Free for academic non-profit institutions. Other users need a Commercial license

Aliases for KRTAP25-1 Gene

Aliases for KRTAP25-1 Gene

  • Keratin Associated Protein 25-1 2 3
  • KAP25.1 3 4
  • Keratin-Associated Protein 25-1 3

External Ids for KRTAP25-1 Gene

Summaries for KRTAP25-1 Gene

GeneCards Summary for KRTAP25-1 Gene

KRTAP25-1 (Keratin Associated Protein 25-1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP25-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP25-1 Gene

Genomics for KRTAP25-1 Gene

Genomic Location for KRTAP25-1 Gene

Start:
30,289,145 bp from pter
End:
30,289,514 bp from pter
Size:
370 bases
Orientation:
Minus strand

Genomic View for KRTAP25-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP25-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP25-1 Gene

No data available for Regulatory Elements for KRTAP25-1 Gene

Proteins for KRTAP25-1 Gene

  • Protein details for KRTAP25-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LHN0-KR251_HUMAN
    Recommended name:
    Keratin-associated protein 25-1
    Protein Accession:
    Q3LHN0
    Secondary Accessions:

    Protein attributes for KRTAP25-1 Gene

    Size:
    102 amino acids
    Molecular mass:
    11738 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP25-1 Gene

Proteomics data for KRTAP25-1 Gene at MOPED

Post-translational modifications for KRTAP25-1 Gene

No Post-translational modifications

Other Protein References for KRTAP25-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP25-1 Gene

Domains for KRTAP25-1 Gene

Gene Families for KRTAP25-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP25-1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KR251_HUMAN
Family:
  • Belongs to the PMG family.:
    • Q3LHN0
genes like me logo Genes that share domains with KRTAP25-1: view

Function for KRTAP25-1 Gene

Molecular function for KRTAP25-1 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP25-1 Gene

Localization for KRTAP25-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP25-1 Gene COMPARTMENTS Subcellular localization image for KRTAP25-1 gene
Compartment Confidence
cytoskeleton 3
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KRTAP25-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP25-1: view

Pathways for KRTAP25-1 Gene

SuperPathways for KRTAP25-1 Gene

No Data Available

Interacting Proteins for KRTAP25-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP25-1 Gene

None

No data available for Pathways by source for KRTAP25-1 Gene

Transcripts for KRTAP25-1 Gene

mRNA/cDNA for KRTAP25-1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP25-1 Gene

No ASD Table

Relevant External Links for KRTAP25-1 Gene

GeneLoc Exon Structure for
KRTAP25-1
ECgene alternative splicing isoforms for
KRTAP25-1

Expression for KRTAP25-1 Gene

mRNA expression in normal human tissues for KRTAP25-1 Gene

SOURCE GeneReport for Unigene cluster for KRTAP25-1 Gene Hs.580882

genes like me logo Genes that share expressions with KRTAP25-1: view

Orthologs for KRTAP25-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP25-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP25-1 37
  • 97 (a)
OneToOne
LOC100613330 36
  • 98.37 (n)
  • 97.06 (a)
dog
(Canis familiaris)
Mammalia KRTAP25-1 37
  • 25 (a)
OneToOne
LOC102153645 36
  • 73.2 (n)
  • 51.96 (a)
Species with no ortholog for KRTAP25-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP25-1 Gene

ENSEMBL:
Gene Tree for KRTAP25-1 (if available)
TreeFam:
Gene Tree for KRTAP25-1 (if available)

Paralogs for KRTAP25-1 Gene

No data available for Paralogs for KRTAP25-1 Gene

Variants for KRTAP25-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP25-1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs2832759 -- 30,289,335(+) TGATT(A/G)CCATA synonymous-codon, reference
rs2832760 -- 30,289,834(+) TGAAG(G/T)AAGGC upstream-variant-2KB
rs2832761 -- 30,290,101(+) AATGT(A/G)TGTGA upstream-variant-2KB
rs8127420 - 30,289,373(+) CCTGG(A/G)CACAA missense, reference
rs9979163 -- 30,291,470(+) ACAGA(A/G)GAGAT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for KRTAP25-1 Gene

Variant ID Type Subtype PubMed ID
nsv834076 CNV Gain 17160897

Relevant External Links for KRTAP25-1 Gene

HapMap Linkage Disequilibrium report
KRTAP25-1

Disorders for KRTAP25-1 Gene

Relevant External Links for KRTAP25-1

Genetic Association Database (GAD)
KRTAP25-1
genes like me logo Genes that share disorders with KRTAP25-1: view

No data available for UniProtKB/Swiss-Prot for KRTAP25-1 Gene

Publications for KRTAP25-1 Gene

  1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3
  2. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PMID: 17903306) Newton-Cheh C. … Larson M.G. (BMC Med. Genet. 2007) 49

Products for KRTAP25-1 Gene

Sources for KRTAP25-1 Gene

Back to Top

Content