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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

KRTAP26-1 Gene

protein-coding   GIFtS: 36
GCID: GC21M031691

Keratin Associated Protein 26-1

  Search for KRTAP26-1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Keratin Associated Protein 26-11 2
Keratin-Associated Protein 26-12
KAP26.13

External Ids:    HGNC: 337601   Entrez Gene: 3888182   Ensembl: ENSG000001976837   UniProtKB: Q6PEX33   

Export aliases for KRTAP26-1 gene to outside databases

Previous GC identifers: GC21M030614 GC21M017100


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for KRTAP26-1 Gene: 
KRTAP26-1 (keratin associated protein 26-1) is a protein-coding gene. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: KR261_HUMAN, Q6PEX3
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,
consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and
resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair
keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000021.8  NC_018932.2  NT_011512.11  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for KRTAP26-1
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidKRTAP26-1 promoter sequence
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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat KRTAP26-1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 21q22.11   Ensembl cytogenetic band:  21q22.11   HGNC cytogenetic band: 21q22.11

KRTAP26-1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
KRTAP26-1 gene location

GeneLoc information about chromosome 21         GeneLoc Exon Structure

GeneLoc location for GC21M031691:  view genomic region     (about GC identifiers)

Start:
31,691,449 bp from pter      End:
31,692,607 bp from pter
Size:
1,159 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
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About This Section

UniProtKB/Swiss-Prot: KR261_HUMAN, Q6PEX3 (See protein sequence)
Recommended Name: Keratin-associated protein 26-1  
Size: 210 amino acids; 22554 Da
Subunit: Interacts with hair keratins
Secondary accessions: B0RZD3

Explore the universe of human proteins at neXtProt for KRTAP26-1: NX_Q6PEX3

Explore proteomics data for KRTAP26-1 at MOPED 

KRTAP26-1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

KRTAP26-1 Protein Expression

REFSEQ proteins: NP_981950.1  
ENSEMBL proteins: 
 ENSP00000353742  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005882intermediate filament IEA--

KRTAP26-1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
KRTAP: Keratin associated proteins

1 InterPro protein domain:
 IPR007951 PMG

Graphical View of Domain Structure for InterPro Entry Q6PEX3

ProtoNet protein and cluster: Q6PEX3

UniProtKB/Swiss-Prot: KR261_HUMAN, Q6PEX3
Similarity: Belongs to the PMG family


KRTAP26-1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: KR261_HUMAN, Q6PEX3
Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix,
consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and
resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair
keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding IPI--
     
KRTAP26-1 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for KRTAP26-1

1 Interacting protein for KRTAP26-1 (Q6PEX31) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
Hoxa1P090221EBI-3957672,EBI-3957603
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for KRTAP26-1 (KR261)

Search CenterWatch for drugs/clinical trials and news about KRTAP26-1 / KR261

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for KRTAP26-1 gene: 
NM_203405.1  

Unigene Cluster for KRTAP26-1:

Keratin associated protein 26-1
Hs.28704  [show with all ESTs]
Unigene Representative Sequence: BC057825
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000360542(uc002ynw.3)
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Additional mRNA sequence: 

AB096936.1 AM941740.1 BC057825.1 

1 DOTS entry:

DT.101964923 

14 AceView cDNA sequences:

BX397981 CR602838 NM_203405 BX111456 H55746 CB996254 CB994995 CD109407 
BC057825 R67568 CD110079 R66691 R66219 BX389687 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

KRTAP26-1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TTTTATCTTG
KRTAP26-1 Expression
About this image


See KRTAP26-1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for KRTAP26-1

SOURCE GeneReport for Unigene cluster: Hs.28704

UniProtKB/Swiss-Prot: KR261_HUMAN, Q6PEX3
Tissue specificity: Localized high up in the well differentiated portion of the hair follicle cuticle (about 10-15
cell layers above the apex of the dermal papilla)

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for KRTAP26-1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for KRTAP26-1 gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Krtap26-11 , 5 keratin associated protein 26-11, 5 69.9(n)1
56.8(a)1
  16 (51.39 cM)5
695331  NM_027105.21  NP_081381.11 
 886468245 


ENSEMBL Gene Tree for KRTAP26-1 (if available)
TreeFam Gene Tree for KRTAP26-1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/110 SNPs in KRTAP26-1 are shown (see all 110)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 21 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs24093671,2
C,F,H--31691208(+) ATCACT/CCCTAA 1 -- int18Minor allele frequency- C:0.09NS EA CSA WA NA 655
rs22266421,2
C,F,H--31691226(+) TTTTCA/CAAACA 1 -- int18Minor allele frequency- C:0.03EA NS CSA WA NA 2139
rs1921013911,2
--31691252(+) TTTTGC/GGTCTC 1 -- int10--------
rs1831868921,2
--31691271(+) ATAGGA/GTCAGA 1 -- int10--------
rs1876336221,2
--31691318(+) AATCCA/CTCTAC 1 -- int10--------
rs1481775431,2
--31691339(+) GAATAC/TATGGT 1 -- int10--------
rs1419442401,2
--31691363(+) TCCAGA/CTCAGT 1 -- int10--------
rs22125051,2
C,F,A,H--31691388(+) TTGACG/ATTGGT 1 -- int112Minor allele frequency- A:0.08NS EA NA CSA WA 792
rs1921535781,2
--31691564(+) AACAAA/GATAAA 1 -- ut310--------
rs22364271,2
C,F,H--31691571(+) TAAAAC/AATGCG 1 -- ut3133Minor allele frequency- A:0.42EA NA NS WA 4837

HapMap Linkage Disequilibrium report for KRTAP26-1 (31691449 - 31692607 bp)

Structural Variations
     Database of Genomic Variants (DGV) 1 variation for KRTAP26-1:    About this table     
Variant IDTypeSubtypePubMed ID
nsv834076CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for KRTAP26-1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with KRTAP26-1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  2. Protein interactions of the transcription factor Hoxa1 . (PubMed id 23088713)1 Lambert B....Rezsohazy R. (2012)
  3. Characterization and expression analysis of the hair keratin associated protein KAP26.1. (PubMed id 18647308)2 Rogers M.A.... Giehl K. (2008)
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
  7. Isolation and characterization of genomic clones of human sequences presumably coding for hair cysteine-rich proteins. (PubMed id 9049802)9 Emonet N....Dhouailly D. (1997)
  8. Hard alpha-keratin degradation inside a tissue under high flux X-ray synchrotron micro-beam: a multi-scale time-resolved study. (PubMed id 19925868)9 Leccia E....Briki F. (2010)
  9. Structure and functions of keratin proteins in simple , stratified, keratinized and cornified epithelia. (PubMed id 19422428)9 Bragulla H.H. and Homberger D.G. (2009)
  10. Molecular evolution of the keratin associated protein gene family in mammals, role in the evolution of mammalian hair. (PubMed id 18721477)9 Wu D.D....Zhang Y.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 388818 HGNC: 33760 AceView: LOC388818 Ensembl:ENSG00000197683 euGenes: HUgn388818
ECgene: KRTAP26-1 H-InvDB: KRTAP26-1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for KRTAP26-1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for KRTAP26-1 gene:
Search GeneIP for patents involving KRTAP26-1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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