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Aliases for KRTAP24-1 Gene

Aliases for KRTAP24-1 Gene

  • Keratin Associated Protein 24-1 2 3
  • KAP24.1 3 4
  • Keratin-Associated Protein 24-1 3

External Ids for KRTAP24-1 Gene

Summaries for KRTAP24-1 Gene

GeneCards Summary for KRTAP24-1 Gene

KRTAP24-1 (Keratin Associated Protein 24-1) is a Protein Coding gene. GO annotations related to this gene include structural molecule activity.

UniProtKB/Swiss-Prot for KRTAP24-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP24-1 Gene

Genomics for KRTAP24-1 Gene

Genomic Location for KRTAP24-1 Gene

Start:
30,281,309 bp from pter
End:
30,282,958 bp from pter
Size:
1,650 bases
Orientation:
Minus strand

Genomic View for KRTAP24-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP24-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP24-1 Gene

Regulatory Elements for KRTAP24-1 Gene

Proteins for KRTAP24-1 Gene

  • Protein details for KRTAP24-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI83-KR241_HUMAN
    Recommended name:
    Keratin-associated protein 24-1
    Protein Accession:
    Q3LI83
    Secondary Accessions:
    • Q1XDX0

    Protein attributes for KRTAP24-1 Gene

    Size:
    254 amino acids
    Molecular mass:
    27719 Da
    Quaternary structure:
    • Interacts with hair keratins.
    Miscellaneous:
    • Has a low cysteine content when compared to the majority of known KAP family members. Possesses several C-terminal tyrosine-containing tandem decameric repeat structures

neXtProt entry for KRTAP24-1 Gene

Proteomics data for KRTAP24-1 Gene at MOPED

Post-translational modifications for KRTAP24-1 Gene

No Post-translational modifications

Other Protein References for KRTAP24-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP24-1 Gene

Domains for KRTAP24-1 Gene

Gene Families for KRTAP24-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP24-1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

KR241_HUMAN
Family:
  • Belongs to the PMG family.:
    • Q3LI83
genes like me logo Genes that share domains with KRTAP24-1: view

Function for KRTAP24-1 Gene

Molecular function for KRTAP24-1 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Gene Ontology (GO) - Molecular Function for KRTAP24-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005198 structural molecule activity IEA --
genes like me logo Genes that share ontologies with KRTAP24-1: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP24-1 Gene

Localization for KRTAP24-1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP24-1 Gene COMPARTMENTS Subcellular localization image for KRTAP24-1 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
nucleus 2
extracellular 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for KRTAP24-1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045095 keratin filament IEA --
genes like me logo Genes that share ontologies with KRTAP24-1: view

Pathways for KRTAP24-1 Gene

SuperPathways for KRTAP24-1 Gene

No Data Available

Interacting Proteins for KRTAP24-1 Gene

Gene Ontology (GO) - Biological Process for KRTAP24-1 Gene

None

No data available for Pathways by source for KRTAP24-1 Gene

Transcripts for KRTAP24-1 Gene

mRNA/cDNA for KRTAP24-1 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP24-1 Gene

No ASD Table

Relevant External Links for KRTAP24-1 Gene

GeneLoc Exon Structure for
KRTAP24-1
ECgene alternative splicing isoforms for
KRTAP24-1

Expression for KRTAP24-1 Gene

mRNA expression in normal human tissues for KRTAP24-1 Gene

mRNA differential expression in normal tissues according to GTEx for KRTAP24-1 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (46.1) and Skin - Sun Exposed (Lower leg) (5.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for KRTAP24-1 Gene

SOURCE GeneReport for Unigene cluster for KRTAP24-1 Gene Hs.580883

mRNA Expression by UniProt/SwissProt for KRTAP24-1 Gene

Q3LI83-KR241_HUMAN
Tissue specificity: Specific expression in the middle/upper hair cuticle.
genes like me logo Genes that share expressions with KRTAP24-1: view

Orthologs for KRTAP24-1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for KRTAP24-1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP24-1 36
  • 98.29 (n)
  • 95.67 (a)
KRTAP24-1 37
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia KRTAP24-1 36
  • 79.13 (n)
  • 67.07 (a)
KRTAP24-1 37
  • 63 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KRTAP24-1 36
  • 81.16 (n)
  • 68.38 (a)
KRTAP24-1 37
  • 68 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Krtap24-1 36
  • 70.7 (n)
  • 60.48 (a)
Krtap24-1 16
Krtap24-1 37
  • 60 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Krtap24-1 36
  • 70.97 (n)
  • 58.06 (a)
Species with no ortholog for KRTAP24-1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP24-1 Gene

ENSEMBL:
Gene Tree for KRTAP24-1 (if available)
TreeFam:
Gene Tree for KRTAP24-1 (if available)

Paralogs for KRTAP24-1 Gene

No data available for Paralogs for KRTAP24-1 Gene

Variants for KRTAP24-1 Gene

Sequence variations from dbSNP and Humsavar for KRTAP24-1 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs1012964 -- 30,284,372(+) ATTCT(A/G)TATTA upstream-variant-2KB
rs1557291 -- 30,282,894(+) CAGAC(A/C)CCAGG reference, synonymous-codon
rs1557292 -- 30,283,078(+) GCCAC(A/G)GAGGC upstream-variant-2KB
rs2832752 -- 30,281,816(+) GGTAG(C/G)TGATA utr-variant-3-prime
rs2832753 -- 30,282,130(+) CCCCA(C/T)TGGGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for KRTAP24-1 Gene

Variant ID Type Subtype PubMed ID
nsv834076 CNV Gain 17160897

Relevant External Links for KRTAP24-1 Gene

HapMap Linkage Disequilibrium report
KRTAP24-1

Disorders for KRTAP24-1 Gene

No disorders were found for KRTAP24-1 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP24-1 Gene

Publications for KRTAP24-1 Gene

  1. Characterization of human KAP24.1, a cuticular hair keratin- associated protein with unusual amino-acid composition and repeat structure. (PMID: 17235325) Rogers M.A. … Schweizer J. (J. Invest. Dermatol. 2007) 3 4
  2. Human hair keratin-associated proteins (KAPs). (PMID: 16939781) Rogers M.A. … Schweizer J. (Int. Rev. Cytol. 2006) 3

Products for KRTAP24-1 Gene

  • antibodies-online peptides for KRTAP24-1
  • antibodies-online antibodies for KRTAP24-1
  • antibodies-online kits for KRTAP24-1

Sources for KRTAP24-1 Gene

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