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Aliases for KRTAP22-1 Gene

Aliases for KRTAP22-1 Gene

  • Keratin Associated Protein 22-1 2 3
  • KAP22.1 3 4
  • Keratin-Associated Protein 22-1 3

External Ids for KRTAP22-1 Gene

Previous GeneCards Identifiers for KRTAP22-1 Gene

  • GC00U906266
  • GC21U900114
  • GC21P030893
  • GC21P030895
  • GC21P031973
  • GC21P017382

Summaries for KRTAP22-1 Gene

GeneCards Summary for KRTAP22-1 Gene

KRTAP22-1 (Keratin Associated Protein 22-1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for KRTAP22-1 Gene

  • In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for KRTAP22-1 Gene

Genomics for KRTAP22-1 Gene

Regulatory Elements for KRTAP22-1 Gene

Genomic Location for KRTAP22-1 Gene

Start:
30,601,087 bp from pter
End:
30,601,382 bp from pter
Size:
296 bases
Orientation:
Plus strand

Genomic View for KRTAP22-1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for KRTAP22-1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for KRTAP22-1 Gene

Proteins for KRTAP22-1 Gene

  • Protein details for KRTAP22-1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3MIV0-KR221_HUMAN
    Recommended name:
    Keratin-associated protein 22-1
    Protein Accession:
    Q3MIV0
    Secondary Accessions:

    Protein attributes for KRTAP22-1 Gene

    Size:
    48 amino acids
    Molecular mass:
    5275 Da
    Quaternary structure:
    • Interacts with hair keratins.

neXtProt entry for KRTAP22-1 Gene

Proteomics data for KRTAP22-1 Gene at MOPED

Post-translational modifications for KRTAP22-1 Gene

No Post-translational modifications

Other Protein References for KRTAP22-1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for KRTAP22-1 Gene

Domains for KRTAP22-1 Gene

Gene Families for KRTAP22-1 Gene

HGNC:
  • KRTAP :Keratin associated proteins

Protein Domains for KRTAP22-1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for KRTAP22-1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with KRTAP22-1: view

No data available for UniProtKB/Swiss-Prot for KRTAP22-1 Gene

Function for KRTAP22-1 Gene

Molecular function for KRTAP22-1 Gene

UniProtKB/Swiss-Prot Function: In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins

Phenotypes for KRTAP22-1 Gene

GenomeRNAi human phenotypes for KRTAP22-1:
genes like me logo Genes that share phenotypes with KRTAP22-1: view

Animal Model Products

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP22-1
    • Block miRNA regulation of KRTAP22-1 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP22-1

    In Situ Assay Products

    Flow Cytometry Products

    No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for KRTAP22-1 Gene

    Localization for KRTAP22-1 Gene

    Subcellular locations from

    COMPARTMENTS
    Jensen Localization Image for KRTAP22-1 Gene COMPARTMENTS Subcellular localization image for KRTAP22-1 gene
    Compartment Confidence
    cytoskeleton 3
    extracellular 3
    cytosol 1
    mitochondrion 1
    nucleus 1

    Gene Ontology (GO) - Cellular Components for KRTAP22-1 Gene

    GO ID Qualified GO term Evidence PubMed IDs
    GO:0005882 intermediate filament IEA --
    genes like me logo Genes that share ontologies with KRTAP22-1: view

    No data available for Subcellular locations from UniProtKB/Swiss-Prot for KRTAP22-1 Gene

    Pathways for KRTAP22-1 Gene

    SuperPathways for KRTAP22-1 Gene

    No Data Available

    Interacting Proteins for KRTAP22-1 Gene

    Gene Ontology (GO) - Biological Process for KRTAP22-1 Gene

    None

    No data available for Pathways by source for KRTAP22-1 Gene

    Transcripts for KRTAP22-1 Gene

    mRNA/cDNA for KRTAP22-1 Gene

    (1) REFSEQ mRNAs :
    (1) Selected AceView cDNA sequences:
    (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

    CRISPR Products

    miRNA Products

    • QIAGEN qRT-PCR Assays for microRNAs that regulate KRTAP22-1
      • Block miRNA regulation of KRTAP22-1 using miScript Target Protectors

      Inhibitory RNA Products

      • Predesigned siRNA for gene silencing in human,mouse,rat for KRTAP22-1

      Primer Products

      • QuantiTect SYBR Green Assays in human,mouse,rat
      • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
      • QuantiFast Probe-based Assays in human,mouse,rat

      Flow Cytometry Products

      Alternative Splicing Database (ASD) splice patterns (SP) for KRTAP22-1 Gene

      No ASD Table

      Relevant External Links for KRTAP22-1 Gene

      GeneLoc Exon Structure for
      KRTAP22-1
      ECgene alternative splicing isoforms for
      KRTAP22-1

      Expression for KRTAP22-1 Gene

      mRNA expression in normal human tissues for KRTAP22-1 Gene

      SOURCE GeneReport for Unigene cluster for KRTAP22-1 Gene Hs.553700

      genes like me logo Genes that share expressions with KRTAP22-1: view

      In Situ Assay Products

      No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for KRTAP22-1 Gene

      Orthologs for KRTAP22-1 Gene

      This gene was present in the common ancestor of human and chimp.

