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Aliases for KRTAP25-1 Gene

Aliases for KRTAP25-1 Gene

  • Keratin Associated Protein 25-1 2 3
  • KAP25.1 3 4
  • Keratin-Associated Protein 25-1 3

External Ids for KRTAP25-1 Gene

Previous GeneCards Identifiers for KRTAP25-1 Gene

  • GC21U900252
  • GC21M030584
  • GC21M031661
  • GC21M017070

Summaries for KRTAP25-1 Gene

GeneCards Summary for KRTAP25-1 Gene

KRTAP25-1 (Keratin Associated Protein 25-1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP25-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP25-1 Gene

Genomics for KRTAP25-1 Gene

Genomic Location for KRTAP25-1 Gene

Start:
30,289,145 bp from pter
End:
30,289,514 bp from pter
Size:
370 bases
Orientation:
Minus strand

Genomic View for KRTAP25-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP25-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP25-1 Gene

No data available for Regulatory Elements for KRTAP25-1 Gene

Proteins for KRTAP25-1 Gene

  • Protein details for KRTAP25-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LHN0-KR251_HUMAN
    Recommended name:
    Keratin-associated protein 25-1
    Protein Accession:
    Q3LHN0
    Secondary Accessions:

    Protein attributes for KRTAP25-1 Gene

    Size:
    102 amino acids
    Molecular mass:
    11738 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP25-1 Gene

Proteomics data for KRTAP25-1 Gene at MOPED

Post-translational modifications for KRTAP25-1 Gene

No Post-translational modifications

Other Protein References for KRTAP25-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP25-1 Gene

Domains for KRTAP25-1 Gene

Gene Families for KRTAP25-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP25-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP25-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3LHN0

UniProtKB/Swiss-Prot:

KR251_HUMAN :
  • Q3LHN0
Family:
  • Belongs to the PMG family.
genes like me logo Genes that share domains with KRTAP25-1: view

Function for KRTAP25-1 Gene

Molecular function for KRTAP25-1 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP25-1 Gene

Localization for KRTAP25-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP25-1 Gene COMPARTMENTS Subcellular localization image for KRTAP25-1 gene
Compartment Confidence
cytoskeleton 3
extracellular 2
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for KRTAP25-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP25-1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP25-1 Gene

Pathways for KRTAP25-1 Gene

SuperPathways for KRTAP25-1 Gene

No Data Available

Interacting Proteins for KRTAP25-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP25-1 Gene

None

No data available for Pathways by source for KRTAP25-1 Gene

Transcripts for KRTAP25-1 Gene

mRNA/cDNA for KRTAP25-1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP25-1
    • Block miRNA regulation of KRTAP25-1 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP25-1

    Primer Products

    • OriGene qSTAR qPCR primer pairs in human,mouse,rat for KRTAP25-1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat

    Flow Cytometry Products

    Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP25-1 Gene

    No ASD Table

    Relevant External Links for KRTAP25-1 Gene

    GeneLoc Exon Structure for
    KRTAP25-1
    ECgene alternative splicing isoforms for
    KRTAP25-1

    Expression for KRTAP25-1 Gene

    mRNA expression in normal human tissues for KRTAP25-1 Gene

    SOURCE GeneReport for Unigene cluster for KRTAP25-1 Gene Hs.580882

    genes like me logo Genes that share expressions with KRTAP25-1: view

    In Situ Assay Products

    No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for KRTAP25-1 Gene

    Orthologs for KRTAP25-1 Gene

    This gene was present in the common ancestor of mammals.

