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Aliases for KRTAP25-1 Gene

Aliases for KRTAP25-1 Gene

  • Keratin Associated Protein 25-1 2 3 5
  • KAP25.1 3 4

External Ids for KRTAP25-1 Gene

Previous GeneCards Identifiers for KRTAP25-1 Gene

  • GC21U900252
  • GC21M030584
  • GC21M031661
  • GC21M017070

Summaries for KRTAP25-1 Gene

GeneCards Summary for KRTAP25-1 Gene

KRTAP25-1 (Keratin Associated Protein 25-1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP25-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP25-1 Gene

Genomics for KRTAP25-1 Gene

Regulatory Elements for KRTAP25-1 Gene

Enhancers for KRTAP25-1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around KRTAP25-1 on UCSC Golden Path with GeneCards custom track

Genomic Location for KRTAP25-1 Gene

Chromosome:
21
Start:
30,289,145 bp from pter
End:
30,289,514 bp from pter
Size:
370 bases
Orientation:
Minus strand

Genomic View for KRTAP25-1 Gene

Genes around KRTAP25-1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
KRTAP25-1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for KRTAP25-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP25-1 Gene

Proteins for KRTAP25-1 Gene

  • Protein details for KRTAP25-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LHN0-KR251_HUMAN
    Recommended name:
    Keratin-associated protein 25-1
    Protein Accession:
    Q3LHN0

    Protein attributes for KRTAP25-1 Gene

    Size:
    102 amino acids
    Molecular mass:
    11738 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP25-1 Gene

Proteomics data for KRTAP25-1 Gene at MOPED

Post-translational modifications for KRTAP25-1 Gene

No Post-translational modifications

Other Protein References for KRTAP25-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP25-1 Gene

Domains & Families for KRTAP25-1 Gene

Gene Families for KRTAP25-1 Gene

Protein Domains for KRTAP25-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP25-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LHN0

UniProtKB/Swiss-Prot:

KR251_HUMAN :
  • Belongs to the PMG family.
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP25-1: view

Function for KRTAP25-1 Gene

Molecular function for KRTAP25-1 Gene

UniProtKB/Swiss-Prot Function:
In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

Phenotypes for KRTAP25-1 Gene

GenomeRNAi human phenotypes for KRTAP25-1:
genes like me logo Genes that share phenotypes with KRTAP25-1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for KRTAP25-1 Gene

Localization for KRTAP25-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP25-1 Gene COMPARTMENTS Subcellular localization image for KRTAP25-1 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
extracellular 2
nucleus 2
plasma membrane 2
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for KRTAP25-1 Gene

Pathways & Interactions for KRTAP25-1 Gene

SuperPathways for KRTAP25-1 Gene

No Data Available

Interacting Proteins for KRTAP25-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP25-1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for KRTAP25-1 Gene

Drugs & Compounds for KRTAP25-1 Gene

No Compound Related Data Available

Transcripts for KRTAP25-1 Gene

mRNA/cDNA for KRTAP25-1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP25-1 Gene

No ASD Table

Relevant External Links for KRTAP25-1 Gene

GeneLoc Exon Structure for
KRTAP25-1
ECgene alternative splicing isoforms for
KRTAP25-1

Expression for KRTAP25-1 Gene

mRNA expression in normal human tissues for KRTAP25-1 Gene

SOURCE GeneReport for Unigene cluster for KRTAP25-1 Gene Hs.580882

genes like me logo Genes that share expression patterns with KRTAP25-1: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for KRTAP25-1 Gene

Orthologs for KRTAP25-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP25-1 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia LOC102153645 35
  • 73.2 (n)
  • 51.96 (a)
KRTAP25-1 36
  • 25 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100613330 35
  • 98.37 (n)
  • 97.06 (a)
KRTAP25-1 36
  • 97 (a)
OneToOne
Species with no ortholog for KRTAP25-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP25-1 Gene

ENSEMBL:
Gene Tree for KRTAP25-1 (if available)
TreeFam:
Gene Tree for KRTAP25-1 (if available)

Paralogs for KRTAP25-1 Gene

No data available for Paralogs for KRTAP25-1 Gene

Variants for KRTAP25-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP25-1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type
rs8127420 - 30,289,373(+) CCTGG(A/G)CACAA reference, missense
rs2832759 -- 30,289,335(+) TGATT(A/G)CCATA reference, synonymous-codon
rs2832760 -- 30,289,834(+) TGAAG(G/T)AAGGC upstream-variant-2KB
rs2832761 -- 30,290,101(+) AATGT(A/G)TGTGA upstream-variant-2KB
rs11910854 -- 30,288,704(+) TAATT(C/T)TCTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KRTAP25-1 Gene

Variant ID Type Subtype PubMed ID
nsv834076 CNV Gain 17160897

Variation tolerance for KRTAP25-1 Gene

Gene Damage Index Score: 0.34; 7.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for KRTAP25-1 Gene

HapMap Linkage Disequilibrium report
KRTAP25-1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP25-1 Gene

Disorders for KRTAP25-1 Gene

Relevant External Links for KRTAP25-1

Genetic Association Database (GAD)
KRTAP25-1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
KRTAP25-1

No disorders were found for KRTAP25-1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for KRTAP25-1 Gene

Publications for KRTAP25-1 Gene

  1. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PMID: 17903306) Newton-Cheh C. … Larson M.G. (BMC Med. Genet. 2007) 48 67
  2. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3

Products for KRTAP25-1 Gene

Sources for KRTAP25-1 Gene

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