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Aliases for KRTAP26-1 Gene

Aliases for KRTAP26-1 Gene

  • Keratin Associated Protein 26-1 2 3 5
  • KAP26.1 4

External Ids for KRTAP26-1 Gene

Previous GeneCards Identifiers for KRTAP26-1 Gene

  • GC21M030614
  • GC21M031691
  • GC21M017100

Summaries for KRTAP26-1 Gene

GeneCards Summary for KRTAP26-1 Gene

KRTAP26-1 (Keratin Associated Protein 26-1) is a Protein Coding gene. Among its related pathways are Keratinization and Developmental Biology.

UniProtKB/Swiss-Prot for KRTAP26-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP26-1 Gene

Genomics for KRTAP26-1 Gene

Genomic Location for KRTAP26-1 Gene

Chromosome:
21
Start:
30,319,124 bp from pter
End:
30,320,316 bp from pter
Size:
1,193 bases
Orientation:
Minus strand

Genomic View for KRTAP26-1 Gene

Genes around KRTAP26-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP26-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP26-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP26-1 Gene

No data available for Regulatory Elements for KRTAP26-1 Gene

Proteins for KRTAP26-1 Gene

  • Protein details for KRTAP26-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PEX3-KR261_HUMAN
    Recommended name:
    Keratin-associated protein 26-1
    Protein Accession:
    Q6PEX3
    Secondary Accessions:
    • B0RZD3

    Protein attributes for KRTAP26-1 Gene

    Size:
    210 amino acids
    Molecular mass:
    22554 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP26-1 Gene

Post-translational modifications for KRTAP26-1 Gene

No Post-translational modifications

Other Protein References for KRTAP26-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP26-1 Gene

Domains & Families for KRTAP26-1 Gene

Gene Families for KRTAP26-1 Gene

Protein Domains for KRTAP26-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP26-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PEX3

UniProtKB/Swiss-Prot:

KR261_HUMAN :
  • Belongs to the PMG family.
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP26-1: view

Function for KRTAP26-1 Gene

Molecular function for KRTAP26-1 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.

Gene Ontology (GO) - Molecular Function for KRTAP26-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 22458338
genes like me logo Genes that share ontologies with KRTAP26-1: view

Phenotypes for KRTAP26-1 Gene

genes like me logo Genes that share phenotypes with KRTAP26-1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for KRTAP26-1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP26-1 Gene

Localization for KRTAP26-1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for KRTAP26-1 gene
Compartment Confidence
cytosol 5
cytoskeleton 3
extracellular 2
plasma membrane 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP26-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP26-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP26-1 Gene

Pathways & Interactions for KRTAP26-1 Gene

SuperPathways for KRTAP26-1 Gene

SuperPathway Contained pathways
1 Developmental Biology
2 Keratinization
genes like me logo Genes that share pathways with KRTAP26-1: view

Pathways by source for KRTAP26-1 Gene

2 Reactome pathways for KRTAP26-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP26-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031424 keratinization TAS --
genes like me logo Genes that share ontologies with KRTAP26-1: view

No data available for SIGNOR curated interactions for KRTAP26-1 Gene

Transcripts for KRTAP26-1 Gene

mRNA/cDNA for KRTAP26-1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for KRTAP26-1 Gene

Keratin associated protein 26-1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP26-1 Gene

No ASD Table

Relevant External Links for KRTAP26-1 Gene

GeneLoc Exon Structure for
KRTAP26-1
ECgene alternative splicing isoforms for
KRTAP26-1

Expression for KRTAP26-1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for KRTAP26-1 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP26-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x43.5) and Skin - Sun Exposed (Lower leg) (x8.2).

Protein differential expression in normal tissues from HIPED for KRTAP26-1 Gene

This gene is overexpressed in Hair follicle (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for KRTAP26-1 Gene



Protein tissue co-expression partners for KRTAP26-1 Gene

SOURCE GeneReport for Unigene cluster for KRTAP26-1 Gene:

Hs.28704

mRNA Expression by UniProt/SwissProt for KRTAP26-1 Gene:

Q6PEX3-KR261_HUMAN
Tissue specificity: Localized high up in the well differentiated portion of the hair follicle cuticle (about 10-15 cell layers above the apex of the dermal papilla).

Evidence on tissue expression from TISSUES for KRTAP26-1 Gene

  • Skin(4.1)
genes like me logo Genes that share expression patterns with KRTAP26-1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for KRTAP26-1 Gene

Orthologs for KRTAP26-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP26-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP26-1 35
  • 100 (a)
OneToOne
LOC100613423 34
  • 99.68 (n)
dog
(Canis familiaris)
Mammalia KRTAP26-1 34 35
  • 79.4 (n)
cow
(Bos Taurus)
Mammalia KRTAP26-1 34
  • 71.19 (n)
mouse
(Mus musculus)
Mammalia Krtap26-1 34 16 35
  • 69.68 (n)
rat
(Rattus norvegicus)
Mammalia Krtap26-1 34
  • 69.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia KRTAP26-1 35
  • 19 (a)
OneToOne
Species where no ortholog for KRTAP26-1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP26-1 Gene

ENSEMBL:
Gene Tree for KRTAP26-1 (if available)
TreeFam:
Gene Tree for KRTAP26-1 (if available)

Paralogs for KRTAP26-1 Gene

No data available for Paralogs for KRTAP26-1 Gene

Variants for KRTAP26-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP26-1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs1000331720 -- 30,320,624(+) GATTT(C/G)CTTTA upstream-variant-2KB
rs1001072724 -- 30,321,010(+) GGAGC(A/T)TCTAA upstream-variant-2KB
rs1001073324 -- 30,321,974(+) AGTAG(A/T)TCTTA upstream-variant-2KB
rs1001261960 -- 30,318,767(+) TATTT(A/G)TCTTA downstream-variant-500B
rs1002273912 -- 30,321,963(+) CAATT(C/T)TATAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP26-1 Gene

Variant ID Type Subtype PubMed ID
nsv1057467 CNV gain 25217958
nsv1059954 CNV loss 25217958
nsv587354 CNV gain 21841781
nsv834076 CNV gain 17160897

Variation tolerance for KRTAP26-1 Gene

Residual Variation Intolerance Score: 80.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.64; 78.31% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTAP26-1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
KRTAP26-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP26-1 Gene

Disorders for KRTAP26-1 Gene

Relevant External Links for KRTAP26-1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP26-1

No disorders were found for KRTAP26-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP26-1 Gene

Publications for KRTAP26-1 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Widespread macromolecular interaction perturbations in human genetic disorders. (PMID: 25910212) Sahni N. … Vidal M. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Host-pathogen interactome mapping for HTLV-1 and -2 retroviruses. (PMID: 22458338) Simonis N. … Twizere J.C. (Retrovirology 2012) 3 64
  5. Protein interactions of the transcription factor Hoxa1. (PMID: 23088713) Lambert B. … Rezsohazy R. (BMC Dev. Biol. 2012) 3 64

Products for KRTAP26-1 Gene

Sources for KRTAP26-1 Gene

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