    Orthologs for KRTAP25-1 Gene

    Organism Taxonomy Gene Similarity Type Details
    chimpanzee
    (Pan troglodytes)
    Mammalia KRTAP25-1 36
    • 97 (a)
    OneToOne
    LOC100613330 35
    • 98.37 (n)
    • 97.06 (a)
    dog
    (Canis familiaris)
    Mammalia KRTAP25-1 36
    • 25 (a)
    OneToOne
    LOC102153645 35
    • 73.2 (n)
    • 51.96 (a)
    Species with no ortholog for KRTAP25-1:
    • A. gosspyii yeast (Ashbya gossypii)
    • Actinobacteria (Mycobacterium tuberculosis)
    • African clawed frog (Xenopus laevis)
    • African malaria mosquito (Anopheles gambiae)
    • Alicante grape (Vitis vinifera)
    • alpha proteobacteria (Wolbachia pipientis)
    • amoeba (Dictyostelium discoideum)
    • Archea (Pyrococcus horikoshii)
    • baker's yeast (Saccharomyces cerevisiae)
    • barley (Hordeum vulgare)
    • beta proteobacteria (Neisseria meningitidis)
    • bread mold (Neurospora crassa)
    • chicken (Gallus gallus)
    • Chromalveolata (Phytophthora infestans)
    • common water flea (Daphnia pulex)
    • corn (Zea mays)
    • cow (Bos Taurus)
    • E. coli (Escherichia coli)
    • filamentous fungi (Aspergillus nidulans)
    • Firmicute bacteria (Streptococcus pneumoniae)
    • fission yeast (Schizosaccharomyces pombe)
    • fruit fly (Drosophila melanogaster)
    • green algae (Chlamydomonas reinhardtii)
    • honey bee (Apis mellifera)
    • K. lactis yeast (Kluyveromyces lactis)
    • lizard (Anolis carolinensis)
    • loblloly pine (Pinus taeda)
    • malaria parasite (Plasmodium falciparum)
    • medicago trunc (Medicago Truncatula)
    • moss (Physcomitrella patens)
    • mouse (Mus musculus)
    • oppossum (Monodelphis domestica)
    • orangutan (Pongo pygmaeus)
    • pig (Sus scrofa)
    • platypus (Ornithorhynchus anatinus)
    • rainbow trout (Oncorhynchus mykiss)
    • rat (Rattus norvegicus)
    • rice (Oryza sativa)
    • rice blast fungus (Magnaporthe grisea)
    • schistosome parasite (Schistosoma mansoni)
    • sea anemone (Nematostella vectensis)
    • sea squirt (Ciona intestinalis)
    • sea squirt (Ciona savignyi)
    • sea urchin (Strongylocentrotus purpuratus)
    • sorghum (Sorghum bicolor)
    • soybean (Glycine max)
    • stem rust fungus (Puccinia graminis)
    • sugarcane (Saccharum officinarum)
    • thale cress (Arabidopsis thaliana)
    • tomato (Lycopersicon esculentum)
    • toxoplasmosis (Toxoplasma gondii)
    • Trichoplax (Trichoplax adhaerens)
    • tropical clawed frog (Silurana tropicalis)
    • wheat (Triticum aestivum)
    • worm (Caenorhabditis elegans)
    • zebrafish (Danio rerio)

    Evolution for KRTAP25-1 Gene

    ENSEMBL:
    Gene Tree for KRTAP25-1 (if available)
    TreeFam:
    Gene Tree for KRTAP25-1 (if available)

    Paralogs for KRTAP25-1 Gene

    No data available for Paralogs for KRTAP25-1 Gene

    Variants for KRTAP25-1 Gene

    Sequence variations from dbSNP and Humsavar for KRTAP25-1 Gene

    SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
    rs2832759 -- 30,289,335(+) TGATT(A/G)CCATA synonymous-codon, reference
    rs2832760 -- 30,289,834(+) TGAAG(G/T)AAGGC upstream-variant-2KB
    rs2832761 -- 30,290,101(+) AATGT(A/G)TGTGA upstream-variant-2KB
    rs8127420 - 30,289,373(+) CCTGG(A/G)CACAA missense, reference
    rs9979163 -- 30,291,470(+) ACAGA(A/G)GAGAT upstream-variant-2KB

    Structural Variations from Database of Genomic Variants (DGV) for KRTAP25-1 Gene

    Variant ID Type Subtype PubMed ID
    nsv834076 CNV Gain 17160897

    Relevant External Links for KRTAP25-1 Gene

    HapMap Linkage Disequilibrium report
    KRTAP25-1

    No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP25-1 Gene

    Disorders for KRTAP25-1 Gene

    Relevant External Links for KRTAP25-1

    Genetic Association Database (GAD)
    KRTAP25-1
    genes like me logo Genes that share disorders with KRTAP25-1: view

    No data available for UniProtKB/Swiss-Prot for KRTAP25-1 Gene

    Publications for KRTAP25-1 Gene

    1. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 3
    2. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PMID: 17903306) Newton-Cheh C. … Larson M.G. (BMC Med. Genet. 2007) 48

    Products for KRTAP25-1 Gene

    Sources for KRTAP25-1 Gene

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