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Aliases for KRTAP22-2 Gene

Aliases for KRTAP22-2 Gene

  • Keratin Associated Protein 22-2 2 3
  • KAP22.2 3 4
  • Keratin-Associated Protein 22-2 3

External Ids for KRTAP22-2 Gene

Summaries for KRTAP22-2 Gene

GeneCards Summary for KRTAP22-2 Gene

KRTAP22-2 (Keratin Associated Protein 22-2) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP22-2 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP22-2 Gene

Genomics for KRTAP22-2 Gene

Genomic Location for KRTAP22-2 Gene

Start:
30,590,105 bp from pter
End:
30,590,397 bp from pter
Size:
293 bases
Orientation:
Minus strand

Genomic View for KRTAP22-2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP22-2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP22-2 Gene

No data available for Regulatory Elements for KRTAP22-2 Gene

Proteins for KRTAP22-2 Gene

  • Protein details for KRTAP22-2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3LI68-KR222_HUMAN
    Recommended name:
    Keratin-associated protein 22-2
    Protein Accession:
    Q3LI68
    Secondary Accessions:

    Protein attributes for KRTAP22-2 Gene

    Size:
    45 amino acids
    Molecular mass:
    5218 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP22-2 Gene

Proteomics data for KRTAP22-2 Gene at MOPED

Post-translational modifications for KRTAP22-2 Gene

No Post-translational modifications

Other Protein References for KRTAP22-2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP22-2 Gene

Domains for KRTAP22-2 Gene

Gene Families for KRTAP22-2 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP22-2 Gene

ProtoNet:

UniProtKB/Swiss-Prot:

KR222_HUMAN
Family:
  • Belongs to the KRTAP type 20 family.:
    • Q3LI68
genes like me logo Genes that share domains with KRTAP22-2: view

Function for KRTAP22-2 Gene

Molecular function for KRTAP22-2 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity).

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP22-2 Gene

Localization for KRTAP22-2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for KRTAP22-2 Gene COMPARTMENTS Subcellular localization image for KRTAP22-2 gene
Compartment Confidence
cytoskeleton 3
cytosol 2
extracellular 2
nucleus 1

Gene Ontology (GO) - Cellular Components for KRTAP22-2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005882 intermediate filament IEA --
genes like me logo Genes that share ontologies with KRTAP22-2: view

Pathways for KRTAP22-2 Gene

SuperPathways for KRTAP22-2 Gene

No Data Available

Interacting Proteins for KRTAP22-2 Gene

Gene Ontology (GO) - Biological Process for KRTAP22-2 Gene

None

No data available for Pathways by source for KRTAP22-2 Gene

Transcripts for KRTAP22-2 Gene

mRNA/cDNA for KRTAP22-2 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP22-2 Gene

No ASD Table

Relevant External Links for KRTAP22-2 Gene

GeneLoc Exon Structure for
KRTAP22-2
ECgene alternative splicing isoforms for
KRTAP22-2

Expression for KRTAP22-2 Gene

mRNA expression in normal human tissues for KRTAP22-2 Gene

SOURCE GeneReport for Unigene cluster for KRTAP22-2 Gene Hs.580880

genes like me logo Genes that share expressions with KRTAP22-2: view

Orthologs for KRTAP22-2 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for KRTAP22-2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KRTAP22-2 37
  • 100 (a)
OneToOne
Species with no ortholog for KRTAP22-2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for KRTAP22-2 Gene

ENSEMBL:
Gene Tree for KRTAP22-2 (if available)
TreeFam:
Gene Tree for KRTAP22-2 (if available)

Paralogs for KRTAP22-2 Gene

No data available for Paralogs for KRTAP22-2 Gene

Variants for KRTAP22-2 Gene

Sequence variations from dbSNP and Humsavar for KRTAP22-2 Gene

SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
rs57054126 -- 30,589,913(+) ACACA(-/CACACACACA)AATAC downstream-variant-500B
rs78392137 -- 30,590,330(+) TAGCT(A/G)CAACC reference, synonymous-codon
rs116705437 -- 30,589,832(+) GGTAG(C/G)AATTT downstream-variant-500B
rs139564657 -- 30,589,922(+) ACACA(A/G)ATGAT downstream-variant-500B
rs146289631 -- 30,589,876(+) TCTCT(C/T)TCTTT downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for KRTAP22-2 Gene

Variant ID Type Subtype PubMed ID
nsv913677 CNV Loss 21882294

Relevant External Links for KRTAP22-2 Gene

HapMap Linkage Disequilibrium report
KRTAP22-2

Disorders for KRTAP22-2 Gene

No disorders were found for KRTAP22-2 Gene.

No data available for UniProtKB/Swiss-Prot for KRTAP22-2 Gene

Publications for KRTAP22-2 Gene

No publications were found for KRTAP22-2 Gene.

Products for KRTAP22-2 Gene

Sources for KRTAP22-2 Gene

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