      Orthologs for KRTAP22-1 Gene

      Organism Taxonomy Gene Similarity Type Details
      chimpanzee
      (Pan troglodytes)
      Mammalia KRTAP22-1 36
      • 98 (a)
      OneToOne
      Species with no ortholog for KRTAP22-1:
      • A. gosspyii yeast (Ashbya gossypii)
      • Actinobacteria (Mycobacterium tuberculosis)
      • African clawed frog (Xenopus laevis)
      • African malaria mosquito (Anopheles gambiae)
      • Alicante grape (Vitis vinifera)
      • alpha proteobacteria (Wolbachia pipientis)
      • amoeba (Dictyostelium discoideum)
      • Archea (Pyrococcus horikoshii)
      • baker's yeast (Saccharomyces cerevisiae)
      • barley (Hordeum vulgare)
      • beta proteobacteria (Neisseria meningitidis)
      • bread mold (Neurospora crassa)
      • chicken (Gallus gallus)
      • Chromalveolata (Phytophthora infestans)
      • common water flea (Daphnia pulex)
      • corn (Zea mays)
      • cow (Bos Taurus)
      • dog (Canis familiaris)
      • E. coli (Escherichia coli)
      • filamentous fungi (Aspergillus nidulans)
      • Firmicute bacteria (Streptococcus pneumoniae)
      • fission yeast (Schizosaccharomyces pombe)
      • fruit fly (Drosophila melanogaster)
      • green algae (Chlamydomonas reinhardtii)
      • honey bee (Apis mellifera)
      • K. lactis yeast (Kluyveromyces lactis)
      • lizard (Anolis carolinensis)
      • loblloly pine (Pinus taeda)
      • malaria parasite (Plasmodium falciparum)
      • medicago trunc (Medicago Truncatula)
      • moss (Physcomitrella patens)
      • mouse (Mus musculus)
      • oppossum (Monodelphis domestica)
      • orangutan (Pongo pygmaeus)
      • pig (Sus scrofa)
      • platypus (Ornithorhynchus anatinus)
      • rainbow trout (Oncorhynchus mykiss)
      • rat (Rattus norvegicus)
      • rice (Oryza sativa)
      • rice blast fungus (Magnaporthe grisea)
      • schistosome parasite (Schistosoma mansoni)
      • sea anemone (Nematostella vectensis)
      • sea squirt (Ciona intestinalis)
      • sea squirt (Ciona savignyi)
      • sea urchin (Strongylocentrotus purpuratus)
      • sorghum (Sorghum bicolor)
      • soybean (Glycine max)
      • stem rust fungus (Puccinia graminis)
      • sugarcane (Saccharum officinarum)
      • thale cress (Arabidopsis thaliana)
      • tomato (Lycopersicon esculentum)
      • toxoplasmosis (Toxoplasma gondii)
      • Trichoplax (Trichoplax adhaerens)
      • tropical clawed frog (Silurana tropicalis)
      • wheat (Triticum aestivum)
      • worm (Caenorhabditis elegans)
      • zebrafish (Danio rerio)

      Evolution for KRTAP22-1 Gene

      ENSEMBL:
      Gene Tree for KRTAP22-1 (if available)
      TreeFam:
      Gene Tree for KRTAP22-1 (if available)

      Paralogs for KRTAP22-1 Gene

      No data available for Paralogs for KRTAP22-1 Gene

      Variants for KRTAP22-1 Gene

      Sequence variations from dbSNP and Humsavar for KRTAP22-1 Gene

      SNP ID Clin Chr 21 pos Sequence Context AA Info Type MAF
      rs198913 -- 30,601,023(+) AAGGC(C/G)CTTAT upstream-variant-2KB
      rs198914 -- 30,601,086(+) CTGAT(C/T)CTGCT upstream-variant-2KB
      rs198915 - 30,601,197(-) CGCTA(A/C/T)GACCA missense, reference
      rs198916 -- 30,601,585(+) CTAGA(C/G)TACCT downstream-variant-500B
      rs724849 - 30,601,206(-) AGCCA(C/T)AGCCG reference, missense

      Structural Variations from Database of Genomic Variants (DGV) for KRTAP22-1 Gene

      Variant ID Type Subtype PubMed ID
      nsv913677 CNV Loss 21882294

      Relevant External Links for KRTAP22-1 Gene

      HapMap Linkage Disequilibrium report
      KRTAP22-1

      No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for KRTAP22-1 Gene

      Disorders for KRTAP22-1 Gene

      No disorders were found for KRTAP22-1 Gene.

      No data available for UniProtKB/Swiss-Prot for KRTAP22-1 Gene

      Publications for KRTAP22-1 Gene

      1. Characterization of a first domain of human high glycine-tyrosine and high sulfur keratin-associated protein (KAP) genes on chromosome 21q22.1. (PMID: 12359730) Rogers M.A. … Schweizer J. (J. Biol. Chem. 2002) 2 3
      2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
      3. The DNA sequence of human chromosome 21. (PMID: 10830953) Hattori M. … Yaspo M.-L. (Nature 2000) 4
      4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

      Products for KRTAP22-1 Gene

      Sources for KRTAP22-1 Gene

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