ynw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP26-1
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP26-1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: KRTAP26-1 (NM_203405) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for KRTAP26-1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRTAP26-1 |
Additional cDNA sequence: AB096936.1 AM941740.1 BC057825.1 1 DOTS entry: DT.101964923 14 AceView cDNA sequences: BX111456 NM_203405 BX397981 CR602838 CD109407 BC057825 CB996254 CB994995 H55746 R67568 CD110079 R66691 BX389687 R66219
GeneLoc Exon Structure
|
Expression
for KRTAP26-1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| KRTAP26-1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTATCTTG
About this image
See KRTAP26-1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRTAP26-1
SOURCE GeneReport for Unigene cluster: Hs.28704
UniProtKB/Swiss-Prot: KR261_HUMAN, Q6PEX3Tissue specificity: Localized high up in the well differentiated portion of the hair follicle cuticle (about 10-15 celllayers above the apex of the dermal papilla)
SABiosciences Custom PCR Arrays for KRTAP26-1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRTAP26-1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat KRTAP26-1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRTAP26-1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRTAP26-1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRTAP26-1 |
Orthologs
for KRTAP26-1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for KRTAP26-1 (if available)
TreeFam Gene Tree for KRTAP26-1 (if available) |
Paralogs
for KRTAP26-1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for KRTAP26-1 gene
- KRTAP27-12 KRTAP24-12 KRTAP11-12
KRTAP26-1 for paralogs About GeneDecksing
|
Genomic Variants
for KRTAP26-1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 21 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for KRTAP26-1 (31691449 - 31692607 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for KRTAP26-1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRTAP26-1 |
|
Disorders
/ Diseases
for KRTAP26-1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for KRTAP26-1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for KRTAP26-1 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with KRTAP26-1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Characterization and expression analysis of the hair keratin associated protein KAP26.1. (PubMed id 18647308)2 Rogers M.A.... Giehl K. (2008)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
- Isolation and characterization of genomic clones of human sequences presumably coding for hair cysteine-rich proteins. (PubMed id 9049802)9 Emonet N....Dhouailly D. (1997)
- Hard alpha-keratin degradation inside a tissue under high flux X-ray synchrotron micro-beam: a multi-scale time-resolved study. (PubMed id 19925868)9 Leccia E....Briki F. (2010)
- Structure and functions of keratin proteins in simple , stratified, keratinized and cornified epithelia. (PubMed id 19422428)9 Bragulla H.H. and Homberger D.G. (2009)
- Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. (PubMed id 18721477)9 Wu D.D....Zhang Y.P. (2008)
- Analysis of the transcriptional regulation of melanocytic genes by alphaMSH using the cDNA microarray technique. (PubMed id 16914083)9 Rouzaud F. and Hearing V.J. (2006)
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External Searches for KRTAP26-1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing KRTAP26-1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing KRTAP26-1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing KRTAP26-1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for KRTAP26-1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for KRTAP26-1 gene:
Search GeneIP for patents involving KRTAP26-1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for KRTAP26-1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for KRTAP26-1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for KRTAP26-1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for KRTAP26-1 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for KRTAP26-1 | | OriGene 3'-UTR Clone for KRTAP26-1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP26-1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for KRTAP26-1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat KRTAP26-1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing KRTAP26-1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRTAP26-1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat KRTAP26-1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat KRTAP26-1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat KRTAP26-1 |
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 | | | KRTAP26-1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRTAP26-1 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat KRTAP26-1 |
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